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Results for “Polyhydroxyethyl Methacrylate”

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Vitreous substitute. Experimental studies and review.

We studied a synthetic hydrogel, PHEA [poly(2-hydroxyethyl acrylate)], experimentally. The material is transparent, autoclavable , highly viscous, nonabsorbable, easily injectable, cohesive, and does not fragment on passage through small-gauge needles. Results in animal studies revealed that injection of PHEA into the vitreous cavity promoted inflammatory changes such as vitreous haziness , membrane formation, and chorioretinal atrophy. Histopathologic studies showed extensive retinal disorganization, chorioretinal scarring, and vitritis . We reviewed the literature and concluded that an ideal vitreous substitute for long-term use in complex cases of retinal detachment is not available at this time.

Animals↗
PubMed1983

[Changes in the pancreas after obliteration of the pancreatic ducts in a dog with Hydron].

The development of pancreatic changes was studied after obliteration of pancreatic ducts by means af 2-hydroxyethylmethacrylate. The drug was injected into the main pancreatic duct of 15 dogs that were put to death successively and examined by histology. Necrosis of pancreatic duct epithelium was found in 4 days after the polymer administration in addition to focal periductal necrosis of acinar tissue and interstitial oedema with fibroblast activation. Later, a rapid development of fibrosis occurred which ensue in an extinction of exocrine tissue after 2 months. Pancreas consisted then but of connective tissue and cumulated Langerhans' islets with positive beta-granulations. Pancreatic ducts obliteration is a reliable method for selective inhibition of exocrine activity.

Animals↗