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At least 811 records · Page 45Linked to original sources
PubMed2006

[The educational program for the management of psoriasis vulgaris according to the rules of the Task Force on Dermatological Prevention: current status].

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory skin disease with a substantial impairment of quality of life. Interdisciplinary outpatient educational programs are an innovative supplementary therapy form for the management of this disorder. SUBJECTS AND METHODS: The Task Force on Dermatological Prevention developed a concept for outpatient instruction of psoriasis patients. Five 2-hour classes by dermatologists, psychotherapists/psychologists and dieticians focus on central topics relevant for the patients and the management of the disease. RESULTS: The results presented are based on own experiences with this educational program. The interdisciplinary program is accepted very well and seen as helpful by the concerned. A structure analysis of the effects in a greater number of cases is a current goal. In some areas, health insurance companies are paying for the classes. CONCLUSION: The educational program for the management of psoriasis vulgaris according to the rules of the Task Force on Dermatological Prevention is a supplement of the treatment of patients with this chronic skin disease. Broader implementation in Germany is desirable.

Ambulatory Care↗
PubMed1998

[History of the Krefeld Dermatology Clinic].

The dermatology clinic in Krefeld has treated a wide range of patients since its founding in 1845. Nowadays the spectrum consists of allergology, occupational dermatology, phototherapy, dermatosurgery, phlebology and proctology as well as special clinics for andrology, sexually transmitted diseases and patients with HIV-infection.

Dermatology↗
PubMed1999

[History of clinical dermatology and venereology in Magdeburg 1906-1997].

The report gives an overview on the history and the development of clinical dermatology and venereology from a small department at the medical clinic of the city-hospital "Magdeburg-Altstadt" (1906) to the University Department of dermatology and venereology at the Medical Faculty of the "Otto von Guericke"-University (1997).

Dermatology↗
PubMed1999

[The death of moulages - wax figures in dermatology].

Wax has been used for illustration purposes back to antiquity. Since the renaissance period human anatomy and different diseases have often been depicted in wax. During the last century the art of moulage preparation evolved to three-dimensional, realistic representations of diseased parts of the human body. Its heyday and wide spread distribution paralleled the growing independence of dermatology. Apart from few exceptions, most mouleurs did not permit access to their technique either to successors or the public. Just like other European hospitals, the Department of Dermatology at Kiel University houses a comprehensive collection of moulages dating back to a century. The 455 objects left today were collected by Professor Viktor Felix Karl Klingmüller (1870-1942) who was head of the department from 1906 to 1937. The mouleur Alfons Kröner from Breslau who died 1937 supplied most (354) of the wax models. Highly esteemed at his time, Kröner was quite secretive about his art of moulagig. 35 of his moulages bear the abbreviation "DRP" standing for Deutsches Reichspatent (German patent); Kröner was granted a patent in 1902. In his patent application both wax mixtures and technical procedure of moulaging are described in great detail. Kröner, similarly to Jules Baretta (Paris), coloured his moulages at the back of the wax layers. Applying for a patent demonstrates his effort to meet increasing commercial pressure among suppliers of teaching aids at that time. Knowledge of individual technical procedures is essential for medical history as well as proper restauration of moulages as they continually deteriorate with time. Because of their three-dimensional and realistic disease representations, moulages still compare well to modern media used today. Consequently, the "dying of moulages" concerning the wax objects themselves as well as public or medical interest has to be stopped to preserve moulages for future generations.

Dermatology↗
PubMed2000

[From scabies room to modern specialty department. 90 years Ludwigshaven Dermatology Clinic].

The dermatology clinic Ludwigshafen was founded in 1910. Dr. Siegfried Fuss was head of the clinic for almost 40 years. The clinic's history reflects the rapid industrial growth of the city, the destruction of two world wars and the progress of dermatology during this century. Today, the clinic is an academic teaching hospital affiliated with the University of Mainz with 45 beds and offers a broad spectrum of modern dematological diagnostic procedures and therapies.

Dermatology↗
PubMed2001

[The University Dermatology Clinic in Bern].

The history of the university dermatology clinic in Bern can be followed back into the 13th century to the founding of the Siechenhaus (hospice for incurable patients) in 1283. The hospice was moved in 1491 to the Breitfeld before the gates of the city, where over the next four centuries it expanded greatly and served patients with leprosy and later syphilis and other skin diseases. In the beginning of the 19th century teaching in dermato-venerology was carried out here. In 1891/82 one of the earliest dermatology clinics was established, as a professorship was established and the clinic moved to a new building on the grounds of the Inselspital, the university hospital. Through the efforts of the first chairmen, E. Lesser and J. Jadassohn, as well as their successors, dermato-venerology has remained well-established in Bern. We review the important dates, individuals and institutions and their role on the long development of dermato-venerology in Bern from its early roots until today.

Dermatology↗
PubMed2001

[Wax model collection of the Department of Dermatology, University of Münster].

Between the 17th century and the middle of the 20th century, wax models were widely used for training in anatomy and other medical fields, especially dermatology. Thereafter, photographic techniques led to the replacement and subsequent dissolution of many European wax model collections. Unfortunately many wax models lose their original colors over time. Since only few mouleurs (wax artists) are still active in Europe conserving wax models, the "dying of moulages" cannot be stopped. Consequently, the existing wax models are of medical and historical interest since they reflect the development of our speciality. The Department of Dermatology in Münster is in the possession of 121 wax models, which are presented in this article.

Dermatology↗
PubMed1995

Management of cutaneous malignant melanoma by dermatologists of the American Academy of Dermatology. II. Definitive surgery for malignant melanoma.

BACKGROUND: During the past few decades there has been increasing interest and training in dermatologic surgery. OBJECTIVE: Our purpose was to determine to what extent members of the American Academy of Dermatology (AAD) are involved in the surgical management of patients with malignant melanomas (MMs), comparing 1982 with 1992. METHODS: Members of the AAD practicing in the United States (N = 7412) were sent a questionnaire that surveyed their role in the definitive treatment of patients with MMs and the surgical margins of normal-appearing skin that they used or recommended for melanomas of various thicknesses. RESULTS: Sixty-four percent of the respondents stated that they performed the definitive surgery for in situ melanoma in 1992, a 14% increase from 1982. Although a significantly greater percentage of dermatologists were performing the definitive surgery for invasive melanoma in 1992 (28%) compared with 1982 (14%), the majority continued to refer their patients to surgical colleagues for definitive treatment. There has been a narrowing of surgical margins recommended or used for melanomas of all thicknesses. In addition, regional differences of the role of the dermatologist in surgical management of patients with MM were observed. CONCLUSION: An increasing proportion of dermatologists are involved in the surgical management of patients with MMs. Most dermatologists appear to be in accord with the guidelines for surgical margins currently recommended in the literature.

Academic Medical Centers↗
PubMed1995

A comparison of diagnosis, evaluation, and treatment of patients with dermatologic disorders.

BACKGROUND: Managed care in the American health care system may limit access to health care specialists. OBJECTIVE: We assessed primary care providers' abilities at diagnosing and treating patients with a previously undiagnosed skin disorder. METHODS: Patients with previously undiagnosed skin disorders were seen and examined sequentially by three groups of physicians: (1) internal medicine residents, (2) board-certified internal medicine attending physicians and (3) dermatology faculty. The internal medicine residents and attending physicians' diagnoses were compared with the dermatologists'. Appropriateness of therapy ordered by the internal medicine residents and attending physicians was assessed. RESULTS: Medical residents' diagnoses were correct in 43% of the patients whereas the attending physicians diagnosed 52% of cases correctly. Attending physicians and residents frequently ordered therapy inappropriate for the patient's diagnosis. Internal medicine residents and attending physicians were more likely to order skin biopsies than dermatologists. CONCLUSIONS: Our results confirm earlier studies that nondermatologists perform poorly in the diagnosis and treatment of skin disease. Primary care providers should receive more training in dermatology, or dermatologists should be permitted to act as primary caregivers to patients with skin disease.

Adult↗
PubMed2006

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.

The naturally occurring retinoids and their synthetic analogs play a key role in differentiation, proliferation, and apoptosis, and their use/potential in oncology, dermatology and a variety of diseases are well documented. This review focuses on the role of all-trans-retinoic acid (ATRA), the principal endogenous metabolite of vitamin A (retinol) and its metabolism in oncology and dermatology. ATRA has been used successfully in differentiated therapy of acute promyelocytic leukemia, skin cancer, Kaposi's sarcoma, and cutaneous T-cell lymphoma, and also in the treatment of acne and psoriasis. However, its usefulness is limited by the rapid emergence of acquired ATRA resistance involving multifactoral mechanisms. A key mechanism of resistance involves ATRA-induced catabolism of ATRA. Thus, a novel strategy to overcome the limitation associated with exogenous ATRA therapy has been to modulate and/or increase the levels of endogenous ATRA by inhibiting the cytochrome P450-dependent ATRA-4-hydroxylase enzymes (particularly CYP26s) responsible for ATRA metabolism. These inhibitors are also referred to as retinoic acid metabolism blocking agents (RAMBAs). This review highlights development in the design, synthesis, and evaluation of RAMBAs. Major emphasis is given to liarozole, the most studied and only RAMBA in clinical use and also the new RAMBAs in development and with clinical potential.

Animals↗
PubMedDate not supplied

Changing paradigms in dermatology: information technology.

Medicine and specifically, dermatology, is undergoing enormous changes in the way in which it is practiced. Much of this is a result of a fundamental change in the manner in which information is exchanged through information technology. With the advent of more advanced telecommunications, imaging capabilities and information transfer, the very ways in which we examine patients, develop diagnoses and plan treatments as dermatologists have changed dramatically. This chapter will briefly review the development of personal computers and the Internet, as well as changes in telecommunications capabilities and how these changes have already altered how we see patients and care for them, as well as how new advances may continue to change the world of medicine and dermatology in the near future.

Confidentiality↗
PubMedDate not supplied

Changing paradigms in dermatology: nuclear hormone receptors.

Nuclear hormone receptors (NHRs) are a family of proteins that function similarly as nuclear transcription factors. The NHR family includes glucocorticoid receptors, retinoic acid and retinoid receptors, vitamin D receptors, thyroxin receptors, and peroxisome proliferator activated receptors. These proteins are targets for some of the most commonly prescribed medications in dermatology, including corticosteroids, retinoids, and vitamin D analogues, all of which have limiting side effects. Advances in this field have led to better understanding of the mechanisms of NHR therapeutic and toxic effects, receptor subtypes, tissue distribution, and interaction with other molecules. New generations of more specific NHR ligands designed to increase therapeutic efficacy and limit adverse effects have dramatically expanded the clinical application of NHR-targeting drugs. The current understanding of NHRs and future directions for NHR ligands in dermatology are discussed.

Adrenal Cortex Hormones↗
PubMed2005

Psychosomatic factors in dermatology: special perspectives for application in clinical practice.

The identification of psychosomatic factors in dermatology has always been one of the principal themes in the history of this field and in the personal experience and research of the author. After a brief review of some of the milestones in the area of psychosomatic factors in dermatology, the author presents the criteria dictated by clinical experience, in the absence to date of more precise scientific data, for the individuation of such psychosomatic factors in clinical practice.

Dermatology↗
PubMed2006

The use of dermatologic drugs in pregnancy and lactation.

Physicians are generally reluctant to prescribe dermatologic drugs to pregnant or nursing women because treatment is often elective and can be harmful to the patient, her fetus, or nursing infant; concerns for potential litigation also give pause. Yet, some effective dermatologic drugs have been determined to be safe during pregnancy and lactation. Of great practicality is an easily accessed reference guide that condenses information on such drugs into a set of tables that list pregnancy and teratogenicity ratings. Indications and contraindications are ordered in relation to the phases and trimesters of pregnancy. A discussion of the necessity of considering stages of childbearing in choosing drug therapies introduces the tables. A summary list of cautions spells out the steps physicians should take in treating women of childbearing age.

Dermatologic Agents↗
PubMed2006

Dermatologic problems of older women.

Women are living longer today, composing the majority of persons aged 65 and over. Their dermatologic needs are unique and cross ethnic and cultural lines. With this increased life expectancy comes an increased occurrence of skin disorders. The identification and treatment of these conditions is important for the practicing clinician. This article reviews some of the more common dermatologic disorders of older women, and discusses the latest treatments and issues facing this geriatric population.

Aging↗
PubMed2004

DNA microarrays: from structural genomics to functional genomics. The applications of gene chips in dermatology and dermatopathology.

The human genome project was successful in sequencing the entire human genome and ended earlier than expected. The vast genetic information now available will have far-reaching consequences for medicine in the twenty-first century. The knowledge gained from the mapping and sequencing of human genes on a genome-wide scale--commonly referred to as structural genomics--is prerequisite for studies that focus on the functional aspects of genes. A recently invented technique, known as gene chip, or DNA microarray, technology, allows the study of the function of thousands of genes at once, thereby opening the door to the new field of functional genomics. At its core, the DNA microarray utilizes a unique feature of DNA known as complementary hybridization. As such, it is not different from Southern (DNA) blot or northern (RNA) blot hybridizations, or the polymerase chain reaction, with the exception that it allows expression profiling of the entire human genome in a single hybridization experiment. The article highlights the principles, technology, and applications of DNA microarrays as they pertain to the field of dermatology and dermatopathology. The most important applications are the gene expression profiling of skin cancer, especially of melanoma. Other potential applications include gene expression profiling of inflammatory skin diseases, the mutational analysis of genodermatoses, and polymorphism screening, as well as drug development and chemosensitivity prediction. cDNA microarrays will shape the diagnostic approach of the dermatology and the dermatopathology of the future and may lead to new therapeutic options.

Dermatology↗
PubMed2005

Molecular diagnosis of infectious diseases in dermatology.

UNLABELLED: The molecular diagnosis of infectious disease has been growing considerably over the past decade. Nucleic acid amplification techniques, such as polymerase chain reaction, ligase chain reaction, transcription-mediated amplification, and nucleic acid sequence-based amplification, provide highly accurate diagnosis of numerous bacterial, viral, fungal, and parasitic infections involved in a variety of dermatologic diseases. In addition, signal amplification with hybrid capture, branched-DNA assays, and in situ hybridization have been used to detect numerous viral pathogens with high degrees of sensitivity and specificity. New technology that involves the use of DNA and protein microarrays has also enabled the detection of a variety of genes and gene mutations. With time, these diagnostic assays are decreasing in cost, gaining approval of the U.S. Food and Drug Administration, and becoming easier and more efficient to use. In the future, these assays will be able to deliver rapid and accurate diagnosis of infectious diseases within a single clinic visit. LEARNING OBJECTIVE: At the completion of this learning activity, participants should be familiar with molecular diagnosis of infectious diseases in dermatology.

Bacteria↗