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At least 811 records · Page 45Linked to original sources
PubMed1994

High concentration of soluble interleukin-2 receptors in ejaculate with low sperm motility.

The various cytokines are involved in infection and immunological reactions and thus may be involved in impairment of sperm function. The present study determined the concentrations of interleukin-1, interleukin-6 and soluble interleukin-2 receptors in ejaculates of normal donors and patients suffering from pure asthenozoospermia and patients suffering from oligoteratoasthenozoospermia. Ejaculates of patients attending the fertility clinic in Hadassah Mount Scopus Hospital, Israel, were evaluated. The patients were divided into three groups: (i) controls (n = 20), (ii) pure asthenozoospermia (n = 30), (iii) oligoteratoasthenozoospermia (n = 36). Significantly higher concentrations of soluble interleukin-2 receptors were found in the ejaculates of patients with pure asthenozoospermia 2243.1 +/- 473.6 mu/ml (mean +/- SE) as compared with controls 673.5 +/- 281.3 mu/ml (P < 0.05) and oligoteratoasthenozoospermic patients 1012.3 +/- 206.9 mu/ml (P < 0.05). Interleukin-1 and interleukin-6 concentrations were comparable in all groups studied. Our results show that human ejaculates contain interleukin-1, interleukin-6 and soluble interleukin-2 receptors. High concentrations of soluble interleukin-2 receptors in the ejaculates of asthenozoospermic patients may be related to either infectious or immunological processes.

Humans↗
PubMed2005

Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey.

BACKGROUND: The importance of estrogen in regulation of fluid absorption and sperm maturation in the rodent epididymis has been established from studies on estrogen receptor-alpha knockout mice. However, functional studies on the role of estrogen in primate epididymis have been few. The main objective of this study was therefore to extend these observations and systematically analyze the presence and function of estrogen receptors in modulating the function of the primate epididymis, using the bonnet monkey (Macaca radiata) as a model system. METHODS: A steroidal estrogen receptor (ER) antagonist, ICI 182780 (ICI), was administered to adult male bonnet monkeys via mini-osmotic pumps for a duration of 30 to 180 days. The expression of key estrogen-regulated genes (ER-alpha, Na-K ATPase alpha-1 and Aquaporin-1) was examined at specific time points. Further, the effect of ICI in modulating fluid reabsorption in efferent ductules was monitored, and critical sperm-maturation parameters were also analyzed. RESULTS: Our studies in the bonnet monkey revealed that both ER-alpha and ER-beta were expressed in all the three regions of the epididymis. We observed an increase in ER-alpha mRNA and protein in the caput of ICI-treated monkeys. Steady state mRNA levels of the water-channel protein, Aquaporin-1, was significantly lower in the caput of ICI-treated monkeys compared to controls, whereas the mRNA levels of Na-K ATPase alpha-1 remained unchanged. In vitro incubation of efferent ductules with ICI resulted in two-fold increase in tubular diameter, indicating affected fluid reabsorption capacity. Furthermore, sperm from ICI-treated monkeys were immotile. CONCLUSION: Taken together, our results point to an integral role for estrogen in modulating the functions of the bonnet monkey epididymis. This study also demonstrates possible differences in the epididymal physiology of rodents and non-human primates, and thus underscores the significance of reports such as these, that examine the physiology of non-human primates (as opposed to rodents), in an attempt to understand similar events in the human.

Absorption↗
PubMed1990

Therapeutic insemination by donor (TDI) achieves high pregnancy rates in infertile couples regardless of male motile sperm density.

Therapeutic insemination by donor (TDI) was just as successful in achieving pregnancies in couples in whom the male counterparts had subnormal motile densities as in those with normal levels. All wives in this study had an infertility factor that was corrected and remained so for at least 8 months. Thus, motile density may not be a particularly good predictor of male fertility potential.

Chi-Square Distribution↗
PubMed1983

Effect of the products of ovulation on in vitro fertilization and sperm motility in the rabbit.

Different concentrations of rabbit or bovine follicular fluid were added to a defined medium or to rabbit oestrous oviduct fluid containing 13 hours in utero incubated sperm. With increasing concentration of follicular fluid, the percentage of fertilization was progressively and significantly lower than in oestrous tubal secretions or Brackett's medium, alone or containing up to 5% of follicular fluid. Utilization of ova, with or without cumulus clot, to the fertilization media, had no significant effect on fertilization of rabbit eggs. Both kinds of follicular fluid used did inhibit the motility of capacitated sperm.

Animals↗
PubMed1999

[Surgery of varicocele: results concerning sperm motility and morphology].

STUDY OBJECTIVE: This study evaluated the changes induced by surgical treatment of varicocele on the classical parameter of the sperm count as well as the parameters of Kruger's classification. MATERIAL AND METHODS: Comparative analysis of sperm concentration, mobility and head morphology was performed on the sperm counts obtained before and 6 months after surgery in 159 infertile patients with clinical left varicocele, suspected of being the only aetiological factor for infertility. RESULTS: Sperm mobility and the percentage of spermatozoa with normal head morphology were significantly increased after treatment. The percentage of spermatozoa with normal morphology was only slightly improved, due to the absence of improvement of flagellar and intermediate segment abnormalities. Fifty-nine term pregnancies were obtained after treatment, corresponding to 41.1% of treated patients. CONCLUSION: Treatment of varicocele in infertile patients can improve sperm count and morphology parameters, particularly abnormalities of the head according to Kruger's strict criteria. The number of pregnancies observed argues in favour of the treatment of varicocele, when it constitutes the only aetiological factor for infertility.

Adult↗