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Results for “DIAGNOSIS, LABORATORY”

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At least 811 records · Page 45Linked to original sources
PubMed1994

[The present status of laboratory diagnosis of thyropathies. An analytical review].

At present, immunoanalysis is of dominant importance in the laboratory diagnostic of the diseases of the thyroid gland. The present paper briefly surveys the current methods of detecting the function of the thyroid gland, of further precision of diagnosis (particularly in the diseases of the autoimmunity origin) and some of the methods of early detection of carcinoma of the thyroid gland. Their methodical development, clinical importance and circumstances which could influence the results of determination and cast doubt on their validity are briefly characterized.

Humans↗
PubMed2004

Laboratory diagnosis of primary and secondary dengue infection.

BACKGROUND: Dengue fever is routinely detected in many laboratories using commercial tests for the specific detection of dengue IgM antibodies. OBJECTIVES: We have studied the sensitivity of IgM antibody detection in paired serum samples of 43 patients with either with primary dengue (PD) or secondary dengue (SD). STUDY DESIGN: Two consecutive samples were drawn from 23 Vietnamese and 20 German patients. All patients were selected for a positive PCR and for the fact that consecutive serum samples were available. The diagnosis of PD was based on seroconversion to dengue antigen and in SD on the detection of virus RNA in the presence of anti-dengue IgG antibodies. RESULTS: In samples of patients with PD fever taken during days 1-3 of the disease no IgM antibody could be detected. During days 4-7 and after day 7, IgM antibody was detected in 55% and 94%, respectively. In patients with SD fever, even less positive IgM samples were found in samples taken during days 4-7 (47%) and after day 7 (78%). IgG titers were significantly higher in SD compared to PD patients, although high (>1280) titers were also found in some PD patients. CONCLUSION: In numerous acute dengue fever patients an early diagnosis will be obtained only by combining IgM antibody detection with detection of virus or virus RNA using RT-PCR.

Antibodies, Viral↗
PubMed1987

[Use of the Reflotron system for laboratory diagnosis in swine and sheep].

The "Reflotron" system (Boehringer Mannheim) was compared with standard laboratory methods for determination of blood values, e.g. haemoglobin, glucose, urea, ASAT/GOT and GGT in pigs and sheep. Various different commercial control sera as well as blood and plasma samples from pigs and sheep were used for evaluation of its precision. The day-to-day precision of all parameters was satisfactory. The accuracy of the values was tested in 56(48) blood samples of healthy and sick pigs (sheep) by using standard substances (glucose, urea) and by comparing them with values measured by standard laboratory methods. There were systematic differences between "Reflotron" and other values in the glucose- and enzyme-values, which can be corrected with the help of conversion factors. In pigs, the enzyme GGT can not be determined accurately with the "Reflotron" system.

Animals↗
PubMed1981

[What value does laboratory diagnosis have in acute abdomen?].

1. We found in a prospective study with routine laboratory tests: As a single test only amylase is of certain value, but there are 27% false positive results in peritonitis and intestinal obstruction. 2. Our standardized program can help to evaluate disturbed vital functions and so far improve pre- and postoperative treatment. 3. A high risk is given by simultanously alterated acid-base-balance, blood sugar and creatinine; but these findings are showing shock, not acute abdomen. 4. Laboratory procedures are of no help to the practitioner; they must not delay the early lifesaving operation.

Abdomen, Acute↗
PubMed1993

The laboratory diagnosis of mycobacterial diseases.

Recent developments in diagnostic mycobacteriology are surveyed with emphasis on laboratory capabilities relevant to the more rapid and accurate detection and identification of mycobacterial pathogens. Some terminologic problems are reviewed, and some newly recognized mycobacterial pathogens are discussed. Newer methodologies presented in some detail include the radiometric technique for detection, identification, and susceptibility testing of mycobacteria, and the use of DNA probes for identification of mycobacterial species and species complexes. The utility of other developing methodologies, such as polymerase chain reaction technology, analysis of body fluids for tuberculostearic acid, and the use of ELISA are also assessed.

Bacteriological Techniques↗
PubMed2000

Current approaches to the laboratory diagnosis of diphtheria.

Despite the success of mass immunization in many countries, diphtheria continues to play a major role as a potentially lethal resurgent infectious disease. Early, accurate diagnosis is imperative since delay in specific therapy may result in death. The microbiologic diagnosis of the disease, the identification of contacts and carriers, and the appropriate clinical management of these patients are therefore crucial. The epidemiology of diseases caused by Corynebacterium diphtheriae has changed dramatically over the decades, a situation that is highlighted by the resurgence of infections in the European region. These factors have strengthened the need for laboratories to screen for C. diphtheriae. Many modified and new methodologies are now used widely within laboratories for diphtheria diagnosis. Recent developments have focused upon methods for detection of the lethal and potent exotoxin produced by the causative organism, C. diphtheriae; this detection is the definitive test for the microbiologic diagnosis of diphtheria.

Bacteriological Techniques↗
PubMed2006

[Limits and relevance of the laboratory diagnosis of malnutrition in the elderly].

Despite the widespread interest in malnutrition in the elderly, the utility of laboratory tests is limited. This is because their diagnostic significance can be impaired by undercurrent diseases, pre-analytical effects and unsatisfactory standardization. This survey summarizes the most important parameters of malnutrition. Thus, "nitrogen balance" is considered the golden standard of nutrition status, while the diagnostic significance of serum proteins depends on their biological half-time. Albumin is seen as the most reliable malnutrition marker, but cholinesterase and cholesterol-decrease must also be mentioned. The so-called "low-T3-phenomenon" which is caused by the production of "reverse T3", seems to be the unique parameter for the "catabolic" state of metabolism. Of special interest are also prognostic markers of mortality, such as orosomucoid. Cytokines, other signal peptides, trace elements and vitamins are from the diagnostic point of view of rather limited significance. In sum, the diagnosis and monitoring of malnutrition in the elderly represents an important challenge for laboratory medicine.

Aged↗