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PubMed1991

California serogroup virus infections in the Ryazan region of the USSR.

Serum samples from 60 people diagnosed in the summer of 1989 as having acute respiratory infections, meningitis or meningoencephalitis, acute pneumonia, Lyme disease, or other illnesses were tested by neutralization and hemagglutination-inhibition with Tahyna, Inkoo, and snowshoe hare viruses of the California serogroup (family Bunyaviridae, genus Bunyavirus). Demonstration of a diagnostic increase in antibody titers between paired serum samples from seven people showed that their illnesses were probably caused by Inkoo or Tahyna viruses. The clinical pictures were less specific. One patient had signs of meningoencephalitis, three had signs of meningitis, and three had influenza-like illnesses. These observations and other results suggest that California serogroup viruses are widespread in Russia and may account for an unexpectedly large number of presently undiagnosed febrile illnesses, some with central nervous system involvement.

Adolescent↗
PubMed1991

A serologic study of California serogroup bunyaviruses in Sri Lanka.

A seroepidemiologic study of California (CAL) serogroup viruses (genus bunyavirus, family Bunyaviridae) was carried out on 952 human and 1,834 animal sera collected from different ecological zones of Sri Lanka (latitudes 5-10 degrees N, longitudes 79-82 degrees E). The sera were screened for neutralizing antibody to Lumbo (LUM), snowshoe hare (SSH), and trivittatus (TVT) viruses by plaque neutralization tests on Vero cells. Of 2,786 sera screened, 262 (9.5%) had antibody to one or more viruses Twenty-two sera, selected to represent different species of origin and reaction profiles, were titrated against nine CAL viruses: LUM, SSH, TVT, Tahyna (TAH), California encephalitis (CE), La Crosse (LAC), Inkoo (INK), Melao (MEL), and Guaroa (GRO). Results suggested that there were multiple CAL viruses active in Sri Lanka, one or more of them closely related to LUMBO and SSH viruses, and another related to MELAO virus. These viruses were active in both the wet and dry zones of the country, and infected humans as well as a range of domestic livestock.

Adolescent↗
PubMed1999

Seroepidemiology of California and Bunyamwera serogroup (Bunyaviridae) virus infections in native populations of Alaska.

This study investigated the geographic distribution and prevalence of antibodies to California and Bunyamwera serogroup viruses in Native populations of Alaska, and demographic and ecologic risk factors associated with exposure. Sera (n = 1,635) from 18 communities were screened using an ELISA. All age groups were tested for antibodies to Jamestown Canyon (JC), Inkoo (INK), snowshoe hare (SSH), and Northway (NOR) viruses; persons > or = 45 years old (n = 90) from six communities were additionally tested for antibodies to Tahyna (TAH), Batai (BAT), Cache Valley (CV), and Sindbis (SIN) viruses. Thirty free-ranging mammals were tested by a plaque reduction neutralization test (PRNT) for antibodies to all eight viruses and to Getah (GET) virus. In Natives, overall antibody prevalence was 24.9% (JC = 17.6%, monotypic JC = 6.5%, INK = 11.1%, monotypic INK = 0.6%, SSH = 6.8%, monotypic SSH = 3.5%, and NOR = 6.2%). Five TAH, CV, and BAT virus exposures may be serologic cross-reactions, and no SIN virus antibodies were detected. Sindbis-like virus antibodies were found in 30% of the mammals. Most mammals had antibodies to NOR (83.3%) and California serogroup (70.0%) viruses; no GET virus exposures were found. Significant risk factors for human bunyavirus exposures were age group, ethnic-linguistic group, biotic province, climate zone, terrestrial vegetation, and presence of some ungulates and small mammals in communities. Sex was not a significant risk factor.

Adolescent↗
PubMed1987

Infection of white-tailed deer (Odocoileus virginianus) in Michigan with Jamestown Canyon virus (California serogroup) and the importance of maternal antibody in viral maintenance.

Sera collected from a captive population of white-tailed deer (Odocoileus virginianus) penned in the lower peninsula of Michigan were assayed over a 29-mo period for neutralizing antibody to California serogroup viruses. In all, 130 individual white-tailed deer were bled one to 22 times between June 1983 and November 1985. Of the 130 sampled after active transmission had ceased, or passage of maternal antibody in colostrum had occurred, only one (0.8%), a newborn fawn, had no serum neutralizing antibody to California group viruses. All 18 1-yr-old does sampled acquired specific neutralizing antibody to Jamestown Canyon (JC) virus within a 6-wk period in 1984 and within a 10-wk period in 1985 indicating the prevalence of infection in this nonimmune age group was 100% for 2 successive yr. All 32 2- to 7-yr-old adult does and eight bucks sampled between June 1983 and June 1985 had specific neutralizing antibody to JC virus. No white-tailed deer had specific neutralizing antibody to trivittatus or La Crosse/snowshoe hare viruses at this study site. In 1984 and 1985, 78% and 63% of the adult does respectively exhibited significant anamnestic responses; all 19 adult does sampled over two seasons (between October 1983 and June 1985) showed a significant anamnestic response during at least 1 of the 2 yr. One-third of adult does with significant springtime antibody titer increases apparently experienced reexposure prior to the emergence of aedine mosquitoes, suggesting an alternate vector may overwinter at this site and transmit viruses in early spring. Specific neutralizing antibody was detected in 98% (66/67) of nursing fawns bled within 5 wk of birth in May-June 1984 and 1985, including three of three nursing fawns bled within 24-96 hr of birth. Of the 66 newborn fawns with specific neutralizing antibody to JC virus in June 1984 and 1985, 95% (54/57) of the surviving fawns lost maternal antibody and had no measurable titer when sampled 20-24 wk after birth, however. Serum antibody titers in 25 newborn (1984-cohort) fawns and their mothers and titers in 38 newborn (1985-cohort) fawns and their mothers were significantly correlated at the 5% and 1% levels respectively, suggesting that maternal antibody rather than a naturally acquired infection was the source of immunity in these suckling fawns.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1963

PERINATAL MORTALITY AND SURVIVAL. A COMPARISON OF EXPERIENCE IN CALIFORNIA IN 1949 AND 1959. I--STATISTICAL TRENDS.

The California State Department of Public Health has made an analysis of descriptive items from 369,304 birth and death certificates for 1959 and 252,400 certificates for 1949 in order to identify demographic characteristics associated with perinatal mortality and survival. If the time span of risk of perinatal death is defined as 20 weeks gestation through 27 days after birth, 97 of 100 infants born in California during 1949 and 1959 were born alive and survived the first month of life. Fetal and neonatal death rates decreased over the decade to new lows. Since most of the improvement was among infants that weighed 2,501 grams or more at birth, a greater proportion of all perinatal deaths occurred among premature infants in 1959 than 1949. Survival chances for premature infants remained 75 out of 100 total births. Trends shown by a comparison of the years 1949 and 1959 include a 47 per cent increase in number of births, proportionately more births to mothers under 20 and to women with four or more previous live births, more Negro births and fewer births outside a hospital. An important gain in perinatal survival was found among babies of multiparous mothers. All types of hospitals had lower fetal and neonatal mortality, but county hospitals showed the greatest improvement. Less populated areas lowered their perinatal death rates more than major metropolitan areas when average rates for 1945-1949 and 1955-1959 were compared.

Black People↗
PubMed1964

CHILDREN WITH EPILEPSY. A STUDY OF THEIR NEEDS IN CALIFORNIA.

The 1959 California Legislature directed the State Department of Public Health to conduct a study of the needs of California children with epilepsy and to determine the costs and feasibility of including medical services to such children under the Crippled Children Services program. A demonstration program of services was provided in Contra Costa and San Bernardino counties. Under these programs, children suspected of having epilepsy were referred for specialists' examinations, tests and recommendations for treatment. Private physicians provided the largest portion of a total of 236 referrals. Children referred were found to have complex medical, social and educational problems, and to be in need of comprehensive diagnostic and treatment services. About half of the children had mixed epilepsy and over one-third had focal seizures. Two-thirds had at least one other major additional handicap. At the time of referral one-fifth of these children had one or more seizures daily.Through specialized care and medications provided under this project, 58 per cent of those with seizures became seizure free, and an additional 24 per cent showed a considerable reduction of seizure frequency. This project provided a practical method of obtaining information necessary for program planning and has also demonstrated the value of such a program in helping private physicians to meet some of the multiple problems presented by these children.

California↗
PubMed1989

[The clinico-laboratory characteristics of cases of diseases connected with viruses of the California encephalitis complex in the inhabitants of Moscow].

To study the role of viruses of the California encephalitis virus complex (the family Bunyaviridae) in infectious pathology, 187 fever patients admitted to the Clinical Infectious Hospital in May-September 1986 were examined. In 10 of these patients the neutralization test revealed the presence of diagnostically significant changes in neutralizing antibodies (neutralization indices), which was indicative of the role played by Tahyna virus or other related viruses belonging to the California encephalitis virus complex in the etiology of the diseases. The analysis of the clinical picture showed that in all patients the disease took an acute course in its initial stage, starting with shivering and characterized by high fever, headache, pronounced toxicosis, the possibility of the formation of intracerebral hypertension and pneumonia.

Acute Disease↗
PubMed1989

Recently introduced Aedes albopictus in the United States: potential vector of La Crosse virus (Bunyaviridae: California serogroup).

A population of Aedes albopictus collected in 1986 in Harris County, Texas, was evaluated for its vector competence with 4 California serogroup viruses (Jamestown Canyon, Keystone, La Crosse and trivittatus). Rates of midgut infection, dissemination of virus beyond the midgut and oral transmission to suckling mice were markedly different for the 4 viruses in a pattern representative of the antigenic relationships known for the California serogroup. Only La Crosse virus was shown to be efficiently transmitted by this recently introduced mosquito population. The results suggest that populations of Ae. albopictus originating from the Harris County population might well be as efficient in transmitting La Crosse virus as are populations of the natural mosquito vector. Aedes triseriatus, from the midwestern La Crosse virus enzootic region. The public health implications of these results are discussed in relation to the rapid spread of Ae. albopictus throughout the eastern half of the United States and into regions where La Crosse virus is known to be enzootic.

Aedes↗
PubMed1989

[Significance of viruses of antigen complex of California encephalitis in pathology].

A study was undertaken to examine 320 patients with seasonal fevers occurred in June to September. These included fever of unknown etiology, acute respiratory virus diseases, pneumonias, bronchitis, enterovirus diseases, and serous meningitis. Serological tests revealed that in 20 (6.3%) of them the viruses of the complex in California encephalitis (Tyagin's virus or antigenically related virus) contributed to the etiology of the disease. Major clinical symptoms of the disease were defined in this group of patients. The disease appeared as neuroinfections (serous meningitis), influenza-like conditions (fever, symptoms of intoxication), occasionally, infiltrative changes in the lung. Thus, the viruses of the antigen complex of California encephalitis makes an etiological contribution to infectious abnormalities.

Adolescent↗
PubMedDate not supplied

[Antiviral activity of ribamidyl in experimental infections with California encephalitis group viruses].

A preparation of ribamydil, an analogue of natural nucleosides, synthesized at the Latvian SSR Institute of Organic Chemistry showed a sufficiently high activity against bunyaviruses of California encephalitis complex both in vitro and in vivo. Various modifications of the enzyme immunoassay may be used for control of the effectiveness of treatment with this drug. Some advantages of the subcutaneous route over the intramuscular one were found. Ribamydil may be useful for treatment of infections of California encephalitis complex.

Animals↗
PubMed1997

Report of the Northern California Conference for Guidelines on Aid-in-Dying: definitions, differences, convergences, conclusions.

In September 1996, the Stanford University Center for Biomedical Ethics convened a conference entitled "Comprehensive Care of the Terminally Ill: The Northern California Consensus Development Conference for Guidelines on Aid-in-Dying." The regionally based, multidisciplinary conference gathered people from a variety of disciplines and diverse perspectives on physician aid-in-dying. This report documents important points of convergence, disagreement, and uncertainty that emerged from the conference and provides commentary on crucial issues: the definition of terminal illness, ensuring adequate palliative care, psychiatric challenges, coping with family pressures, the doctor-patient relationship, the managed care context, the role of ethics committees, and institutional challenges. Should physician aid-in-dying become a legal practice in California, the report will provide guidance to health care organizations, health professionals, and public policy officials engaged in local or state guideline or policy development.

California↗
PubMed1997

Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California.

OBJECTIVE: To determine whether neurological and psychiatric symptoms predict survival time among patients with Alzheimer disease (AD) after adjusting for the influence of sociodemographic variables, health conditions, and dementia severity separately for men and women. DESIGN: The sample consisted of 936 men and women diagnosed as having probable or possible AD at 1 of 7 Alzheimer's Disease Diagnostic and Treatment Centers throughout California from 1986 through 1990. Data on dementia severity, comorbid conditions, and demographic characteristics were collected at the time of AD diagnosis. Data on vital status and dates of death were obtained by linking the patient file to several administrative databases maintained by the California State and federal governments. The mean length of follow-up was 31 months. Data were analyzed with Kaplan-Meier survival curves and Cox proportional hazards models. RESULTS: Men had shorter survival times than did women (log-rank test, 30.93, P < .001). Among men, but not women, survival times were negatively associated with selected neurological and psychiatric symptoms. Among women, but not men, a history of cardiovascular conditions was associated with poorer survival. CONCLUSIONS: Patterns of survival and predictors of survival time among patients with AD differ by sex. Future studies of survival and progression of AD need to examine men and women separately.

Age of Onset↗
PubMed2000

Adolescent violence prevention practices among California pediatricians.

OBJECTIVES: To examine pediatricians' provision of violence prevention services to their adolescent patients and to identify factors associated with pediatricians' implementation of these services. DESIGN: A cross-sectional sample of California pediatricians completed a self-report questionnaire. The "Precede/Proceed" theoretical model guided the questionnaire in identification of factors associated with pediatricians' screening and intervening practices in preventing adolescent violence. RESULTS: Two hundred twenty pediatricians (54% female, 66% white, 24% Asian, 5% Latino, and 5% other) participated in the study. On average, participants screened their patients for violence-related risk factors 31% of the time for fighting, 39% of the time for violence in the home, and 29% of the time for weapon carrying. Participants provided their at-risk patients with violence-related interventions less than 50% of the time (on average) implementing the following interventions: written materials, follow-up appointments, discipline counseling, or referral to a community organization, Child Protective Services, or a specialized adolescent clinic. Factors associated with violence prevention screening practices included the following: positive attitudes and beliefs regarding screening for violence, familiarity with violence prevention guidelines, use of prompts in medical records, perceptions of greater skills, and positive reinforcement from patients and colleagues for providing violence prevention services (R(2)=0.44; P<.001). Factors associated with violence prevention intervention practices included: positive attitudes and beliefs in screening for violence, availability of resources, and positive reinforcement from patients and colleagues for providing violence prevention services (R(2)=0.37; P<.001). CONCLUSIONS: California pediatricians are not widely screening their adolescent patients for risk factors associated with adolescent violence, nor are they providing interventions to their adolescent patients who may be at risk for violence. The factors associated with pediatricians' implementation of violence prevention services may assist in the development of effective interventions designed to enhance their delivery of these services to their adolescent patients.

Adolescent↗
PubMed2004

Gun threats against and self-defense gun use by California adolescents.

OBJECTIVE: To assess hostile gun use against and self-defense gun use by adolescents. DESIGN, SETTING, AND PARTICIPANTS: We use random-digit-dial telephone survey data collected from approximately 5800 California adolescents, aged 12 through 17 years, between November 1, 2000, and October 31, 2001. MAIN OUTCOME MEASURES: The prevalence and correlates of reported hostile gun use against and self-defense gun use by adolescents, as well as qualitative information about these 2 types of gun uses. Correlates include age, sex, ethnicity, smoking, alcoholic binge drinking, threatening others, parents knowing their adolescent's whereabouts in the afternoon after school, attending school, area urbanization and poverty level, and living in a household with a gun. RESULTS: Approximately 4% of the adolescents reported ever having been threatened with a gun; only 0.3% reported using a gun in self-defense. Boys, smokers, adolescents who threatened others, and adolescents whose parents knew little about their whereabouts in the afternoon after school were more likely to report being threatened with a gun. Most episodes of self-defense gun use seem to be hostile interactions between adolescents with weapons. CONCLUSIONS: Far more California adolescents are threatened with a gun than use a gun in self-defense. Self-defense gun use is rare; many of the reported self-defense gun uses seem to be armed confrontations.

Adolescent↗
PubMed1994

Eradication of Haemophilus influenzae type b disease in southern California. Kaiser-UCLA Vaccine Study Group.

OBJECTIVE: To assess the effects of Haemophilus influenzae vaccination of infants. RESEARCH DESIGN: We evaluated H influenzae type b (Hib) disease rates in Los Angeles County, California (population, 9 million; 1983 through 1992), and in the Southern California Kaiser Health Plan (2.5 million enrollees; 1988 through 1992) during the past decade. Cases were obtained through active and passive disease surveillance in the two populations. The following vaccines were used during the study period (1983 through 1992): (1) Hib polysaccharide vaccine (polyribosyl ribitol phosphate) (used from 1985 through 1987 for children 24 through 60 months of age); (2) Hib polysaccharide-diphtheria toxoid conjugate, Hib polysaccharide CRM197 mutant diphtheria toxoid conjugate vaccine, and Hib polysaccharide outer-membrane protein of group B meningococcus conjugate vaccine in older children (1988 through 1990; ages 15 through 60 months); and (3) Hib polysaccharide CRM197 mutant diphtheria toxoid conjugate vaccine and Hib polysaccharide outer-membrane protein of group B meningococcus conjugate vaccine used in infants (1991 through 1992). MEASUREMENTS AND RESULTS: Between 1983 and 1988, the Hib disease incidence in Los Angeles County was unchanged (32.7 to 42.5/100,000 person-years in children younger than 5 years). In 1989 through 1990, before Hib conjugate licensure for infant use, Hib disease rates in all age groups declined. After licensure of Hib vaccines for infants in 1990, there was a further fivefold decrease in infants. More dramatic decreases occurred in the better-immunized Kaiser Health Plan children aged 0 through 60 months (53 cases in 1989, only two cases in 1992). CONCLUSIONS: The Hib disease has been nearly eradicated in a fully immunized population (Kaiser Health Plan), and significant reductions have also occurred in Los Angeles County.

California↗
PubMed1982

Stone-Roth model of civil commitment and the California dangerousness standard: operational comparison.

Professional opposition to making "dangerousness" the primary criterion for involuntary civil commitment has galvanized in support of the proposed "new medical model." The Stone-Roth criteria for commitment were applied to patients being committed under California's version of the dangerousness standard. Results showed that 86% of the patients committed under the California statute were viewed by the examining psychiatrists as committable under the Stone-Roth procedures as well.

Adult↗
PubMed1998

Racial and ethnic variations in the prevalence of orofacial clefts in California, 1983-1992.

To investigate variations in the prevalence of oral cleft anomalies according to parental race and ethnicity and maternal country of birth, the authors analyzed a cohort of 2,221,755 live births and fetal deaths delivered between 1983 and 1992 to residents of California. A total of 2,329 cleft lip with or without cleft palate (CL +/- P) cases and 1,475 cleft palate alone (CP) cases were identified by the California Birth Defects Monitoring Program, a population-based registry. Compared to Whites, the prevalence of CL +/- P was lower among African Americans (prevalence ratio (PR) = 0.56, 95% confidence interval (CI) = 0.45-0.69), higher among Native Americans (PR = 1.81, CI = 1.20-2.69), and the same among the Japanese (PR = 1.07, CI = 0.62-1.82) and Chinese (PR = 0.96, CI = 0.71-1.29). The risk of CL +/- P was slightly lower among the offspring of foreign-born Chinese women relative to U.S.-born Chinese women (PR = 0.71, CI = 0.33-1.57), and slightly higher among foreign-born Filipinos relative to their U.S.-born counterparts (PR = 1.37, CI = 0.57-3.53), although confidence intervals around these risk estimates were wide owing to sparse data. For CP, lower prevalences were observed among African Americans (PR = 0.72, CI = 0.58-0.91) and Hispanics (PR = 0.77, CI = 0.67-0.87) than among Whites. The risk of CP was higher among foreign-born Filipinos compared to U.S.-born Filipinos (PR = 1.52, CI = 0.58-4.33), although the confidence interval around this estimate included unity. These prevalence variations may reflect differences in both environmental and genetic factors affecting clefting risk.

California↗
PubMed1996

Epidemiologic characteristics of conotruncal heart defects in California, 1987-1988.

In this population-based case-control study, we explored the association of selected parental and infant characteristics from the birth certificates of children with conotruncal heart defects. We compared 252 cases to a random sample of 5,000 nonmalformed infants from a cohort of 341,839 California live births for 1987-1988. The prevalence of conotruncal defects was 0.732 per 1,000 total births. A decreased risk (OR = 0.55, 95% CI0.33-0.89) for delivering infants with conotruncal defects was found among mothers born in Mexico compared to mothers born in California. An increased risk was observed for Native American mothers compared to non-Hispanic whites (OR = 2.6, 95% CI 1.1-6.0). We also compared risks associated with the individual diagnoses that comprise the group of conotruncal defects. Only minor differences in risk estimates between the anatomic diagnoses were observed, lending support to the methodologic approach of using conotruncal defects as a single category of heart defects in etiologic investigations.

California↗