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[Differences in hypothalamic monoaminergic mechanisms in heterogeneous conditioned reflexes in rats].

Monoamines and aminoacids were microinjected in the middle medial hypothalamus of rats following the elaboration of conditioned food-procuring or avoidance reflexes. The glutamine acid had no effect on the avoidance reflex (AR), but stimulated the motor activity and the food-procuring reflex (FR), shortening its latencies, increasing the number of the conditioned food-procuring movements and the reflex size. Dopamine decreased the motor activity, but did not influence the AR latencies, whereas norepinephrine prolonged the AR latencies without changing the motor activity. Both catecholamines, while having no effect on the muscle tone, suppressed FR, prolonging the latencies and decreasing the reflex and the number of conditioned food-procuring movements. Local administration into the hypothalamus of GABA prolonged the latencies of heteromodal conditioned reflexes, whereas the serotonin had no effect on the recorded FR parameters, but facilitated AR significantly reducing its latencies.

Animals↗