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PubMed1992

[Therapeutic strategy in malignant polyps of the gastrointestinal tract].

Malignant polyps in the stomach are identical with early gastric carcinoma type I and IIa. Even if carcinomatous growth is restricted to the mucosa lymph node, metastases may occur; therefore, local measures like polypectomy or surgical excision are exceptional. Malignant gastric polyps should be treated according to classical tumour surgery. Things are different in malignant colonic polyps, i.e. adenomas with a carcinoma invading the submucosa. Unless one is dealing with a dedifferentiated carcinoma or invasion of lymph or blood vessels is seen a few millimetre of security are sufficient to save the patient from radical surgery.

Algorithms↗
PubMed1989

[Mucin histochemical changes in various colo-rectal polyps in relation to carcinoma of the large bowel].

210 various colo-rectal polyps including 46 inflammatory polyps, 21 juvenile polyps, 9 hyperplastic polyps, 65 tubular adenomas, 51 familial polyps, 11 villous adenomas, 7 adenomatous polyps with focal cancer, and 14 carcinoma of the large bowel were investigated by HE,HID-AB,PAT-KOH-PAS staining in order to study the mucin changes of these lesions. N-acetylated and C7,C9 O-acetylated sialomucin were mainly obtained in those adenomas with moderate and severe dysplasia (55-64.3%) and the proportion was even higher in cases of villous adenomas, familial polyps, adenomas with focal cancer and advanced carcinoma. These mucins might be assumed as a criteria in representing malignant transformation.

Biomarkers, Tumor↗