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[Propagation of congenital anomalies of sexual development in the newborn population of Moscow].

The prevalence of congenital abnormalities of the genitals was estimated in newborns of the Moscow population in 1992 and 1993. The prevalence was found to be one case per 1500-1550 newborns. The pattern and structure of the observed pathology were studied. The range of patients who were not detected during the study, due to clinical peculiarities of their pathology, was estimated.

Congenital Abnormalities↗

The effect of 17beta-estradiol on the gonopodial development and sexual activity of Gambusia holbrooki.

Many chemicals have recently been demonstrated to possess estrogenic activity and may potentially interfere with normal sexual development. In the present study, we quantified the effects of waterborne exposure to 17beta-estradiol on the gonopodial development and sexual activity of male eastern mosquitofish (Gambusia holbrooki). Juvenile males were exposed during the period of sexual maturation to nominal concentrations of 20, 100, and 500 ng/L of 17beta-estradiol and a solvent control (0.00003% w/v ethanol) for 84 d under continuous-flow conditions. Following exposure, significant differences were found among the test treatments with respect to gonopodial length and degree of gonopodial elongation of the fish. Sexual activity, measured as the number of approaches and copulatory attempts made by the exposed males to nonexposed females, also significantly decreased with increasing concentrations of 17beta-estradiol. Because the degree of gonopodial maturation and frequency of sexual activity are important characteristics for the reproductive success of male mosquitofish, it is suggested that these traits provide sensitive and ecologically relevant endpoints for assessing estrogenic activity under both laboratory--and field-exposure conditions.

Animals↗