Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “RESPIRATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 811 records · Page 45Linked to original sources
PubMed1991

Effects of respirators on performance of physical, psychomotor and cognitive tasks.

Possible work decrements caused by respirator usage were examined. A battery of physical, psychomotor and cognitive tasks was used to investigate the effects of respirator wear on 12 subjects. A repeated measures experimental design was used to study the effects of three types of respirators: a disposable dust mask; an air purifying half-mask; and a full-face airline mask. Performance while wearing a mask was compared to the control condition without a respirator. The results from the physical work task of riding a bicycle ergometer indicated approximately a 10% increase in oxygen consumption when subjects wore half and full-face masks in comparison to when they performed the tasks without a mask. The results indicate that wearing the respirators did not have a significant effect on the performance of cognitive tasks but did affect significantly the performance of psychomotor tasks such as steadiness of work performance and movements requiring accurate control for positioning of objects.

Adult↗
PubMed1976

Photodynamic action of thiopyronine on the respiration and fermentation in yeast.

The efficiency of photodynamic treatment with thiopyronine (TP) on the respiration and fermentation of yeast cells, on the metabolic oxygen uptake of isolated mitochondrial preparations from yeast, and on the enzyme activity of alcohol dehydrogenase (ADH) in vivo and in vitro were studied. Respiration was inactivated by treatment with TP and visible light more at the initial stage than was the fermentation. Isolated mitochondria and ADH in vitro were not as sensitive to treatment as were respiration and fermentation in vivo. Inactivation patterns of respiration and fermentation in vivo showed that the inactivation was not due to damage to the DNA. The hindrance of respiration and fermentation might be one of main causes of cell-death resulting from photodynamic treatment.

Alcohol Oxidoreductases↗
PubMed2002

Total dust, respirable dust, and microflora toxin concentrations in Colorado corn storage facilities.

To aid in the process of characterizing corn dust exposures on farms and in elevators in northeastern Colorado, several parameters were examined. Total dust and respirable dust samples were collected and evaluated. Potentially dangerous dust components evaluated were respirable silica, endotoxin, and mycotoxin levels. Many of the total dust samples (58%) would have exceeded 8-hour time-weighted average (TWA) had sampling been conducted for 8 hours; on farms the operation takes between two and four hours. The same statement may be made for respirable dust samples collected for this project. Nearly 33 percent of the respirable dust samples collected would have exceeded the Occupational Safety and Health Administration (OSHA) TWA had sampling been conducted over an 8-hour period. Respirable silica standards were exceeded at 25 percent of the sampling locations. Presence of mycotoxins at all sites was confirmed by the use of ELISA kits. The most significant finding of this study was high levels of endotoxin at several of the sampling sites. Eighty-five percent of the sampling locations had endotoxin levels above 500 EU/m3. One location, Farm 4, had endotoxin levels of above 1.7 million EU/m3.

Agriculture↗
PubMed2002

Quantification of respirable, thoracic, and inhalable quartz exposures by FT-IR in personal impactor samples from construction sites.

The classification of quartz as a group I human carcinogen by the International Agency for Research on Cancer (IARC) highlights the need to develop a method to assess quartz exposures in the thoracic and inhalable particle size fractions to supplement the current method for the respirable size fraction. Heavy and highway construction operations can produce high respirable quartz exposures, but inhalable and thoracic exposures have not previously been well characterized. These larger particle size fractions may well contribute to the elevated cancers of the buccal cavity, throat, and GI tract in occupational cohorts of construction workers. A description is provided of the application of FT-IR for quartz analysis of personal cascade impactor air samples collected from highway construction sites. Separate calibration curves were generated for each stage of the four-stage personal impactor by using the impactor to sample quartz dust (Min-U-Sil 5 and Min-U-Sil 30) in an aerosol-generating loop. In addition, three separate calibration curves were generated using filters spiked with bulk Min-U-Sil 5, Min-U-Sil 30, and SRM 1878a (a respirable standard from NIST). The results showed that bulk Min-U-Sil 5 and SRM 1878a calibrations were identical and accurately estimated the respirable quartz fraction. Bulk Min-U-Sil 30 underestimated quartz in stages 1, 2, and 3 by 46 percent, 38 percent, and 18 percent, respectively. Using a respirable standard (bulk Min-U-Sil 5 or SRM 1878a) to quantify the larger particle sizes underestimated quartz in stages 1, 2, and 3 by 73 percent, 72 percent, and 63 percent, respectively. Until a standard reference material for quartz is developed for the larger particle sizes, the method described here, with some modifications, can be used to provide estimates of these biologically relevant particle size fractions. The results of this study also reaffirmed the need to collect narrow ranges of particle size in order to minimize quantification errors, since the FT-IR and XRD instrumental response is particle size-dependent.

Air Pollutants, Occupational↗
PubMed2002

Comparison of five methods for fit-testing N95 filtering-facepiece respirators.

Five fit-testing methods (Bitrex, ambient aerosol condensation nuclei counter using the TSI PortaCount Plus, saccharin, modified ambient aerosol condensation nuclei counter using the TSI PortaCount Plus with the N95-Companion, and generated aerosol using corn oil) were evaluated for their ability to identify poorly fitting N95 filtering-facepiece respirators. Eighteen models of NIOSH-certified, N95 filtering-facepiece respirators were tested by a panel of 25 subjects using each fit-testing method. The penetration of the corn oil and the ambient aerosols through the filter media of each respirator was measured in order to adjust the corresponding generated and ambient aerosol overall fit factors, reflecting only face-seal leakage. Fit-testing results were compared to 5th percentiles of simulated workplace protection factors. Beta errors (the chance of passing a fit-test in error) ranged from 3 percent to 11 percent. Alpha errors (the chance of failing a fit-test in error) ranged from 51 percent to 84 percent. The ambient aerosol using the TSI PortaCount Plus and the generated aerosol methods identified poorly fitting respirators better than the saccharin, the Companion, and Bitrex methods. These errors rates should be considered when selecting a fit-testing method for fitting N95 filtering-facepieces. When both types of errors were combined as an assignment error, the ambient aerosol method using the TSI PortaCount Plus had the lowest percentage of wearers being assigned a poor-fitting respirator.

Aerosols↗
PubMed2003

Fatal injuries in the United States involving respirators, 1984-1995.

There is little published information concerning the epidemiology of fatal injuries involving respiratory protection. We compiled a case series from U.S. Occupational Safety and Health Administration investigation reports from 1984 through 1995. For the 12-year period there were 41 incidents resulting in 45 deaths due to asphyxiation or chemical poisoning while wearing a respirator. There were 23 deaths related to airline respirators, 17 deaths involving use of negative pressure (air purifying) respirators, and 5 deaths involving self-contained breathing apparatus. Among the 23 deaths involving airline respirators, 15 were associated with compatible connection couplings for breathable air and inert gases. Three workers with beards died who wore tight-fitting respirators in an atmosphere that was immediately dangerous to life and health. Most of the fatalities involved regulatory and procedural violations, and would have been prevented by proper training and compliance with existing regulations. The information concerning the victims was limited but it did not appear that medical screening would have prevented any of the deaths.

Accidents, Occupational↗
PubMedDate not supplied

Communication using a telephone while wearing a respirator.

Respirators have been found to degrade communication effectiveness when wearers speak face-to-face. However, little is known about communication effectiveness when using the telephone and wearing a respirator. Eleven pairs of subjects were asked to pronounce and identify words chosen from Modified Rhyme Test lists. Each word appeared on a computer screen in one room and the speaker said the word into the telephone. The listener in another room identified the word and typed it into a computer linked with the first. Subjects wore U.S. Army M40 full-facepiece air-purifying respirators with hoods. Three different speech diaphragm arrangements and two hood materials were tested. Results show that accuracy suffered by about 10% when respirators and hoods were worn compared with the control condition. Word identification speed was one-third to one-half of the control (no respirator or hood) condition depending on specific equipment worn.

Adolescent↗
PubMed1980

Inhalation exposure of cadmium workers: effects of respirator usage.

The objective of this study was to determine the average reduction in inhalation exposures produced by intermittent use of filter cartridge respirators by cadmium workers. Inhalation exposure was estimated by measuring the cadmium concentration inside the respirator while it was worn or hanging around the worker's neck. Air concentrations of cadmium were measured simultaneously inside the respirator and at the worker's lapel with a dual sampling system. Each of nine workers were measured on three consecutive days for a full work shift. The average inhalation exposures ranged from 3 to 67 micrograms/m3 while the TWA lapel concentrations ranged from 19 to 3600 micrograms/m3; respirator use produced a substantial reduction in inhalation exposures when lapel concentrations were above 100 micrograms/m3. On the average, the inhalation exposure was 26% of the lapel concentration, but the effective protection varied widely between individuals and from day to day. If used cautiously, this relationship may be useful for estimating the approximate average inhalation exposure of a group of workers routinely using half mask respirators.

Air Pollutants↗
PubMed1983

Correlation of qualitative and quantitative results from testing respirator fit.

Three qualitative respirator fit tests were evaluated for their ability to adequately measure respiratory protection. The evaluated methods were the negative pressure test, the isoamyl acetate test, and the irritant smoke test. Each test was performed concurrently with a single quantitative fit test, the dioctylphthalate (DOP) test, during 274 half-mask and 274 full facepiece wearings. The quantitative values of DOP penetration obtained after passing or failing each qualitative fit test were lognormally distributed. For each qualitative test performed on each mask type, the average log penetration values obtained after passing and failing each test were statistically different from each other. The mean of the log penetration values associated with the failed qualitative test was always larger than the mean of the log penetration values associated with passed qualitative tests for all three qualitative methods. Most (95%) of the tested study had adequately fitting respirators as determined by quantitative testing. Of these subjects, 96% to 100% passed the qualitative fit tests. Of the 5% of the study subjects with inadequately fitting half mask respirators, 93% to 100% of the inadequate fits were detected by qualitative methods. Twenty three to 46% of the poorly fitting full face masks were detected by qualitative methods. The probability of passing or failing a qualitative test with an inadequately fitting respirator can be estimated; however, the uncertainty associated with each estimate is large due to the small number of study subjects with poorly fitting respirators.

Adult↗
PubMed1984

Effect of facial hair on the face seal of negative-pressure respirators.

The effect of facial hair on the face seal of negative-pressure respirators, both half-masks and full facepieces, has been investigated. Three hundred and seventy (370) male employees were fit tested both qualitatively and quantitatively. Of these, sixty-seven (67) had fully established beards varying in length, shape, density and texture. Bearded subjects consistently failed the qualitative fit test protocol. Quantitative fit testing with half-mask respirators indicated that bearded employees had a median fit factor of 12 (8% leakage). A median fit factor of 2950 (0.03% leakage) was obtained on clean-shaven employees. An average two hundred and forty-six (246) fold drop in protection was experienced by bearded employees. With full facepiece respirators, the bearded employees had a median fit factor of 30 (3% leakage). A median fit factor of greater than 10 000 (less than 0.01% leakage) was obtained on clean-shaven employees. At least a three hundred and thirty (330) fold drop in protection was experienced by bearded employees. Results indicate that the presence of a beard greatly increases the leakage through the respirator face seal, and this leakage should not be permitted when employees are required to wear respirators.

Face↗
PubMed1985

A critique of MSHA procedures for determination of permissible respirable coal mine dust containing free silica.

The literature in selected technical subject areas related to the Mine Safety and Health Administration's (MSHA) respirable mine dust control policy was critically reviewed. Specific topics included: (1) the technical aspects of respirable dust sampling, (2) the development of a sampling strategy and (3) currently used analytical techniques for free silica content of respirable coal mine dust. The 2.0 Lpm MSHA respirable dust sampling flow rate does not conform with published results which indicate that to simulate existing pulmonary particle deposition models, the sampling flow rate should range from 1.4 to 1.7 Lpm. MSHA's sampling strategy focuses on controlling respirable coal mine dust with both area and personal samples of workers in selected occupations or activities. Many uncertainties are encountered as area samples are used to estimate personal exposures. Although all of the analytical methods for crystalline free silica are sufficiently sensitive to be able to detect and quantitate free silica at environmentally significant concentrations, they are all plagued with similar difficulties. Analytical standards representing the various forms of silica are not available. Available analytical methods do not differentiate among polymorphs of silica. Recommendations are presented to resolve identified problem areas.

Air Pollutants, Occupational↗
PubMed1985

The quality of respirator programs: an analysis from OSHA compliance data.

The quality of respirator programs in typical workplaces was investigated by analyzing the history of compliance with OSHA Standard 29 CFR 1910.134 (respiratory protection). Analysis was focused on the approximately 47 000 health inspections conducted in the manufacturing industries [Standard Industrial Classification (SIC) Codes 2000-3999] in the period of October 1, 1976 to September 30, 1982. During this period, approximately 27% of inspections in which respirator programs were reviewed resulted in a citation for a specific program deficiency. Of inspected worksites in which respirators were in use to provide protection from concentrations of air contaminants in excess of OSHA Permissible Exposure Limits, 56% had deficiencies in at least one program area. Since the violations were of the type that have been shown to lower the level of protection provided by respirators, many workers may have been exposed to inhalation hazards as the result of ineffective respirator programs.

Air Pollutants, Occupational↗
PubMed1988

Experiments supporting the use of ambient aerosols for quantitative respirator fit testing.

Most methods for testing facial seal leakage on subjects undergoing respirator fit tests involve comparing the generated aerosol particulate concentration inside the subject's respirator to the concentration in a test chamber. These aerosols are produced by fogging substances such as corn oil, dioctyl sebacate, or dioctyl phthalate (DOP) into the test chamber. The health effects of these substances and of their aerosols on respiratory systems are uncertain. The proposed alternate method uses as a test medium ambient particles which exist in most room atmospheres. The proposed method eliminates the need for a test chamber and for an intentionally produced aerosol. The subject is tested for respirator inleakage by comparing the particulate count concentration inside the subject's respirator to that of the room atmosphere outside the respirator. This method is less expensive and simpler to administer than the use of oil or other deliberately produced aerosols because it uses an existing ambient test medium. Statistical analysis of the test data indicates favorable comparison with the conventional chamber-aerosol method.

Aerosols↗
PubMed1989

Ozone removal capability of a welding fume respirator containing activated charcoal.

Development of air purifying respirators for protection against ozone has been slowed by concerns about oxidation of charcoal and other available sorbents. The suitability of a charcoal sorbent for low concentrations of ozone was evaluated as a part of the development of a half-mask air purifying respirator designed for welding fumes and ozone. Testing of the respirator confirmed that charcoal can be a suitable sorbent for low levels of ozone. Where the respirator is properly selected, fit tested, and worn, respirator use against welding fumes and ozone at concentrations not exceeding 10 times the permissible exposure limit had been recommended.

Charcoal↗
PubMed1991

Regulatory implications of airborne respirable free silica variability in underground coal mines.

The respirable dust standard for respirable free crystalline silica in underground coal mines is expressed as milligrams per cubic meter (mg/m3) of respirable dust and is determined by the silica content of the dust. The Mine Safety and Health Administration (MSHA) regulates silica exposure by determining and enforcing compliance with the respirable dust standard for each active mine section. The MSHA strategy for regulation is examined in the context of respirable free crystalline silica and dust data. Deficiencies of the strategy include the same enforcement efforts regardless of compliance history, inappropriate treatment of data, and emphasis on short-term variability of silica content. These deficiencies result in inadequate enforcement in chronically dusty mines, "game playing" with optional samples, and an overall approach that does not focus on the long-term impact of silica exposure on lung health. Alternative approaches include enforcement efforts proportional to compliance history, use of a moving average silica content, and more statistically sound approaches to data interpretation.

Air Pollutants, Occupational↗
PubMed1991

Simplified pressure method for respirator fit testing.

A simplified pressure method has been developed for fit testing air-purifying respirators. In this method, the air-purifying cartridges are replaced by a pressure-sensing attachment and a valve. While wearers hold their breath, a small pump extracts air from the respirator cavity until a steady-state pressure is reached in 1 to 2 sec. The flow rate through the face seal leak is a unique function of this pressure, which is determined once for all respirators, regardless of the respirator's cavity volume or deformation because of pliability. The contaminant concentration inside the respirator depends on the degree of dilution by the flow through the cartridges. The cartridge flow varies among different brands and is measured once for each brand. The ratio of cartridge to leakflow is a measure of fit. This flow ratio has been measured on human subjects and has been compared to fit factors determined on the same subjects by means of photometric and particle count tests. The aerosol tests gave higher values of fit.

Humans↗
PubMed1992

A probability model for assessing exposure among respirator wearers: Part I--Description of the model.

The basic respirator equation states that the contaminant level inside a respirator (CI) is the product of the contaminant level outside the respirator (CO) and the decimal fraction penetration (P). On the basis of this relation, the authors present a probability model for the lognormal total distribution of CI levels among a respirator-wearing population; the model accounts for between-wearer and within-wearer variability in both CO levels and P values. The assumptions underlying the model are shown to be consistent with current knowledge about the variability in CO levels and P values. The model provides the basis for assessing the probability of overexposure to acute toxicants and to chronic toxicants among a respirator-wearing population.

Air Pollutants, Occupational↗
PubMed1992

An assessment of critical anthropometric dimensions for predicting the fit of a half-mask respirator.

The purpose of this study was to determine if facial dimensions for a group of subjects were predictive of the fit factors measured while one brand of half-mask respirator was worn. Fit factors and 12 facial dimensions measured on 30 female and 38 male subjects were analyzed by correlation coefficients; weighted, multiple linear regression; and discriminant analysis. Data were analyzed for all subjects, gender subgroups, a race subgroup (whites only), and race/gender subgroups. Significant correlation coefficients with the log-transformed fit factors were found for four dimensions; four dimensions had significant coefficients in four or more multiple linear regression models. Only two dimensions had significant coefficients in four or more discriminant analysis models. Menton-subnasale (lower face) length was the only dimension included in all three of these groups. Gender-specific regression models had very high coefficient of determination values (R2 > 0.85). Discriminant analysis of the data for all subjects and race/gender subgroups found very good predictive scores for statistical software-generated models and menton-subnasale length alone; these scores were significantly better than those for the model with the respirator test panel dimensions (face length and lip width). These analyses found that facial dimensions were good predictors of respirator fit for those subjects wearing one brand of half-mask respirator. Lower face length was consistently indicated as being correlated or associated with fit. These results would indicate that dimensions other than those currently used may be more appropriate to define a half-mask respirator test panel.

Adult↗