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Clinicians' autonomy till the bitter end--can we learn from the extraordinary case of Harold Shipman?

Harold Shipman has attained the dubious reputation of being the greatest mass murderer of modern times. A specific feature of his murders was that these were committed during regular general practice care, over a period of 20 years. There are no grounds to assume that Shipman's case is unique in itself, or unique to British general practice and this paper analyses ways in which the medical profession can safeguard itself against future medical murderers.

Clinical Competence↗
PubMed2005

A bitter tale.

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Anion Exchange Resins↗
PubMed2005

Antioxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats.

The aim of the present study is to investigate the antioxidant activities of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) respectively in streptozotocin induced diabetic rats. Oral administration of both the seed extracts at a concentration of 150 mg/kg b.w for 30 days showed a significant decrease in fasting blood glucose, hepatic and renal thiobarbituric acid reactive substances and hydroperoxides. The treatment also resulted in a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase in the liver and kidney of diabetic rats. The results clearly suggest that seeds of Momordica charantia treated group may effectively normalize the impaired antioxidant status in streptozotocin induced-diabetes than the glibenclamide treated groups. The extract exerted rapid protective effects against lipid peroxidation by scavenging of free radicals there by reducing the risk of diabetic complications. The effect was more pronounced in MCSEt1 compared to MCSEt2.

Animals↗