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PubMed2002

Proteomic analysis in the neurosciences.

Proteomics is a field of study directed toward providing a comprehensive view of the characteristics and activity of every cellular protein. Rapid innovations in the core technologies required to characterize proteins on a global scale are poised to bring about a comprehensive understanding of how dynamic changes in protein expression, post-translational modification, and function affect complex signaling and regulatory networks. These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease.

Animals↗
PubMed2002

The neuroscience of Helmholtz and the theories of Johannes Müller. Part 2: Sensation and perception.

In this, our continuation paper on Helmholtz and Müller, we examine Helmholtz's contributions to sensation and perception, with emphasis on his extension and modification of Müller's theory of specific nerve energies. The material is again presented in biographical-chronological context. We also examine Helmholtz's views on depth and space perception, and his empirical theory of knowledge, which are also compared to Müller's views. It will be shown that Helmholtz remained stimulated by the thoughts and doctrines of Johannes Müller in the sensory-perceptual part of his career, which began early in the 1850s and ended with his death. Nevertheless, Helmholtz's own experiments and new discoveries by others sometimes led him to quite different conclusions.

Germany↗
PubMed1999

The Golgi Stain: invention, diffusion and impact on neurosciences.

The black reaction, invented in 1873 by Camillo Golgi (1843-1926, was the first technique to reveal neurons in their entirety, i.e. with all their processes. This important development passed unnoticed at first and only received wide international attention after a long delay. The Golgi stain was widely employed for almost thirty years and was directly responsible for major advances in our knowledge of the microscopic anatomy of the nervous system, as well as in other fields of study. In the hands of other researchers, the black reaction provided vital evidence that helped to establish the neuron theory. The Golgi stain was almost forgotten in the period between the two World Wars, but the introduction of the electron microscope to neurocytological resarch revived its use around the middle of the twentieth century. Today, the black reaction is still used extensively not only in combination with electron microscopy, but also as an autonomous technique in studies on the evolution, ontogeny, and organization of the nervous system.

Cell Biology↗
PubMed2003

Dissociation and neuroscience: history and new perspectives.

History of the study of dissociation begins in the second half of the nineteenth century. It begins in the works of Hughlings Jackson and Pierre Janet, and markedly influences development of psychoanalysis and other psychological trends. According to the modern definition, dissociation represents a disturbance or alteration in the normally integrative functions of identity, memory, or consciousness. Dissociative symptoms occur mainly due to some traumatic events and probably cannot be generally explained on the basis of neurological focal lesion. However, from recent findings, it may be inferred that temporal lobe epileptic activity is important in the generation of dissociative symptoms. Recent findings show that neural networks provide an attractive framework for modeling dissociative mental processes and dissociative mechanisms. In the article we propose a new theoretical connection among neural network models of dissociation, Freeman's model of chaos in the brain and electrophysiological findings regarding dissociative states. Concluding remarks are concerned with connections of dissociation and inter-hemispheric communication.

Dissociative Disorders↗