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[Improvement of computer program for cytology screening of the female population in Bialystok].

In the article authors present a new edition of computer programme managing active and population cytology screening in the selected group of women in Bialystok. All improvements came out of the slow date base transforming. From the other hand so called "2000 year mistake" was eliminated. In the previous programme single date transfer between only two PC terminals was possible. Additionally way of assignment of particular groups of women to proper out patient rooms districts also by the zip codes were presented. Process of creation of cytology invitations to all women participating in screening examination was accelerate. Increase effectiveness of screening examinations was available as a result of using a new edition of computer programme. Percentage of mistakes and exam expenses were also minimized. Two main cytology screening foundation, its active and population were achieved.

Female↗

[Detection by a computer program of drug interactions in chronic patients. Its practical usefulness in a health center].

OBJECTIVES: To evaluate a computer programme which was used to detect drug interactions (DI) from the Long Treatment Cards (LTC) and to analyse the factors possibly linked to these interactions. DESIGN: An observational, descriptive study. SETTING: Primary Health Care: an urban Health Centre. PATIENTS: The reference context was 1,640 chronic patients being cared for at a nursing clinic. We selected 141 cases at random by taking 10 LTCs from each list. (Alpha risk = 0.05; Confidence Interval = 0.05). RESULTS: The sample was mainly feminine (2:1), with an average age of 67. The most common diagnosis was Diabetes or AHT. 55% had accumulated 4 or more medicines per card, with multiple medication most common among men. The programme enabled 58 drug interactions, affecting 34% of the LTCs, to be identified. CONCLUSIONS: Special attention should be paid to the LTCs with 7 or more drugs prescribed because of their association with DI and NIV. The programme's efficacy would increase, both if the DIs were more accurately defined and if the programme could be computerised and applied massively to chronic treatments.

Aged↗

Microcomputers in enzymology. A versatile BASIC computer program for analyzing kinetic data.

Direct curve-fitting is uncontested as the method of choice for evaluating kinetic experiments. If carried out by computer, the numerical solution of such problems is superior to customary graphical procedures in any respect. However, most programs available to date, cannot be executed by small systems. We now describe a BASIC program for desk-top microcomputers that performs linear and non-linear regression analysis of kinetic data. It may be directly applied to a number of problems common in enzyme kinetics, and is easily modified to handle further ones. The performance of the program is illustrated by some typical applications; in addition, fundamental statistical methods are discussed that allow a critical examination of the results obtained.

Aminopeptidases↗

Pocket computer program for fitting the Hill equation.

This paper presents a program written in the BASIC language for the Radio Shack TRS-80 PC-1 or the Sharp PC 1211 pocket computers for fitting the Hill equation to experimental data. The program is based on a procedure involving a combination of an optimization technique and non-linear regression. The program determines precisely all three parameters of the Hill equation and in addition, it performs a simulation of the kinetic experiment using the parameter values previously estimated, calculating the sum of squares of residuals.

Allosteric Regulation↗

A computer program for drawing structure formulas of the hormonal steroids used most frequently in endocrinology.

A BASIC program has been developed for plotting planar structure formulas of steroid hormones. The structure formulas can be designed either by selecting distinct root-molecule shapes for further figuration of the wanted formula, i.e. androstane, 4-androstene, estrogen, cholestane, pregnane or 4-pregnene structures, or by editing detailed information concerning the molecule to be designed, starting with the number of carbon atoms, etc. The position of hydroxy and/or keto groups, as well as some stereochemical details, are also freely selectable according to the systematic steroid name. Graphs are displayed on the screen and can be printed. The program is supported by most of the conventional BASIC versions running on personal computers with graphic abilities, since graphic symbols are predominantly used for drawing the structure formulas instead of lettering the symbols.

Chemical Phenomena↗

Calculation of NMR relaxation, covolume, and scattering-related properties of bead models using the SOLPRO computer program.

The hydrodynamic properties of macromolecules and bioparticles, represented by bead models, can be calculated using methods implemented in the computer routine HYDRO. Recently, a new computer routine, SOLPRO, has been presented for the calculation of various SOLution PROperties. These include (1) time-dependent electro-optic and spectroscopic properties related to rotational diffusion, (2) non-dynamic properties like scattering curves, and (3) dimensionless quantities that combine two or more solution properties in a form which depends on the shape of the macromolecule but not on its size. In the present work we describe the inclusion of more of those types of properties in a new version of SOLPRO. Particularly, we describe the calculation of relaxation rates in nuclear magnetic resonance (NMR). For dipolar coupling, given the direction of the dipole the program calculates values of the spectral density, from which the NMR relaxation times can be obtained. We also consider scattering-related properties, namely the distribution of distances for the bead model, which is directly related to the angular dependence of scattered intensity, and the particle's longest distance. We have devised and programmed a procedure to calculate the covolume of the bead model, related to the second virial coefficient and, in general, to the concentration dependence of solution properties. Various shape-dependent dimensionless quantities involving the covolume are calculated. In this paper we also discuss some aspects, namely bead overlapping and hydration, that are not explicitly included in SOLPRO, but should be considered by the user.

Mathematical Computing↗