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Persistent fatigue in well women.

Fatigue is the subjective report of a sustained sense of exhaustion with reduced motivation and capacity for physical and/or mental activity. Although factors associated with fatigue have been explored in specific patient populations, minimal study has been devoted to exploring both the magnitude of fatigue and associated variables among women generally thought to be well. This cross-sectional, descriptive study examined the relationship of behavioral, socio-demographic, and emotional factors to subjective ratings of fatigue among women in the community who perceived themselves as being fatigued but otherwise healthy. A convenience sample of 155 adult women completed the Piper Fatigue Self-Report Scale (PFS), the Beck Depression Inventory (BDI), and an investigator-designed questionnaire that collected behavioral and socio-demographic data. Correlation and regression analyses were used with fatigue as measured by the PFS as the outcome variable. Statistically significant relationships were noted between PFS and BDI scores as well as PFS and sleep pattern, rest quality, and perceived stress. Construction of a multiple regression model revealed an adjusted R2 of .43 with the BDI score serving as the major predictor variable for fatigue. Persistent fatigue is a consistent element in the lives of many women. As such it can significantly undermine women's quality of life.

Adult↗

Design and performance of a multiwavelength airborne polarimetric lidar for vegetation remote sensing.

The University of Nebraska has developed a multiwavelength airborne polarimetric lidar (MAPL) system to support its Airborne Remote Sensing Program for vegetation remote sensing. The MAPL design and instrumentation are described in detail. Characteristics of the MAPL system include lidar waveform capture and polarimetric measurement capabilities, which provide enhanced opportunities for vegetation remote sensing compared with current sensors. Field tests were conducted to calibrate the range measurement. Polarimetric calibration of the system is also discussed. Backscattered polarimetric returns, as well as the cross-polarization ratios, were obtained from a small forested area to validate the system's ability for vegetation canopy detection. The system has been packaged to fly abroad a Piper Saratoga aircraft for airborne vegetation remote sensing applications.

Journal Article↗

Insecticidal activity of synthetic amides on Spodoptera frugiperda.

The phytochemistry of the genus Piper (Piperaceae) has been widely studied due to the biological properties of amides from these plants. In this work, we have synthesized and evaluated the toxic effect of 11 amides against the fall armyworm Spodoptera frugiperda larvae. The naturally occurring piperine was also evaluated. The most active amide was N-[3-(3',4'-methylenedioxyphenyl)-2-(E)-propenoyl]piperidine with a LD50 of 1.07 microg mg(-1) larvae. This amide was also evaluated by ingestion.

Amides↗

An observation of thromboxane A2 in arterial blood after cholesterol feeding in rabbits.

Agents responsible for the entry of cholesterol-bearing lipoproteins into the arterial wall represent local risk factors in atherogenesis. In an attempt to identify these agents, we inserted a catheter into the ascending aorta of rabbits and 5 ml of arterial blood sample was withdrawn. The contraction of the aortic strip of rabbit against Piper and Vane's antagonists with application of this sample was observed. Samples obtained after feeding of 1 Gm/Kg of cholesterol and after an intravenous administration of thromboxan A2 (TXA2) contracted the aortic strip. Samples from non-treated rabbits or those obtained after intravenous administration of 10 microgram of epinephrine or norepinephrine did not contract the strip. Previous administration of 20 mg/Kg of indomethacin decreased the contraction developed after feeding of 1 Gm/Kg of cholesterol. It was suggested that TXA2 might be released into the arterial blood by the ingestion of cholesterol and might be one of the agents repsonsible for the entry of lipoproteins.

Animals↗

Effects of intradialytic nutrition on dialysis adequacy and fatigue in hemodialysis patients: a randomized crossover study.

OBJECTIVE: To assess intradialytic nutrition's effects on dialysis adequacy and fatigue in maintenance hemodialysis patients. METHODS: A randomized, two-period, two-sequence, self-controlled crossover trial was conducted in two outpatient hemodialysis centers in Türkiye. Thirty-six patients were randomized; 32 completed both periods. The participants received standardized intradialytic nutrition in one period and no food intake during the control period. Dialysis adequacy was evaluated using the urea reduction ratio and single-pool Kt/V. Intradialytic blood pressure was recorded during dialysis sessions, and fatigue severity was measured using the Piper Fatigue Scale at the end of each period. RESULTS: No significant differences were observed in dialysis adequacy or fatigue scores between the two periods. Intradialytic nutrition was associated with greater reductions in systolic and diastolic blood pressure, particularly during the second hour of dialysis. No clinically relevant adverse events occurred. CONCLUSION: Intradialytic nutrition did not compromise dialysis adequacy or worsen fatigue severity but was associated with increased intradialytic blood pressure reductions. Individualized clinical decisions and careful hemodynamic monitoring are warranted when implementing intradialytic nutritional interventions. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT07687498.

Humans↗

Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases.

Extracts of 13 Brazilian medicinal plants were screened for their antimicrobial activity against bacteria and yeasts. Of these, 10 plant extracts showed varied levels of antibacterial activity. Piper regnellii presented a good activity against Staphylococus aureus and Bacillus subtilis, a moderate activity on Pseudomonas aeruginosa, and a weak activity against Escherichia coli. Punica granatum showed good activity on S. aureus and was inactive against the other standard strains. Eugenia uniflora presented moderate activity on both S. aureus and E. coli. Psidium guajava,Tanacetum vulgare, Arctium lappa, Mikania glomerata, Sambucus canadensis, Plantago major and Erythrina speciosa presented some degree of antibacterial activity. Spilanthes acmella, Lippia alba, and Achillea millefolium were considered inactive. Five of the plant extracts presented compounds with Rf values similar to the antibacterial compounds visible on bioautogram. Of these, three plants belong to the Asteraceae family. This may mean that the same compounds are responsible for the antibacterial activity in these plants. Anticandidal activity was detected in nine plant extracts (P. guajava, E. uniflora, P. granatum, A. lappa, T. vulgare, M. glomerata, L. alba, P. regnellii, and P. major). The results might explain the ethnobotanical use of the studied species for the treatment of various infectious diseases.

Anti-Bacterial Agents↗

Prevalence and intensity of Haemobaphes diceraus (Copepoda: Pennellidae) from shiner perch, Cymatogaster aggregata (Embiotocidae).

The prevalence and intensity of the hematophagous pennellid copepod Haemobaphes diceraus were monitored over a 10-mo period in shiner perch Cymatogaster aggregata at Pipers Lagoon, Nanaimo, British Columbia. The prevalence and mean intensity of metamorphosed adult female H. diceraus (n = 421) were 10.0% and 1.2 (+/-0.5 SD), respectively. The majority (97.9%) of infected fish had single infections, reflecting the possibility of intensity-dependent parasite-induced mortality, rejection of additional parasites, or both. Transforming females were detected throughout the year; however, there was no detectable seasonal pattern of colonization. Neither copepodids nor adult males of H. diceraus were observed on the gills of shiner perch, and this was consistent with the hypothesis that an intermediate host harbors these stages. Males of Haemobaphes sp. infected the gills of bay pipefish Syngnathus griseolineatus with a prevalence and mean intensity of 56.0% and 6.8 +/- 3.7, respectively. Transmission of H. diceraus to shiner perch probably occurs in inshore protected areas, where shiner perch ecologically overlap with the probable intermediate host of H. diceraus, the bay pipefish.

Animals↗

Longitudinal study of quality of life in patients with localized prostate cancer undergoing radiotherapy.

This study prospectively evaluated quality of life (QOL) in localized prostate cancer patients undergoing radiotherapy, and it examined the relationships between QOL, depression, fatigue, and sleep disturbance. Instruments that were used are Functional Assessment of Cancer Therapy for Prostate (FACT-P), Beck Depression Inventory (BDI), Piper Fatigue Scale (PFS), and Epworth Sleepiness Scale (ESS). We evaluated patients at preradiotherapy (PRT), midway radiotherapy (MRT), completion of radiotherapy (CRT), follow-up radiotherapy (4 to 8 wk) (FRT), and long-term follow-up radiotherapy (FRT2) (12 mo or more). Forty participants with a mean age of 67.8 yr were studied. Duration of radiotherapy was 7-8 wk. Mean long-term follow-up period post-CRT was 16.2 mo (range 12- 24 mo). All patients had clinical T1c to T2b prostate cancer. Prostate Cancer Specific (PCS) and Physical Well-Being (PWB) subscales of FACT-P, scores at MRT and CRT were significantly lower than at PRT. At FRT2, PWB scores declined further, while PCS scores increased. PFS median scores were significantly higher at CRT and at FRT2 as compared with PRT. Patients scoring higher on PFS were more likely to report a poorer QOL and PWB as measured with FACT-P questionnaire. No significant changes were noted in the BDI and ESS scores during the study periods. The PWB declined during and at CRT and worsened at FRT2. Decline in PCS subscale scores during and at CRT reflects worsening of urinary symptoms and appearance of bowel problems. The scores improved at long-term follow-up. A relationship was found to exist between physical well-being and fatigue.

Aged↗

Statistical evaluation of geochemical parameter distribution in a ground water system contaminated with petroleum hydrocarbons.

A shallow-depth ground water area was investigated to identify the dominant processes governing the distribution of hydrocarbon contaminants and hydrogeochemical parameters. The ground water in the study site has been highly contaminated with petroleum hydrocarbons. A preliminary pump-and-treatment remediation technology was applied for 4 yr at the site. Multivariate analyses were applied to hydrogeochemical data obtained before and after the rainy season. The pump-and-treatment application, indigenous biodegradation, and mixing by precipitation recharge are the major factors or events involved in the distribution of geochemical parameters of the ground water in the study area. Site-specific artificial pavement also played an important role in the evolution of the ground water chemistry. A conventional graphical analysis method (Piper plot) of major ions did not effectively reveal these effects. In this study, we demonstrate the usefulness of multivariate analysis (factor and cluster analyses) using biodegradation indicator parameters, as well as major cations and anions, for the study of the ground water system in the hydrocarbon-contaminated site.

Biodegradation, Environmental↗

Potential of carbon accumulation in no-till soils with intensive use and cover crops in southern Brazil.

The area under no-till (NT) in Brazil reached 22 million ha in 2004-2005, of which approximately 45% was located in the southern states. From the 1970s to the mid-1980s, this region was a source of carbon dioxide to the atmosphere due to decrease of soil carbon (C) stocks and high consumption of fuel by intensive tillage. Since then, NT has partially restored the soil C lost and reduced the consumption of fossil fuels. To assess the potential of C accumulation in NT soils, four long-term experiments (7-19 yr) in subtropical soils (Paleudult, Paleudalf, and Hapludox) varying in soil texture (87-760 g kg(-1) of clay) in agroecologic southern Brazil zones (central region, northwest basaltic plateau in Rio Grande Sul, and west basaltic plateau in Santa Catarina) and with different cropping systems (soybean and maize) were investigated. The lability of soil organic matter (SOM) was calculated as the ratio of total organic carbon (TOC) to particulate organic carbon (POC), and the role of physical protection on stability of SOM was evaluated. In general, TOC and POC stocks in native grass correlated closely with clay content. Conversely, there was no clear effect of soil texture on C accumulation rates in NT soils, which ranged from 0.12 to 0.59 Mg ha(-1) yr(-1). The C accumulation was higher in NT than in conventional-till (CT) soils. The legume cover crops pigeon pea [Cajanus cajan (L.) Millsp] and velvet beans (Stizolobium cinereum Piper & Tracy) in NT maize cropping systems had the highest C accumulation rates (0.38-0.59 Mg ha(-1) yr(-1)). The intensive cropping systems also were effective in increasing the C accumulation rates in NT soils (0.25-0.34 Mg ha(-1) yr(-1)) when compared to the double-crop system used by farmers. These results stress the role of N fixation in improving the tropical and subtropical cropping systems. The physical protection of SOM within soil aggregates was an important mechanism of C accumulation in the sandy clay loam Paleudult under NT. The cropping system and NT effects on C stocks were attributed to an increase in the lability of SOM, as evidenced by the higher POC to TOC ratio, which is very important to C and energy flux through the soil.

Agriculture↗

A systematic review of the safety of kava extract in the treatment of anxiety.

This paper systematically reviews the clinical evidence relating to the safety of extracts of the herbal anxiolytic kava (Piper methysticum). Literature searches were conducted in four electronic databases and the reference lists of all papers located were checked for further relevant publications. Information was also sought from the spontaneous reporting schemes of the WHO and national drug safety bodies and ten manufacturers of kava preparations were contacted. Data from short-term post-marketing surveillance studies and clinical trials suggest that adverse events are, in general, rare, mild and reversible. However, published case reports indicate that serious adverse events are possible including dermatological reactions, neurological complications and, of greatest concern, liver damage. Spontaneous reporting schemes also suggest that the most common adverse events are mild, but that serious ones occur. Controlled trials suggest that kava extracts do not impair cognitive performance and vigilance or potentiate the effects of central nervous system depressants. However, a possible interaction with benzodiazepines has been reported. It is concluded that when taken as a short-term monotherapy at recommended doses, kava extracts appear to be well tolerated by most users. Serious adverse events have been reported and further research is required to determine the nature and frequency of such events.

Anti-Anxiety Agents↗

Interactions between herbal medicines and prescribed drugs: a systematic review.

Despite the widespread use of herbal medicines, documented herb-drug interactions are sparse. We have reviewed the literature to determine the possible interactions between the seven top-selling herbal medicines (ginkgo, St John's wort, ginseng, garlic, echinacea, saw palmetto and kava) and prescribed drugs. Literature searches were performed using the following databases: Medline (via Pubmed), Cochrane Library, Embase and phytobase (all from their inception to July 2000). All data relating to herb-drug interactions were included regardless of whether they were based on case reports, case series, clinical trials or other types of investigation in humans. In vitro experiments were excluded. Data were extracted by the first author and validated by the second author. 41 case reports or case series and 17 clinical trials were identified. The results indicate that St John's wort (Hypericum perforatum) lowers blood concentrations of cyclosporin, amitriptyline, digoxin, indinavir, warfarin, phenprocoumon and theophylline; furthermore it causes intermenstrual bleeding, delirium or mild serotonin syndrome, respectively, when used concomitantly with oral contraceptives (ethinylestradiol/desogestrel), loperamide or selective serotonin-reuptake inhibitors (sertaline, paroxetine, nefazodone). Ginkgo (Ginkgo biloba) interactions include bleeding when combined with warfarin, raised blood pressure when combined with a thiazide diuretic and coma when combined with trazodone. Ginseng (Panax ginseng) lowers blood concentrations of alcohol and warfarin, and induces mania if used concomitantly with phenelzine. Garlic (Allium sativum) changes pharmacokinetic variables of paracetamol, decreases blood concentrations of warfarin and produces hypoglycaemia when taken with chlorpropamide. Kava (Piper methysticum) increases 'off' periods in Parkinson patients taking levodopa and can cause a semicomatose state when given concomitantly with alprazolam. No interactions were found for echinacea (Echinacea angustifolia, E. purpurea, E. pallida) and saw palmetto (Serenoa repens). In conclusion, interactions between herbal medicines and synthetic drugs exist and can have serious clinical consequences. Healthcare professionals should ask their patients about the use of herbal products and consider the possibility of herb-drug interactions.

Drug Interactions↗

Herb-drug interactions: a literature review.

Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been published reporting enhanced anticoagulation and bleeding when patients on long-term warfarin therapy also took Salvia miltiorrhiza (danshen). Allium sativum (garlic) decreased the area under the plasma concentration-time curve (AUC) and maximum plasma concentration of saquinavir, but not ritonavir and paracetamol (acetaminophen), in volunteers. A. sativum increased the clotting time and international normalised ratio of warfarin and caused hypoglycaemia when taken with chlorpropamide. Ginkgo biloba (ginkgo) caused bleeding when combined with warfarin or aspirin (acetylsalicylic acid), raised blood pressure when combined with a thiazide diuretic and even caused coma when combined with trazodone in patients. Panax ginseng (ginseng) reduced the blood concentrations of alcohol (ethanol) and warfarin, and induced mania when used concomitantly with phenelzine, but ginseng increased the efficacy of influenza vaccination. Scutellaria baicalensis (huangqin) ameliorated irinotecan-induced gastrointestinal toxicity in cancer patients.Piper methysticum (kava) increased the 'off' periods in patients with parkinsonism taking levodopa and induced a semicomatose state when given concomitantly with alprazolam. Kava enhanced the hypnotic effect of alcohol in mice, but this was not observed in humans. Silybum marianum (milk thistle) decreased the trough concentrations of indinavir in humans. Piperine from black (Piper nigrum Linn) and long (P. longum Linn) peppers increased the AUC of phenytoin, propranolol and theophylline in healthy volunteers and plasma concentrations of rifamipicin (rifampin) in patients with pulmonary tuberculosis. Eleutheroccus senticosus (Siberian ginseng) increased the serum concentration of digoxin, but did not alter the pharmacokinetics of dextromethorphan and alprazolam in humans. Hypericum perforatum (hypericum; St John's wort) decreased the blood concentrations of ciclosporin (cyclosporin), midazolam, tacrolimus, amitriptyline, digoxin, indinavir, warfarin, phenprocoumon and theophylline, but did not alter the pharmacokinetics of carbamazepine, pravastatin, mycophenolate mofetil and dextromethorphan. Cases have been reported where decreased ciclosporin concentrations led to organ rejection. Hypericum also caused breakthrough bleeding and unplanned pregnancies when used concomitantly with oral contraceptives. It also caused serotonin syndrome when used in combination with selective serotonin reuptake inhibitors (e.g. sertraline and paroxetine). In conclusion, interactions between herbal medicines and prescribed drugs can occur and may lead to serious clinical consequences. There are other theoretical interactions indicated by preclinical data. Both pharmacokinetic and/or pharmacodynamic mechanisms have been considered to play a role in these interactions, although the underlying mechanisms for the altered drug effects and/or concentrations by concomitant herbal medicines are yet to be determined. The clinical importance of herb-drug interactions depends on many factors associated with the particular herb, drug and patient. Herbs should be appropriately labeled to alert consumers to potential interactions when concomitantly used with drugs, and to recommend a consultation with their general practitioners and other medical carers.

Animals↗

Therapeutic potential of kava in the treatment of anxiety disorders.

Anxiety disorders are among the most common psychiatric disorders that affect all age groups of the general population. Currently, the preferred treatment is with pharmacological drugs that have antidepressant or anti-anxiety properties. However, these agents have numerous and often serious adverse effects, including sedation, impaired cognition, ataxia, aggression, sexual dysfunction, tolerance and dependence. Withdrawal reactions on termination after long-term administration are also a major limiting factor in the use of these agents. Herbal remedies, including kava (Piper methysticum), have been shown to be effective as alternative treatments, at least in mild to moderate cases of anxiety. Kava is a social and ceremonial herb from the South Pacific. It is available in the west as an over-the-counter preparation. Its biological effects, due to a mixture of compounds called kavalactones, are reported to include sedative, anxiolytic, antistress, analgesic, local anaesthetic, anticonvulsant and neuroprotective properties. The pharmacological properties of kava are postulated to include blockade of voltage-gated sodium ion channels, enhanced ligand binding to gamma-aminobutyric acid (GABA) type A receptors, diminished excitatory neurotransmitter release due to calcium ion channel blockade, reduced neuronal reuptake of noradrenaline (norepinephrine), reversible inhibition of monoamine oxidase B and suppression of the synthesis of the eicosanoid thromboxane A(2), which antagonises GABA(A) receptor function. Clinical studies have shown that kava and kavalactones are effective in the treatment of anxiety at subclinical and clinical levels, anxiety associated with menopause and anxiety due to various medical conditions. Until recently, the adverse effects attributed to kava use were considered mild or negligible, except for the occurrence of a skin lesion. This disorder, called kava dermopathy, occurs only with prolonged use of large amounts of kava and is reversible on reduced intake or cessation. Rare cases of interactions have occurred with pharmaceutical drugs that share one or more mechanisms of action with the kavalactones. In the past few years, about 35 cases of severe liver toxicity associated with kava intake have been reported in Europe and the US. However, a direct causal relationship with kava use has been difficult to establish in the majority of the cases, and there is insufficient evidence to implicate kava as the responsible agent. Nevertheless, until further research clarifies any causality, kava should be used with caution.

Animals↗

Sex and the Barnum effect: rationality versus helpfulness.

In 1998 Piper-Terry and Downey found that women accepted friends' bogus test interpretations more readily than did men and the researchers attributed this to women's helpfulness. Layne countered that women are more open and thus rationally expected their friends' interpretations to be more accurate. Later Downey asked participants how accurately they believed their friends could describe their personalities. Although this pilot study's sensitivity to differences was low, the women's accuracy ratings still tended to exceed those of men (p < .06) as Layne predicted. This may suggest that the rationality hypothesis is better supported than the female-helpfulness hypothesis.

Adult↗

Effect of brown midrib and normal genotypes of sorghum X sudangrass on ruminal fluid and particulate rate of passage from the rumen and extent of digestion at various sites along the gastrointestinal tract in sheep.

The objectives of this experiment were to determine fluid and particulate rate of passage from the rumen and extent of digestion at various sites along the gastrointestinal tract in sheep fed normal and brown midrib sorghum X sudangrass hybrids. Four Suffolk wethers (80 kg) with ruminal, duodenal and ileal cannulae were assigned to one of four diets in a 4 X 4 Latin square with a 2 X 2 factorial arrangement of treatments. Diets were hays of two sorghum X sudangrass varieties, Redlan X Greenleaf and Redlan X Piper, and their corresponding brown midrib mutants. There were no compositional differences resulting from variety or genotype in lignin content or fiber components, although alkali-soluble phenolic acids were higher in normal genotypes than in brown midrib. Vanillin was lower, whereas para-coumaric acid was higher, in normal genotypes than in brown midrib mutants. Ruminal digestibility of neutral detergent fiber, acid detergent fiber and cellulose was lower (P less than .05) for normal genotypes than for the brown midribs. Total-tract digestibility of cellulose was higher (P less than .05) for brown midrib mutants than for corresponding normal genotypes. No quantitative differences in fiber composition or lignin content were detected between normal and brown midrib genotypes; however, differences in composition of alkali-soluble phenolic acids of the lignin fraction could explain differences in digestibility detected between the two genotypes.

Animal Feed↗

Metabolism of some kava pyrones in the rat.

1. The metabolism in rats of several kava pyrones from Piper methysticum Forst. was studied. The compounds were the 5,6-dihydro-alpha-pyrones, dihydrokawain, kawain and methysticin, and the alpha-pyrones, 7,8-dihyroyangonin and yangonin. 2. Approx. half the dose (400 mg/kg, p.o.) of dihydrokawain was found in the urine in 48 h. About two-thirds of this was hydroxylated metabolites (three mono- and three di-hydroxylated derivatives), of which p-hydroxydihydrokawain was the most abundant. The remaining third consisted of metabolites formed by scission of the 5,6-dihydro-alpha-pyrone ring and included hippuric acid (9--13% dose). 3. Lower amounts of urinary metabolites were excreted when kawain was given, but both hydroxylated and ring-opened products were formed. 4. Methysticin gave rise to only small amounts of two urinary metabolites formed by demethylenation of the methylenedioxyphenyl moiety. 5. Urinary metabolites of the alpha-pyrones, 7,8-dihydroxyangonin and yangonin, were formed via omicron-demethylation. No ring-opened products were detected. 6. These lipophilic kava pyrones have extremely low solubility in water, which would be expected to reduce their absorption rates and appears to be responsible for the variable and low extent of metabolism observed.

Animals↗

Rumen turnover and digestion of normal and brown midrib sorghum x sudangrass hybrid silages in dairy cattle.

Eight growing Holstein heifers and four ruminally cannulated adult Holstein steers fed ad libitum were used in 4 X 4 Latin square designs. Diets included two sorghum X sudangrass varieties, Redlan X Greenleaf and Redlan X Piper, and their corresponding brown midrib mutants. Acid detergent fiber and acid detergent lignin concentrations tended to be lower for brown midrib mutants than for normal genotypes of the same variety. Digestion kinetics for in situ studies showed no difference in rate constants between normal and brown midrib sorghums, but extent of digestion at 72 h was significantly higher for brown midrib mutants than for normal genotypes, suggesting that lignin has no effect on digestion rate but does result in a decreased extent of digestion. In growing dairy heifers, brown midrib sorghum X sudangrass had higher digestibilities for organic matter, neutral detergent fiber, acid detergent fiber, cellulose, and hemicellulose fractions than did the normal genotype for Redlan X Greenleaf.

Animal Feed↗