Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Self Stimulation”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 811 records · Page 45Linked to original sources
PubMed1979

Free-operant and auto-titration brain self-stimulation procedures in the rat: a comparison of drug effects.

Rats were implanted with bipolar stimulating electrodes aimed at the medial forebrain bundle of the lateral hypothalamus, and trained to press a lever in one of two different procedures in order to receive electrical stimulation through the electrodes. In a free-operant procedure, each response produced a 200 msec train of electric pulses at a suprathreshold current, the intensity of which remained constant throughout the session. In an auto-titration procedure, each response produced an electrical stimulus which was initially set at a suprathreshold intensity. Every 15th response reduced the stimulation current by 3 muA. The animal could reset the current to its initial intensity at any time by pressing a second lever in the test chamber. The average current at which the animal pressed the reset lever was defined as the reinforcement threshold. Dose-response functions were determined for d- and l-amphetamine, alpha-methyltyrosine, and haloperidol. The reinforcement threshold was decreased by both d- and l-amphetamine, increased by haloperidol, and not changed by alpha-methyltyrosine. These effects on reinforcement threshold were not consistently related to the drug-induced changes in response rate in either procedure. The auto-titration procedure may be useful for distinguishing between drugs which cause nonspecific changes in the rate of ongoing behavior and those which specifically modify the reinforcement efficacy of brain stimulation.

Amphetamine↗
PubMed1999

Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine.

Typical and atypical antipsychotic agents were tested on rats responding for variable-interval electrical stimulation of the ventral tegmental area (VTA). The typical neuroleptics, chlorpromazine and haloperidol, led to prolonged depression of responding lasting at least 4 h, whereas response rates after similarly effective doses of the atypical agents, clozapine and risperidone, recovered to control levels in the same period. The role of alpha 2-adrenoceptors in producing these differences was investigated by administering clozapine together with an alpha 2-adrenoceptor agonist, clonidine, and chlorpromazine together with an alpha 2-adrenoceptor antagonist, idazoxan. The addition of clonidine extended the response-depressant activity of clozapine, resulting in prolonged depression comparable to that produced by chlorpromazine or haloperidol. Conversely, the addition of idazoxan to chlorpromazine shortened the duration of chlorpromazine's suppressant action to a level comparable to that of clozapine or risperidone. These results suggest that the brevity of clozapine's effects on operant behaviour (a feature which may be related to its reduced liability to extrapyramidal side-effects) may be a consequence of its alpha 2-adrenoceptor antagonist properties.

Adrenergic alpha-Agonists↗
PubMed1970

Circadian rhythm of brain self-stimulation behavior.

Under constant conditions of light, sound, temperature, and humidity, rats exhibited circadian rhythmicity in rate of bar-pressing with hypothalamic and septal reinforcing brain stimulation. Variations in reinforcer magnitude aflected absolute levels of operant response emission but not the frequency of the circadian rhythm. In long sessions, the time of peak responding deviated systematically from a strict 24-hour period. Such data show marked similarity to free-running rhythms of motor activity.

Animals↗
PubMed1991

Housing conditions alter the acquisition of brain self-stimulation and locomotor activity in adult rats.

Rats were implanted with stimulating electrodes in the medial forebrain bundle-lateral hypothalamus (MFB-LH). After recovery from surgery, they were assigned to one of two groups equalized for body weight. One group was housed four animals to a cage and animals in the other group were housed individually. After four weeks in these housing conditions, animals were tested during the fifth week for locomotor activity in five daily 15-min sessions, and their reactivity to handling was also measured. During the sixth and seventh weeks, animals were allowed to self-train for brain stimulation (ICSS) during daily 15-min sessions. Animals housed in groups had higher levels of locomotor activity and were less reactive to handling than were animals housed individually. When tested for the acquisition of ICSS, animals housed as a group made more responses than did animals housed individually. These results indicate that, within the time frame of a few weeks, the housing conditions of adult animals caused differences in both unconditioned behavior, such as locomotor activity, and in the acquisition of a highly reinforcing brain self-stimulation task.

Animals↗