Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “BONE REGENERATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 811 records · Page 45Linked to original sources
PubMed2004

Bone regeneration by bodily tooth movement: dental computed tomography examination of a patient.

A 32-year-old man was examined with computed tomography before and after orthodontic treatment, and alveolar bone levels at the edentulous spaces were assessed. When the computed tomography scans were compared, 2.2 to 5.2 mm of additional craniocaudal alveolar bone remodeling by bodily tooth movement was found in the space-opening region. Bodily movement was achieved with single- and crossed-lever-arm mechanics. Root resorption measuring 1 to 4 mm was observed at the mandibular anterior region, where teeth were used for anchorage to upright the molars.

Adult↗
PubMedDate not supplied

[Use of xydiphone diphosphonate for correcting the course of posttraumatic bone regeneration in protracted hypodynamia].

Experiments were conducted on rats to study the effect of daily injection of xydiphone diphosphonate in a dose of 5 mg/100 g on bone tissue in normal motor activity and in hypodynamia caused by amputation of a limb and posttraumatic regeneration. It was established that xydiphone inhibits thinning of the diaphyseal cortical layer induced by hypodynamia and normalizes the parameters which characterize posttraumatic bone tissue regeneration in an unsupported position of the limb.

Animals↗
PubMed1981

Bone regeneration in animals and in man. A contribution to understanding the relative value of animal experiments to human pathophysiology.

Under both normal and pathophysiological conditions the relationship between bony histology and the regionally associated vascular pattern was studied. Three independent methods of research were employed (microangiography, fuchsin stained ground sections, polychrome sequential labeling) and, thus, the limitations inherent in each method were minimized. Animals of different ages and different species were found to have relatively different amounts of primary and secondary bone. In all instances primary bone was associated with a network vascular pattern emanating from the periosteal surface and secondary bone was associated with an arborial vascular pattern arising from the endosteal circulation. Adult dogs, unlike sheep, were found to have a significant complement of secondary bone and, therefore, in consideration of human bony regeneration, the dog is a superior experimental model.

Age Factors↗
PubMed2000

Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration.

Platelet-derived growth factor-BB (PDGF-BB) releasing porous chondroitin-4-sulfate (CS)-chitosan sponge was designed with an aim of controlling growth factor delivery in order to improve bone formation. Porous CS-chitosan sponge was fabricated by freeze drying and crosslinking aqueous CS-chitosan solution. PDGF-BB was incorporated into the CS-chitosan sponge by soaking CS-chitosan sponge into the PDGF-BB solution. CS-chitosan sponge retained a porous structure with a 150-200-microm pore diameter that was suitable for cellular migration and osteoid ingrowth. Release rate of PDGF-BB could be controlled by varying the composition of CS in the sponge or initial loading content of PDGF-BB. CS-chitosan sponge induced increased osteoblast migration and proliferation as compared with chitosan sponge alone. Furthermore, the release of PDGF-BB from CS-chitosan sponge significantly enhanced osteoblast proliferation. These results suggest that PDGF-BB-releasing CS-chitosan sponge may be beneficial to enhance bone cell adaptation and regenerative potential when applied in wound sites.

Animals↗
PubMed1991

Guided bone regeneration next to osseointegrated implants in humans.

The purpose of this investigation was to evaluate the technique of guided tissue regeneration on a clinical and histologic level for generating new bone adjacent to osseointegrated implants. Cylindrical, press-fitted, titanium plasma flame-coated implants were modified by a disk screwed onto the implant. After implant insertion, the disk-implant assembly was covered by an expanded polytetrafluorethylene membrane. In one group, the space underneath the membrane was filled with hydroxylapatite granules; in the control group, no membrane was used. Clinical and histologic results demonstrate that the principle of guided tissue regeneration is applicable to osteogenesis in humans.

Adult↗
PubMed2000

Cartilage and bone regeneration using gene-enhanced tissue engineering.

Joint cartilage injury remains a major problem in orthopaedics with more than 500,000 cartilage repair procedures performed yearly in the United States at a cost of hundreds of millions of dollars. No consistently reliable means to regenerate joint cartilage currently exists. The technologies of gene therapy and tissue engineering were combined using a retroviral vector to stably introduce the human bone morphogenic protein-7 complementary deoxyribonucleic acid into periosteal-derived rabbit mesenchymal stem cells. Bone morphogenic protein-7 secreting gene modified cells subsequently were expanded in monolayer culture, seeded onto polyglycolic acid grafts, implanted into a rabbit knee osteochondral defect model, and evaluated for bone and cartilage repair after 4, 8, and 12 weeks. The grafts containing bone morphogenic protein-7 gene modified cells consistently showed complete or near complete bone and articular cartilage regeneration at 8 and 12 weeks whereas the grafts from the control groups had poor repair as judged by macroscopic, histologic, and immunohistologic criteria. This is the first report of articular cartilage regeneration using a combined gene therapy and tissue engineering approach.

Animals↗