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At least 811 records · Page 45Linked to original sources
PubMed2004

Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats.

Male Holtzman rats weighting 200-250 g were anesthetized with zoletil 50 mg/Kg (tiletamine chloridrate 125,0 mg and zolazepan chloridrate 125,0 mg) into quadriceps muscle and submitted an electrolytic lesion of the lateral hypothalamus (LH) and a stainless steel cannula was implanted into their median preoptic nucleus (MnPO). We investigated the effects of the injection into the (MnPO) of FK 409 (20 microg/0.5 microl), a nitric oxide (NO) donor, and N(W)-nitro-L-arginine methyl ester (L-NAME) 40 microg/0.5 microl, a nitric oxide synthase inhibitor (NOSI), on the water and sodium appetite and the natriuretic, diuretic and cardiovascular effects induced by injection of L-NAME and FK 409 injected into MnPO in rats with LH lesions. Controls were injected with a similar volume of 0.15 M NaCl. L-NAME injected into MnPO produced an increase in water and sodium intake and in sodium and urine excretion and increase de mean arterial pressure (MAP). FK 409 injected into MnPO did not produce any change in the hydro electrolytic and cardiovascular parameters in LH-sham and lesioned rats. FK 409 injected before L-NAME attenuated its effects. These data show that electrolytic lesion of the LH reduces fluid and sodium intake as well as sodium and urine excretion, and the pressor effect induced by L-NAME. LH involvement with NO of the MnPO excitatory and inhibitory mechanisms related to water and sodium intake, sodium excretion and cardiovascular control is suggested.

Animals↗
PubMed2006

Traces of vocabulary acquisition in the brain: Evidence from covert object naming.

One of the strongest predictors of the speed with which adults can name a pictured object is the age at which the object and its name are first learned. Age of acquisition also predicts the retention or loss of individual words following brain damage in conditions like aphasia and Alzheimer's disease. Functional Magnetic Resonance Imaging (fMRI) was used to reveal brain areas differentially involved in naming objects with early or late acquired names. A baseline task involved passive viewing of non-objects. The comparison between the silent object naming conditions (early and late) with baseline showed significant activation in frontal, parietal and mediotemporal regions bilaterally and in the lingual and fusiform gyri on the left. Direct comparison of early and late items identified clusters with significantly greater activation for early acquired items at the occipital poles (in the posterior parts of the middle occipital gyri) and at the left temporal pole. In contrast, the left middle occipital and fusiform gyri showed significantly greater activation for late than early acquired items. We propose that greater activation to early than late objects at the occipital poles and at the left temporal pole reflects the more detailed visual and semantic representations of early than late acquired items. We propose that greater activation to late than early objects in the left middle occipital and fusiform gyri occurs because those areas are involved in mapping visual onto semantic representations, which is more difficult, and demands more resource, for late than for early items.

Adult↗
PubMed2005

Neural mechanisms involved in the detection of our first name: a combined ERPs and PET study.

In everyday social interactions, hearing our own first name captures our attention and gives rise to a sense of self-awareness, since it is one of the most socially self related stimulus. In the present study, we combined ERPs and PET scan methods to explore the cerebral mechanisms underlying the detection of our own name. While categorical analyses of PET data failed to reveal significant results, we found that the amplitude of the P3 component, elicited when hearing one's own name, correlates with regional cerebral blood changes in right superior temporal sulcus, precuneus and medial prefrontal cortex. Additionally, the latter was more correlated to the P3 obtained for the subject's name compared to that obtained for other first names. These results suggest that the medial prefrontal cortex plays the most prominent role in self-processing.

Adult↗
PubMed2004

Microinjection of the nitric oxide synthase inhibitor L-NAME into the lateral basal forebrain alters the sleep/wake cycle of the rat.

The effects of N(G)-nitro-L-arginine methyl ester (L-NAME) (0.19-0.74 micromol), a competitive inhibitor of the enzyme nitric oxide synthase (NOS); L-arginine (48.0-191.0 nmol), a nitric oxide (NO) precursor; and molsidomine (0.06-0.24 nmol), an NO donor, on spontaneous sleep were studied in adult rats implanted for chronic sleep recordings. Direct bilateral application of L-NAME into the nucleus of the horizontal limb of the diagonal band of Broca (HDB) increased waking (W) and reduced slow wave sleep (SWS). On the other hand, intra-HDB injection of L-arginine or molsidomine induced slight but inconsistent changes of sleep variables that did not attain significance. Pretreatment with L-arginine (191.0 nmol) or molsidomine (0.24 nmol) prevented the increase of W and the reduction of SWS induced by L-NAME (0.37 micromol), thus indicating that a decrease in the availability of NO may be involved in the effects of L-NAME on sleep variables. An increase in the release of acetylcholine (ACh) and/or a reduction in the output of gamma-aminobutyric acid (GABA) and adenosine could tentatively explain the effects of L-NAME on SWS and W.

Acetylcholine↗
PubMed2005

Effect of pioglitazone on L-NAME induced hypertension in diabetic rats.

The present study investigates the effect of pioglitazone treatment on blood pressure, vascular reactivity and antioxidant enzymes in L-NAME induced hypertension in normal and STZ-diabetic rats. Diabetes was induced in male Sprague Dawley rats (200+/-15 g) by single intravenous injection of 55 mg/kg of streptozotocin (STZ). Rats were randomized into diabetic and nondiabetic groups, Nomega-nitro-L-arginine-methyl ester (L-NAME, 50 mg/kg) was administered in drinking water for 4 weeks. They were treated with pioglitazone (10 mg/kg/day, p.o.) for 4 weeks and following protocol was carried out. Blood pressure, blood glucose levels and body weight were measured. Thoracic aorta was isolated and dose response curve of phenylephrine (PE) with intact and denuded endothelium was recorded. Dose response curve of acetylcholine (Ach) and sodium nitroprusside (SNP) was recorded in precontracted rings. Lipid peroxidation, superoxide dismutase, catalase, and reduced glutathione were estimated in liver, kidney, and aorta. Pioglitazone produced no significant effect on blood glucose levels, body weight and blood pressure of L-NAME administered nondiabetic and diabetic rats. Pioglitazone treatment had no significant effect on PE induced contraction and Ach induced relaxation in L-NAME diabetic and nondiabetic rats. SNP completely relaxed aortic rings of all the groups. Higher oxidative stress in case of diabetic rats was significantly (p<0.05) reduced by pioglitazone treatment. Although pioglitazone reduced oxidative stress in diabetic rats, there was no significant effect on blood pressure as there was complete absence of nitric oxide due to administration of L-NAME. Hence from the present study it can be concluded that reduction in blood pressure in case of STZ-diabetic rats is nitric oxide mediated.

Animals↗
PubMed2005

Naming ability after tailored left temporal resection with extraoperative language mapping: increased risk of decline with later epilepsy onset age.

Standard temporal resection in the left hemisphere carries the risk of postoperative naming ability decline, especially with later epilepsy onset age/absence of hippocampal sclerosis. Language mapping has been performed routinely at some centers to minimize postoperative primary language impairment, but its effect on changes in naming performance has not been explored. This study examined naming outcome in 24 patients with nonlesional epilepsy who had left temporal resection after extraoperative language mapping. The mean decline in Boston Naming Test (BNT) score was 7.8, and 13 (54%) patients had a BNT decline greater than the Reliable Change Index. Simple correlations found significant relationships between BNT score decline and: later onset age, higher preoperative BNT score, and resection of isolated language sites. A multiple regression analysis showed that onset age was the best predictor of BNT decline. Although naming ability in patients with early onset age is stable with language mapping, there is still a risk of decline for those with later onset age.

Adolescent↗
PubMed1997

Modulatory effect of L-NAME, a specific nitric oxide synthase (NOS) inhibitor, on stress-induced changes in plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats: physiological significance of stress-induced NOS activation in hypothalamic-pituitary-adrenal axis.

We investigated whether NG-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide synthase (NOS), can modify the stress-induced adrenocorticotropic hormone (ACTH) and corticosterone responses, because we found that immobilization-induced stress increases NOS mRNA and protein levels and enzyme activity in the adrenal cortex. The physiological significance of these phenomena, however, remains unknown. Plasma ACTH and corticosterone levels were determined by radioimmunoassay (RIA) of systemic blood samples and NOS enzyme activity was measured as the rate of [3H]arginine conversion to [3H]citrulline in the presence of tissue homogenate of adrenal cortex separated from the adrenal gland. The NOS enzyme activity in the adrenal cortex of rats pre-injected with saline at 2 h after the 2-h immobilization was significantly higher (P < 0.01) than that in the non-stressed controls. Pre-injection of L-NAME (100 mg/kg, s.c.) almost completely abolished the activity. This dose of L-NAME maintained a significantly elevated plasma corticosterone level (P < 0.05, compared with basal level) even 2 h after the 2-h stress, whereas the plasma corticosterone level in rats pre-injected with saline returned to the basal level at the same time point. Plasma ACTH level in L-NAME-pre-treated rats was higher than that in those pre-treated with saline 2 h after the stress, but the difference was not significant. This dose of L-NAME did not influence plasma ACTH or corticosterone levels under resting conditions without stress. These findings suggest that the stress-induced increase in NO synthesis in the adrenal cortex can modify the stress-induced corticosterone response to facilitate the recovery from the elevated corticosterone secretion by stress in the adrenal cortex to the resting basal level.

Adrenocorticotropic Hormone↗
PubMed1998

Shape and representational status in children's early naming.

Why are ontological distinctions commonly ignored in ordinary language use? For example, why is a toy bear called a 'bear'? Jones and Smith argue that shape is central to the semantic representations of both children and adults (Jones, S.S., Smith, L.B., 1993. The place of perception in children's concepts. Cognitive Development 8, 113-139). In contrast, Soja et al. suggest that children do not rely on shape per se, but rather name representations, which are often indexed by shape (Soja, N.N., Carey, S., Spelke, E.S. 1992. Perception, ontology, and word meaning. Cognition 45, 101-107). Two studies were designed to test the latter hypothesis. Forty-seven children (2 years 5 months-3 years 11 months) and 32 adults participated. Each saw a series of line-drawings roughly shaped like various namable objects (e.g. a man). For half the participants, each line-drawing was described as depicting a shape that was created intentionally (e.g. someone painted a picture). For the remaining participants, each drawing was described as depicting a shape that was created accidentally (e.g. someone spilled some paint). Participants were simply asked to name each picture. We hypothesized that subjects would use shape as the basis of naming primarily when the shapes were intentional (and thus plausibly representations). The findings supported the predictions, for both children and adults. These results suggest that, although shape does play an important role in children's early naming, other factors are also important, including the mental state of the picture's creator (intentional vs. not). Thus, the data suggest that from an early age, children's picture naming incorporates their theory of mind.

Adult↗
PubMed2005

Proper name anomia after left temporal subcortical hemorrhage.

We report here a patient with proper name anomia following subcortical hemorrhage in the left superior temporal gyrus. Despite the preserved ability to retrieve common names, the patient could not retrieve the names of people, countries, or racehorses, which he could recognize quite well. Semantic knowledge regarding people, countries, and racehorses was also preserved. In addition. the finding that phonological cueing was effective with preservation of the ability to point to photos corresponding to their names suggested that the lexicon of proper names was preserved in this patient. Thus, the output lexicon appeared to be partially disconnected from semantic knowledge. This rare and limited lesion suggested that the superior temporal gyrus plays an important role in connecting semantic knowledge and the output lexicon.

Anomia↗
PubMed1997

Optic aphasia: evidence of the contribution of different neural systems to object and action naming.

Visual stimulus naming was studied in a 66-year-old male patient with optic aphasia subsequent to left occipito-temporal infarction. While having difficulty in naming objects perceived visually, he was able to name objects by viewing gestures illustrating their use, and to name actions shown in pictures. These results suggest that naming performance depends on the kind of stimulus that is visually presented (object vs. action). The present findings lend support to congnitive models which postulate the existence of visual and functional semantic systems.

Aged↗
PubMed1998

Object and action naming in Alzheimer's disease.

We administered measures of object naming and action naming to matched groups of ten patients with Alzheimer's disease (AD) and ten normal control subjects. AD patients were impaired in both object and action naming, with object naming impaired to a significantly greater extent than action naming. This difference remained after controlling for the effects of word frequency. We propose that the pattern of pathological changes in AD impairs both conceptual and lexical retrieval systems for objects but only conceptual systems for actions. The similar patterns of error during the two tasks suggest quantitative rather than qualitative differences in the breakdown of the two abilities.

Aged↗
PubMed1999

Selective sparing of verb naming in a case of severe Alzheimer's disease.

A patient with severe Alzheimer's disease (AD) presented with a severe impairment in naming nouns but selective sparing of the naming of verbs. Her impairment in naming nouns was presented across a wide range of categories investigated. To our knowledge, this is the first case documenting the selective preservation of verb naming in a patient with AD. The implications for the notion of an intrinsic vulnerability of verb naming in AD and for the current knowledge of anatomical correlates of noun/verb processing are discussed.

Aged↗
PubMed1987

Naming errors in healthy aging and dementia of the Alzheimer type.

Naming errors were analyzed for healthy younger and older adults and patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). Three types of errors were identified, varying in relatedness to the target word: near synonyms; semantically related naming errors; and unrelated naming errors. Older adults made relatively more related errors than did younger adults. SDAT patients were distinguished by the number of unrelated responses given. In addition, SDAT patients who scored within the normal range were identified by the high number of response attempts relative to the number of initial errors. We suggest that error patterns on naming tasks may potentially serve as clinical markers to distinguish healthy older persons with mild naming disorders from patients with SDAT.

Adult↗
PubMed2002

Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats.

Endothelial dysfunction ensuing inhibition of nitric oxide synthase (NOS) was investigated in male Sprague-Dawley rats given N(omega)-nitro-L-arginine methyl ester (L-NAME) in drinking water for 8 weeks. Age-matched rats served as controls. L-NAME-treated rats, as compared to control animals, showed: (1) a clear-cut increase in systolic blood pressure; (2) a consistent decrease of endothelial-cell NOS (eNOS) gene expression in aortic tissue; (3) a reduction of the relaxant activity of acetylcholine (ACh, from 10(-10) to 10(-4) M) on norepinephrine-precontracted aortic rings (reduction by 52+/-5%); (4) a marked decrease (-50%) of the basal release of 6-keto-prostaglandin F(1 alpha) (6-keto-PGF(1 alpha)) from aortic rings. In L-NAME-treated rats, administration in the last 2 weeks of either the angiotensin-converting enzyme inhibitor enalapril (1 mg/kg/day) or the cognate drug quinapril (1 mg/kg/day) decreased systolic blood pressure levels, completely restored eNOS mRNA levels in aortic tissue, and allowed a consistent recovery of both the relaxant activity of ACh and the generation of 6-keto-PGF(1 alpha). No difference was present in the ability of the two angiotensin-converting enzyme inhibitors to reverse NAME-induced endothelial dysfunction. These findings indicate that L-NAME-induced hypertension in the rat relies on the marked impairment of the endothelial vasodilator function, with an ensuing contribution by a decreased production of prostacyclin by the endothelial cells. Angiotensin-converting enzyme inhibition by enalapril or quinapril was equally effective in improving endothelial vasodilator function, prostacyclin endothelial production and restoring aortic eNOS mRNA.

6-Ketoprostaglandin F1 alpha↗
PubMedDate not supplied

The influence of vocabulary age and spatial dimension on rapid picture naming in children with reading disorders.

The present study measured naming reaction times of normal and reading disordered (RD) children to a series of centrally presented picture stimuli of varying vocabulary age and spatial dimension. Results of the ANOVA on reaction times indicated significant interactions of Group x Dimension and Group x Vocabulary. Post hoc tests on the former interaction suggested that the feature of dimension differentially affected naming reaction times for the two groups. The control group produced faster naming reaction times to the three-dimensional pictures, while the reading disordered group was faster in naming two-dimensional stimuli. In the later interaction, the normal readers produced faster reaction times to the lower-level vocabulary. Although the same pattern of response was obtained for the reading disordered children, they were found to evidence a generalized slowing in their responses with a greater temporal difference occurring between the two levels of vocabulary. These findings suggest that children with reading disorders exhibit deficits in rapid lexical access of later acquired and more complex vocabulary.(1). As a result of this activity, the participant will be able to identify critical stimulus features of pictorial stimuli that effect rapid retrieval abilities. (2). As a result of this activity, the participant will be able to explain the individual subsystems and interactions of processes (Cascade Model) that characterize picture naming. (3). As a result of this activity, the participant will be able to differentiate between patterns of lexical access as a function of critical stimulus features, for children with reading disorders and normal reading abilities.

Age Factors↗
PubMedDate not supplied

A case study of gesturally cued naming in aphasia: dominant versus nondominant hand training.

Gestural plus verbal facilitation of naming was investigated in an aphasic right handed adult with apraxia and hemisensory deficit but no hemiplegia secondary to a left hemisphere lesion. An alternating treatments design was followed in combined gesture/speech training of picture naming to compare speech facilitation with dominant vs. nondominant hand iconic gesturing. A small but consistent facilitation effect was observed for naming associated with verbal plus left hand gestural training over naming of items trained in association with verbal plus right hand gesturing. This same pattern of gestural facilitation was replicated with a second set of lexical targets, those for which only verbal training was initially provided. Overall gains were retained over a six-month follow-up period for trained stimuli. Although findings are limited to the performance of a single subject, results of this study may provide data relevant to understanding mechanisms of facilitation in gesture-cued naming in aphasia.

Aged↗
PubMed2001

ERP indexes of functional differences in brain activation during proper and common names retrieval.

Functional neuroimaging and neuropsychological findings suggest that memory retrieval of common and proper names is subserved by different neuro-functional systems but little is known about the topographic localization of neural generators. In the present study brain electrical activity was recorded with a high density electrode montage in healthy young volunteers during lexical retrieval upon written definition. ERPs spatio-temporal mapping showed on one side a strong activation of left anterior temporal and left central-frontal areas for proper names, and on the other side a greater involvement of occipital areas for common names retrieval. The specific pattern of bio-electrical activity recorded during proper names retrieval might index the activation of neural circuits for recalling names of high contextual complexity, poor of sensory-motor associations and dependent on precise spatio-temporal coordinates.

Adult↗
PubMed2003

Preventing L-NAME inhibitory effects on rat sexual behavior with hydralazine, isradipine or captopril co-treatment.

The effects of the chronic oral treatment with N(G)-nitro-L-arginine methyl ester (L-NAME), separately or in combination with isradipine, captopril or hydralazine, on standard and temporal patterning sexual behavior of male rats were evaluated. L-Arginine and filtered water were used as control. L-NAME treatment decreased the copulatory rate and hit rate factors of sexual behavior. However, the initiation factor and temporal patterning were less modified by the drug. After 14 days of L-NAME treatment suspension the male rat sexual response was recovered. The three antihypertensive agents were able to reverse partially or totally the inhibitory effects of L-NAME, suggesting that the chronic oral treatment with L-NAME induces penile erection dysfunction by peripheral mechanisms. The present results suggest that chronic oral treatment with nitric oxide (NO) synthase inhibitor can be a relevant and powerful peripheral erectile dysfunction model to evaluate the effects of drugs on erectile function of male rats.

Angiotensin-Converting Enzyme Inhibitors↗