Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “OLEIC ACID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 811 records · Page 45Linked to original sources
PubMed2006

Lymphatic recovery of exogenous oleic acid in rats on long chain or specific structured triacylglycerol diets.

Specific structured triacylglycerols, MLM (M = medium-chain fatty acid, L = long-chain fatty acid), rapidly deliver energy and long-chain fatty acids to the body and are used for longer periods in human enteral feeding. In the present study rats were fed diets of 10 wt% MLM or LLL (L = oleic acid [18:1 n-9], M = caprylic acid [8:01) for 2 wk. Then lymph was collected 24 h following administration of a single bolus of 13C-labeled MLM or LLL. The total lymphatic recovery of exogenous 18:1 n-9 24 h after administration of a single bolus of MLM or LLL was similar in rats on the LLL diet (43% and 45%, respectively). However, the recovery of exogenous 18:1 n-9 was higher after a single bolus of MLM compared with a bolus of LLL in rats on the MLM diet (40% and 24%, respectively, P = 0.009). The recovery of lymphatic 18:1 n-9 of the LLL bolus tended to depend on the diet triacylglycerol structure and composition (P= 0.07). This study demonstrated that with a diet containing specific structured triacylglycerol, the lymphatic recovery of 18:1 n-9 after a single bolus of fat was dependent on the triacylglycerol structure of the bolus. This indicates that the lymphatic recovery of long-chain fatty acids from a single meal depends on the overall long-chain fatty acid composition of the habitual diet. This could have implications for enteral feeding for longer periods.

Administration, Oral↗
PubMed1998

Digestion and absorption rates of [3H]-oleic acid and [14C]-triolein do not differ in rats fed heated (-) and (+) gossypol cottonseed and soybean flours.

This study was conducted to compare in vivo the acute effects of heated (+) and (-) gossypol cottonseed flours with those of soybean flour on lipid digestion and absorption in growing rats. Rats were fed by gastric intubation mixed [3H]-oleic acid and [14C]-triolein with heated flours or without flour (control). Lipid digestion and absorption were determined for 6 h after meal intubation. Both radioactivities recovered in gastrointestinal tract were significantly higher in rats fed (+) gossypol cottonseed flour than in all other groups. The majority of both recovered radioactivities was found in stomach contents, then in stomach wall and finally in intestinal wall. The distribution of both radioactivities at different gastrointestinal levels was similar. In stomach contents and wall, [14C]-radioactivity was primarily in triacylglycerols, but was also recovered in free fatty acids and diacylglycerols. In intestinal wall (mucosa + tunica) [3H]-radioactivity was found at greatest levels in free fatty acids, then in triacylglycerols and diacylglycerols. Greatest [14C]-radioactivity was found in triacylglycerols, then in free fatty acids, in diacylglycerols and last in phospholipids in rats fed the three flours. Therefore no quantitative differences in lipid digestion and absorption were observed among the rats fed the three flours. In conclusion, both cottonseed flours slowed lipid digestion and absorption compared with soybean flour and this delay was greater in the rats fed (+) gossypol cottonseed flour than in those fed (-) gossypol cottonseed flour. However, this inhibiting effect was probably too low to induce physiologically important effects on lipid digestion or absorption.

Animals↗
PubMed1980

Pituitary and adrenal control of pancreatic endocrine function in the duck. III. Effects of glucose, oleic acid, arginine, insulin and glucagon infusions in hypophysectomized or normal ducks.

The existence of plasma metabolites (glucose, free fatty acids [FFA[, aminoacids [AA])--pancreatic hormones (insulin, glucagon) feedback mechanisms and of insulin-glucagon relationships were studied in hypophysectomised ducks; the insulinogenic effect of glucagon was also studied in normal ducks in physiological conditions. Glucose infusion stimulated insulin secretion in hypophysectomised ducks; during oleic acid infusion, plasma IRI (immunoreactive insulin) was not modified whereas plasma GLI (glucagon like immunoreactivity) level drops slightly. Arginine induced insulin and glucagon secretion. Plasma GLI did not decrease during insulin infusion. In normal ducks glucagon was insulinogenic, hyperglycaemic and hypoaminoacidaemic. These biological properties of glucagon were lost in hypophysectomised ducks, except the effect on plasma aminoacids. It is concluded that the anterior pituitary and the adrenal cortex indirectly control the endocrine function of the pancreas, via the plasma metabolites and the insulin-glucagon interactions. In normal ducks, glucagon is probably insulinogenic in physiological conditions.

Adrenal Glands↗
PubMed1994

Mechanism of efficacy of 2-amino oleic acid for inhibition of calcification of glutaraldehyde-pretreated porcine bioprosthetic heart valves.

BACKGROUND: Calcification is a frequent cause of the clinical failures of glutaraldehyde-pretreated bioprosthetic heart valves (BPHV) fabricated from glutaraldehyde-cross-linked porcine aortic valves. 2-Amino oleic acid (AOA) has been shown in previous in vivo studies to be a promising anticalcification agent. Our objective was to investigate the mechanism of calcification inhibition mediated by AOA pretreatment of porcine aortic valve bioprostheses. METHODS AND RESULTS: BPHV tissues were treated with an AOA solution for 72 hours before experimentation. The diffusion of AOA across both cusp and aortic wall was evaluated. The lag time for AOA to diffuse across the aortic wall was prolonged compared with that of the cusp. An extraction study was performed to determine the stability of AOA binding; the results indicated that the binding was relatively stable regardless of solvent extraction conditions. The interaction between ionic calcium and AOA on treated tissue also was investigated by evaluating the patterns of calcium diffusion across both treated and untreated tissues. The results showed that AOA significantly reduced the diffusion of calcium. AOA inhibition of aortic valve calcification (calcium level, 5.5 +/- 3.0 mg/g of tissue compared with control; calcium level, 91.2 +/- 19.5 mg/g of tissue) but not aortic wall (calcium level, 158.7 +/- 10.3 mg/g of tissue compared with control; calcium level, 157.5 +/- 7.9 mg/g of tissue) was demonstrated on representative specimens from valves implanted in left ventricular apicoaortic shunts explanted after 150 days. CONCLUSIONS: AOA covalently binds to glutaraldehyde-pretreated bioprosthetic heart valve tissue, presumably as the result of an aldehyde-amino reaction. Covalently bound AOA diminishes Ca2+ diffusion compared with non-AOA-pretreated bioprosthetic tissues. This may explain in part the anticalcification mechanism of AOA. Furthermore, AOA inhibits calcification of porcine BPHV cusps in the circulation.

Animals↗
PubMed1996

Improved arterial oxygenation after oleic acid lung injury in the pig using a computer-controlled mechanical ventilator.

We compared computer-controlled mechanical ventilation programmed for biologic variability of respiratory rate (RR) and tidal volume (VT) with conventional intermittent positive-pressure ventilation (IPPV) in an oleic acid (OA) lung injury model. Seventeen pigs were ventilated with an Ohio 7000 anesthesia ventilator. Minute ventilation (VE) was adjusted to maintain PaCO2 at 30 to 35 mm Hg at baseline and was not altered further. OA was infused at 0.2 ml/kg/h until PaO2 decreased to < 125 mm Hg (F(I)O2 = 0.5). Animals were randomly assigned to continue with conventional IPPV (control group; n = 8) or had IPPV computer-controlled (computer group; n = 9). Hemodynamic, respiratory gas, airway pressure, and volume data were obtained at baseline (before OA infusion), at Time 30 (after infusion), and at 30-min intervals for 240 min after OA. At experiment completion, the lungs were removed to determine the wet:dry weight ratios. The control group had RR fixed at 20 breaths/min. The computer group had a RR of 20 +/- 2.3 breaths/min (range, 15 to 27 breaths/min), comprising 369 different RR values with reciprocal changes in VT over 1,089 s before the program looped to repeat itself. There was no difference between groups in the volume of OA infused. By 120 min after lung injury, animals in the computer group had significantly greater PaO2, associated with a lower Qs/QT. Mean airway pressures and mean peak airway pressures were not different in the two groups. By 180 min, respiratory system compliance (Crs) was significantly lower in the control group. The wet:dry lung weight ratios were greater in the control group. Thus, in a porcine model of OA lung injury, computer-controlled mechanical ventilation, which is programmed for biologic variability, resulted in improved blood oxygenation without increasing mean airway pressures when compared with conventional IPPV.

Animals↗
PubMed1994

Effect of 2-amino oleic acid exposure conditions on the inhibition of calcification of glutaraldehyde cross-linked porcine aortic valves.

Postimplant calcific degeneration is a frequent cause of clinical failures of glutaraldehyde cross-linked porcine bioprosthetic heart valves (BPHV). It was demonstrated previously that 2-amino oleic acid (AOA) used as a bioprosthesis treatment was highly effective in mitigating aortic valve cusp but not aortic wall calcification. Our main objective was to study the efficacy of various AOA exposure conditions for inhibiting calcification of both cusps and aortic wall tissues using rat subdermal implants. BPHV tissues were treated with a saturated AOA solution for different time intervals before experimental. Aortic wall AOA levels were consistently lower than that of the cusps after the same exposure times. The diffusion of calcium ion across both cusp and aortic wall tissues was evaluated, and the results demonstrated that there was an AOA exposure time-dependent retardation of calcium ion penetration for cusp but not aortic wall. An 8-month extraction study was performed to determine the stability of AOA binding. When Tween 80 was used as an extraction medium, cusp and aortic wall retained 12.9 and 48.7%, respectively, of their initial AOA levels. AOA inhibition of calcification in rat subdermal implants (60 days) was found to be exposure time-dependent with maximum treatment time (120 h), resulting in the lowest calcium levels (20.1 +/- 10.3 and 71.4 +/- 5.4 micrograms/mg of cusp and aortic wall, respectively) as compared with controls (219.1 +/- 6.8 and 104.9 +/- 8.5 micrograms/mg of cusp and aortic wall, respectively). The significance of AOA binding on BPHV tissue was determined by either blocking or reducing BPHV's (cusp and aortic wall) free aldehyde residues with lysine or NaBH4, respectively, before AOA treatment. For aortic cusps, the AOA contents after 72 h were 98.3 +/- 2.7, 34.2 +/- 3.6, and 54.1 +/- 3.0 nM/mg of tissue for AOA (control), lysine-pretreated (plus AOA) and NaBH4-pretreated (plus AOA) tissues, respectively. However, their calcium levels after 60 days of rat subdermal implant were all comparable (i.e., 48.1 +/- 6.2, 38.2 +/- 9.1, and 47.0 +/- 15.0 micrograms calcium per mg of tissue). Similar results were observed on BPHV aortic wall. It can thus be concluded that AOA inhibition of BPHV calcification is exposure time-dependent, but the efficacy of AOA for aortic wall is less than that noted for aortic cusps, perhaps because of lower AOA binding and differences in calcium diffusion kinetics.

Animals↗
PubMedDate not supplied

Oleic acid serum phospholipid content is linked with the serum total- and LDL-cholesterol in elderly subjects.

INTRODUCTION: Increased dietary intake of the olive oil has been found to lower several cardiovascular risk factors. Aim of our study was to check if there is any link between the oleic acid (OL-18:1n9) serum phospholipid (SPL) content and some of these factors in subjects living relatively far from the Mediterranean region and in habitual conditions, i.e. without any dietary intervention. MATERIAL AND METHODS: The investigated group included 62 out-patients older than 51 yr. Serum lipids were measured using standard hospital laboratory methods, the LDL-cholesterol was calculated using Friedewald's formula. Gas chromatography was used for estimation of fatty acids (FA) in SPL, their values were calculated as relative percentages of all FA. RESULTS: There was a statistically significant inverse correlation between the OL SPL content and the serum total cholesterol (TCHOL) in all 62 patients (r = -0.294; p = 0.020). Analogous correlation was marginally significant for the LDL (r = -0.245; p = 0.055). After a division into 2 groups based on the median of the OL, the group with OL higher than median had significantly lower both TCHOL and LDL (p = 0.014; p = 0.033, respectively). OL correlated positively with the alpha-linolenic acid (18:3n3; r = 0.281; p = 0.027) but inversely with the stearic acid (18:0; r = -0.303; p = 0.017). CONCLUSION: The subjects with less OL in their SPL had higher TCHOL and LDL serum levels and also their fatty acid SPL spectrum showed some other features which may be characterized as undesirable. This is an independent argument emphasizing the need for enhancing OL dietary intake.

Aged↗