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Results for “Retinal Neovascularization”

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At least 793 records · Page 44Linked to original sources
PubMed2006

Attenuation of retinal vascular development and neovascularization in transgenic mice over-expressing thrombospondin-1 in the lens.

Thrombospondin-1 (TSP1) is an endogenous inhibitor of angiogenesis and induces endothelial cell (EC) apoptosis. To study the role TSP1 plays during vascular development and neovascularization, we assessed the effects of ectopic TSP1 expression in the lens on retinal vascularization in transgenic mice. The TSP1 over-expressing mice showed abnormalities in the development of retinal vasculature. There was a dramatic decrease in the density of superficial and deep vascular plexuses of the retina in transgenic mice. The retinal vessels in TSP1 transgenic mice also appeared nonuniform and abnormal in maturation. We detected an increase in the number of EC undergoing apoptosis, which was compensated, in part, by an increase in cell proliferation in retinal vasculature of TSP1 transgenic mice. The TSP1 transgenic mice also exhibited increased levels of vessel obliteration and a limited preretinal neovascularization during oxygen-induced ischemic retinopathy (OIR). Our results indicate increased expression of TSP1 attenuates normal retinal vascularization and preretinal neovascularization during OIR. Therefore, modulation of TSP1 expression may provide an effective mechanism for regulation of ocular angiogenesis.

Animals↗
PubMed2006

Intravitreal bevacizumab (Avastin) associated with the regression of subretinal neovascularization in idiopathic juxtafoveolar retinal telangiectasis.

PURPOSE: To describe the clinical, angiographic, and optical coherence tomography findings of a patient with subretinal neovascularization (SRN) in idiopathic juxtafoveolar retinal telangiectasis (IJRT) treated with intravitreal bevacizumab injection. METHODS: In the setting of a tertiary referral center, a patient with bilateral acquired IJRT, complicated with juxtafoveal SRN in one eye, was treated with a single intravitreal injection of 1.5 mg of bevacizumab and then prospectively followed for 24 weeks. RESULTS: Vision improved from 20/40(-1) to 20/20(-2) by 24 weeks of follow-up. Fluorescein angiography demonstrated the absence of leakage from a previously active SRN. Optical coherence tomography revealed gradual neovascular lesion contraction and the resolution of subretinal fluid over the 24-week follow-up period. No obvious adverse events were noted. CONCLUSIONS: In the short-term, intravitreal bevacizumab treatment resulted in partial restoration of the macular architecture and vision improvement by means of neovascular lesion regression and the resolution of associated serohemorrhagic complications.

Angiogenesis Inhibitors↗
PubMed1988

Regression of disc neovascularization by photocoagulation in the acute retinal necrosis syndrome.

Disc neovascularization developed in one eye of a 40-year-old white woman with the acute retinal necrosis syndrome. Krypton laser scatter photocoagulation was placed in areas of nonnecrotic and segmentally nonperfused retina that were demonstrated by fluorescein angiography. Marked reduction in disc neovascularization was noted clinically 16 days after laser treatment and was confirmed angiographically 4 weeks after treatment. Neovascularization was completely regressed at 9 weeks after treatment. The authors postulate that the retinal vasculitis and nonperfusion produced retinal ischemia which stimulated neovascular proliferation, and that photocoagulation caused regression of the neovascularization.

Adult↗
PubMed1983

Posterior epiretinal neovascularization associated with sectoral retinal ischemia.

Two cases of large, posteriorly located epiretinal neovascular membranes are presented that were associated with a nasal wedge of retinal ischemia of unknown cause in young Caucasian men without associated systemic disease. A technique of staged, argon laser scatter photocoagulation to the ischemic retina resulted in dramatic regression of the neovascular fronds in both cases.

Adult↗
PubMedDate not supplied

Treatment of intravitreal and prepapillary neovascularization following branch retinal vein occlusion.

Ten eyes which had developed retinitis proliferans following branch retinal vein occlusion were treated with xenon photocoagulation utilizing an ablative technique limited to the effected retinal quadrants. In eight of the ten eyes, complete regression of the vessels was obtained, as evidenced by nonfilling on subsequent fluorescein angiography. The remaining two eyes showed significant but incomplete closure. There were no postoperative vitreous hemorrhages, no significant permanent complications, and the visual acuity remained at or better than pretreatment levels in all cases. In conclusion, we wish to reemphasize the limited scope of this report. The series, though consecutive, is small and the follow-up period relatively short. On the basis of the cases presented here, we believe that continued investigation using this mode of treatment is warranted, and that this method may prove to be of significant value in the management of complicated retinal branch vein occlusion.

Adult↗
PubMed2000

Hereditary retinal dystrophies and choroidal neovascularization.

BACKGROUND: Choroidal neovascularization infrequently occurs in patients affected by hereditary retinal dystrophies. METHODS: We studied eight patients suffering from different hereditary retinal dystrophies (Best's disease, reticular dystrophy, butterfly-shaped dystrophy, gyrate atrophy, and retinitis pigmentosa) who developed choroidal neovascularization. All patients underwent complete ophthalmic evaluation, electrophysiology, colour vision testing, and fluorescein angiography. In some patients, ICG video-angiography was also performed. Laser treatment was carried out in only one patient. RESULTS: The mean duration of follow-up was 41.7 months (range 6-148 months). At CNV diagnosis, the mean VA was 0.23 (range 0.02-0.6). At the last follow-up, mean VA was 0.34 (range HM to 0.9). At the last follow-up, fluorescein angiography showed a focal, atrophic scar in seven eyes, a fibrotic membrane in two eyes and a still active membrane in two cases. CONCLUSION: We emphasize the relatively favourable visual prognosis in patients suffering from inherited retinal dystrophies complicated with choroidal neovascularization. Therapeutic approaches other than laser treatment could be attempted in these patients.

Adult↗
PubMed2006

Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy.

PURPOSE: To study the effects of intravitreous triamcinolone acetonide (TA) on neovascularization (NV), capillary density, and retinal endothelial cell (REC) viability in a model of oxygen-induced retinopathy (OIR). METHODS: Newborn rats exposed to OIR underwent intravitreous injections (right eye) at day 14 to achieve intravitreous concentrations of: dexamethasone (DEX) (0.3 mg/mL), triamcinolone (TA; 0.4-4 mg/mL), or PBS. Animals were removed to room air and at day 18, retinal flatmounts were assayed for clock hours of NV, percent peripheral avascular retina, capillary density, apoptosis, and VEGF protein. At day 15, retinas were assayed for insulin-like growth factor (IGF)-1 receptor phosphorylation (IGF-1Rphos). Human RECs exposed to TA were assayed for trypan blue exclusion or activated caspase-3. RESULTS: TA but not DEX or PBS reduced NV (ANOVA, P < 0.001), capillary density (ANOVA, P < 0.001), and systemic weight gain (ANOVA, P = 0.002). VEGF protein was not different between TA- and PBS-injected or noninjected groups. Apoptosis was not increased in vivo or in vitro between groups, but there was a dose-dependent toxic effect of TA on cultured RECs (P < 0.001). At day 15, retinas from the 4 mg/mL TA-injected OIR group had a trend toward reduced IGF-1Rphos compared with room air-raised PBS- or non-injected OIR groups. CONCLUSIONS: TA caused dose-dependent reductions in NV, retinal vascularization, and systemic weight gain associated with a reduction in IGF-1Rphos. Long-term studies are needed to assess TA toxicity in vivo. TA doses should be carefully considered before administering the drug in diseases with ongoing retinal vascular development, such as retinopathy of prematurity.

Animals↗
PubMed1997

Surgical removal of subfoveal neovascularization in idiopathic juxtafoveolar retinal telangiectasis.

PURPOSE: To investigate the efficacy of the surgical removal of subfoveal choroidal neovascularization in patients with type 2A idiopathic juxtafoveolar retinal telangiectasis. METHODS: Two patients with bilateral acquired idiopathic juxtafoveolar retinal telangiectasis and a subfoveal choroidal neovascular membrane underwent surgical excision of the membrane using standard subretinal surgical techniques. RESULTS: In both cases, surgical removal of the neovascular membrane was complicated by an intimate adherence of the membrane with the overlying neurosensory retina in an area of retinochoroidal anastomosis. A retinal dehiscence occurred in both instances at the time of surgery. Postoperative visual outcome was poor. CONCLUSION: The retinochoroidal anastomoses often visualized in cases of subretinal neovascularization complicating bilateral acquired IJFRT could indicate that there is a fairly marked adherence of the neovascular membrane to the neurosensory retina. Attempts at surgical removal of subretinal membranes in this disease entity with current techniques may be contraindicated.

Choroid↗
PubMed1994

Retinal and optic disc neovascularization in leukaemia.

We report a case of chronic myeloid leukaemia initially presenting with a vitreous haemorrhage associated with bilateral retinal and optic disc neovascularization. The literature is briefly reviewed and the probable reasons for the observed microcirculatory disturbances are discussed.

Aged↗
PubMed1996

Essential thrombocythemia and central retinal vein occlusion with neovascular glaucoma.

PURPOSE: We report a case of unilateral central retinal vein occlusion resulting from essential thrombocythemia, a rare myeloproliferative disorder with abnormally increased platelet count. METHODS: A 59-year-old man had central retinal vein occlusion in the left eye as the initial sign of essential thrombocythemia. He later developed neovascular glaucoma and optic disk neovascularization. RESULTS: Laser panretinal photocoagulation, goniophotocoagulation, glaucoma medications, and control of the platelet count were effective treatment. CONCLUSIONS: Early thrombocythemia is associated with systemic and ocular thrombotic and embolic complications. Early diagnosis, recognition of ocular complications, and appropriate treatment were crucial in controlling central retinal vein occlusion and ocular neovascularization associated with essential thrombocythemia.

Adrenergic beta-Antagonists↗
PubMed2003

[Clinical results of photodynamic therapy of choroidal neovascularization].

In some retinal diseases subretinal neovascular membranes (SNM) are formed in macular region, which is associated with persistent decrease of central vision. Photodynamic therapy is the new promising method of SNM treatment that allows selective impact on their structure, which results in its regression without decrease of visional function.

Choroidal Neovascularization↗
PubMed1981

Treatment of neovascularization secondary to branch retinal vein obstruction.

Fifty patients who developed preretinal or papillary neovascularization following tributary vein occlusion were treated by laser photocoagulation. Areas of non-perfused retina within the distribution of the obstructed vein were identified by fluorescein angiography and ablated using moderately intense laser photocoagulation burns. In forty-six patients there was satisfactory atrophy of both preretinal and papillary neovascularization without further complication or vitreous haemorrhage. Four patients who responded poorly to laser photocoagulation did so either because areas of ischaemic retina were inadequately treated or because they were unamenable to laser photocoagulation e.g., sited in the parafoveal region. Ablation of ischaemic perimacular retina together with associated intraretinal microvascular abnormalities aided the resolution of macular oedema in 19 patients. No post-operative complications could be attributed to laser photocoagulation excepting the development of fine perimacular retinal folds in one patient.

Constriction, Pathologic↗
PubMed1990

[Spot-like to reticular pigment displacement in a patient with pseudoxanthoma elasticum (Grönblad-Strandberg syndrome)].

The authors report a rare observation of leopard spot-like and reticular pigmentary patterns in a patient with pseudoxanthoma elasticum (PXE). Characteristic fundus changes associated with PXE have been described as angioid streaks, subretinal neovascularization membranes, peau d'orange, focal retinal pigment epithelium atrophy (salmon spots), drusen, and optic nerve head drusen. The new manifestation of PXE in the fundus of the patient described here is a random scattering of small, dark brown pigment dots throughout the macula and around the disk. These clumps may flow into one another or join together like a string of pearls. These changes are rare and should be distinguished from the others mentioned above. To the authors' knowledge no more than ten cases have been reported in the literature so far.

Angioid Streaks↗