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At least 811 records · Page 45Linked to original sources
PubMed1987

Recovery of the failing canine heart with biventricular support in a previously fatal experimental model.

Prolonged normothermic ischemia in the canine model is generally fatal with standard resuscitative techniques. To determine whether such myocardial injury is recoverable with biventricular support, we subjected 10 dogs to 45 minutes of ischemia at 37 degrees C. After ischemia, the animals were supported for 24 hours with biventricular assist with the centrifugal pump. During early reperfusion, none of the hearts could sustain a stable rhythm or blood pressure. Myocardial adenosine triphosphate concentration, expressed as micromoles per gram of heart protein, was dramatically reduced from a control of 31.5 +/- 2.4 to 14.6 +/- 2.9 (p less than 0.01 versus control), a 54% reduction. Ultrastructural analysis did not reveal the explosive cell swelling of irreversible cell injury. After 12 hours of biventricular assist, developed pressure partially recovered to 60.0 +/- 10 mm Hg (p less than 0.01 versus control) and maximal positive dP/dt measured 2,649 +/- 412 mm Hg/sec (p less than 0.01 versus control). Adenosine triphosphate concentration increased to 25.2 +/- 5.5 (p less than 0.01 versus control). Electron microscopic examination showed less chromatin clumping, no further mitochondrial distortion, and more abundant glycogen. After 24 hours of biventricular assist, cardiac output in the seven dogs successfully weaned from biventricular assist measured 3.6 +/- 0.6 L/min, developed pressure recovered to 76.3 +/- 8.9 mm Hg, and its first derivative recovered to 4,282 +/- 585 mm Hg/sec (all measurements not significant compared with control). Examination by an electron microscope revealed no severe mitochondrial injury.

Adenosine Triphosphate↗
PubMed1985

The spindle pump--a new concept for a nonpulsatile bloodpump.

The spindle pump--a new nonpulsatile bloodpump--has been developed as paracorporeal ventricular assist pump. The experiments with calves clearly demonstrated, that this pump as LVAD empties the left ventricle completely, the aortic pressure curve showing the typical nonpulsatile profil. A problem is the traumatic hemolysis, the free hemoglobin was in all experiments slightly but always above our standard. To solve this problem we will optimize shapes of the spindle and of the housing and coate all parts of the pump with polyurethane.

Animals↗
PubMed1983

Development and in vitro fatigue testing of a new bloodpump.

1. Three different types of blood pumps (LVAD 80 ml, LVAH 100 ml, TAH 1 120 ml, TAH r 100 ml) with two variations had been designed, fabricated and fatigue tested. 2. The optimizing of the blood diaphragm thickness by analyzing the results of the fatigue testing was impossible up to now because of the long functional times of pumps even with very thin diaphragms (50-80 microns). 3. First in vivo experiments showed no problems with the blood compatibility, the anatomical fit, the fixation of the valves and the toxicity of the used combination of materials. There was no pump related termination in LVAD as well as in TAH experiments.

Animals↗
PubMed1989

Traumatic tears of the thoracic aorta: improved results using the Bio-Medicus pump.

Traumatic disruption of the descending thoracic aorta is a relatively rare but dramatic injury. Controversy remains regarding the use of shunts during operative repair. Discouraged by our results using the "no shunt" technique, we adopted the recently reported technique using the Bio-Medicus pump for left atrium-femoral artery bypass without heparin sodium. At Charlotte Memorial Hospital and Medical Center, 39 patients were treated for tears of the descending thoracic aorta between January 1979 and October 1988. Eight patients died before repair could be completed. Four patients underwent repair using femorofemoral bypass with 1 death and no instances of paraplegia. Fifteen patients had repair using the no-shunt technique with 4 deaths and three instances of paraplegia. Since January 1986, 12 patients have been treated using the Bio-Medicus heparinless pump with no deaths and no instances of paraplegia. We present our experience to confirm the reports of others regarding the efficacy of this technique. We believe it reduces the morbidity and mortality associated with this serious injury and aids in the hemodynamic management of the patient during aortic clamping.

Adult↗