Surnames in Taiwan: interpretations based on geography and history.
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The incidence of gastric carcinoma was analysed in Zabrze in the years 1965-1975 taking into account the sex, age, place of birth (autochthonous and immigrated populations) and place of residence in different city districts in relation to drinking water hardness. A correlation was revealed between low incidence of the neoplasm and drinking water of high hardness grade (over 25 degrees u) with a relatively high content of mineral components.
The genetic patterns of 25 populations from seven ethnic groups living in the Ural region (Komi, Komi-Permyaks, Udmurts, Mansi, Nentsy, Tatars, and Chuvashes) were studied. Immunological, biochemical, and physiological markers of the loci ABO, FUT, RH, P, FY, DI, KEL, LU, LE, JK, HP, GC, C'3, TF, PI, ACP1, GLO1, ESD, PGD, PGM1, PTC, and CB were studied. The average ethnic frequencies of the alleles and haplotypes studied were estimated. It was demonstrated that the Ural populations living to the west of the Urals, although of different origin, were more similar genetically than populations of common (Ural) origin living on different sides of the Urals, with respect to the majority of the traits studied.
The age adjusted death rate from prostate cancer in Japan is one of the lowest in the world but is rising steadily. The vast majority of cases of prostate cancer remain undetected during life, the prevalence of prostate cancer detected at autopsy being 2800 times that of lethal cancer in Japanese in Japan, 570 times in whites in the USA and 470 times in blacks in the USA. A case-control study of prostate cancer carried out in Japan and the Netherlands revealed a number of statistically significant risk factors, including rural residence, more brothers, colon neoplasms in relatives, no morning erections, frequent sexual intercourse in 30s, episodes of sexually transmitted disease, lower plasma testosterone and dihydrotestosterone concentrations and lower beta-carotene intake.
Cancer of the prostate is perhaps the commonest urological malignancy affecting Africans. The incidence between different countries varies and mirrors very closely the socioeconomic status of the countries and the life expectancy. The disease has an early peak incidence at ages 55-64 years, compared to 65-74 years for whites. This is primarily due to the low life expectancy in Africans. Late presentation is a common feature in Africans. Stilboestrol is widely used in treating disseminated cancer of the prostate not only because it is cheap and effective, but also because the cardiovascular side effects of stilboestrol seem not to be serious in Africans compared to whites. Further study of cancer of the prostate gland in indigenous Africans should provide vital data on the epidemiology and aetiology of this important cancer and may shed light on why the clinical aggressiveness of the disease varies from one part of the world to another.
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The search for more efficient treatments for prostate cancer continues. In localized prostate cancer, the combination of neo-adjuvant or adjuvant hormone therapy with surgery may improve curability rates. In the palliation of advanced prostate cancer, novel concepts of varying forms of maximal androgen blockade, including the re-introduction of safer forms of oestrogen therapy, should be capable of lengthening the time to progression and improving the quality of life of patients with advanced disease. The chemotherapy of prostate cancer remains experimental, but its earlier introduction may enable better dosing schedules to further limit advanced disease.