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At least 793 records · Page 44Linked to original sources
PubMed1990

Potential use of live viral and bacterial vectors for vaccines. WHO meeting, Geneva, 19-22 June, 1989.

The use of vaccinia virus vector for the delivery of antigens was first described by Moss and Paoletti and their colleagues in 1982. Such vaccines could be of particular value in developing countries because they would be cheap, stable, easy to administer and provide long-lasting immunity. WHO recognized the potential value of such a delivery system by convening two meetings, one at the National Institutes of Health, USA in November 1984 and the second at WHO headquarters, Geneva, Switzerland in September 1985, to discuss the possibility of using such products, particularly with regard to their safety. Since that time, other vehicles which could be useful for the delivery of antigens have been described. These include Escherichia coli, Salmonella typhimurium, BCG, all other poxviruses, adenovirus, herpesvirus and poliovirus. At its meeting in July 1988, the Scientific Advisory Group of Experts of the Programme for Vaccine Development (SAGE) concluded that it was appropriate to discuss the general topic of live vectors and proceeded to arrange a meeting to discuss the present position and to prepare a report on the following key issues: requirements for safety and efficacy; immunological factors which may influence efficacy; medical constraints on use. The present report results from a meeting held in Geneva from 19 to 22 June 1989.

Adenoviridae↗
PubMed1994

Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines.

This article reviews studies concerning the characteristics of a vaccinia virus strain, LC16m0, and its recombinant virus vaccines. The LC16m0 strain is one of several temperature-sensitive and further attenuated variants derived from the Lister (Elstree) strain of vaccinia virus, which has a proven safety record in human populations. Several types of recombinant vaccinia viruses expressing a foreign antigen gene from a pathogenic virus have been constructed using the LC16m0 strain as a vector, and their immunological and virological characteristics have been investigated extensively. These studies indicate that the LC16m0 strain has potential as a vector in a live recombinant vaccine. The advantages, disadvantages and future prospects of vector are discussed.

Hepatitis B Vaccines↗
PubMed2002

Crookes, carbolic and cattle plague.

Forging a scientific career in 19th-century Britain was difficult for most middle-class scientists. Despite his discovery of thallium in 1861 and later distinction as an experimental physicist that led him to the Presidency of the Royal Society (1913-1915), William Crookes (1832-1919) never obtained one of the limited number of academic or official positions. Scientific journalism and commercial activities were eventually to bring him financial security, but before that he was an opportunist willing to try his hand at anything that would win him national publicity. This is illustrated by his intervention in the great cattle plague epidemic that swept the UK between 1865 and 1866.

Animals↗