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Self and social functions: individual autobiographical memory and collective narrative.

The personal functions of autobiographical memory build on the basic biological functions of memory common to most mammals that, however, do not have the kind of episodic memories that compose human autobiographical memory according to present theory. The thesis here is that personal autobiographical memory is functionally and structurally related to the use of cultural myths and social narratives, and that the relative emphasis put on the self in different cultural and social contexts influences the form and function of autobiographical memory and the need for developing a uniquely personal life narrative in those contexts. Historical and cross-cultural trends revealed in psychological and literary research are invoked to support this thesis.

Biological Evolution↗

The Delphic oracle: a multidisciplinary defense of the gaseous vent theory.

Ancient historical references consistently describe an intoxicating gas, produced by a cavern in the ground, as the source of the power at the oracle of Delphi. These ancient writings are supported by a series of associated geological findings. Chemical analysis of the spring waters and travertine deposits at the site show these gases to be the light hydrocarbon gases methane, ethane, and ethylene. The effects of inhaling ethylene, a major anesthetic gas in the mid-20th century, are similar to those described in the ancient writings. We believe the probable cause of the trancelike state of the Priestess (the Pythia) at the oracle of Delphi during her mantic sessions was produced by inhaling ethylene gas or a mixture of ethylene and ethane from a naturally occurring vent of geological origin.

Amnesia↗

Myth, marula, and elephant: an assessment of voluntary ethanol intoxication of the African elephant (Loxodonta africana) following feeding on the fruit of the marula tree (Sclerocarya birrea).

Africa can stir wild and fanciful notions in the casual visitor; one of these is the tale of inebriated wild elephants. The suggestion that the African elephant (Loxodonta africana) becomes intoxicated from eating the fruit of the marula tree (Sclerocarya birrea) is an attractive, established, and persistent tale. This idea now permeates the African tourist industry, historical travelogues, the popular press, and even scholastic works. Accounts of ethanol inebriation in animals under natural conditions appear mired in folklore. Elephants are attracted to alcohol, but there is no clear evidence of inebriation in the field. Extrapolating from human physiology, a 3,000-kg elephant would require the ingestion of between 10 and 27 L of 7% ethanol in a short period to overtly affect behavior, which is unlikely in the wild. Interpolating from ecological circumstances and assuming rather unrealistically that marula fruit contain 3% ethanol, an elephant feeding normally might attain an ethanol dose of 0.3 g kg(-1), about half that required. Physiological issues to resolve include alcohol dehydrogenase activity and ethanol clearance rates in elephants, as well as values for marula fruit alcohol content. These models were highly biased in favor of inebriation but even so failed to show that elephants can ordinarily become drunk. Such tales, it seems, may result from "humanizing" elephant behavior.

Africa↗

Telling the stories of people with AIDS in rural Haiti.

For 20 years, Hospital Albert Schweitzer (HAS) in Haiti's Artibonite Valley has struggled with the evolving acquired immune deficiency syndrome (AIDS) epidemic. Initial efforts to confront the disease met numerous obstacles including denial, stigmatization, powerlessness, and mistrust. Over time, HAS and local community organizations developed a new approach to the AIDS problem. The first step in this approach flowed from the founding principle of HAS: Reverence for Life; hospital staff and community leaders provided hospice care to people dying of AIDS. Caring for people with AIDS and hearing the stories of people with AIDS quickly generated sympathy and a personal sense of vulnerability among community leaders and created a desire for community human immunodeficiency virus (HIV) education and prevention. Using the stories of people with AIDS as a basis, a community education program was launched. More than 1,000 church leaders, voodoo priests, and schoolteachers were trained. The majority of these leaders returned to their communities and started creative and unexpected initiatives to confront the AIDS problem.

Acquired Immunodeficiency Syndrome↗

Sisyphus and prediction of protein structure.

The problem of predicting protein structure from the sequence remains fundamentally unsolved despite more than three decades of intensive research effort. However, new and promising methods in three-dimensional (3D), 2D and 1D prediction have reopened the field. Mean-force-potentials derived from the protein databases can distinguish between correct and incorrect models (3D). Inter-residue contacts (2D) can be detected by analysis of correlated mutations, albeit with low accuracy. Secondary structure, solvent accessibility and transmembrane helices (1D) can be predicted with significantly improved accuracy using multiple sequence alignments. Some of these new prediction methods have proven accurate and reliable enough to be useful in genome analysis, and in experimental structure determination. Moreover, the new generation of theoretical methods is increasingly influencing experiments in molecular biology.

Computers↗

Provider assumptions about long-term care in American Indian communities.

A brief survey of 208 Indian Health Service (IHS) providers and allied personnel revealed the extent to which they subscribed to a number of myths about long-term care. With some exceptions, long-term care is equated with the nursing home, perceived as involving essentially health care professionals, and service objectives are assumed to be primarily rehabilitative and protective in nature. Underscored is the importance of past recommendations of geriatric training for IHS and tribal human service providers.

Aged↗