Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Pulpitis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 793 records · Page 44Linked to original sources
PubMed1987

Pulp response to Streptococcus mutans.

The maxillary molar pulps of germ-free rats were mechanically exposed, and suspensions of a strain of freshly grown Streptococcus mutans were applied to the pulp wounds. The pulps were left open to the oral environment, and the animals were maintained in the isolator until they were killed in groups after 2, 7, and 28 days. After 2 days there was little evidence of any pulp response. In the 7-day group early pulp necrosis was present. No evidence of inflammatory infiltration was detected in either the 2- or 7-day animals. After 28 days there was extensive pulp necrosis in many specimens. Dentine bridges were present in fewer than one fourth of the teeth.

Animals↗
PubMed1987

Pulp response to and cariogenicity of Lactobacillus casei in monoinfected gnotobiotic rats.

The maxillary molar pulps of germ-free rats were mechanically exposed and suspensions of a strain of freshly grown Lactobacillus casei were applied to the pulp wounds. The pulps were left open to the oral environment, and the animals were maintained within the isolator until death. In the majority of teeth, pulp necrosis was evident and apical inflammation was present in 40% of the specimens. The remaining monoinfected animals were bred and the litters were placed on a 46% sucrose diet to determine the cariogenicity of the test strain of L. casei in the mandibular molars. The organism proved to be noncariogenic. The effects of mechanical exposure of the maxillary molars in these animals were similar to those observed in the direct-inoculation study, with the exception of a reduced incidence of apical inflammation.

Animals↗
PubMed1987

Bacterial contamination as a factor influencing the toxicity of materials to the exposed dental pulp.

Three materials, which had been previously found to be toxic when applied as pulp-capping agents in conventional rat molar pulps, were retested in germ-free rats. All produced much more favorable responses in the pulp, with a lack of inflammation and the presence of dentine bridges in the majority of teeth. It appears that much of the pulp damage previously attributed to the chemical toxicity of materials may be caused by the presence of bacteria. The design of studies intended to evaluate the response of the pulp to materials should include staining techniques that will detect the presence of bacteria on the floors of test cavities.

Aluminum Hydroxide↗
PubMed1987

Influence of the enlargement of the apical foramen in periapical repair of contaminated teeth of dog.

Root canals of dogs' premolar teeth were exposed to contamination and to the development of periapical inflammation over a period of 45 days. Root canals were overinstrumented 2 mm beyond the apical foramen with file No. 60 and were underfilled by 2 to 3 mm short of the roentgenographic apex. Ninety days after endodontic treatment, healing and ingrowth of connective tissue into the root canal occurred in 67.8% of the cases. These results suggest that the diameter of the apical foramen and the intensity of the canal contamination are determining factors for periapical tissue repair in cases of pulpal necrosis.

Animals↗
PubMed1988

Acute pulpal-alveolar cellulitis syndrome. IV. Exacerbations during endodontic treatment. Part 3. A case report.

An asymptomatic abscessed maxillary premolar, which had undergone previous endodontic treatment, was retreated. The initial attempt to remove the silver cone seal was unsuccessful. Early the next morning, the patient appeared with a severe cellulitis exacerbation. The silver cone was now loose: a lateral "blowout." Specific cultures of the silver cone and exudate revealed three aerobic microbes: a Streptococcus sp and two obligate Pseudomonas spp. Anaerobes were shown to be absent with anaerobic subcultures. This case would appear to substantiate the alteration of the tissue oxidation-reduction potential as the major factor in endodontic cellulitis exacerbations, as previously reported.

Abscess↗
PubMed1990

Reactions of rat odontogenic tissues to heat.

Twenty-four Wistar rats were anesthetized and 200 degrees C heat was applied for 4 minutes to each mandibular left first molar. Eight of these rats were then killed at 2, 8, and 14 weeks. The subject and control teeth were radiographed and compared. They were then prepared for histologic evaluation and scored for levels of inflammation in both the pulpal and periradicular tissues. Furcal, interproximal, and apical radiographic changes were found at all three time intervals. These changes involved progressively larger percentages of teeth at 8 and 14 weeks. Histologically, complete necrosis and/or abscess formation were found in the coronal portions of all experimental pulps. With time, inflammatory changes increased in intensity and progressed through the radicular pulps, resulting in necrosis or calcific changes and, finally, inflammatory changes in the periradicular areas. The pathosis created by the application of heat was devoid of microorganisms as evaluated by the Brown and Brenn stain.

Animals↗
PubMed1990

Periodontitis and angular alveolar lesions: a critical distinction.

Modern anthropologic and epidemiologic studies reveal that the incidence of periodontitis is low in both ancient and modern populations. The distribution of plaque and gingivitis has little or no correlation with the distribution of pathologic alveolar bone loss or with periodontitis. The assumption that a distance from cementoenamel junction to alveolar crest (CEJ-AC distance) greater than 2 mm equates with disease overlooks the interrelationship between the CEJ-AC distance and continuous eruption in compensation for tooth wear and growth of the lower face height. Anatomic, physiologic, and pathologic factors increasing CEJ-AC distances are reviewed. Where horizontal periodontitis does result from gingivitis, it is usually of minimal significance and probably occurs when the host defenses have been diminished by environmental factors commonly associated with other chronic diseases. A pulpal-alveolar explanation for localized angular alveolar lesions better fits the clinical features of this form of periodontal bone loss than does the conventional hypothesis of primary periodontal infection by specific oral bacteria.

Bone Resorption↗
PubMed1990

Healing of primate dental pulps capped with Teflon.

The pulps of Rhesus monkey teeth were exposed and capped with three materials: Teflon, a commercial hard-set calcium hydroxide (Ca(OH)2) material, and Ca(OH)2 plus saline. Experimental test periods were 3, 10, and 21 days, and 5 and 8 weeks. After treatment, the teeth were removed and processed for routine histologic evaluation. Teeth treated with the two Ca(OH)2 materials showed resolution of the inflammatory response and hard tissue formation at the exposure site as early as 10 days postoperatively, with consistent healing at 21 days and longer. Teflon had a similar soft tissue healing pattern but at a slower rate. Hard tissue formation at the exposure site in the teeth treated with Teflon was infrequent at the early time periods and present in only 20% of the teeth treated for 5 and 8 weeks. By evaluating the soft and hard tissue responses of the Ca(OH)2-capped and Teflon-capped teeth it may be possible, in future studies, to identify events unique to odontoblast differentiation during pulpal healing.

Animals↗
PubMed1990

Comparison of prophylactic and on-demand diflunisal for pain management of patients having one-visit endodontic therapy.

To determine whether the posttreatment prophylactic use of diflunisal (Dolobid 500) would be more effective than the on-demand use of diflunisal in reducing endodontic posttreatment pain, the current open-label, randomized study was undertaken. After one-visit nonsurgical endodontic therapy, 100 patients with asymptomatic teeth having either vital-inflamed pulp, pulpal necrosis, or pulpal necrosis with periapical radiolucent lesion were randomly given either prophylactic diflunisal (two tablets immediately at the conclusion of the visit, then four tablets to be taken in the schedule of one every 8 to 12 hours for pain if needed) or on-demand diflunisal (same dosage schedule; pills to be taken only if needed). The outcome showed that compared to the on-demand usage, the posttreatment prophylactic administration of diflunisal resulted in a statistically significant reduction in the number of episodes of endodontic posttreatment pain that required analgesic intervention. It appears from the results of this study that the posttreatment prophylactic use of diflunisal is significantly more effective than the on-demand usage of diflunisal in reducing endodontic posttreatment pain for one-visit endodontic therapy with all types of originally asymptomatic endodontic conditions. Further studies are necessary to determine whether pretreatment prophylactic deflunisal would be more effective, and also the effectiveness of prophylactic diflunisal in reducing posttreatment pain in presenting symptomatic cases and for cases treated in multiple visits.

Adolescent↗
PubMed1991

Histologic evaluation of the pulpal response to temperature probe placement in the Macaca fascicularis monkey.

A method to measure intrapulpal temperatures during cavity preparation and restorative procedures has been developed. It involves placement of temperature probes to the dentinoenamel and dentinopulpal junctions. After placement of the probes, the pulps of the test teeth were examined histologically to determine whether their placement caused a pulpal response. The test teeth displayed no adverse response in the areas of the pulp opposite or adjacent to the position of the probes. Therefore the developed method of temperature probe placement to measure intrapulpal temperatures does not interfere with those measurements by adversely affecting the pulp tissues.

Animals↗
PubMed1991

Intentional replantation: a successful alternative for hopeless teeth.

An interesting case of intentional reimplantation, in which the distal root of a mandibular molar was reimplanted after hemisection, is reported for the first time. This root served as the distal abutment for a three-unit bridge. A 3-year follow-up revealed a successful outcome, with a clinically asymptomatic and functional tooth with no radiographic signs of resorption or ankylosis.

Calcinosis↗
PubMed1991

Immediate and delayed direct pulp capping with the use of a new visible light-cured calcium hydroxide preparation.

The pulpal response to mechanical exposure and capping either immediately or after 24 hours was investigated in 64 teeth of four cynomolgus monkeys with the use of Dycal, VLC Dycal, or Prisma-Bond. All overlying amalgam restorations were surface-sealed with zinc oxide-eugenol cement. After 2 months the teeth were removed and prepared for histologic examination; dentine bridges were present in almost all teeth filled with Dycal or VLC Dycal, and pulpal inflammation was observed in only one tooth that showed evidence of infection. Dentine bridges were usually incomplete when Prisma-Bond was used, although pulpal inflammation was only observed in 2 of 22 teeth. The success rate of pulp capping delayed for 24 hours was as high as that for immediate capping.

Animals↗
PubMed1991

Pulpal response to tricalcium phosphate as a capping agent.

The purpose of this study was to evaluate tricalcium phosphate (TCP) as a pulp-capping agent. Two adult male beagle dogs were used for this investigation. Class I cavities were prepared in the posterior teeth and Class V cavities in the anterior teeth. With the use of a rubber dam and high speed with water coolant, minimal pulp exposures were created in both the experimental and control teeth, by means of a 1/2 round bur. Zinc oxide-eugenol was the temporary filling material used to restore all cavities. In each dog, five teeth served as control and were capped with the use of calcium hydroxide. In one dog, 10 teeth from two quadrants were capped with the tested material (TCP). In the other dog, 11 teeth were capped with TCP. Four teeth from the fourth quadrant in each dog were capped with a mixture of calcium hydroxide and TCP in a ratio of 1:1 by weight (50/50 group.) The two dogs were killed after 70 days. The histologic evaluation of the response to the capping agents and at the exposure site was recorded. A total of 39 teeth were evaluated in this study. It was found that TCP as a capping agent precipitated the highest mean inflammatory response and also demonstrated the highest percentage of reparative dentin formation.

Animals↗
PubMed1991

Endodontic therapy of traumatized incisors with crown and transverse intra-alveolar root fractures.

A case involving traumatic injury to the maxillary anterior teeth with crown and transverse intra-alveolar root fractures is reported. The patient did not seek immediate treatment after trauma. Treatment included pulpectomy, fixation of a fractured root, root canal obturation, endodontic therapy of the coronal segment, and postoperative observation. Follow-up showed good results. Thus effective nonsurgical endodontic therapy of traumatized anterior teeth can result in a good prognosis in cases involving crown and intra-alveolar root fractures.

Adolescent↗
PubMed1993

Human pulpal response to hydroxyapatite and a calcium hydroxide material as direct capping agents.

Forty maxillary and four mandibular first premolars that were to be extracted for orthodontic reasons were used in this study to evaluate human pulpal response to hydroxyapatite and Dycal as direct capping materials. After the postoperative periods of 2 days, 30 days and, 60 days, teeth were extracted and prepared for the histologic examination. The results of this study showed that hydroxyapatite does not induce hard tissue bridging at the exposure site in human dental pulp. No hard tissue bridging at the exposure site was observed in any of the teeth capped with hydroxyapatite. Moderate infiltration of the inflammatory cells was seen generally in the teeth capped with hydroxyapatite. However, this study has verified that exposed human dental pulp will heal under Dycal application with hard tissue bridging and with none or minimal inflammatory response.

Bicuspid↗
PubMed1993

Chronic focal sclerosing osteomyelitis associated with a cracked tooth. Report of a case.

Chronic focal sclerosing osteomyelitis is a periapical lesion that involves reactive osteogenesis evoked by chronic inflammation of the dental pulp. In most cases, this lesion develops in the mandibular molar region in response to a low-grade infection of the pulp that results from a deep carious lesion. A case is presented in which incomplete tooth fracture was the apparent cause of this type of periapical pathosis.

Adult↗
PubMed1994

Pharmacology of peripheral neuropeptide and inflammatory mediator release.

Research conducted in the last 10 years has increased our knowledge on pain mechanisms substantially. Although many local tissue mediators, including neuropeptides, are known to exert pro-inflammatory effects, comparatively little is known about the actual tissue levels of these inflammatory mediators and their pharmacologic regulation. This article describes two new methods, clinical microdialysis and superfusion of dental pulp, which provide data on the pharmacology of peripheral neuropeptide and inflammatory mediator release. Collectively, these methods provide a biochemically based approach toward determining the mechanisms and management of orofacial pain.

Bradykinin↗