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PubMed1994

Therapy of Graves' ophthalmopathy with intravenous high-dose steroid followed by orbital irradiation.

We investigated the effects of intravenous high-dose steroid therapy followed by orbital irradiation for Graves' ophthalmopathy in eight patients. All patients presented with diplopia or fixed globes. Extraocular muscle dysfunction showed excellent improvement after the combined therapy; diplopia disappeared completely in five of them, and one patient with fixed globes showed normal eye movement. Two other patients also exhibited great improvement, although their diplopia persisted. Their ophthalmopathy index was decreased from (mean +/- SD) 4.25 +/- 0.82 to 0.75 +/- 1.48. Extraocular muscle enlargement, assessed by magnetic resonance imaging study after the radiotherapy, was also reduced after the combined therapy, although two patients did not show remarkable enlarged extraocular muscles. There was no change in extraocular muscle thickness 6-9 months after the therapy, and the ophthalmopathy index did not show change in a long follow-up (maximum 37 months after the therapy). These results suggest that high-dose methylprednisolone followed by orbital radiotherapy is a good therapeutic design for Graves' ophthalmopathy and justify a prospective randomized trial.

Adult↗
PubMed1996

Combined paresis and restriction of the extraocular muscles after orbital fracture: a study of 16 patients.

Sixteen patients with combined paresis and restriction of extraocular muscle(s) orbital fracture repair were studied before and after in order to determine the clinical features and management of such patients. All 16 patients showed limited ductions of the involved eye in the field of action of the entrapped, paretic muscle and of the antagonist muscle after orbital fracture. Single extraocular muscles (13 patients) and two extraocular muscles (three patients) were demonstrated adjacent to the fracture site on orbital computed tomography (CT). In three patients prior to orbital surgery, a deviation in primary position was present. After fracture repair with release of the entrapped muscle in all patients, evidence of paresis of the muscle was demonstrated by underaction in its field of action and overaction in the field of its antagonist. There was a resultant manifest tropia or phoria in the primary position. In seven patients, the paresis gradually improved with no tropia and little diplopia in the functional fields of gaze. Three patients had minimal deviations and required no further treatment. Six patients with significant deviations required prisms (three patients) or strabismus surgery (three patients). The latter three patients had two muscles involved. Results of this study demonstrate that the ophthalmologist must appropriately diagnose patients with paresis and restriction of an extraocular muscle and counsel them that "new" diplopia may occur after orbital fracture repair and that this diplopia may require additional therapy.

Adolescent↗
PubMed2006

Combined transcutaneous transethmoidal/transorbital approach for the treatment of medial orbital blowout fractures.

BACKGROUND: The transcutaneous transorbital approach to medial orbital wall fractures facilitates placing a large implant or autogenous graft. However, its major disadvantage is the difficulty of accurately reducing the fractured medial orbital wall and herniated soft tissues with minimal morbidity. METHODS: To resolve this problem, a combined transcutaneous transethmoidal/transorbital approach through the same skin incision was developed at the Chonnam National University Medical School. Between 1997 and 2003, this approach was used in 54 patients with pure medial orbital blowout fractures. All fractures were larger than 2 cm in defect size and had 3 mm or more of bone displacement. RESULTS: Postoperative computed tomographic scans showed complete release of entrapped soft tissues and accurate reconstruction of bone defects in all cases. Complications related to the operation such as intraorbital and intramuscular hemorrhage, infection, and eyeball and optic nerve injuries were not observed, except in two cases with slight implant displacement. Follow-up ranged from 2 to 22 months, with an average of 9 months. Forty-one patients were evaluated 6 months or more after their reconstructive procedure. At the time of surgery, diplopia was present in 39 patients, eyeball movement limitation in 35 orbits, and enophthalmos of more than 2 mm in 16 orbits. Postoperatively, diplopia and eyeball movement limitation were resolved in most cases. Two patients had persistent diplopia for more than 1 year after surgery, and one of these needed extraocular muscle surgery. Enophthalmos of more than 2 mm developed in three orbits, but enophthalmos of more than 3 mm was not observed in any orbit. Cosmetic results at the incision site were acceptable in all patients. CONCLUSIONS: The combined transcutaneous transethmoidal/transorbital approach is a safe procedure that can be performed with minimal morbidity; it offers the advantages of both the transcutaneous approach and the trans-nasal approach. Therefore, the authors suggest that this method be considered as a surgical alternative for the treatment of medial orbital blowout fractures, especially large and combined fractures of the medial wall and other parts of the orbit.

Accidents, Traffic↗
PubMed1990

Orbital blowout fractures--the influence of age on surgical outcome.

We report the frequency of troublesome diplopia in 17 patients (11 patients less than or equal to 21 years) who underwent surgical repair of traumatic orbital blowout fractures. Thirteen patients had primary surgery performed within 21 days of injury, 2 patients at 4 and 6 weeks and 2 cases at 6 and 24 months. The latter continues to complain of diplopia. Contrary to previous studies, we found that young patients were no more likely to suffer from symptomatic post-operative residual diplopia than their adult counterparts.

Adolescent↗
PubMed1978

Visual evoked responses and visual symptoms in multiple sclerosis.

Absolute latency, interocular difference in latency, and waveform of visual evoked responses (VER) to checkerboard reversal stimuli recorded from the midline of the skull were studied in 104 multiple sclerosis patients, 25 to 50 years of age, classified according to visual symptomatology. Group 1 had strong evidence of past or present optic neuritis. Patients with blurring of vision, diplopia, and undefined visual complaints were assigned to group 2, while group 3 contained patients with no visual symptoms but suspected diagnosis of multiple sclerosis on other grounds. The three parameters explored showed consistent association with the degree of visual involvement, as assessed by clinical impression, but their discriminatory power was diverse. Absolute latency was significantly longer in group 1 patients compared with groups 2 and 3, but it did not discriminate between the last two, whereas interocular difference in latency proved to be sensitive to differences between symptomatic (diplopia, blurring) and asymptomatic groups (2 and 3). Waveshapes were grouped into three categories based upon degree of distortion of the major positive peak, and their relative distribution among the three patient groups was found to be associated with symptomatology. We suggest that, in the production of symptoms such as diplopia, a temporal disparity of afferent impulses might be involved in much the same way that spatial incongruities between both eyes lead to impaired function. In this regard, interocular difference in latency rather than absolute latency would be a more accurate predictor of symptom development. The analysis of VER waveshape suggests, in addition, the importance of inhomogeneous involvement of the visual pathways in the production of symptoms during the evolution of multiple sclerosis.

Adult↗
PubMed2003

Orbital fractures in sport: a review.

Orbital fractures represent a small proportion of sports-related injuries in the US and abroad. However, the significant functional and cosmetic sequelae of such fractures warrant a comprehensive evaluation of any athlete sustaining facial trauma. Initial evaluation is directed at excluding neurological impairment or the presence of vision-threatening injury. Subsequent examination should ascertain the presence of signs and symptoms consistent with orbital fracture. These include gross bony deformity, limitation of gaze, diplopia and malposition of the globe. The presence of any of the aforementioned symptoms should prompt further investigation using computed tomography to corroborate or refute clinical suspicion. Orbital fracture mandates referral to an ophthalmologist or oculoplastic surgeon; initial management is dictated by the severity of functional symptoms, and may necessitate early surgical intervention. Those patients who are managed conservatively should return for frequent follow-up, as progressive diplopia, enophthalmos, or gaze limitation are indications for late operative repair. The majority of patients who sustain orbital fractures are able to return to sport, however, persistent diplopia is not uncommon, and may persist despite optimal treatment.

Athletic Injuries↗
PubMed2005

Spontaneous resolution of residual pituitary adenoma. Case report.

A 34-year-old man presented with progressive diminution of vision in the left eye for 7 years. He had suffered left hemicranial headache associated with left retro-orbital pain and diplopia for 3 months. Magnetic resonance (MR) imaging revealed a pituitary tumor located in the sella and extending into the right cavernous sinus. After transsphenoidal surgery, the vision improved drastically but the diplopia persisted. Postoperative MR imaging showed residual tumor in the right cavernous sinus. Follow-up examination after 3 years showed the diplopia had completely recovered and the residual tumor in the cavernous sinus had disappeared. Spontaneous resolution of a large intracavernous sinus residue of a pituitary adenoma may occur due to tumor necrosis.

Adenoma↗
PubMed2004

Anticholinesterase therapy for patients with ophthalmoplegia following snake bites: report of two cases.

Although ophthalmoplegia following snake bites is not indicative of a serious neurotoxic complication, symptoms of diplopia, dizziness and ocular discomfort can be emotionally devastating for patients. The authors experienced two cases of ophthalmoplegia following snake bites in Korea. The patients complained of diplopia that had developed several hours after the snake bites. The diplopia did not improve with antivenom treatment, but resolved completely after several injections of neostigmine.

Adolescent↗
PubMed2005

Ocular motility disturbances in orbital wall fracture patients.

It is difficult to identify the exact cause of ocular motility disturbances in orbital wall fracture patients. By performing CT and ocular motility tests before and after surgery, this study analyzes the functions of the extraocular muscles and determines correlations between the results. Between February 2001 and January 2003, 45 eyes of 45 patients with orbital wall fractures, whose medical records could be traced back at least 6 months, underwent surgical repair in our hospital. All variables were analyzed using the independent t-test, paired t-test, and Chi-square test. There was no significant difference in the location and degree of fracture and the incarceration pattern of 6 patients who had moderate or severe diplopia, and of the remaining patients 6 months after surgery. However, in the case of diplopia, the sum of ocular motility limitation was 5.67 +/- 4.18, and the degree of extraocular motility disturbance was 3.67 +/- 2.42 before surgery. When there was no diplopia, the sum of ocular motility limitation was 1.13 +/- 1.38, and the degree of extraocular motility disturbance was 1.08 +/- 1.16 (p < 0.005, independent t-test). Ocular movement was successfully recovered by surgical reduction within 3 weeks from trauma. Postoperative ocular motility disturbance was more related to various ocular motility test results than CT findings. Ocular motility disturbances can remain after surgery if ocular motility limitation and extraocular motility disturbance are significant after trauma. Additional studies on the various tests to examine functions of extraocular muscles are required to identify and analyze the exact cause of ocular motility disturbance.

Adult↗
PubMedDate not supplied

Long-term results: botulinum for sixth nerve palsy.

Eight patients with intracranial malignancies or vascular lesions and sixth nerve palsies were treated with botulinum toxin chemodenervation of the antagonist medial rectus muscle. Primary deviation ranged from 20 to 75 prism diopters (pd) of esotropia. Six were treated acutely (within 3 months of onset) and two, which demonstrated partial recovery of lateral rectus function but with residual esotropia and diplopia, were treated after 6 months. After a mean follow-up of 20.6 months, seven were diplopia-free with excellent rotations. Five had complete resolution of the esotropia and diplopia, with near complete recovery of abduction. One had 6 pd residual esotropia, while another, whose sixth nerve had been resected, required a modified Jensen procedure, resulting in full rotations. The single case of bilateral sixth nerve palsy had a functional improvement but was lost to follow-up. One patient had a vertical strabismus induced with the injection and had a gradual return of the esotropia.

Abducens Nerve↗
PubMed1996

Less common orbital fracture patterns: the role of computed tomography in the management of depression of the inferior oblique origin and lateral rectus involvement in blow-in fractures.

During the past decade, advances in radiographic imaging have made it possible for the surgeon managing orbital fractures to adopt a rational therapeutic strategy based on a knowledge of alterations in surgical anatomy secondary to traumatic injury. To illustrate the value of computed tomography in the surgeon's armamentarium for management of orbital fractures, cases are presented in which imaging proved decisive in planning a course of therapy. Two patients presented with two types of isolated lateral blow-in fracture, an uncommon fracture pattern. The other cases underscore the value of defining involvement of the inferior oblique origin and lateral rectus muscles in imaging complex orbital fractures, issues not emphasized in earlier literature. Although diplopia alone does not always warrant surgical intervention, diplopia in the context of computed tomography-defined muscle entrapment or muscle origin displacement justifies operative therapy. These cases demonstrate the value of computed tomography in directing surgical therapy with resolution of diplopia and prevention and correction of enophthalmos.

Accidental Falls↗
PubMed2000

Transnasal endoscopic orbital decompression and Graves' ophtalmopathy.

AIM OF THE STUDY: To assess the validity and the limits of endoscopic endonasal orbital decompression for Graves' ophtalmopathy resistant to the medical theapy. MATERIAL AND PATIENTS: Between September 1994 and May 1998, 16 patients with Graves' ophtalmopathy resistant to the medical treatment underwent an orbital decompression transnasally. 27 orbits were decompressed. The surgery was bilateral in 11 patients. In the 5 remaining cases, the surgery was unilateral. It was carried out on the left side in 2 cases and on the right side in 3 cases. RESULTS: Preoperatively, the average visual acuity was 8/10. Postoperatively, the visual acuity was 9.5/10. The average preoperative exophtalmometry measurement was 25.04 mm and the average postoperative measurement was 21.83 mm. The average retrodisplacement was 3.17 mm (range: 2-8). Preoperatively, 3 patients had mild diplopia whereas 5 others had moderate to severe extraocular muscle dysfunction. Postoperatively, 6 patients had mild diplopia whereas 10 patients required squint surgery for moderate to severe extraocular muscle dysfunction. CONCLUSION: Endoscopic orbital decompression improve all the symptoms of Graves' ophtalmopathy but one: the extraocular muscle dysfunction. Its cardinal indication is the treatment of compressive optic neuropathy whereas this surgical approach provides an excellent control of the medial wall of the orbit and the orbital apex. But the average reduction of proptosis of 3.17 mm is not high enough to propose this approach alone for the treatment of disfiguring proptosis. In such cases, a 2 or 3 wall orbital decompression should be performed to get marked cosmetic and functional improvement. In all cases, the patient should be informed about the risk of postoperative diplopia.

Adult↗
PubMed2000

The usefulness of the cervical range of motion device in the ocular motility examination.

OBJECTIVES: To determine if the cervical range of motion (CROM) device, an instrument designed to assess the range of motion in the cervical spine, may be suited for accurately quantifying the magnitude of a patient's abnormal head posture, limitation of ductions, or range of single binocular vision at distance fixation. METHODS: The CROM device was used to measure abnormal head postures in 10 subjects and limitations of ductions in 12 patients by 2 masked observers. In addition, it was used to test the diplopia field in 17 patients at one third of a meter and 6 m. These findings were compared with a standard diplopia field performed on a Goldmann perimeter. RESULTS: For 10 subjects with abnormal head postures, the findings of the 2 observers had a mean+/-SD difference of 1.0 degrees +/-0.7 degrees (P=.15, paired t test). For the assessment of limitations of ductions, the findings of the 2 observers had a mean+/-SD difference of 1.1 degrees +/-2.6 degrees (P=.17, paired t test). For the 17 patients undergoing diplopia field testing, the results obtained on the Goldmann perimeter and with CROM device at the same test distance were essentially identical (mean+/-SD difference of 1.3 degrees +/-0.95 degrees; P=.88, paired t test); however, there was a significant difference between the results at one third of a meter and 6 m (mean+/-SD difference of 6.0 degrees +/-1.1 degrees for esotropic patients [P=.001]; mean+/-SD difference of 6.0 degrees +/-2.6 degrees for exotropic patients [P=.002]). CONCLUSION: The CROM device seems to be suitable for testing abnormal head postures, limitations of ductions, and the range of single binocular vision. Arch Ophthalmol. 2000;118:946-950

Cervical Vertebrae↗
PubMedDate not supplied

Ocular fixation to nasal periosteum with a superior oblique tendon in patients with third nerve palsy.

PURPOSE: To report a new surgical approach that uses ocular fixation to the nasal periosteum with superior oblique tendon for patients with complete third nerve palsy. METHODS: Prospective study of 15 patients with complete third nerve palsy who underwent surgery using a superior oblique tenectomy and ocular fixation to the nasal periosteum with the superior oblique tendon fragment. RESULTS: Eleven (73%) patients achieved good ocular alignment, 1 (7%) patient had a cosmetically acceptable result, and 3 (20%) patients had a cosmetically unacceptable result. Five (30%) patients had preoperative diplopia; all achieved resolution of their double vision in the primary position of gaze after surgery. Two patients without preoperative diplopia did not achieve good alignment and had diplopia postoperatively. Follow-up ranged from 8-41 months (mean: 19 months). No operative complications occurred. CONCLUSION: Ocular fixation to the nasal periosteum with superior oblique tendon is a safe, effective, and technically undemanding option for the surgical management of patients with complete third nerve palsy.

Adolescent↗
PubMed2000

[Progressive paralysis of divergence in an adult with midbrain angioma].

A 37-year-old woman was admitted to the hospital with the complaint of progressive horizontal diplopia of six years' duration when viewing distant objects. On admission she had a slight left convergent strabismus. Homonymous diplopia was present beyond 50 cm and increased on distance fixation. Both eyes were fully mobile in the horizontal plane with a mild decrease in the velocity of horizontal eye movement to the left, and slight impairment of upward eye movement. The left eye did not fully adduct during convergence. The right pupil was slightly larger than the left. Prism cover test showed 6 delta esophoria at 30 cm and 14 delta esophoria at 5 m. The Hess chart showed a convergent deviation. MRI revealed a small right-side paramedian lesion of the midbrain tegmentum lying ventral to the aqueduct of Sylvius, at the level between the superior colliculi and the intercollicular area. A venous angioma with arteriovenous shunts in the right midbrain was diagnosed by angiography. We suggest that lesions that damage the divergence neurons in the tegmentum of the midbrain and also interrupt the supranuclear fibers having an inhibitory effect on the convergence neurons may produce homonymous diplopia on distant fixation combined with the esotropia.

Adult↗
PubMed1995

Pseudo-entrapment of extraocular muscles in patients with orbital fractures.

Diplopia is a prominent finding in patients who have suffered orbital fractures. If the patient's double vision or ocular motility restriction was caused by soft tissue entrapment into the fracture site, surgery is frequently performed in order to release this entrapment and restore normal eye movement. However, the presence of diplopia should not necessarily be an indication for surgery. Brief case reports are hereby presented to illustrate that the symptoms of diplopia and motility restriction are not always attributable to the presence of orbital fractures that require surgical repair. The purpose of this article is to describe other causes of abnormal ocular motility that are associated with orbital trauma but which are not caused by soft tissue entrapment.

Abducens Nerve Injury↗
PubMed2002

[Surgical treatment of orbital blow-out fracture].

OBJECTIVE: To evaluate the effect of surgical treatment for blow-out fractures. METHODS: Fifty-six cases with blow-out fracture treated by surgery from 1994 to 1999 were reviewed and summarized, and their surgical effects were analyzed. RESULTS: The surgical approaches were as follows: anterior orbitotomy in 52 cases, through brow in 2 cases, anterior orbital with oral approach in 2 cases. The enophthalmos was from the mean of 3.4 mm to 1.2 mm after operation. The diplopia completely disappeared in 18 cases and partly disappeared in 25 cases after operation. Diplopia was still presented in 9 cases post-operatively. There were 4 cases with inferior orbital nerve anesthesia after operation. CONCLUSIONS: Surgical management is an effective means of blow-out fractures. The effect is related to the time selected for surgery. Transconjunctival approach has advantages of easy operation, full exposure and invisible scar. This is the key method to eliminate diplopia since it may fully loose the incarcerated muscle and reduce secondary adhesion.

Adolescent↗
PubMed1992

Surgery on the extra-ocular muscles after orbital fracture.

We analyzed the files of 61 patients presenting with diplopia due to orbital fractures. Thirty-four patients needed a primary orbital reconstruction and this diminished the complaints of diplopia in most cases. In only 5 cases additional ocular surgery on the extra-ocular muscles was indicated. Of the 27 patients who did not require orbital surgery, 5 underwent extra-ocular muscle surgery to diminish diplopia. We present our guidelines for treatment, based on forced duction testing, ocular motility, primary position and field of binocular single vision.

Diplopia↗