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Developments in blood management: the potential therapeutic role for epoetin alfa in orthopedic trauma.

Orthopedic trauma is a major source of morbidity and mortality in the United States and other countries. Major orthopedic trauma often results in significant blood loss, which is the most common cause of shock in the trauma setting. Transfusion of allogeneic blood and blood products may be used to maintain blood pressure but may not be the most effective therapy for the acute anemia that results from trauma-induced hemorrhage. Because acute anemia can interfere with successful and timely rehabilitation of these patients, it is important to be aggressive in treating anemia. One approach is to administer Epoetin alfa to stimulate erythropoiesis. A pilot study is currently in progress to test the efficacy of this approach in major trauma patients.

Blood Transfusion↗

Blood management challenges in orthopedic oncology.

Because anemia is associated with reduced long-term survival, and because allogeneic transfusion is linked to increased recurrence of disease and reduced rates of long-term survival, alternative options for managing anemia in the orthopedic oncologic patient have been sought. Managing the anemia of cancer is particularly challenging given the many obstacles to employing conventional blood management options. One potential means of treating perioperative anemia in orthopedic oncologic patients involves the use of Epoetin alfa. The clinical utility of Epoetin alfa in this setting, however, must be determined in controlled trials.

Anemia↗

[Plasma C reactive protein in elective orthopedic surgery].

BACKGROUND: C reactive protein (CRP) is used as a marker of inflammatory, infectious and surgical processes. AIM: To measure post operative plasma CRP levels after elective orthopedic surgery. MATERIALS AND METHODS: Four groups of 25 patients each were defined according to the type of surgical procedure performed. Group I corresponded to pure arthroscopic meniscectomy. Group II to arthroscopic anterior cruciate ligament reconstruction or knee osteotomy. Group III to elective primary total hip or knee arthroplasty and group IV to instrumented elective spine surgery. Plasma CRP levels were measured prospectively at the preoperative day and at the 1st, 2nd, 3rd, 7th and 15th postoperative day. Patients that had any complication were evaluated independently. RESULTS: In all uncomplicated patients, a similar shape and distribution of plasma CRP curves were observed, with maximum postoperative levels observed between the second and third day. Patients with more complex surgical procedures had higher CRP values. In all groups, CRP levels decreased significantly at 7th and 15th day, with respect to the higher measured value. In patients with surgical complications, PCR values were higher or did not decrease significantly at the seventh postoperative day, as in patients without complications. CONCLUSION: Plasma CRP levels fluctuate after elective orthopedic surgical procedures, with maximum values observed between the 2nd and 3rd postoperative day followed by an ulterior decrease. This behavior changes if postoperative complication appear. Serial measurements of CRP levels may be useful in the early detection of surgical complications.

Adult↗

Breed susceptibility for developmental orthopedic diseases in dogs.

A large-scale epidemiological study was conducted to determine breeds at risk for 12 developmental orthopedic diseases (DODs). Developmental orthopedic diseases investigated included canine hip dysplasia (CHD); craniomandibular osteopathy (CMO); fragmented coronoid process; hypertrophic osteodystrophy; Legg-Calvé-Perthes disease; osteochondrosis of the medial humeral condyle, caudal humeral head, femoral condyles, and talar trochlear ridges; panosteitis; patella luxation; and ununited anconeal process. Dogs that were diagnosed with any one of the diseases of interest at any of 10 veterinary teaching hospitals participating in the Veterinary Medical Database from 1986 to 1995 were included as cases. Odds ratios and corresponding 95% confidence intervals were calculated to determine risk. Frequency of diagnosis during the 10-year period ranged from 35 cases (CMO) to 10,637 cases (CHD). The number of breeds at increased risk for a disease ranged from one (CMO) to 35 (CHD). Breed susceptibility for a DOD may suggest a genetic component in the disease etiology. The results of this study serve to increase veterinarians' awareness of breeds susceptible to DODs and may facilitate the control of such diseases by identifying breeds that might benefit from breeding programs or environmental intervention such as dietary modification.

Animals↗

Rehabilitation of orthopedic and rheumatologic disorders. 4. Musculoskeletal disorders.

This self-directed learning module highlights assessment and therapeutic options in the rehabilitation of patients with orthopedic and musculoskeletal disorders. It is part of the chapter on rehabilitation of orthopedic and rheumatologic disorders in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article discusses new advances in such topics as idiopathic scoliosis, nontraumatic shoulder pain, rotator cuff tendinitis, and Dupuytren's disease.

Braces↗

Laser technology in orthopedics: preliminary study on low power laser therapy to improve the bone-biomaterial interface.

Low Power Laser (LPL) seems to enhance the healing of bone defects and fractures. The effect of LPL in other orthopedic areas such as osteointegration of implanted prosthetic bone devices is still unclear. In the present study, 12 rabbits were used to evaluate whether Ga-Al-As (780 nm) LPL stimulation has positive effects on osteointegration. Hydroxyapatite (HA) cylindrical nails were drilled into both distal femurs of rabbits. From postoperative day 1 and for 5 consecutive days, the left femura of all rabbits were given LPL treatment (Laser Group-LG) with the following parameters: 300 Joule/cm2, 1 Watt, 300 Hertz, pulsating emission, 10 minutes. The right femura were sham-treated (Control Group-CG). At 4 and 8 weeks after implantation, histologic and histomorphometric investigations evaluated bone-biomaterial-contact. Histomorphometry showed a higher degree of osteointegration at the HA-bone interface in the LG Group at 4 (p < 0.0005) and 8 weeks (p < 0.001). These preliminary positive results seem to support the hypothesis that LPL treatment can be considered a good tool to enhance the bone-implant interface in orthopedic surgery.

Animals↗

Orthopedic trauma. Managing secondary medical problems.

Caring for the multiply injured orthopedic trauma patient is a challenge. Managing secondary medical problems associated with injury is enhanced when rehabilitation clinical nurse specialists, orthopedic advanced practice nurses, and the interdisciplinary team are consulted immediately following trauma. Educating the public on actions and behaviors that reduce the likelihood of accidents is an important role of the RN. Nurses play a key role in restoring the patient to the preinjury level of functioning or assisting the patient in adapting to temporary/permanent disability. Early intervention may result in shortened length of hospital stay, earlier return to work, restoration of family role function, and healthier psychologic and physical recovery. All RNs must be actively involved in educating the public on injury prevention, which includes teaching responsible behavior and the adverse effects of alcohol use.

Humans↗

[Often an orthopedic problem can manifest as chest pain. Cervical vertebrae syndrome mimics myocardial infarct].

Up to 20% of all patients with pectoral symptoms have an underlying orthopedic problem. The most common orthopedic conditions that may mimic chest pain radiating into the left arm include slipped disc, cervicothoracic tension syndrome, blockage of intervertebral or rib joints, and intercostal neuralgia. Less common causes of such pain are arthrosis of the shoulder, spondylocystitis, osteoporotic fractures or tumors of the bone. Management is oriented to the underlying cause, and treatment extends from physiotherapeutic measures (rest, heat treatment) via medication (non-steroidal anti-inflammatory drugs, myotonolytic agents) to operative interventions.

Cervical Vertebrae↗

[Possibilities and profits of blood saving in orthopedics and traumatology].

The author presents his own experiences related to blood saving methods in orthopedics and traumatology. The analysis was carried out on 56 patients who underwent major orthopedic procedures: 35 total hip arthroplasties, 19 total knee arthroplasties and two fusions of fractures of the spine performed between the end of 1998 and the beginning of 1999. Patients were prepared for elective surgery by carrying out autotransfusion, which gave on average 2 units of blood for each patients. During the post operative period blood for retransfusion was obtained through active drainage using CBC Consta VAC (Strayker) equipment and through active drainage using standard Baxter transfusion bags. This gave approx. 350-700 ml of blood after hip arthroplasties, 500-800 ml after knee arthroplasty and 500 ml after stabilization of spine fractures. An analysis of the morphotic values of blood from CBC (Strayker) and the transfusion bags (Baxter) did not reveal any statistically significant differences. This confirmed that both methods are equally useful for obtaining blood from the post-operative wound. However, the low cost and simplicity of downward drainage make this method more suitable for our hospitals. Autotransfusion yielded in our department an annual saving of 250 l of blood and in many planned operations eliminate the necessity for allogenic blood transfusion.

Adult↗

[Research and establishment of the computerized orthodontic and orthopedic prediction system].

OBJECTIVE: The aim of this study was to develop a computerized orthopedics and orthodontics interactive prediction system and verify its reliability. METHODS: 24 cases of Angel II division I patients were selected in the study. All of them had been treated by activator or Frankel functional appliance, and had the satisfied therapy result. Both pre and post-treatment cephalogram of them were used verifying veracity of therapy prediction. RESULTS: All of cephalometric measure items include 11 angle measure items and 14 distance measure items. There were 9 coincidence indicators in angle measure items and 7 in distance measure items. CONCLUSION: The results indicate it is liable and effective to use the computerized orthopedics and orthodontics system for prediction.

Activator Appliances↗

Orthopedic aspects of bone dysplasias.

Although the number of bone dysplasias and their variable forms of expression seem to be increasing almost daily, in almost all instances orthopedic disease is detected at rather specific locations--the cervical spine, the thoracic and lumbar spine, and the knee and hips--and the orthopedic deformity is surprisingly constant.

Abnormalities, Multiple↗

Intrathoracic migration of a humeral orthopedic pin.

Intrathoracic migration of orthopedic fixation pins occurs infrequently but can have dire consequences if not recognized. Described herein is the case of an orthopedic pin that migrated from the proximal humerus into lung parenchyma. After preoperative computed tomography and fluoroscopy, the pin was removed via thoracotomy.

Adult↗

[Conservative treatment of femoral fractures in children in data from the Orthopedic Clinic of the 2nd Medical Faculty of Charles University].

PURPOSE OF THE STUDY: Conservative therapy is the method of choice for treating femoral fractures in younger children all over the world. At the Department of Orthopedic Surgery of the Second Faculty of Medicine, Charles University in Prague, this approach has had a long tradition and has only partly been replaced by other, more recent methods. It is not always necessary to abandon well-established and reliable techniques because of new achievements and this is demonstrated by the results of our study. MATERIAL: In a period of 22 years, 112 boys and 97 girls were treated by Bryant's traction and 62 boys and 46 girls by Weber's traction. The former was used in children younger than 5 years, weighing less than 20 kg. The latter was applied in patients between 5 and 10 years of age whose body mass was between 20 to 35 kg. METHODS: Bryant's traction, used in the younger age category, offered the advantage of easy application without total anesthesia. Both legs were suspended in an apparatus that keeps the patient's pelvis slightly elevated above the bed level. Counter traction was provided by the weight of the suspended pelvis. In Weber's traction, used in children aged 5 to 10 years, a Kirschner's wire was inserted in the distal metaphysis of each femur in the frontal plane. The ends of each wire were attached to a metal U-shaped spreader. This apparatus holds the legs at right angles both in the knees and hips. Each patient was examined by X-ray at 1 week to check the correction of displacement and at 3 weeks to check callus development. All the patients were immobilized in a plaster cast spica for a period of 6 to 8 weeks after injury and each child was also shortly hospitalized for cast removal and early physical therapy. RESULTS: Fractures in the middle of the diaphysis with an oblique fracture line were most frequent. These and long spiral fractures responded well to these two methods in almost all cases. In transverse fractures, which are less common, when an angular dislocation persisted it was tolerated owing to the subsequent remodelation. The most serious complication was a shortening of the leg involved, which often occurred with the use of Bryant's traction. The shortening was found in 80% of the patients shortly after the fracture had healed. A low body mass of the child was generally responsible for failure to stretch the femur to its full length. In children treated by Weber's traction, the shortening was observed in 55% immediately after fracture healing. On examination at 1 and 3 weeks, its presence was markedly lower, occurring in 25% and 17% of the children, respectively. Lengthening was found only occasionally on examination in adolescence or adulthood, but this may have been due to other causes. Excessive movement of the child in bed, usually when the parents came to visit, sometimes interfered with good correction of the displacement. DISCUSSION: Bryant's traction was used in our department for conservative treatment even in very young children. The plaster cast spica was applied primarily to non-displaced fractures. Pavlík's harness, recommended by Rockwood and Stannard, was used in pediatric injuries only occasionally. When conservative treatment was indicated in older children, Weber's traction was applied. The Göteborg traction described by Havránek was not used. The shortening of the leg treated was the most frequent complication, but our results were not in agreement with the data reported by Stahelim, who described a greater and more frequent shortening in children older than our patients. In our study, younger children suffered from leg shortening more often, as was also reported by Náhoda and Stryhal. The subsequent lengthening was found only occasionally; the average values of 2.6 cm and 2.3 cm in younger and older children, respectively, as reported by Náhoda and Stryhal, were not recorded. When lengthening was observed, its value was always lower. A 30 degrees rotational deviation, observed by Verbeek in one third of his patients, was not seen in our children. Pseudoarthrosis or infection were absent in our population and a literature search showed that, when treated conservatively, femoral fractures were not associated with these complications. CONCLUSIONS: Well-established methods of conservative treatment of femoral fractures in children were evaluated with the objective to advocate their importance for today's orthopedic surgery. Although the children treated by these methods are confined to bed for a longer period than when more recent techniques are used, they may avoid many of the complications that accompany these new approaches.

Child↗

[Effect of artificial mountain air on the immune system state of immunosuppressed orthopedic and traumatologic patients].

The artificial mountain air influence on immunity indices of orthopedic and traumatologic patients with immunodepression was studied. The positive effect of interrupted normobaric hypoxitherapy on the immune state of patients was shown by means of increase of stromal elements of bone marrow, developing microsurroundings for maturation of immunocompetent cells. It was suggested to apply orotherapy in the preoperative preparation complex of orthopedic and traumatologic patients with immunodepression.

Air↗

[The effect of Class III intermaxillary functional orthopedic force on the remodeling of pubescent rhesus monkeys' temporomandibular joint: an radiographic study].

OBJECTIVE: To study the effect of Class III intermaxillary functional orthopedic force on the remodeling of pubescent Rhesus monkeys' TMJ for different lengths of time. METHODS: Six pubescent Rhesus monkeys were divided into test group and control group. Monkeys in the test group wore TMAIII while the control group did not. Cephalometric technology and CT scanning were employed in this study. RESULTS: 1. Compared with the control groups, the cephalometric results showed that the relationship of the occlusion changed in the test groups. The growth of the maxilla was promoted and the development of the mandible was inhibited, but the mandibular length was not decreased. 2. Compared with the control groups, CT scanning results showed that the posterior space of TMJ in the test group narrowed and the anterior space widened. There was a statistical difference between the test group and the control group(P < 0.01), but no difference within the test group. CONCLUSION: Under Class III Orthopedic therapy, the occlusion relation was changed. The growth of maxilla was promoted and the development of mandible was inhibited. The posterior space of TMJ narrowed and the anterior space widened in test group.

Animals↗

Occult spinal cord abnormalities in children referred for orthopedic complaints.

This study reviews spinal cord abnormalities found in children initially referred for an orthopedic problem. Over a 5-year period in an academic pediatric orthopedic referral clinic, 167 children aged 3 months to 18 years (average, 9.4 years) underwent spine magnetic resonance imaging (MRI) scans and had records available for review. The patients were divided into 7 major groups based on the primary indication for the MRI. The frequency of spinal cord pathology was as follows: 3 of 35 patients with atypical idiopathic scoliosis, 1 of 19 with neuromuscular scoliosis, 6 of 18 with congenital scoliosis, 1 of 50 with unexplained back pain, 3 of 17 with gait abnormality, 5 of 14 with limb pain or weakness, and 4 of 8 with rigid or recurrent foot deformity. Spine MRI was not very helpful in evaluating children who had some degree of back pain without neurological signs or symptoms. However, the spine MRI was helpful in evaluating children with atypical idiopathic scoliosis or congenital scoliosis, gait abnormality, limb pain or weakness, or rigid or recurrent foot deformities. Given the high frequency of occult spinal cord abnormality in children with severe foot deformity, the use of screening spine MRI may be especially useful in this group.

Adolescent↗

[Presurgical orthopedic treatment for cleft lip and palate].

INTRODUCTION: A multidisciplinary approach with several specialits allows a complete treatment for Cleft Lip and Palate. We show our experience in presurgical orthopedic treatment in these patients, their advantages, their problems and the results. MATERIAL AND METHODS: Since 1999 presurgical orthopedy has been applied to 12 patients (3 bilateral cleft lip and palate and 9 unilateral cleft lip and palate). This approach was applied when there was a long distance between the alveolar segments. A palate mould and the location of Latham's appliance have been made in the operating room under general anesthesia. The patients were controlled by the orthodoncist and Latham's appliance was removed when cleft lip was closed. RESULTS: Latham's appliance was kept for 4-7 weeks with once a week controls until the distance between the maxillary segments was less than 1 mm; in bilateral cases of cleft lip and palate the premaxilla was moved between lateral segments. Then, lip closure and nasoplasty was made and, sometimes, an obturador was placed. CONCLUSIONS: Latham's appliance permit to achieve a perfect alignment of alveolar segments decreasing the soft tissues tension and facilitating the lip surgery, thus, a better aesthetic and functional results can be achieved. A more anatomic position of palate can be made and easier future orthopedic treatments are possible.

Child, Preschool↗