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Surgery of the frontal recess and frontal sinus.

Surgery on the frontal recess and frontal sinus remains a challenge for endoscopic sinus surgeons. This paper examines the philosophy behind such surgery and presents a technqiue for 3-dimensional reconstruction of the anatomy of the frontal recess and frontal sinus. Utilizing this anatomical reconstruction the surgeon is encouraged to develop a pre-operative step-by-step surgical plan for each cell identified within the frontal recess and frontal sinus and thereby predict the anatomy of this region before surgery is undertaken. An increased understanding of the anatomy of this region should improve the surgeon's surgical confidence and ability to remove all the obstructing cells from the frontal sinus ostium.

Endoscopy↗

Expression of four growth factors in recessed extraocular muscles of rabbits.

BACKGROUND AND OBJECTIVE: The study was designed to determine the temporal expression of insulin-like growth factor (IGF)-I, IGF-II, basic fibroblast factor 2 (bFGF-2), and transforming growth factor beta 1 (TGF-beta1) in recessed extraocular muscles. MATERIALS AND METHODS: Sixteen eyes of eight rabbits were subjected to conventional 4-mm recession of superior rectus muscles. Two rabbits were untreated as control. The rabbits were killed and their eyes were enucleated at 3 (group 3), 6 (group 6), 24 (group 24), and 72 (group 72) hours after the operation (two rabbits per group), and the expression of IGF-I, IGF-II, bFGF-2, and TGF-beta1 was immunohistochemically examined. RESULTS: The peak levels of IGF-I, IGF-II, and TGF-beta1 expression were observed in groups 24, 6, and 3, respectively. However, bFGF-2 was less expressed than the other growth factors in all groups. CONCLUSIONS: IGF-I, IGF-II, bFGF-2, and TGF-beta1 in regenerating muscle cells were expressed by different kinetics, suggesting a distinct role of each growth factor during wound healing after recession of extraocular muscles.

Animals↗

[Treatment of multi-segmental lumbar intervertebral disc protrusion with limited recessive decompression].

OBJECTIVE: To retrospectively analyze the clinical and imaging features of multi-segmental lumbar intervertebral disc protrusion and its treatment with the limited recessive decompression operation. METHODS: Twenty-two patients (14 males and 8 females, aged 49-68 years) were admitted to hospital from March 1999 to March 2004. They suffered from multi-segmental lumbar intervertebral disc protrusion that involved L1-S1 and were treated with the limited recessive decompression operation. RESULTS: The follow-up for 4-21 months showed that 16 of the patients had an excellent outcome, 5 had a good outcome, and 1 had fair outcome. There were no such operative complications as nerve root lesions and putamen lesions. CONCLUSION: The limited recessive decompression operation is one of the available good treatments for multi-segmental lumbar intervertebral disc protrusion. It solves problems of herniation and stenosis and maintains stability of the spine.

Aged↗

[Spiral computed tomographic analysis of frontal recess regions].

OBJECTIVE: The purpose of the study was to determine the prevalence of frontal recess cells in Chinese patients who did not have frontal sinus disease related symptoms. METHODS: Forty-nine Chinese patients without frontal sinus disease symptoms were undergone spiral computed tomography (CT). Then multiplanar reconstruction images were evaluated using a standard triplanar reconstruction protocol on a computer workstation. RESULTS: The prevalence of agge rnasi cell was 94% (92/98). Sixty-four uncinate processes (65%, 64/98) had one superior attachment for each uncinate process, the other thirty-four uncinate processes (35%, 34/98) had two superior attachments for each uncinate process. The uncinate process' single superior attachment into the surrounding structures was identified to have the following distribution: 53% (52/98) to the lamina papyracea, 9% (9/98) to the middle turbinate, 3% (3/98) to the skull base. Most of the uncinate process' two superior attachments were either into the lamina papyracea and the skull base (24%, 23/98) or into the lamina papyracea and the middle turbinate (10%, 10/98). Only one uncinate process (1%) superiorly attached to the skull base and the middle turbinate. The prevalence of recessus terminalis was 87% (85/98). Of all the frontal cells identified in 32 sides (33%) of frontal recesses, the prevalence of type I, type II, type II and type IV cells were 23% (23 sides), 2% (2 sides), 7% (7 sides) and 0% (0 side) respectively. Supra bullar cell, frontal bullar cell and interfrontal septal cell were identified in 30 sides (31%), 7 sides (7%) and 7 patients (14%) respectively. CONCLUSIONS: The result characterized normal frontal recess pneumatization in Chinese. That, together with the variations of the uncinate process' superior attachment emphasized the roles of agger nasi cell and the uncinate process in endoscopic frontal sinus surgery.

Adult↗

The pineal recess of the opossum: a scanning and transmission electron microscope study.

Scanning and transmission electron microscope studies were performed in the pineal recess region of eighteen adult Didelphis albiventris opossums. With the scanning electron microscope, three concentric regions could be observed in the pineal recess: a central zone lined by cells free of cilia or microvilli, or by a meshwork of interdigitating cell processes; an intermediate zone lined by microvillous cells; and a peripheral zone, lined by ciliated cells. The transmission electron microscope revealed that the central zone is lined mainly by pinealocytes. The lining cells are frequently overlaid by a meshwork of pinealocytic and glial processes. A "subsurface labyrinth" (a meshwork of cellular processes underneath the lining cells) is constantly seen in the central zone. The intermediate zone is lined by elongated microvillous ependymal cells, and the peripheral zone by typical ependyma. The large liquor-contacting area in the pineal recess region, as well as the peculiar organization of its surface, suggest a complex interrelationship between the liquor and the pineal gland of the opossum.

Animals↗

Changes in the activity of the ependyma in the infundibular recess of the brain of Rana esculenta L. in the annual cycle.

Volume of the cell nuclei of the ependyma of the infundibular recess was measured in 30 female and 30 male water frogs (Rana esculenta L.) obtained from their natural environment, taking into account the phase of the annual cycle. Karyometry of the ependymal cell nuclei in the infundibular recess in males and females showed statistically significant differences of volume (activity) in the annual cycle. The largest volume of nuclei of the ependymal cells in females and males was observed in the first decade of April (end of hibernation), and the smallest in the first decade of September (end of the period of active life). Activity of nuclei of cells from the infundibular recess clearly correlated with gonadal development.

Activity Cycles↗

Report of a family with an unusual expression of recessive ichthyosis. Review of 42 cases.

A family with a history of ichthyosis is described in which the type of scale was thin and fine, resembling that of ichthyosis vulgaris, but the inheritance is of the autosomal recessive type. We have reviewed our previous experience with 42 additional patients whose condition had been diagnosed as recessively inherited ichthyosis and conclude that there is considerable heterogeneity in the cutaneous manifestations. We suggest that it is not possible to classify all patients into categories such as lamellar ichthyosis or congenital ichthyosiform erythroderma, and it may be better to use a more general term such as recessive ichthyosis until specific causes can be established.

Adolescent↗

Genetic analysis of non-recessive factors of resistance to diazinon in the SKA strain of the housefly (Musca domestica L.).

The recent allocation of many visible mutants to specific linkage-groups has made possible their use as genetic markers in the study of the inheritance of insecticide resistance. In most organophosphorus-resistant strains, resistance is controlled by a single gene on the V linkage-group responsible for resistance and low ali-esterase activity, but in some strains more than one factor is present. The present work was done to analyse the genetics of resistance to diazinon in a strain (the SKA strain) bred from two diazinon-resistant strains. Crosses between the SKA flies and four susceptible recessive marker strains, each marked on one linkage-group, followed by test-crosses with recessive markers and by bioassays of each cross, have shown that non-recessive factors for resistance to diazinon are present on the IV and V linkage-groups. The SKA strain genetically resembles its parents but differs by being considerably more resistant.

Animals↗

A scanning electron microscope study of the pineal recess of the adult brush-tailed possum (Trichosurus vulpecula).

The ventricular surface features of the pineal recess of 35 adult brush-tailed possums (Trichosurus vulpecula) were studied, mainly with the scanning microscope. The complex and interesting details observed have not been reported before. The pineal recess shows three distinct zones, and it is suggested that these be called: central, paracentral, and peripheral. The surface cells of the central zone show neither cilia nor microvilli, the paracentral zone shows microvilli (in a polygonal and homogeneous array), supraependymal cells and CSF-contacting nerve processes, while the peripheral zone is heavily ciliated. These features are consistent with the hypothesis that, in certain physiological states, the CSF from the pineal recess carrying pineal secretion is momentarily 'swept' forward in the direction of the median eminence to influence hypothalamic functions directly.

Age Factors↗

Gingival recession in 15-year old pupils.

In a clinical examination of 174 15-year old pupils approximately 62 per cent showed some degree of gingival recession on the labial surfaces of maxillary teeth. The number of affected teeth per individual was low, one tooth in about 35 per cent and teeth in 25 per cent of the individuals. First molars and first premolars were the teeth most often affected. The majority of the defects were not extensive, i.e. the gingival margin was situated at the cemento-enamel junction. The number of cases affected by recession was lower in individuals using an "unspecific" toothbrushing technique compared with those using roll or vibratory technique. This difference may not be due to the technique but rather to a minor interest in oral hygiene measures in the "unspecific" groups. No statistically significant correlation was found between frequencies of recession and the stiffness of the toothbrushes used.

Adolescent↗

Wedge recession for treatment of recurrent luxation of the patella: a preliminary report.

Wedge recession is a method which utilizes the geometry of similar triangles to recess an articular wedge into the underlying bone. This concept has been applied to congenital luxating patellae in the dog. A trochlear wedge recession deepens the femoral trochlea and provides stability to the patella. Preliminary trials of the procedure in dogs produced excellent results.

Animals↗

[Topographic radiologic anatomy of the right subcarinal and retrobronchial pulmonary recess (author's transl)].

Depending on the size of the subcarinal and retrobronchial recess the medial wall of the right and perhaps the left main bronchus can be recognized. The medial extension of the recess is very variable. On lateral films with slight anterior rotation of the right shoulder, the posterior wall of the right main bronchus can be shown in 97% of patients. Awareness of this recess and its boundaries is essential for diagnosis of subcarinal and tracheobronchial node enlargement. The following 4 signs will assist in diagnosis: 1. The dorsal margin of enlarged nodes may be recognized posterior and inferior to the carina. 2. The posterior wall of the right main bronchus can no longer be seen. 3. The medial wall of the right main bronchus can no longer be seen. 4. Clearer demonstration of the right main bronchus or bronchus intermedius occurs, due to an "air bronchogram" effect. Due to the application of these 4 signs, enlargements of the subcarinal or tracheobronchial nodes can be recognized, at a stage where the tracheal bifurcation is not yet splayed, and when the nodes have not yet caused bronchostenosis.

Bronchography↗

Three-dimensional distribution of basement membrane components in dystrophic recessive epidermolysis bullosa.

Absent or defective collagen VII at the dermo-epidermal junction is the hallmark of dystrophic recessive epidermolysis bullosa. Little is known of the alterations of other collagenous and non-collagenous components of the basement membrane; it is likely that their assembly may be disturbed by the lack of collagen VII molecules. The spatial relationship of collagen IV and laminin has been studied, both in bullous and in non-bullous areas. Skin biopsies from five patients affected by severe dystrophic recessive epidermolysis bullosa were rapidly frozen and freeze-dried. Collagen IV and laminin were labelled with specific monoclonal antibodies and FITC- or TRITC-conjugated secondary antibodies. Sections were observed with conventional light/fluorescence microscopy and with confocal laser scanning microscopy. Collagen IV and laminin were not co-localized: the former displayed a split image, being present at the floor and the roof of the blister, while the latter was confined to the roof. Confocal microscopy also allowed three-dimensional (3D) reconstruction of the dermo-epidermal junction from a series of optical sections, with viewing of the reconstructed specimen from a sequence of angles. By this procedure, laminin exhibits an irregular, coarsely granular distribution, both in affected and in apparently non-affected areas, while collagen IV appears as a homogeneous sheet. These results show that freeze-drying is the technique of choice for high-resolution immunofluorescence of skin samples and suggest that in dystrophic recessive epidermolysis bullosa, a complex disruption of the extracellular matrix assembly exists even before blister formation, probably due to the lack of collagen VII.

Basement Membrane↗

Computerised tomography evaluation of the frontal recess in inflammatory diseases of the frontal sinus: standardisation of a new technique.

The authors present a new investigation technique by means of CT of the frontal sinus drainage pathway, the frontal recess, which could be of considerable help in defining its potential role in determining a chronic or recurrent inflammatory process of this cavity. Among the main characteristics of this technique are: (1) a clear presentation of the course and conformation of the recess and its relations with surrounding structures; (2) speedy, and therefore economical, operation (12 min for a complete examination); and (3) tolerability, because this examination starts off with axial-scans, which, compared to CT coronal projections and MRI scans, are less prone to defects and do not require strained postures. This this means that all kinds of patients can be assessed, which is a basic requirement for achieving standardisation. With axial scans the authors work from paraxial reconstructions (oblique sagittal) which, in their opinion, give the best definition of the frontal recess so far recorded.

Adult↗

Computed tomography of the retropancreatic peritoneal recess: a case of gastric leiomyosarcoma.

We report computed tomography of the retropancreatic peritoneal recess in a case in which gastric leiomyosarcoma developed. Because of its location behind the pancreas, an abnormal finding in the retropancreatic peritoneal recess may be radiologically mistaken for a retroperitoneal abnormality. Knowledge of anatomy of posterior peritoneal recesses and understanding of fetal development are important in the radiological diagnosis of the lesions behind the pancreas.

Diagnosis, Differential↗

Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.

Sporadic inclusion-body myositis (s-IBM) is the most common progressive muscle disease of older persons. The muscle biopsy demonstrates mononuclear cell inflammation and vacuolated muscle fibers containing paired helical filaments and 6- to 10-nm fibrils, both resembling those of Alzheimer disease brain and Congo red positivity. The term hereditary inclusion-body myopathies (h-IBMs) designates autosomal-recessive or autosomal-dominant disorders with muscle biopsies cytopathologically similar to s-IBM but without inflammation. Vacuolated muscle fibers of both s-IBM and the h-IBMs contain accumulations of several "Alzheimer-characteristic proteins" including beta-amyloid protein and beta-amyloid precursor protein, and their paired helical filaments are composed of phosphorylated tau. We used six well characterized antibodies against several residues of presenilin 1 (PS1) to immunostain muscle biopsies of 12 patients with s-IBM, 5 patients with autosomal-recessive inclusion-body myopathy, and 16 normal and disease controls. Seventy to eighty percent of the vacuolated muscle fibers of both s-IBM and autosomal-recessive inclusion-body myopathy had inclusions that were strongly PS1-immunoreactive, which by immunoelectron microscopy localized mainly to paired helical filaments and 6- to 10-nm filaments. None of the control biopsies had PS1-positive inclusions characteristic of the s- and h-IBM abnormal muscle fibers. Mutations of the newly discovered PS1 gene are responsible for early-onset familial Alzheimer disease (AD), and PS1 is abnormally accumulated in sporadic and familial AD brain. Our study provides the first demonstration of PS1 abnormality in non-neural tissue and in diseases other than AD and suggests that the cytopathogenesis in AD brain and IBM muscle may share similarities.

Adult↗

Quantification (grading) of inferior oblique muscle recession for V-pattern strabismus.

PURPOSE: To determine the effectiveness of grading such surgery according to the magnitude of the V pattern and inferior oblique muscle overaction (IOOA). METHODS: We retrospectively reviewed all 53 cases we operated since 1984 for V pattern with IOOA, who had undergone graded inferior oblique recession, recessed according to the anatomical recession table of Apt and Call, ranging from 8mm for V pattern of 12 PD with +1 IOOA to 12mm for 30+ PD with +3 IOOA. RESULTS: A "satisfactory outcome" (defined as = V pattern of 8 PD or less) was observed in 75% of the cases with a preoperative V pattern less than 20 PD, in 70% of those with a preop' V pattern between 20 PD and 29 PD, and in 57% of those with a preop' V pattern greater than 29 PD. There were no overcorrections. All unsatisfactory outcomes were undercorrections. CONCLUSIONS: The principle of grading this surgery is supported and affirmed by these results. However, the results also suggest a need to increase the amount of surgery for all categories and add anterior transposition for larger V patterns.

Adolescent↗

Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome.

The syndrome of congenital hypoparathyroidism, mental retardation, facial dysmorphism and extreme growth failure (HRD or Sanjad-Sakati syndrome; OMIM 241410) is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. A similar syndrome with the additional features of osteosclerosis and recurrent bacterial infections has been classified as autosomal recessive Kenny-Caffey syndrome (AR-KCS; OMIM 244460). Both traits have previously been mapped to chromosome 1q43-44 (refs 5,6) and, despite the observed clinical variability, share an ancestral haplotype, suggesting a common founder mutation. We describe refinement of the critical region to an interval of roughly 230 kb and identification of deletion and truncation mutations of TBCE in affected individuals. The gene TBCE encodes one of several chaperone proteins required for the proper folding of alpha-tubulin subunits and the formation of alpha-beta-tubulin heterodimers. Analysis of diseased fibroblasts and lymphoblastoid cells showed lower microtubule density at the microtubule-organizing center (MTOC) and perturbed microtubule polarity in diseased cells. Immunofluorescence and ultrastructural studies showed disturbances in subcellular organelles that require microtubules for membrane trafficking, such as the Golgi and late endosomal compartments. These findings demonstrate that HRD and AR-KCS are chaperone diseases caused by a genetic defect in the tubulin assembly pathway, and establish a potential connection between tubulin physiology and the development of the parathyroid.

Amino Acid Sequence↗