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At least 811 records · Page 45Linked to original sources
PubMed1997

Effects of bilateral hypoglossal and glossopharyngeal nerve blocks on epiglottic and soft palate position in exercising horses.

OBJECTIVE: To determine the effect of bilateral hypoglossal and and glossopharyngeal nerve block on epiglottic and soft palate position and tracheal and pharyngeal pressures in exercising horses. ANIMALS: 5 Standardbreds. PROCEDURE: Tracheal and pharyngeal pressures were measured in 5 Standardbreds exercising at the speed at which the horses achieved 50, 75, and 100% of maximal heart rate after bilateral hypoglossal and glossopharyngeal nerve block and without nerve block. Nerve block was achieved by injection of 1 to 2 ml of 2% mepivicaine hydrochloride between the glossopharyngeal and hypoglossal nerves, as they coursed through the medial compartment of the diverticulum of the auditory tube (guttural pouch), using videoendoscopic guidance and an injection apparatus. RESULTS: Compared with control values, peak inspiratory tracheal pressure was significantly (P = 0.02) more negative, and peak pharyngeal inspiratory pressure was less negative (P = 0.004) after bilateral hypoglossal and glossopharyngeal nerve block. Respiratory frequency was significantly (P = 0.024) lower after nerve block, compared with control values. The epiglottis was unstable and retroflexed through the rima glottis during inspiration after bilateral hypoglossal and glossopharyngeal nerve block. Despite loss of contact between the epiglottis and the caudal free margin of the soft palate, dorsal displacement of the soft palate did not occur. CONCLUSIONS AND CLINICAL RELEVANCE: Loss of contact of the epiglottis with the soft palate did not affect soft palate position, suggesting that when the soft palate is normal, the epiglottis does not function as a support, holding the soft palate in a ventral position. Therefore, epiglottic dysfunction is not solely responsible for intermittent dorsal displacement of the soft palate in horses, and neuromuscular dysfunction involving the hyoepiglotticus muscle, geniohyoideus muscle, or the hypoglossal nerve may cause epiglottic retroflexion in horses.

Animals↗
PubMed1997

Glycosaminoglycan biosynthesis during 5-fluoro-2-deoxyuridine-induced palatal clefts in the rat.

The biosynthesis and hydration of glycosaminoglycans (GAG) has been implicated in the generation of palatal shelf-elevating force(s) in mammals, although the nature of the palatal shelf extracellular matrices during cleft palate formation remains poorly understood. This study quantifies the GAG composition in the palatal shelves of Wistar rat fetuses at various periods of palatogenesis where clefts were induced experimentally using 5-fluoro-2-deoxyuridine (FUDR). For both normal and cleft palatal shelves, hyaluronan, heparan sulphate and chondroitin-4-sulphate were detected but not dermatan sulphate or chondroitin-6-sulphate. Throughout the period of cleft development studied, the total amount of GAG was significantly decreased (by approx. 30%) compared with normal development, this decrease being particularly marked at a time equivalent to post-elevation during normal development (approx. 75%). Furthermore, and unlike normal palatogenesis, no significant differences were recorded between the anterior and posterior parts of the palatal shelves during cleft formation. As for normal palatogenesis, however, the percentages of each GAG were not altered at any stage. The findings are consistent with the view that suppression of GAG biosynthesis is related to the development of cleft palate in FUDR-treated rat fetuses and can therefore be interpreted as providing evidence of a role for the mesenchymal glycoconjugates in shelf elevation during normal palatogenesis.

Animals↗
PubMed1994

Presurgical orthopedic premaxillary alignment in cleft lip and palate reconstruction.

Premaxillary malposition is a difficult problem in cleft lip and palate repair. Orthopedic palatal devices are excellent in positioning the premaxilla, though they are somewhat cumbersome and require complex techniques in adjusting precisely the position of the premaxilla prior to repair. A new technique has been developed for premaxillary repositioning in conjunction with palatal shelf expansion and obturation. The procedure implements microplate fixation anterior to the premaxillary segment and linked to a palatal splint by adjustable elastics. The microplate is inserted through a nasal floor incision and secured by a tight submucosal tunnel through minimal dissection between the prolabium and premaxilla. The last hole of each microplate protrudes through the mucosa and is attached to a pin-retained palatal splint by an elastic chain. Differential tension is applied to the chains to allow gradual repositioning of the protruding maxilla while the splint expands and maintains positioning of the lateral palatal segments. These elastic retractors can be adjusted by staff in the outpatient office. During the past 2 years, this technique has been used successfully in 21 consecutive patients with unilateral or bilateral cleft lip and palate. Its technical ease and design allows simple adjustments to control premaxillary positioning and growth before definitive surgical closure.

Bone Plates↗
PubMed1998

Articulation and nasality changes resulting from sustained palatal fistula obturation.

OBJECTIVE: The purpose of the study was to determine differences in articulation and nasality with obturation over time in children with a palatal fistula. DESIGN: Articulation and nasality were measured with the fistula open, immediately after obturation, and 4 to 7 weeks postobturation. SETTING, PATIENTS, PARTICIPANTS: Subjects were 15 patients with a palatal fistula secondary to a repaired cleft palate who were seen through the Orofacial Program, Utah Department of Health, ranging in age from 4 years 6 months to 13 years 1 month. INTERVENTIONS: Acrylic palatal obturators were designed to provide coverage specific to the unique shape and location of each child's fistula. Obturators were cemented to molar teeth using wire clasps for control of usage. MAIN OUTCOME MEASURES: Measurements consisted of listener judgments of hypernasality, hyponasality, and nasal emissions; instrumental ratings of nasalance using the Nasometer 6200-2; and performance on a standardized articulation test. RESULTS: Significant improvement occurred only on nasal emission measures from the preobturation condition to immediate postobturation. However, significant improvement was found in articulation, listener judgments of hypernasality, nasal emissions, and Nasometric Nasal Sentence mean scores from the preobturation condition to 4 to 7 weeks postobturation and from the immediate postobturation condition to 4 to 7 weeks postobturation. No significant differences were found between conditions for listener judgments of hyponasality and Nasometric Zoo and Rainbow Passage scores. Obturation of the palatal fistula over a 4- to 7-week period resulted in no adverse effect on articulation ability, perceptual ratings of nasality, or instrumental ratings of nasalance. CONCLUSIONS: Clinical management of patients with a palatal fistula can be enhanced with treatment using obturation over time. For subjects who continue to exhibit hypernasality immediately postobturation, sustained obturation is advocated prior to consideration of surgical intervention for treatment of a palatal fistula and/or velopharyngeal dysfunction.

Acrylic Resins↗
PubMed2003

[A study of lateral skull radiography of patients with submucous cleft palate].

OBJECTIVE: To investigate the insertion position of the levator veli palatini in the soft palate with SMCP comparing normal group and find out reliance diagnosis methods for SMCP. METHODS: Experimental group: lateral skull radiography film were taken in 50 patients with SMCP at rest and "i" phonation. Five parameters were measured which are relative length of soft palate and hard palate; levatorveli palatini insertion in the soft palate; elongation and angle of soft palate when lifting up on phonation. CONTROL GROUP: Ten sets (rest and pronouncing "i") of lateral skull radiography were used as control group. X-rays were taken for ten normal subjects without speech disorder or other abnormal physical situations. All data were subjected to the t-test of statistical significance. RESULTS: The difference of measures between patients with SMCP and normal control was significant (P <or= 0.05). CONCLUSION: It was obvious that both absolute and relative length of soft palate are short and levator muscle insert into soft palate arterially in patients with SMCP comparing with normal group, which caused VPI and become one of the criterias for SMCP.

Adolescent↗
PubMed2005

Fixed presurgical orthopaedics for bilateral cleft lip and palate.

BACKGROUND: Presurgical orthopaedics has been employed since the 1950s as an adjunctive neonatal therapy for the correction of cleft lip and palate. It is accepted that presurgical orthopaedic plates facilitate lip repair and balanced orofacial growth. AIMS: The aims of this retrospective study of newborns with bilateral cleft lip and palate were two-fold: to describe the use of a fixed appliance to reposition the displaced fragments, and to determine if the magnitude of the palatal changes was age-related. METHODS: Study models of 12 infants with bilateral cleft lip and palate were used. The models recorded the condition prior to expansion (2-3 weeks after birth) and at the end of retention (at the time of lip surgery). The intercanine width, intertuberosity width, palatal length, palatal depth and intercanine arch length were measured. RESULTS: As a result of the expansion the intercanine width and intertuberosity width increased, and the palatal length and intercanine arch length decreased. These changes were not age-related. CONCLUSIONS: Fixed presurgical orthopaedic expansion appliances can be used to expand the upper facial skeleton in newborns.

Age Factors↗
PubMed1989

Adaptive functional changes in the swallowing pattern of the tongue following expansion of the maxillary dental arch in subjects with and without cleft palate.

In seven subjects with unilateral cleft lip and palate (UCLP), two subjects without cleft but with complete lingual crossbite, and two subjects with normal occlusion, tongue contact patterns against the hard palate, lingual surfaces of maxillary and mandibular teeth, and mandibular lingual mucosa during swallowing were analyzed three-dimensionally using electropalatography (EPG), before and after lateral expansion of the maxillary dental arch and after 3 months of retention. Before maxillary lateral expansion, all of the subjects with cleft palate showed no palate-tongue contact at rest, and limited movement of the tongue anteriorly and upward through the entire swallow cycle. Furthermore, the tongue contacted the hard palate for a relatively brief time during swallowing compared with the subjects without cleft with normal occlusion. After expansion, the tongue was seen to contact all areas of the hard palate and the lingual surface of the maxillary dentition for a longer period of time. After 3 months of retention, the tongue maintained contact with all lingual areas of the mandibular and maxillary arches and the hard palate.

Cheek↗
PubMed2005

Is palatability of a root-hemiparasitic plant influenced by its host species?

Palatability of parasitic plants may be influenced by their host species, because the parasites take up nutrients and secondary compounds from the hosts. If parasitic plants acquired the full spectrum of secondary compounds from their host, one would expect a correlation between host and parasite palatability. We examined the palatability of leaves of the root-hemiparasite Melampyrum arvense grown with different host plants and the palatability of these host plants for two generalist herbivores, the caterpillar of Spodoptera littoralis and the slug Arion lusitanicus. We used 19 species of host plants from 11 families that are known to contain a wide spectrum of anti-herbivore compounds. Growth of M. arvense was strongly influenced by the host species. The palatability of the individual host species for the two herbivores differed strongly. Both A. lusitanicus and S. littoralis discriminated also between hemiparasites grown with different host plants. There was no correlation between the palatability of a host species and that of the parasites grown on that host, i.e., hemiparasites grown on palatable host species were not more palatable than those grown on unpalatable hosts. We suggest an interacting pattern of specific effects of chemical anti-herbivore defences and indirect effects of the hosts on herbivores through effects on growth and tissue quality of the parasites.

Animals↗
PubMed1999

Restricting access to palatable foods affects children's behavioral response, food selection, and intake.

BACKGROUND: Restricting children's access to palatable foods may appeal to parents as a straightforward means of promoting moderate intakes of foods high in fat and sugar; however, restricting access to palatable foods may have unintended effects on children's eating. The efficacy of restricting children's access to palatable foods as a means of promoting patterns of moderate intake of those foods is unknown. OBJECTIVE: Two experiments were conducted to test the hypothesis that restricting access to a palatable food enhances children's subsequent behavioral responses to, selection of, and intake of that restricted food. DESIGN: Both experiments used a within-subjects design to examine the effects of restricting access to a palatable food on children's subsequent behavior, food selection, and food intake. The first experiment examined the effects of restriction within and outside the restricted context and the second experiment focused on the effects within the restricted context. RESULTS: In both experiments, restricting access to a palatable food increased children's behavioral response to that food. Experiment 2 showed that restricting access increased children's subsequent selection and intake of that food within the restricted context. CONCLUSIONS: Restricting access focuses children's attention on restricted foods, while increasing their desire to obtain and consume those foods. Restricting children's access to palatable foods is not an effective means of promoting moderate intake of palatable foods and may encourage the intake of foods that should be limited in the diet.

Analysis of Variance↗
PubMed1994

Effect of postgastric energy loads on intake of sham meals of different palatability in rats.

Food intake depends on the palatability of the diet and on the energy delivered to the body. It is not known, however, whether the palatability of a diet is able to modulate the inhibitory effect of energy input on food intake. To address this question, we have measured intake during sham feeding for diets of different palatabilities in rats receiving varying levels of duodenal energy load. Rats were offered sucrose solutions (6, 10, or 30%) or mixed liquid diets without or with physiological duodenal energy loads using a mixed liquid diet. Compared with that seen during real feeding, meal size during sham feeding was increased for palatable diets but not for less palatable diets. Intraduodenal infusion of the mixed liquid diet inhibited the intake of all diets given by sham feeding. This inhibition was dependent on the level of duodenal energy load and was significantly greater for more palatable diets than for less palatable ones. We conclude that the inhibitory effects of intestinal nutrient load on intake are significant for all diets but have a more pronounced effect on the intake of highly palatable diets.

Animals↗
PubMed2004

A novel cognitive palatability assessment protocol for dogs.

Assessment of canine palatability is important for both the pet food and pharmaceutical industries; however, the current palatability assessment protocols are limited in their utility. The most common technique, the two-pan test, does not control for the satiating effects of food and may not be useful for long-term palatability analysis because nutritional or caloric characteristics of the diets may interfere with the results. Furthermore, the large quantities of foods consumed may be detrimental to the health of animals that do not self-limit their food intake. The purpose of this study was to determine whether a cognitive protocol could be used to determine food palatability in dogs. Five beagle dogs were trained on a three-choice object-discrimination learning task. After establishing object preferences, the preferred object was associated with no reward, a second object was associated with the dog's normal laboratory diet (Purina Agribrands Canine Lab Chow No. 5006; Agribrands Purina Canada, Inc., Woodstock, ON, Canada), and the third object was associated with a commercial (Hill's P/D; Hill's Pet Nutrition Inc., Topeka, KS) diet. In the discrimination-training phase, dogs were trained until they learned to avoid the no-reward object. They were subsequently given an additional 20 test sessions, which were used to determine food preference. In the reversal phase, which involved reversal learning, the object-food associations were modified, such that the object that was previously associated with Hill's P/D diet was now associated with the normal laboratory diet and vice versa. Once the dogs learned to avoid the no-reward object, they were tested for an additional 20 sessions. All subjects learned to avoid the no-reward object during the initial learning, and the number of choices to the object associated with the Hill's P/D diet was greater than the number of choices to the objects associated with the dry laboratory diet (P < 0.05) and no reward (P < 0.05), indicating a strong preference for the Hill's P/D diet. The object preferences were reversed in only three of five dogs when the food-choice associations were reversed, although the two phases did not differ significantly from one another. The protocol in the present study provides a robust measure of food palatability and circumvents many of the limitations associated with other palatability assessment techniques. The present protocol should be useful as a replacement or adjunct to other tests of palatability, but requires further validation by comparing the assessment of more similar and novel foods directly with other palatability tests.

Animal Feed↗
PubMed1988

Secalonic acid D-induced changes in palatal cyclic AMP and cyclic GMP in developing mice.

Secalonic acid D (SAD) induces cleft palate in the developing mouse by an unknown mechanism. To investigate possible roles of cyclic nucleotides (cAMP and cGMP) in the teratogenesis of SAD, cAMP and cGMP levels were measured in the extracts of fetal palates of gestational age 13(0) through 16(12) (days(hours]. Fetuses were obtained from pregnant CD-1 mice treated on day 11(0) of gestation, with either 5% (wt./vol.) sodium bicarbonate (NaHCO3, control) or 30 mg/kg of SAD in 5% NaHCO3, intraperitoneally (i.p.). Radioimmunoassay was used to quantitate cyclic nucleotide levels. Cyclic AMP levels peaked on day 14(12) of gestation in controls. In the SAD group there was a significant decrease in cAMP levels on days 13(12) and 14(0) of gestation and a decrease of 30% in total cAMP on days 13(0) through 14(0) of gestation, with little or no change at the peak on day 14(12). On day 15(12), however, the SAD group had a 68% increase in palatal cAMP level over the control. Control levels of cGMP appeared to follow a diurnal pattern reaching maximal levels at the end of the dark cycle. In contrast, SAD decreased the cGMP level by 31% on day 13(12) (P less than 0.05) and increased it 100% above that of the control level on day 15(0) (P less than 0.01). Total cGMP during days 15(0) through 16(12) of gestation was 33% higher than control (P less than 0.01). The number of clefts in the SAD group was significantly higher at all points following palate closure in the control fetuses (14(0) through 16(12] with values ranging from 20% to 34% versus 0% in the control (P less than 0.01-0.005). Morphological changes on days 13(0) through 15(0) indicated a failure of shelf elevation in middle and posterior palatal regions of SAD-treated fetuses. These results suggest that the induction of cleft palate by SAD is associated with dynamic changes (initial decrease followed by later increase), in vivo, in established cyclic nucleotide patterns and support a mechanistic role for cyclic nucleotide-mediated cellular processes in normal as well as abnormal palate development.

Animals↗
PubMed1985

Inhibition of arachidonic acid metabolism is not involved in dexamethasone-induced growth inhibition in embryonic palatal development.

Previous studies have shown that glucocorticoids induce cleft palate in susceptible strains of mice and inhibit proliferation of palatal mesenchyme cells in vivo and in culture. The present study shows that the synthetic glucocorticoid, dexamethasone (DEX), inhibits serum-stimulated arachidonic acid release in cultured mouse palatal mesenchyme cells. Arachidonic acid could neither prevent the DEX effect on cell proliferation when added in culture nor prevent glucocorticoid-induced cleft palate when administered in vivo. Furthermore, the time course for DEX-induced inhibition of arachidonic acid release (maximal by 5h) is markedly different from the time courses for both inhibition of cell proliferation in culture and cleft palate induction in vivo (3 to 4 days). These results suggest that both DEX-induced cleft palate formation and inhibition of palatal cell proliferation arise from some mechanism other than a DEX-induced inhibition of arachidonic acid metabolism.

Animals↗
PubMed2005

The contribution of electromyography to the diagnostics of some rare palatal anomalies.

The paper presents the electromyographic (EMG) findings of the soft palate in three patients: a patient with Mohr syndrome and cleft palate, a patient with palatal asymmetry and rhinolalia and a patient with vertical oro-ocular facial cleft with marked asymmetry of the cleft palate. In the first patient, electrical silence was registered in one half of the palate. In the second patient, moderate loss of active motor units was registered in the hypoplastic part of the palate. In the third patient, in spite of asymmetry, the EMG finding was normal on both sides of the palate.

Child, Preschool↗
PubMed1978

Pathosis of the hard and soft palate.

In this article a few of the more recently emphasized and pertinent conditions that may affect the hard and soft palate have been discussed. The purpose of the article is not to present in all-inclusive classification of lesions occurring the palate. Disease of the palate may be local in nature or may reflect a systemic condition. Dentists must be conscious of the palate as the site of many possible pathoses. The prosthodontist in particular must observe and carefully evaluate the palate and insure its good health before he can prescribe a prosthesis to cover it. Dentistry provides a health service which affects the entire human organism and not just the oral cavity. Therefore an understanding of the varied nature of pathosis as it relates to the oral cavity, and especially the palate, is essential. Continuous surveillance of the palatal regions insures that the dentist's obligation to detect oral abnormalities in patients is in large measure fulfilled.

Ameloblastoma↗
PubMed1984

Role of glucocorticoids and epidermal growth factor in normal and abnormal palatal development.

The purpose of this chapter has been to discuss glucocorticoid and EGF involvement in normal and abnormal palatal development. It is to be hoped that we have made clear the important point that these hormone/growth factors and their receptors are present during normal embryonic palatal development to provide for regulation of growth and cellular differentiation. When these hormone/growth factors are administered in pharmacological or large doses that result in teratogenesis, these potent chemicals and their receptors then become inducers of cleft palate. The primary reason for this is that the hormone/growth factor receptors have unique and special areas of localizations in target (embryonic and fetal) tissues, e.g., glucocorticoids in the palate. Therefore, large amounts of these chemicals are specifically bound to receptors in these target tissues and these high levels of hormone/growth factor-receptor complexes result in aberrant development, e.g., glucocorticoids cause inhibition of palatal mesenchymal cell growth. These effects are distinct from the interactions of physiological levels of these hormone/growth factors with their receptors in these target tissues during development, e.g., glucocorticoids cause induction of key enzymes and modulation of EGF receptor levels. The exact molecular mechanism(s) by which high levels of hormone/growth factors--receptor complexes exert harmful effects on embryos or fetuses is (are) unknown and remain(s) a challenge for the future. Interaction of hormone/growth factors and their receptors certainly cannot provide an explanation for the mechanism of all types of craniofacial teratogenesis, but this concept certainly appears capable of providing important information relating to the mechanisms of many animal and human teratogens. The fact that these chemicals and their receptors are involved in normal development makes them all the more important since subtle alterations in their levels or activities could result in teratogenesis without an exposure to pharmacological levels of these hormone/growth factors. It seems that progress in this area will develop quickly since the techniques of recombinant DNA research are available in conjunction with responsive in vitro cell systems such as the established line of human embryonic palatal mesenchymal cells. Clearly, the future looks very exciting for understanding the role that these hormone/growth factors and their receptors play in normal and abnormal palate development.

Animals↗
PubMed1984

Genetics of palate development.

We are beginning to see a tantalizing picture by looking into the "genetic window" on the teratogenesis of cortisone-induced cleft palate and on normal palate development. We must continue to open this window. So far, all strains of mice that have been treated with cortisone do react with induced cleft palate and, from their dose-response behaviors, they appear to react in the same way. It is tempting to conclude that dosage tolerance is the only genetic variation in the reaction. We do not attach any significance to this because we must emphasize the fact that these different strains represent an insignificant sample of the hundreds of genetically different, recognized strains of the mouse. We have emphasized previously that systematic strain surveys must become an active part of teratological genetics in order to obtain an approximation of how much genetic variation exists in a trait in the species (e.g., Biddle, 1981). Now, we need to go beyond strain surveys. Crosses between strains must become part of this activity. Dominance appears to be a property of the homeostatic model of palate development as far as the cortisone probe is concerned, but it may not be a universal property. The significance of dominance and the architecture of gene action can only be interpreted by exploring more strain pairs in the mouse. A study of two or three or four strains is simply inadequate. From the crosses between a limited number of strains, major genetic factors in cortisone reactivity have been identified. These major genetic factors may regulate the homeostatic model of palate development, but we do not know this for a fact. The identification of major genetic factors has moved us to a new horizon; we can move now from a purely descriptive biology to a study of the functional biology of the process of palate development. This move will require not only the molecular probes with which to walk along the specific chromosomes to the major genetic factors but also a library of fully characterized strains of the mouse in which to use these probes. The library of strains that have been genetically characterized for the cleft palate reaction is missing.

Animals↗
PubMed1993

A comparison of surgical and prosthetic treatment for speech disorders attributable to surgically acquired soft palate defects.

Surgical and prosthetic treatments for speech disorders attributable to surgically acquired soft palate defects were investigated. Ten patients who had undergone soft palate resection for extensive cancer served as the subjects. In four patients, the resected portion of the soft palate was confined to the anterior or middle segments, with an intact posterior band, whereas in the remaining six patients the resected portion extended into the posterior edge. An obturator with or without a speech appliance was adapted to all patients in the former group and to one patient in the latter group. The remaining five patients in the latter group underwent surgical reconstruction using a free radial forearm flap immediately after resection of the soft palate. The speech of each patient was evaluated either before and after surgery in those treated only surgically or with and without the obturator in the other patients using a standard intelligibility test of 100 Japanese syllables. These tests showed that two of the four patients with a posterior band of soft palate remaining postsurgically achieved excellent restoration of speech and improvement of velopharyngeal function following placement of a special prosthesis. The patients who had resection extending into the posterior edge of the soft palate obtained better restoration of speech and function from surgical reconstruction rather than prosthetic management. All three patients who had surgical reconstruction, in whom the special obturator was applied achieved a slight increase in speech intelligibility scores resulting from the improvement of velopharyngeal function. These results suggest that surgical reconstruction and prosthetic management may best be applied selectively based on the extent of resection of the soft palate.

Adult↗