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PubMed1985

Development, growth and eruption of permanent incisor teeth in Romney sheep.

The development of permanent incisor teeth of sheep was followed from the age of six weeks to 116 weeks. The teeth were observed through the bud, cap and bell stages, and the development of enamel and dentine. At the same time that amelogenesis started, the papillary layer developed from the intermediate layer and the outer dental epithelium began to form the cell rests of Malassez. The ameloblasts went through secretory, transitional and maturational phases, and in due course disappeared, after which cementum was laid down over the enamel surface. Initially the connective tissue of the follicle surrounding the growing tooth was very loose, but was replaced from the crown end as the tooth developed, by more dense connective tissue. Around the time of eruption, melanocytes were found on the lingual surface of the coronal end of the follicle. The root was formed under the influence of Hertwig's epithelium, and the cell rests of Malassez appeared to continue to develop from the outer enamel epithelium. Odontoblasts, which arose from the pulp connective tissue, were initially cuboidal but became fusiform as the tooth matured. At the time of eruption, amelogenesis was almost complete and cementum covered the majority of the tooth surface. The cell rests and melanocytes of the tootth follicle appeared to migrate with the tooth as it erupted. The deciduous tooth was resorbed from the lingual surface. The junctional epithelium of the erupted permanent tooth may have arisen from the cell rests, remnants of the dental lamina or gingival epithelium, depending on the presence or absence of inflammation.

Amelogenesis↗
PubMed2006

[Integrin 3 mRNA changes after orthodontic teeth movement in periodontitis rats].

OBJECTIVE: To study the integrin beta3 mRNA changes after orthodontic treatment on normal teeth and periodontitis teeth in rats. METHODS: 96 adult SD rats of 10 weeks old were randomly divided into normal tooth move-ment group and periodontitis tooth movement group. The rats in the two groups were sacrificed after 0 d, 12 h, 1 d, 3 d, 5 d and 7 d of tooth movement. The alveolar specimens were prepared. The integrin beta3 mRNA were detected using in situ hybridization in the specimens. The OD index of positively stained osteoclasts for integrin beta3 mRNA after orthodontic tooth movement in the two groups were measured and compared. RESULTS: There were weak positive signals on the cytoplasm of osteoclasts in periodontum in both groups after 12 hours and 3 days force activation. No positive signals were detected in the rest samples. There was no difference in the OD of positive stained osteoclasts between normal and periodontitis groups. Strong expressions were present on cells with one or two nuclei in the alveolar marrow. CONCLUSION: It is suggested that integrin beta3 mRNA is related with osteoclasts maturation and migration in orthodontic tooth movement.

Animals↗
PubMed1998

On the phenomenon of intraosseous migration of nonerupting teeth.

Little is know about intraosseous migration of nonerupting teeth, a rare natural condition of horizontal tooth movement and impaction. It occurs only in the mandible and involves primarily the second premolar or the canine. When the second premolar is the affected tooth, it always is found distal to its normal position. The origins of the second premolar intraosseous migration phenomenon are obscure and usually no treatment is recommended. Intraosseous migration involving the canine is commonly called transmigration because the affected canine moves mesially across the mandibular symphysis to the opposite side of the mandible. Analysis of 50 published cases of canine transmigration indicated higher occurrence in women and no sidedness preference. In over 80% of the studied cases, the canine remained nonerupted and, of the 24 cases receiving some treatment, all but two underwent extraction of the anomalous canine. The canine transmigration phenomenon appears to show signs of having some genetic determinants.

Bicuspid↗
PubMed2006

Characteristics and prevalence of non-syndrome multiple supernumerary teeth: a retrospective study.

OBJECTIVE: The goal of this study was to evaluate the radiological and clinical findings of non-syndromic multiple (five or more) supernumerary teeth in patients radiographically examined between 1999 and 2004. METHODS: Among 9550 patients, 251 cases of supernumerary teeth were found, including six cases of multiple supernumerary teeth. Patients with multiple supernumerary teeth were evaluated for age, sex, unilateral or bilateral distribution of the teeth, localization, morphology and complications or associated pathologies such as dentigerous cysts, eruption anomalies, resorption of adjacent teeth, displacement of tooth germ, malformation, migration, neurological symptoms, and secondary and periapical infections. RESULTS: All patients were male and most of the multiple supernumerary teeth were seen in the premolar region. The prevalence of multiple supernumerary teeth was 0.06%. Out of 37 multiple supernumerary teeth examined, 30 were impacted. Various associated anomalies were seen in 21.6% of cases. Although the mean age was high (23.1 years), no pathologies such as root resorption on adjacent teeth or cystic formation were observed, in contradiction of previous studies. CONCLUSION: In agreement with previous studies, the majority of supernumerary teeth were seen in the lower premolar region. That all patients with multiple supernumerary teeth were male and that most of these teeth were impacted was also in agreement with previous studies. The order of location frequency in previous studies has been premolar-molar-anterior; we found the order to be premolar-anterior with no supernumerary molar teeth observed. It was also interesting that no serious pathological findings were recorded.

Adolescent↗
PubMed1980

In vitro cytotoxicity of periodontally diseased root surfaces.

The purpose of this experiment was to develop a model system for controlled in vitro testing of root surface toxicity. Human gingival fibroblasts were placed into a depression created in the root surfaces of ten heat sterilized periodontally involved teeth, one half of which were root planed to remove all irritants. The teeth and fibroblasts were incubated in culture medium for 5 days, after which the cells were fixed and stained. Each tooth was examined for migration of cells onto the root planed and non-root planed areas of the tooth, and for evidence of any cytotoxic reaction. No difference in pattern of cell growth, cell migration, or cytotoxic reaction was discernible between root planed and non-root planed areas. Normal fibroblasts could be detected on the surfaces of dentin, calculus, periodontally involved cementum, and enamel. It appears that heat-sterilized periodontally-involved root surfaces, as well as calculus and calculus-laden enamel, were not toxic to human gingival fibroblasts in cell culture.

Cell Division↗
PubMed2003

Transmigration of impacted canines.

Pre-eruptive migration of a tooth across the midline is termed "transmigration". This condition has not been reported for teeth other than mandibular canines. Bilateral transmigration is extremely rare, and associated pathological lesions are also reported. The aim of this report is to present the first case of maxillary canine transmigration as well as additional cases of transmigrated mandibular canines, with special emphasis on their classification.

Adolescent↗
PubMed1996

Contribution of early-emigrating midbrain crest cells to the dental mesenchyme of mandibular molar teeth in rat embryos.

Teeth are formed by reciprocal interactions between the epithelium and mesenchyme in the first pharyngeal arch. Although the contribution of midbrain and hindbrain crest cells to the first pharyngeal arch has been previously examined in rodent embryos, no direct evidence exists that these cells are actually involved in the dental mesenchyme. In order to elucidate the contribution of the cranial neural crest cells in tooth formation, we first identified the emigration sites and stages providing the crest cells that migrate to the presumed tooth-forming region of the mandibular prominence. Focal labeling with DiI was performed at the midbrain and anterior hindbrain crests in rat embryos, and the labeled embryos were cultured for 30 or 60 hr. The resultant migration patterns indicated that posterior midbrain crest cells emigrating by the end of the 4-somite stage predominantly migrated to the region where tooth buds normally develop. Second, we established a new type of long-term culture system in which whole embryo culture is followed by a mandibular organ culture. Using this system, rat embryos were maintained from the early-somite stage and the molars in the explants were able to reach the bud stage within 8 days. Finally, to ascertain if posterior midbrain crest cells emigrating by the end of the 4-somite stage were involved in the dental mesenchyme, these cells were labeled with DiI and processed for the long-term culture. Labeled crest cells were clearly detectable in the dental mesenchyme. These findings indicate that the early-emigrating posterior midbrain crest cells contribute to mandibular molar tooth development in rat embryos.

Animals↗
PubMed1991

[The rate of the eruption of human teeth. A review].

The speed that a tooth bud or growing tooth attains on its way to the level of occlusion merits biological and clinical interest. In this work, all data available in the literature related to the eruptive movement of the various permanent teeth in man, both prior and after their clinical emergence in the oral cavity, have been gathered and recalculated in rates of movement per day. For comparative purposes, the rates of migration of nonerupted teeth, of bone resorption and bone apposition, as well as the rate of elongation of growing tooth roots were also collected from the literature. The standardized data (rates in micron/day) revealed the intraosseous movements of tooth buds and growing teeth are dependent and limited in speed by the rates of bone resorption and bone apposition. The extra-alveolar movement of clinically visible tooth crowns on their course of prefunctional eruption occurs at a much higher speed which probably results from a combination of the rate of bone apposition in the apical region and the rate of root elongation. These findings are discussed in connection with our present knowledge on the mechanisms of tooth eruption.

Bone Development↗
PubMed1990

Spontaneous reeruption of a secondarily retained permanent lower molar and an unusual migration of a lower third molar.

Secondary retention refers to cessation of eruption of a tooth after its emergence. It occurs mainly in the deciduous dentition, but it is also seen on rare occasions in the permanent dentition. Although ankylosis has been suggested as the main etiologic factor, the exact biologic mechanism of secondary retention is not yet known. This article presents a case of spontaneous reeruption of a secondarily retained permanent molar, which is very rare. It also describes an unusual migration of a lower third molar in the same patient.

Adult↗
PubMed1993

A histological study of the exfoliation of human deciduous teeth.

For clarification of the histological details of the shedding of human deciduous teeth, exfoliated and extracted deciduous teeth were examined by light and electron microscopy. After the roots were completely resorbed, the dentogingival junction migrated along the inner resorbing surface and finally reached the pulpal surface of the crown. At the same time, the gingival epithelium also proliferated and migrated under the crown of the deciduous tooth in such a way that part of it lined the residue of the pulp and another part lined the surface overlying the erupting successional tooth. This phenomenon took place from various sides of the tooth surface. Therefore, just before exfoliation, the migrated gingival epithelium formed narrow necks of tissue, and the crown was only superficially attached to the gingiva by them. The final shedding of the tooth appeared to occur by a tearing of these narrow tissue regions. The results of the present study suggest that the dento-gingival junction as well as gingival epithelium play important roles in the process of exfoliation of human deciduous teeth.

Cell Division↗
PubMed2005

LEF1 is a critical epithelial survival factor during tooth morphogenesis.

LEF1 is a cell-type-specific transcription factor and mediates Wnt signaling pathway by association with its co-activator beta-catenin. Wnt signaling is known to be critical for the specification of cranial neural crest (CNC) cells and may regulate the fate diversity of the CNC during craniofacial morphogenesis. Loss of Lef1 results in arrested tooth development at the late bud stage and LEF1 is required for a relay of a Wnt signaling to a cascade of FGF signaling activities to mediate the epithelial-mesenchymal interaction during tooth morphogenesis. It remains unclear, however, what is the cellular mechanism of LEF1 signaling in regulating tooth morphogenesis. To test the hypothesis that LEF1 signaling regulates the fate of the dental epithelial and the CNC-derived mesenchymal cells during tooth morphogenesis, we investigated and compared the cellular migration, proliferation, and apoptotic activity within the tooth germ between the wild-type and Lef1 null mutant mice. Using the Wnt1-Cre/R26R transgenic system for indelibly marking the progenies of CNC cells, we show that there is no CNC migration defect in the Lef1 null mutant mice, indicating that the arrest in tooth development is not the result of shortage of the CNC contribution into the first branchial arch in the Lef1 mutant. Furthermore, there is no alteration in cell proliferation or condensation of the CNC-derived dental mesenchyme in the Lef1 null mutant, suggesting that LEF1 may not affect the cell cycle progression of the multipotential CNC cells during tooth morphogenesis. Importantly, apoptotic activity is significantly increased within the dental epithelium in the Lef1 null mutant mice. As the result of this increased cell death, the bud stage tooth germ fails to advance to the cap stage in the absence of Lef1. Inhibition of apoptotic activity by FGF4 rescues the tooth development in the Lef1 null mutant. Our studies suggest that LEF1 is a critical survival factor for the dental epithelial cells during tooth morphogenesis.

Animals↗
PubMed1987

Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption.

Movement of fibroblasts in the periodontal ligament of the lower incisor of the mouse was studied by pulse-labeling with tritiated thymidine and proline. 3H-Thymidine was administered to mark the nuclei of the cells in the proliferative compartment near the basal end of the tooth; 3H-proline gave rise to a narrow band of radioactivity in the dentin, which served as a reference line for measurement of eruption. One or three weeks after injection in each animal, the lower right incisor was prevented from further eruption by being pinned to its alveolar process. The animals were killed 0, 1, or 2 weeks later, and their mandibles processed for LM-radioautography. It was found that in the left incisors, which were not inhibited in their eruption, labeled cells in the tooth-half of the periodontal ligament moved incisally at a rate similar to the eruption rate. In the pinned incisors, no further incisal migration could be established. It is concluded that fibroblast migration in the tooth-half of the ligament is strictly coupled to the eruptive process.

Animals↗
PubMed1996

Mucogingival considerations in orthodontic treatment.

Alterations in the mucogingival complex will occur during orthodontic tooth movement, but these are independent of the apico-coronal width (height) of the gingiva. The integrity of the periodontium can be maintained during orthodontic therapy also in areas that have only a minimal zone of gingiva. In terms of changes in the position of the soft tissue margin and in gingival dimensions, the important factors to consider are the direction of the tooth movement and the bucco-lingual thickness of the gingiva. Lingual tooth movement will result in an increased bucco-lingual thickness of the tissue at the facial aspect of the tooth which results in coronal migration of the soft tissue margin (decreased clinical crown height). Facial tooth movement, on the other hand, will result in a reduced bucco-lingual tissue thickness and thereby a reduced height of the free gingival portion and an increased clinical crown height. The risk for development of recession type defects in conjunction with orthodontic tooth movement is present only if the tooth has been moved out of the alveolar bone housing, ie, when an alveolar bone dehiscence has been created.

Adult↗
PubMed2005

Tooth follicle extirpation and uvulectomy.

Migration is not only the movement of people, but also of their culture, customs and beliefs. As more people from developing countries in Africa migrate to industrialized countries, the more likely health professionals will find themselves providing care for people of whose customs and practices they have little knowledge. This review of the literature suggests that removal of deciduous canine follicles and uvulectomy are frequently practised in some African and neighbouring countries. Reasons given for deciduous canine extirpation include the prevention of vomiting, fever and diarrhoea. The indications for uvulectomy appear widespread, including treatment for persistent fever, coughing and growth retardation. The practices are usually performed by traditional healers. Risks for children who undergo these procedures are extensive, including septicaemia, potential for HIV transmission, numerous dental complications and death. With improved understanding between Western health teams and local, traditional people, an improved system may develop whereby the two systems can work together in providing improved health outcomes for the people.

Africa↗
PubMed2002

The use of orthodontic intrusive movement to reduce infrabony pockets in adult periodontal patients: a case report.

Clinicians often encounter osseous defects that are best treated by conventional surgical techniques, including bone grafting and guided tissue regeneration, with a goal of establishing a new connective tissue attachment. On occasion, the recognition of an infrabony defect proximal to a tooth with a large diastema may present an opportunity to consider resolution by orthodontic tooth movement. Ideally, the tooth could be moved in the proximal direction until there was no further radiographic or clinical evidence of the predisposing defect. The authors decided to treat an advanced case of adult periodontitis, with extrusion and migration of a maxillary central incisor, using a multidisciplinary approach. Radiologically, a large infrabony defect was present on the mesial aspect of the incisor, with an initial probing depth of 9 mm. After the surgical periodontal therapy, the orthodontic movement started and the incisor was repositioned using an intrusive mechanism, also leading to the closure of the diastema. At the end of the treatment, there was a significant clinical decrease in the probing depth values, and radiographs showed a remarkable reduction of the infrabony defect volume.

Adult↗
PubMed2006

Mandibular first and second molar tooth transposition: a case report.

A case is reported of what appears to be a transposition affecting the mandibular first, second, and third molars. The possible aetiology is discussed in relation to previously published studies. In the case described the primary actilogical factor appears to intraosseous migration of the developing tooth germ.

Child↗
PubMed1990

[Impacted bilateral first permanent molars induced by the migrated second permanent molars].

It is a relatively common clinical experience to see an impacted permanent tooth. In most cases, the cause is considered to be the existence of a supernumerary tooth or developmental crowding, but occasionally, the impacted tooth may occur with no apparent cause. The tooth most frequently impacted in the dental arch is a maxillary permanent canine or the third permanent molar, but the occurrence of the first permanent molar is an extremely rare situation. The patient, an eight-year, seven-month-old male was referred to the Pediatric Dentistry Clinic at the Higashi-Nippon-Gakuen University, School of Dentistry, for a detailed dental examination of his impacted lower permanent first molars. The oral findings through dental examination revealed that the bilateral upper first permanent molars were erupted, while the lower ones showed no clinical signs of eruption. Radiographic examination revealed that the lower second permanent premolars placed under the distal root of the second deciduous molars, and the first molars, inclined to the mesial position, placed at the under the second premolars bilaterally. There was nothing particular in his medical and dental history during the "teething" period. The authors determined that the cause of this impacted condition for the first molars seemed to be induced by a migration of an unerupted second permanent premolars. After extraction of the second deciduous molars and second permanent premolars, orthodontic therapy was undertaken in an attempt to move the impacted first molars into the arch.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗