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Speech intelligibility after partial glossectomy in children with Down's syndrome.

Twenty-three children with Down's syndrome, aged between 3.7 and 17.5 years, underwent partial glossectomy for improvement of cosmetic appearance. Improved speech was also expected. Preoperative and postoperative audiotaped samples of spoken words and connected speech on a standardized articulation test were rated by three lay and three expert listeners on a five-point intelligibility scale. Five subjects were eliminated from both tasks and another four from connected-speech testing because of inability to complete the experimental tasks. Statistical analyses of ratings for words in 18 subjects and connected speech in 14 of them revealed no significant difference in acoustic speech intelligibility preoperatively and postoperatively. The findings suggest that a wedge-excision partial glossectomy in children with Down's syndrome does not result in significant improvement in acoustic speech intelligibility; in some patients, however, there may be an aesthetic improvement during speech.

Adolescent↗

Paternal age and intelligence: implications for age-related genomic changes in male germ cells.

BACKGROUND: A robust association between advancing paternal age and schizophrenia risk is reported, and genetic changes in the germ cells of older men are presumed to underlie the effect. If that is so, then the pathway may include effects on cognition, as those with premorbid schizophrenia are reported to have lower intelligence. There are also substantial genetic influences on intelligence, so de novo genetic events in male germ cells, which accompany advancing paternal age, may plausibly influence offspring intelligence. OBJECTIVE: An association of paternal age with IQ in healthy adolescents may illuminate the mechanisms that link it to schizophrenia. METHOD: We examined the association of paternal age and IQ scores using the Israeli Army Board data on 44 175 individuals from a richly described birth cohort, along with maternal age and other potential modifiers. RESULTS: A significant inverted U-shaped relationship was observed between paternal age and IQ scores, which was independent from a similar association of IQ scores with maternal age. These relationships were not significantly attenuated by controlling for multiple possible confounding factors, including the other parent's age, parental education, social class, sex and birth order, birth weight and birth complications. Overall, parental age accounted for approximately 2% of the total variance in IQ scores, with later paternal age lowering non-verbal IQ scores more than verbal IQ scores. CONCLUSION: We found independent effects of maternal and paternal age on offspring IQ scores. The paternal age effect may be explained by de novo mutations or abnormal methylation of paternally imprinted genes, whereas maternal age may affect fetal neurodevelopment through age-related alterations in the in-utero environment. The influence of late paternal age to modify non-verbal IQ may be related to the pathways that increase the risk for schizophrenia in the offspring of older fathers.

Cohort Studies↗

Emotionally intelligent case managers make a difference.

Emotional intelligence is a skill necessary for case managers because of the diversity of their work, the multiple stakeholders they have to deal with on daily basis, and the increased potential for conflict. Managers and administrators need to be cognizant of the role emotional intelligence plays in employee performance and the importance of developing training programs to assist case managers in learning to deal with change and conflict. Case managers must assume responsibility for their actions and work to develop and improve their emotional intelligence skills set. Ultimately, patients and work associates will appreciate the case manager's efforts. Finally, case managers will find work an enjoyable experience and look forward to new opportunities the future holds.

Case Management↗

Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain.

Proton magnetic resonance spectroscopy (1H-MRS) offers a unique non-invasive approach to measurement of N-acetylaspartate (NAA) and choline (Cho), putative markers of neuronal and glial integrity. Previous studies revealed that these neurochemicals predict cognitive impairment in diseased subjects, although little is known about their relationship to cognitive functioning in healthy people. We measured the concentrations of NAA and Cho in the left occipitoparietal white matter of 26 healthy adults and compared them with intellectual performance assessed by the Wechsler Adult Intelligence Scale-3. We found that NAA (b = 0.6, p < 0.01) and Cho (b = -0.42, p < 0.01) were independently associated with the Full-Scale Intelligence Quotient. Together, these metabolites accounted for a large proportion of the variance in intelligence (r2 = 0.45). Possible mechanisms underlying these correlations, such as mitochondrial function and myelin turnover, are discussed. 1H-MRS is a sensitive new tool to assess the neuronal underpinnings of cognitive function non-invasively.

Adult↗

Animal intelligence as encephalization.

There is no consensus on the nature of animal intelligence despite a century of research, though recent work on cognitive capacities of dolphins and great apes seems to be on one right track. The most precise quantitative analyses have been of relative brain size, or structural encephalization, undertaken to find biological correlates of mind in animals. Encephalization and its evolution are remarkably orderly, and if the idea of intelligence were unknown it would have to be invented to explain encephalization. The scientific question is: what behaviour or dimensions of behaviour evolved when encephalization evolved? The answer: the relatively unusual behaviours that require increased neural information processing capacity, beyond that attributable to differences among species in body size. In this perspective, the different behaviours that depend on augmented processing capacity in different species are evidence of different intelligences (in the plural) that have evolved.

Adaptation, Biological↗

Intelligent control of a planning system for astronaut training.

This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconstrained environment. Formulating the planning problem in the domain of discrete-event systems under a unified framework such that it can be modeled, designed, and analyzed as a control system will provide a self-contained theory for such planning systems. This will also provide a means to certify various planning systems for operations in the dynamical and complex environments in space. The work presented here completes the design, development, and analysis of an intricate, large-scale, and representative mathematical formulation for intelligent control of a real planning system for Space Station crew training. This planning system has been tested and used at NASA-Johnson Space Center.

Algorithms↗

Intelligent inferencing and haptic simulation for Chinese acupuncture learning and training.

This paper presents an intelligent virtual environment for Chinese acupuncture learning and training using state-of-the-art virtual reality technology. It is the first step toward developing a comprehensive virtual human model for studying Chinese medicine. Students can learn and practice acupuncture in the proposed 3-D interactive virtual environment that supports a force feedback interface for needle insertion. Thus, students not only "see" but also "touch" the virtual patient. With high performance computers, highly informative and flexible visualization of acupuncture points of various related meridian and collateral can be highlighted to guide the students during training. A computer-based expert system using our newly proposed intelligent fuzzy petri net is designed and implemented to train the students to treat different diseases using acupuncture. Such an intelligent virtual reality system can provide an interesting and effective learning environment for Chinese acupuncture.

Acupuncture↗

An intelligent service-based network architecture for wearable robots.

We are developing a novel robot concept called the wearable robot. Wearable robots are mobile information devices capable of supporting remote communication and intelligent interaction between networked entities. In this paper, we explore the possible functions of such a robotic network and will present a distributed network architecture based on service components. In order to support the interaction and communication between the components in the wearable robot system, we have developed an intelligent network architecture. This service-based architecture involves three major mechanisms. The first mechanism involves the use of a task coordinator service such that the execution of the services can be managed using a priority queue. The second mechanism enables the system to automatically push the required service proxy to the client intelligently based on certain system-related conditions. In the third mechanism, we allow the system to automatically deliver services based on contextual information. Using a fuzzy-logic-based decision making system, the matching service can determine whether the service should be automatically delivered utilizing the information provided by the service, client, lookup service, and context sensors. An application scenario has been implemented to demonstrate the feasibility of this distributed service-based robot architecture. The architecture is implemented as extensions to the Jini network model.

Algorithms↗

Intelligence in relation to later beverage preference and alcohol intake.

AIMS: The health effects of drinking may be related to psychological characteristics influencing both health and drinking habits. This study aims to examine the relationship between intelligence, later beverage preference and alcohol intake. DESIGN: Prospective cohort study. SETTING: Zealand, Denmark. PARTICIPANTS: A total of 900 obese men and a random population sample of 899 young men. MEASUREMENTS: Intelligence testing at the draft board examinations over a 22-year period between 1956 and 1977. Percentage of wine of total alcohol intake (wine pct), preference for wine (wine pct >50), heavy drinking (>21 drinks per week) and non-drinking (<1 drink per week), and vocational education from follow-ups of the initial study sample in 1981-83 and 1992-94. FINDINGS: A strong dose-response-like association was found between intelligence quotient (IQ) in young adulthood and beverage preferences later in life in both the obese and the random population sample. At the first follow-up a 30-point advantage in IQ [2 standard deviations (SD)] was found to be associated with an odds ratio (OR) for preferring wine over beer and spirits of 1.7 (1.3-2.4). At the second follow-up the corresponding OR was 2.8 (2.0-3.9). A 30-point advantage in IQ was found to be associated with an OR for being a non-drinker of 0.5 (0.3-0.8) at the first follow-up and second follow-up. We examined whether, at the second follow-up, the association between IQ, beverage preferences and non-drinking could be explained by socio-economic position (SEP). The association between IQ and non-drinking disappeared when controlling for SEP. The association between IQ and beverage preferences was attenuated, but remained statistically significant. IQ was not associated with heavy drinking. CONCLUSION: Irrespective of socio-economic position, a high IQ was associated with preference for wine to other beverages, but IQ was not related similarly to alcohol consumption.

Adult↗

A comparison of three intelligence tests for the assessment of mental retardation.

Thirty-six mentally retarded adolescents were administered the Wechsler Intelligence Scale for Children (WISC), the Peabody Picture Vocabulary Test (PPVT), and the Slosson Intelligence Test (SIT) to determine reliability and comparable performance among the three intelligence tests. Correlations as a function of IQ and MA, by sex, were computed among the three tests. All were significant (p less than .01), but the WISC and SIT had consistently higher relationships than any other comparisons on both IQ and MA. Analyses also indicated that the PPVT produced higher IQ scores than the WISC or SIT and that MA in the PPVT was influenced by the previous administration of the SIT. It was concluded that, as a screening device, the SIT is more reliable and approximates WISC scores more consistently than the PPVT.

Adolescent↗

Phenylketonuria with normal intelligence.

A review was made of the literature with respect to cases of untreated phenylketonuria (PKU) with normal intelligence. Six families were found in which a person with classical PKU and normal intelligence, and a sibling with PKU and severe mental handicap had been reported. Details are given of another similar family, and possible reasons are discussed for the preservation of intelligence in the affected individual with an IQ of 82. Among the reasons proposed are breast feeding, which has a low phenylalanine level and a raised biopterin level, which may help in the production of brain neurotransmitters. Studies of similar cases are suggested.

Adolescent↗

A longitudinal study of children with developmental language delay at age three: later intelligence, reading and behaviour problems.

A large sample of Dunedin (New Zealand) children were assessed at age three to identify those with language delay. 2.6 per cent were defined as delayed in verbal comprehension only, 2.3 per cent as delayed in verbal expression only, and 2.3 per cent as delayed in both ('general language delay'). Most of these children, and the remainder of the sample, were assessed for intelligence, reading and behaviour problems at ages seven, nine and 11. Those in every language-delay group had significantly lower mean IQs and lower mean reading scores than the remainder of the sample. They also more often had a low IQ or a lower reading score at ages seven and nine and a lower Verbal and Full-scale IQ at 11. The groups with delayed verbal comprehension and general language delay had significantly more behaviour problems than the remainder of the sample. The group with general language delay was consistently the most disadvantaged in later intelligence, reading and behaviour. Two of the language-delay groups (comprehension and general language) had significantly higher scores on a family disadvantage index. The results of this study confirm the importance of early language delay as a predictor of lower than average intelligence and reading ability and increased behaviour problems.

Child↗

Benign epilepsy of children with centrotemporal EEG foci: intelligence, behavior, and school adjustment.

Sixteen children aged 7-12 years with benign epilepsy of childhood and centrotemporal (Rolandic) EEG foci were investigated as regards intelligence, visuomotor coordination, behavior, and school adjustment. They were compared with partly the same-sex class-population, partly randomly selected class controls of the same sex and age. There were no differences between the children and their class controls regarding intelligence, behavior, and school adjustment. The epileptic seizures did not influence the children's intelligence. The visuomotor coordination was impaired in most children (tested by Bender's test), but this was not true for their verbal and nonverbal functions.

Age Factors↗

Verbal fluency as a function of a measure of verbal intelligence and in relation to different types of cerebral pathology.

A measure of verbal fluency was derived from groups of patients with focal lesions and dementia and from normal control subjects. A regression equation was also derived to predict fluency from an index of verbal intelligence. Subjects with right or left frontal lesions and those with dementia had depressed fluency scores. When verbal intelligence was taken into account using the regression equation, fluency still remained depressed in subjects with frontal lesions, but for dements the obtained fluency score was similar to that predicted from the measure of verbal intelligence. The results suggest that impaired fluency is a specific phenomenon following frontal lesions but is merely a consequence of intellectual deterioration in dementia.

Alzheimer Disease↗

Effects of increased vertical dimension on size of constriction port and fricative sound intelligibility.

The effect of increased vertical bite dimension on fricative sound productions was studied in five adults who wore dentures. Oral port size and sound intelligibility were evaluated at different degrees of artificially induced open bite. The data demonstrate that rapid compensatory adjustments occurred and oral port size changed minimally at all degrees of opening tested. However, in three of the subjects, sound intelligibility declined at the 6-mm opening, and in all subjects, a four-fold increase in sound distortions occurred in the edentulous state. This finding suggests the possibility that either physiological parameters are controlled more successfully than acoustical parameters or that compensatory efforts to maintain constrictor size may, under certain circumstances, adversely affect sound intelligibility.

Adult↗

Derivation of primary parameters and procedures for use in speech intelligibility predictions.

The literature on various parameters that appear in the articulation index-type calculations of speech intelligibility is reexamined. Based on the reported data, the best estimates of these parameters and the most appropriate procedures for their use are suggested. These included: (1) the analysis and specification of the importance of various frequency bands to speech intelligibility; (2) the procedures used for measuring threshold and the calculation of threshold-based parameters used for predicting intelligibility of low-level speech; and (3) the calculation and measurement of relevant speech parameters. All results are given so that the calculations can be performed either in critical bands, 1/3 octaves, or octaves.

Algorithms↗

Effects of a single reflection with varied horizontal angle and time delay on speech intelligibility.

Previously, almost all physical measures for estimating speech intelligibility in a room have been derived from only temporal-monaural criteria. This paper shows that speech intelligibility for a sound field with a single reflection depends not only on the temporal-monaural factor but also on the spatial-binaural factor of the sound field. Articulation tests for sound fields simulated with a single reflection of delay time delta t1 after the direct sound were conducted changing the horizontal incident angle xi of the reflection. Remarkable findings are as followings: (1) speech intelligibility (SI) decreases with increasing delay time delta t1, (2) SI increases when xi approaches 90 degrees; the horizontal angle of the reflection causes a significant effect on SI, and (3) the analysis of variance for articulation test scores clearly demonstrated that the effects of both delta t1 and xi on SI are fully independent. Concerning result (2), if listeners get a spatial separation of signals at the two ears, then the listener's capability for speech perception is assumed to be improved due to "adding" further information to the temporal pattern recognition.

Acoustics↗

Effects of temporal smearing on temporal resolution, frequency selectivity, and speech intelligibility.

Envelopes of speech were smeared in 23 parallel frequency channels. The smeared speech was presented to normal-hearing listeners, and the effects of different smearing magnitudes on speech intelligibility were measured by obtaining speech recognition scores. It was demonstrated theoretically and experimentally that the system consisting of the computer smearing and the auditory system had reduced temporal resolution but nearly normal frequency resolution. Speech intelligibility of the processed vowel-consonant nonsense syllables was tested for low- and high-pass filter conditions. The overall speech recognition scores as well as the recognition scores of the consonants grouped according to articulatory features were analyzed. The results indicated that smearing with a narrow temporal window did not degrade speech. The larger equivalent rectangular durations (ERDs) of the resultant temporal window (RTW) of the combined system (temporal smearing plus auditory system) produced a small but significant reduction in speech intelligibility for the low-pass filter condition. Scores for the RTWs > 16 ms were significantly different from the score for the 7.7-ms RTW for the high-pass filter condition, but this effect was small and did not differ across articulatory features.

Adolescent↗