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Diversity among French Bacillus anthracis isolates.

While outbreaks of animal anthrax zoonoses still regularly occur in France, little is known about the epidemiology links between them. We have used the eight-locus multilocus variable-number tandem repeat analysis typing technique against a collection of 50 Bacillus anthracis isolates from France. There were eight distinct genotypes belonging to two dissimilar genetic clusters. Regional strain patterns were observed, with the B2 genotypes prevalent in southern France and the A1a genotypes found only in northern France.

Animals↗

Interprofessional liaison in Scotland.

Communication between the medical, veterinary and environmental health professions has been established in Scotland since the early 1970s and was strengthened by the introduction of the Zoonoses Order 1975. The secondment of a veterinary officer to the Communicable Diseases (Scotland) Unit in Glasgow provides veterinary expertise on matters relating to public health, in addition to improving liaison, surveillance and the other functions of the unit.

Animals↗

Xenotransplantation.

The need for an alternative source of donor organs, together with the expansion of scientific data in this field, has focused attention on xenotransplantion as a possible alternative to allotransplantation in the treatment of patients with end-stage disease of vital organs. However, xenotransplantation is rarely successful. Not only are the immunological barriers to the acceptance of xenogeneic tissue more powerful than those seen in allotransplantation, but the potential for the transmission of xenograft-associated zoonoses to the human host at the time of transplantation is also present. In addition, data on the physiological performance of the xenograft in the human environment are lacking, although a few functioning xenografts have been shown to be capable of supporting human life. Although progress has been made in clarifying some of the barriers to xenotransplantation and in defining appropriate therapeutic interventions, including interventions aimed at the removal of natural antibody and at the limitation of complement activation, xenotransplantation is not yet a viable alternative to allotransplantation in the clinical setting.

Animals↗

Pasteurella multocida peritonitis in an HIV-positive patient on continuous cycling peritoneal dialysis.

Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therapy consisted of continuous cycling peritoneal dialysis. To our knowledge this is the first report of this unique infection in an HIV-positive end-stage renal disease patient. In addition, the recent literature on this unusual organism is reviewed in detail. These findings emphasize the potential for increased susceptibility to zoonoses in immunocompromised patients, particularly with indwelling intraperitoneal catheters which may serve as a portal of entry for unusual organisms.

AIDS-Associated Nephropathy↗

Perspectives on applied spatial analysis to animal health: a case of rodents in Thailand.

Geographic information systems (GIS) and remote sensing have been increasingly used in ecology and epidemiology, providing a spatial approach for animal health issues. Recent development of earth environmental satellites--i.e., their growing number, improving sensor resolutions and capabilities--has offered new opportunities to delineate possible habitats and understand animals and associated parasites in their environment, by identifying the nature and structure of land use, hydrological network, soil hydromorphy, and human settlements. Integrated into GIS, remotely sensed and other geo-referenced data allow both spatial and temporal analyses of animal ecology and health. However, a review of their applications has showed the poor quality of data sources and processing used, revealing limitations between theory and practical implementations. As an example, the assessment of the expected distribution of Bandicoot rats, main agricultural pest and vector of zoonoses in Phrae province (North Thailand), illustrates a rational use of spatial analysis, with the choice of relevant data, scales, and processing. Vegetation indices are computed on a TERRA ASTER image and further classified using elevation data. The biotopes of Bandicota indica and Bandicota savilei are delimited, providing a major source of knowledge for rodent and human health analyses.

Animals↗

Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases.

Diseases such as plague, typhus, malaria, yellow fever, and dengue fever, transmitted between humans by blood-feeding arthropods, were once common in the United States. Many of these diseases are no longer present, mainly because of changes in land use, agricultural methods, residential patterns, human behavior, and vector control. However, diseases that may be transmitted to humans from wild birds or mammals (zoonoses) continue to circulate in nature in many parts of the country. Most vector-borne diseases exhibit a distinct seasonal pattern, which clearly suggests that they are weather sensitive. Rainfall, temperature, and other weather variables affect in many ways both the vectors and the pathogens they transmit. For example, high temperatures can increase or reduce survival rate, depending on the vector, its behavior, ecology, and many other factors. Thus, the probability of transmission may or may not be increased by higher temperatures. The tremendous growth in international travel increases the risk of importation of vector-borne diseases, some of which can be transmitted locally under suitable circumstances at the right time of the year. But demographic and sociologic factors also play a critical role in determining disease incidence, and it is unlikely that these diseases will cause major epidemics in the United States if the public health infrastructure is maintained and improved.

Animals↗

Prevalence of antibodies to five selected zoonosis agents in monkeys.

The prevalence of antibodies against 5 zoonosis agents was determined in serum samples of 443 breeding monkeys. Of the monkeys, 296 were bred or kept for a long time at R institute, and the remaining 147 were newly imported from the Philippines and kept at S institute for quarantine. Antibodies to simian virus 40 were highly prevalent at 89.1% among monkeys of R institute, whereas no antibody could be detected in those of S institute. Antibodies to Chlamydia psittaci and Yersinia pseudotuberculosis were detected in 14.4 and 11.6% at R institute, and in 9.0 and 3.5% at S institute, respectively, evidencing a significant difference (P less than 0.05) between those of the two institutes for both agents. Antibodies to Toxoplasma gondii and Leptospira interrogans were found in 3.6 and 2.9% of the overall, respectively, showing no difference in positive rates in relation to breeding place. Even in cases positive to the latter 4 zoonosis agents, the antibody titers were low. The results obtained suggest that all zoonoses tested do not seem to be so serious diseases among monkeys at the present time except simian virus 40 infection, which is highly prevalent among breeding monkeys in Japan.

Animals↗

Recent animal disease outbreaks and their impact on human populations.

Over the past 20 years, headlines have documented an increasing number of emerging diseases; most have an animal source (zoonoses). Recent examples include West Nile virus, severe acute respiratory syndrome (SARS), avian influenza, and monkeypox. While some emerging diseases occur among both humans and animals, others affect only animals or only humans. Nevertheless, all these new or reemerging infections have societal implications, often tied to local and national economies. It is important to understand the implications of emerging animal diseases and encourage stronger collaboration of veterinary and medical practitioners, especially in rural areas. Illnesses in agricultural workers may be the index cases for newly emerging diseases.

Agricultural Workers' Diseases↗

Detection and identification of pathogens and host DNA in unfed host-seeking Ixodes ricinus L. (Acari: Ixodidae).

In this study, we have developed molecular methods for the identification of reservoir hosts of sylvatic tick-borne zoonoses. The methods are based on the analysis of the blood meal remnant in the tick gut and include detection of pathogens and identification of the host origin of the blood meal. For host identification, a universal primer pair was used to amplify part of the vertebrate 18S rRNA gene followed by reverse line blot hybridization using subgroup-specific probes. Analyses of DNA from whole blood of vertebrates identified the correct subgroup of a broad range of vertebrate species (e.g., Ruminantia, Leporidea, Canidae, Murinae, Arvicolinae, Insectivora, Galliformes, Passeriformes) using probes based on the 18S rDNA sequences. Host DNA in the remnants of larval blood meals was detected in the gut of Ixodes ricinus nymphs maintained under natural conditions up to 9 mo after molting. For pathogen identification, a multiplex polymerase chain reaction was used that targeted parts of the 18S rRNA gene of piroplasm protozoa, the 16S rRNA gene of bacteria, and the intergenic spacer of the Borrelia burgdorferi genospecies complex. The utility of both methods was demonstrated under laboratory conditions by detecting Babesia microti (Franca) and gerbil DNA in 3-mo-old I. ricinus nymphs that had fed on B. microti-infected gerbils as larvae, and under field conditions by analyzing unfed ticks that were collected in a forest. The field study showed that the majority of ticks had fed on ruminants or birds and few on rodents, which is in accord with our knowledge of the fauna in this forest. Few pathogens were detected but the discovery of Borrelia valaisiana and B. burgdorferi s.s. in ticks that had fed on deer and Borrelia afzelii in a tick that had fed on a bird raises questions about the mode of transmission of these spirochetes and possibly about their host specificity.

Animals↗

Historical perspective of the origins and development of international veterinary public health in the World Health Organisation.

The World Health Organisation (WHO) worked vigorously to implement and develop veterinary public health (VPH) activities during the first twenty years of its existence. These activities have continued and expanded into new fields in subsequent years, and will no doubt continue. The initial challenge was to establish the importance and usefulness of the veterinary profession to human medical and public health problems. Collaborative actions and coordinated research on the major zoonoses, food hygiene and comparative medicine helped to achieve this result along with programmes applying this knowledge in member nations, and particularly developing countries which comprise the vast majority of world population. The VPH discipline must now take into account and adapt its effort to the ever-changing social and economic conditions affecting human health. The veterinary profession can help to improve human health, and VPH structures offer an effective channel for doing so.

Animals↗

Organisation of veterinary public health in the south Asia region.

In the South Asia region vast human populations are exposed daily and with considerable intensity to close contact with vast animal populations and their excreta. There is no veterinary public health unit in the World Health Organisation (WHO) South-East Asia Regional Office (SEARO) in New Delhi (India), the Western Pacific Regional Office (WPRO) in Manila (Philippines) or the Eastern Mediterranean Regional Office (EMRO) in Alexandria (Egypt). However, these offices do support a number of activities on zoonoses and food-borne diseases in WHO member countries of the region. Maintenance of the health of farmers and of their families (often termed "rural health") has assumed increasing importance in most member countries of the region. In most of the countries, there is no actual veterinary public health unit functioning as a national body common to the ministries of health and agriculture. Among the commonest zoonotic diseases prevalent in member countries are rabies, brucellosis, Japanese encephalitis, echinococcosis, tuberculosis, visceral leishmaniasis, taeniasis, salmonellosis, campylobacteriosis and leptospirosis. A national plan is necessary for each country to give priority to controlling these diseases, based on health systems research or primary health care, with intersectoral and regional cooperation through the South Asian Association for Regional Cooperation (SAARC) under Technical Cooperation among Developing Countries (TCDC). There should be a strong unit for veterinary public health in all WHO regional offices to coordinate zoonotic disease surveillance, training and control programmes in countries of the region.

Animals↗

Organization of veterinary public health in the United States of America and Canada.

Veterinarians in the United States of America and Canada are involved in a variety of activities which contribute to improving human health and well-being. Some of these activities can be considered as a part of veterinary public health (VPH), including: zoonoses control, food safety, environmental protection, comparative medicine, disaster medicine and animal welfare. Both countries have federal systems, and their VPH activities are dependent on close interaction between health and agricultural agencies at the national, state or provincial, and local levels. In addition to governmental agencies, other entities such as academic institutions and various professional associations are also important contributors to VPH activities in the two countries.

Animal Welfare↗

Veterinary public health in world-wide animal health and production.

The first section of this paper presents a concise analysis of the current world situation in animal health, zoonoses, food production and hygiene and Veterinary Services. The second section discusses future perspectives for healthy animal production in relation to veterinary public health problems. The coming decades will be crucial for the future of Veterinary Services. The protection of human health and the improvement of food production through animal health will continue to be the priorities of these services. Scientific and technological developments and the many associated changes in human living conditions and needs, as well as in animal production, call for a general revision of veterinary philosophy, strategy and programmes. In this context, it is recommended that efforts be made to significantly strengthen activities aimed at protecting human health against diseases of animal origin.

Animals↗

Public health hazards of meat from small ruminants: the perspective of Australia.

The production of meat from sheep and goats in Australia occurs almost entirely at pasture in zones known as the semi-arid pastoral zone, the wheat-sheep zone (where sheep and crops form an agricultural rotation system) and the high rainfall zone. Each zone has particular factors which affect the human health hazards associated with sheep and goat meat and the opportunities for prevention. The authors provide an overview of small ruminant production in Australia and a synopsis of the diseases encountered, including the factors which influence epidemiology. Animal health arrangements for underwriting food safety at the pre-harvest and post-harvest stages of production in Australia are also outlined. Specific public health hazards related to sheep and goat meat, together with measures for prevention, are considered under the headings of zoonoses, enteropathogens and chemical residues.

Animal Husbandry↗

European perspectives on the public health risks posed by farmed game mammals.

As consumers have become aware of the health risks associated with the high levels of saturated fats present in conventional red meats, an interest in new domesticants has developed. Meat from these species represents the only sector of the European red meat industry which is currently experiencing growth. The production of meat from grazing animals other than cattle and sheep is not subsidised within the European Union (EU), so that despite the fact that game farming for meat exists in all the Member States, much of the farmed game meat consumed within Europe is imported from the rapidly developing deer farming industry in New Zealand. Less severely regulated industries world-wide also export a great variety of wild game into Europe, but health controls and labelling do not permit the consumer to discriminate between wild and farmed produce, or even between species or countries of origin. This paper describes the scale of game farming within Europe, and the quantities of game imported. The author reviews the diverse production systems in different regions of Europe and the various harvesting systems, including the present measures enforced for veterinary public health reasons, and considers the threats posed by the zoonoses known to affect game mammals and the public health risks posed by contamination. An explanation is given of the differences between the production and processing of farmed and wild game.

Abattoirs↗

[The dangers for public health connected to the consumption of horse meat].

After an outline of the ways in which horse meat is produced and consumed, the authors review specific and general risks associated with this product, and methods for the control and prevention of these risks are given. With regard to biological hazards transmitted by horse meat, the relevant zoonoses are considered, followed by a discussion of the two principal agents responsible for foodborne disease in human beings: Salmonella and Trichinella. Among chemical hazards, the toxic effects of cadmium are prominent. Although these hazards can be identified, the actual risks to human health are difficult to estimate, because of the paucity of scientific data.

Animals↗

The present and future organisation of Veterinary Services in Asia: the examples of the Republic of Korea and Japan.

The Veterinary Services of the Republic of Korea and Japan are reviewed and summarised. To cope with ever-increasing demands on Veterinary Services, both countries have made continued efforts to expand the services, which currently only have a limited number of government personnel. To overcome some of the problems associated with international trade, e.g. outbreaks of foot and mouth disease and classical swine fever (hog cholera), the authorities of the Republic of Korea are considering strengthening quarantine services by combining the National Veterinary Research and Quarantine Service and the National Plant Quarantine Service of the Ministry of Agriculture and Forestry (MAF). In the field of veterinary public health services, the Republic of Korea and Japan have different organisational structures. All Veterinary Services, including veterinary public health, are kept within the MAF in the Republic of Korea, whereas in Japan, the Ministry of Agriculture, Forestry and Fisheries (MAFF) deals with general animal production and health services and the Ministry of Health, Labour and Welfare (MHLW) deals with the safety of animal products, food poisoning and the prevention/control of zoonoses, such as rabies and Q fever. In Japan, after the occurrence of bovine spongiform encephalopathy in 2001, the authorities undertook a thorough review of the Veterinary Services, focusing particularly on food safety. A reorganisation of the administrative structure was proposed, and will be completed by the end of 2003. Subject to the approval of the Diet (House of Councillors), an independent 'Food Safety Commission' will be created within the cabinet office which will undertake risk analyses related to foods, and risk management will be carried out by the relevant ministry, i.e. the MAFF or the MHLW. The Animal Health Division of the MAFF will also be moved from the Livestock Industry Department to a new 'Consumer Safety Department' of the MAFF, where additional responsibilities in fish health control and feed safety control will be assumed.

Commerce↗