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Results for “Splenic Neoplasms”

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At least 811 records · Page 45Linked to original sources
PubMed2006

Cutaneous metastasis of primary appendicular osteosarcoma in a dog.

A 6-year-old, neutered male Rottweiler was presented to the University of Illinois Veterinary Teaching Hospital because of a lytic bone lesion involving the distal portion of the right radius and possible pulmonary metastases on thoracic radiographs. Results of serum biochemical analysis were unremarkable. Aspiration and cytologic examination of the bone lesion indicated likely sarcoma with reactive bone. Cutaneous masses were found on the left thigh, interscapular region, and dorsal lumbar region, 4 weeks after initial presentation. Neoplastic spindle cells were found in aspirates from 2 of the masses. The neoplastic cells stained positive for alkaline phosphatase activity using cytochemistry. Re-evaluation of serum biochemical values at this time revealed a marked increase in alkaline phosphatase activity (413 U/L, reference interval 12-110 U/L) compared with the initial value (26 U/L). Due to progressive disease, the dog was euthanized and a necropsy was performed. Histologic findings included primary osteosarcoma of the distal portion of the right radius, with metastases in the lungs, spleen, left fourth and fifth ribs, soft tissue of the right medial thigh, and T1-T3/interscapular region. Cutaneous metastasis of primary appendicular osteosarcoma has been reported rarely in animals and humans. Increased serum alkaline phosphatase activity may be a potential indicator of poor prognosis for this neoplasm.

Alkaline Phosphatase↗
PubMed1981

Ultrasonic characterization of abdominal tissues via digital analysis of backscattered waveforms.

Ultrasonic waveforms backscattered from normal and abnormal livers and spleens were recorded in vivo with the aid of a high-speed data acquisition system. Frequency-domain analysis of the digitized waveforms was employed to derive values for mean spacing of ultrasonic scatterers in tissue. Amplitude-domain analysis yielded measures of mean amplitude and variance, an indication of the distribution of amplitude values. Studies indicated that cirrhotic liver is characterized by a higher mean amplitude, a broader amplitude distribution, and a larger mean scatterer spacing than normal liver. Amplitude- and frequency-domain statistics for livers with other diffuse disease processes or tumor, as well for abnormal spleens. also differed from those of normal tissues. These data give information which may not be evident from B-mode sonograms, and which appears to be related to histological features.

Computers↗
PubMed1987

Hepatic metastases: randomized, controlled comparison of detection with MR imaging and CT.

To determine the accuracy of magnetic resonance (MR) imaging relative to computed tomography (CT) in the diagnosis of liver metastases, a randomized, controlled study was conducted of 135 subjects, including 57 with cancer metastatic to the liver, 27 with benign cysts or hemangiomas, and 51 without focal liver disease. The sensitivity of MR imaging for detecting individual metastatic deposits was 64%, significantly greater than 51% for CT (P less than .001); the difference in sensitivity for identifying patients with one or more hepatic metastases was less (82% for MR imaging vs. 80% for CT). In patients without hepatic metastases, the specificity of MR imaging was 99% versus 94% for CT. Significant differences were found between individual MR pulse sequences in detection of individual lesions. The sensitivity of both T1-weighted spin-echo (SE) (64%) and inversion-recovery (IR) (65%) pulse sequences was significantly (P less than .001) greater than either the TE (echo time) 60 msec (43%) or TE 120 msec (43%) T2-weighted pulse sequences. Overall, the accuracy of a single T1-weighted (10-minute) pulse sequence was superior to that of contrast-enhanced CT.

Adrenal Gland Neoplasms↗
PubMed2000

Uncommon metastasis of a glioblastoma multiforme in liver and spleen.

A case of a glioblastoma multiforme is presented. Craniotomy was performed with total resection of the right temporal tumor. Postoperatively, the patient received adjuvant radiotherapy, but 6 months after therapy he developed severe nausea and weight loss. Recurrence of an intracranial tumor in the right temporal region with nodules in the liver and spleen were detected by CT scan. Fine-needle biopsies of the liver confirmed the diagnosis of a glioblastoma metastasis with characteristic immunohistochemical staining for glial fibrillary acidic protein. This rare case of an intracerebral glioblastoma metastasizing to liver and spleen was managed by systemic chemotherapy.

Brain Neoplasms↗
PubMed1988

Carcinogenicity testing of black pepper (Piper nigrum) using the Egyptian toad (Bufo regularis) as a quick biological test animal.

Milled black pepper (Piper nigrum) force-fed to Egyptian toads as a suspension in amphibian saline or injected subcutaneously in the dorsal lymph sac as an ethanol extract, induced primary tumours in the liver and secondary tumours in other organs (kidney and spleen). When applied to the skin of experimental animals as an ethanol extract, black pepper induced primary tumours in the liver and secondary tumours in the ileum and stomach. Tumours of the liver were diagnosed as hepatocellular carcinomas and those of the other organs as metastases of the primary liver tumours. It is speculated that one or more constituents of black pepper may be responsible for tumour induction in the organs of the Egyptian toad Bufo regularis.

Administration, Cutaneous↗
PubMedDate not supplied

Malignant fibrous histiocytoma of the spleen and chronic myelogenous leukemia. A case report.

We report a rare case of a patient with an intrasplenic malignant fibrous histiocytoma (MFH) and chronic myelogenous leukemia. The neoplasms were synchronous in their onset and evolution. The peculiarity of the primary site of the MFH, the genetic implications of multiple primary tumors in a single patient, and the controversy about the cell precursors of MFH are briefly outlined.

Adult↗
PubMed1984

Assessment of liver and spleen involvement in Hodgkin's disease.

Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accuracy: liver and spleen involvement is of particular importance in this regard. We have evaluated, in 113 consecutive patients, the accuracy of clinical parameters to detect histologically documented HD involvement by comparing hepatosplenomegaly, liver function tests, liver and spleen scan, inspection of liver and spleen surface at laparoscopy with histologic findings. Our data suggest that of all the parameters studied, laparoscopy has the highest sensitivity and specificity values (about 100%). Laparoscopy may precede laparotomy as a staging procedure in HD and may give, in patients not submitted to laparotomy whatever the reasons, very reliable information.

Adolescent↗
PubMed1983

Morphologic studies on a murine reticulum cell sarcoma (histiocytic sarcoma) of histiocytic origin and its metastases.

The M5076 tumor, a reticulum cell sarcoma of histiocytic origin that arose spontaneously in the ovary of a C57BL/6 mouse, is highly invasive and metastatic. Regardless of the site of the primary tumor, this neoplasm rapidly and preferentially metastasizes to the liver and spleen, killing the host. Numerous other organs also are involved, including the lungs and bone marrow. This tendency to metastasize to osseous tissues appears to be a characteristic of the M5076 tumor that rarely is found with other rodent neoplasms. However, these extrahepatic foci are evident only microscopically and are seen relatively late in the progression of tumor growth. We describe the sequential gross and microscopic lesions that develop in syngeneic mice during the metastatic spread of the M5076 tumor. Since viable tumor cells form small tumor colonies in most organs, we suggest that the gross pattern of metastasis, with the apparent predilection for hepatic tissue, is caused by variations in tumor cell proliferation rather than by distinctive patterns of neoplastic cell spread and entrapment.

Animals↗