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At least 811 records · Page 45Linked to original sources
PubMed1995

Selective adverse reactions to diflunisal.

BACKGROUND AND OBJECTIVE: Diflunisal is a difluorophenyl derivative of salicylic acid. We report two patients who presented immediate adverse reactions to diflunisal (Dolobid) that consisted of generalized urticaria and chest tightness. METHODS: Diflunisal was conjugated to human serum albumin in order to perform in vivo and in vitro tests (skin prick and intradermal tests, leukocyte histamine release, and RAST). The patients were challenged following a single-blind, placebo-controlled oral procedure with diflunisal and other nonsteroidal antiinflammatory drugs. RESULTS: Skin tests with diflunisal were negative as were leukocyte histamine release tests and RAST in both patients. They tolerated therapeutic doses of aspirin, salsalate, salicylamide, lysine acetylsalicylate, acetaminophen, dipyrone, and propyfenazone. The oral provocation with diflunisal elicited an immediate response at the cumulative dose of 400 mg in both patients. CONCLUSION: These are two exceptional cases of selective adverse reactions to diflunisal with good tolerance to other salicylates and nonsteroidal antiinflammatory drugs. Thus, the inhibition of cyclooxygenase does not seem to be the mechanism involved. The pathogenic mechanism implicated in the reaction remains unclear, both idiosyncratic and immunologic mechanisms could explain our patients' adverse responses.

Aged↗
PubMed1976

[Intradermal toxoplasmin tests in Nigeria].

The occurrence of the positivity of an intracutaneous test with Toxoplasmin was followed among a normal urban population of Kaduna (men and women being included). The positivity of males showed a higher frequency in comparison with that of females. The positivity of males however did not increase so fast with the increasing age, as that of females, where the difference between the last two age groups was found to be statistically significant.

Adolescent↗
PubMed1980

The influence of local factors on the reaction to tuberculin. 1. The effect of injection.

Forty-three patients being evaluated for the presence of clinical tuberculosis received careful simultaneous cutaneous tests with intermediate-strength tuberculin, comparing reactions elicited with intradermal tests to those elicited by subcutaneous tests. In another study, reactions elicited by 0.1 ml of tuberculin were compared to those elicited by 0.05 ml of the same material in the other forearm. Analysis of scattergrams comparing sizes of reactions to each technique show that differences in the sizes of the reactions elicited by intradermal and subcutaneous tests are usually small and insignificant, but subcutaneous tests unexpectedly were found to often produce larger, rather than smaller, reactions. Likewise, differences in cutaneous reactions to 0.05 and 0.1 ml of tuberculin were not impressive. We conclude that the common impression that errors of technique in the application of cutaneous tests are common explanations for false-negative tests is unwarranted.

False Negative Reactions↗
PubMed2002

Allergy testing.

Percutaneous and intradermal skin tests and laboratory assays of specific IgE antibodies may be useful in selected cases of allergy management. Percutaneous testing kits are available from various manufacturers. A number of common allergens are available in standardized preparations. Positive and negative skin controls are important in establishing reliable results. Antihistamine medications can interfere with skin testing and should be stopped beforehand. Serious reactions to skin testing are rare. Establishing the sensitivity and specificity of percutaneous testing is difficult because there is no widely accepted gold standard for defining a true allergic reaction. Intradermal testing is more sensitive than percutaneous methods but much less specific. Its use is restricted to testing for allergy to insect stings or penicillin. In cases where skin testing is not available or desirable, laboratory assays for IgE antibodies to specific allergens may be used. These assays are generally less sensitive than skin testing methods. Selected patients with allergic rhinitis or asthma that is not controlled with standard therapy may benefit from allergy testing, especially when it can target allergen avoidance measures or guide immunotherapy.

Adult↗
PubMed2000

Nasal polyposis: role of subclinical delayed food hypersensitivity.

Nasal polyposis is a common problem in otolaryngology. The cause remains unclear, and treatment with medication and surgery is often unsatisfactory. We present our controlled study, which suggests a strong association between food allergy and nasal polyposis. The study was conducted in 2 parts. A postal survey of 900 patients with nasal polyps showed 53 respondents (5.9%) had a known food allergy. In the prospective study, 80 nasal polyp patients and 36 control subjects completed intradermal tests for food allergy. Sixty-five nasal polyp patients (81%) and 4 control subjects (11%) had positive intradermal food test results. This is highly significant. We believe that food allergy may play a significant role in the pathogenesis of nasal polyposis and should be further studied.

Adolescent↗
PubMed2003

[Clinical and biological surveillance after the cessation of Hymenoptera venom desensitization].

107 patients have discontinued Hymenoptera venom immunotherapy between 1988 and 2000. 31 have been seen again with intradermal tests with IgEs, and 81 responded to a questionnaire. Intradermal reactions and IgEs decrease together significantly during immunotherapy and then persist at low level during three years. Beyond, the number of patients is insufficient. 32 patients were stung by the same Hymenoptera and not had any systemic reaction. However, five have beta blockers, three have IEC and half of the patients don't take precautions to avoid Hymenoptera.

Adolescent↗