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PubMed1989

Electrocorticographic (ECoG) correlates of language. I. Desynchronization in temporal language cortex during object naming.

The electrocorticogram (ECoG) was recorded during a language task, silent naming, from sites identified as essential for naming by electrical stimulation mapping and from surrounding cortex of left dominant temporal cortex at craniotomies under local anesthesia. The ECoG was analyzed quantitatively for a reduction in spectral density in 7-12 Hz frequencies indicating 'desynchronization.' These measurements were made on the averaged ECoG in 3 subjects and on individual ECoG segments in 4. Statistically significant increases in desynchronization were identified during silent naming at most sites essential for language, most often in the epoch from 700 to 1200 msec after presentation of the item to be named. During silent naming, there was a greater degree of desynchronization at those sites than in surrounding cortex. At several sites essential for language in several subjects, significantly less desynchronization was evident during a spatial task using physically identical stimuli. Thus, localized desynchronization in temporal cortex is an ECoG change with temporal, anatomic, and sometimes behavioral specificity to a language task. This finding provides insights into cortical physiologic mechanisms active during human language.

Adult↗
PubMed1995

Substantial regional and hemispheric differences in brain nitric oxide synthase (NOS) inhibition following intracerebroventricular administration of N omega-nitro-L-arginine (L-NA) and its methyl ester (L-NAME).

Nitric oxide synthase (NOS) enzyme activity was determined in a comprehensive selection of regions of the rat brain. The effects of lateral ventricular administration of N omega-nitro-L-arginine (L-NA, 30 micrograms) and its methyl ester (L-NAME, 3-100 micrograms) on NOS activity were examined in the ipsilateral and contralateral areas of 4 of these brain regions and in the cerebellum. NOS activity was determined using a new and rapid ex vivo assay method which ensures minimal dissociation of the enzyme-inhibitor complex. Following infusion of L-NAME, NOS activity was rapidly and dose-dependently inhibited in all brain regions studied (cerebral cortex, striatum, hippocampus, cerebellum and thalamus). However, NOS activity of brain regions within the contralateral hemisphere was inhibited significantly less than in ipsilateral regions, with the exception of the thalamus. The degree of NOS inhibition varied markedly between brain regions within each hemisphere and correlated with their ventricular proximity to the site of NOS inhibitor administration. Therefore, NOS in the thalamus was inhibited most effectively and NOS in the cerebral cortex the least. Within the cerebral cortex further regional differences could be observed, with NOS in the frontal/parietal areas inhibited more effectively than NOS in the temporal/occipital areas. Maximal inhibition of NOS was sustained for approx 6 hr after administration of 30 and 100 micrograms L-NAME. No inhibition of NOS was observed 24 hr after administration. Lateral ventricular administration of the metabolite and active moiety of L-NAME, L-NA, resulted in a similar degree of inhibition and time of inhibitory onset. In contrast, when L-NAME was administered i.p., a significant delay in the onset of NOS inhibition was observed in the above brain regions compared to L-NA. However, no regional or hemispheric differences in NOS inhibition were detected following peripheral administration of these inhibitors. These results indicate that central administration of NOS inhibitors yields a complex pattern of NOS inhibition and that data obtained on brain physiology following the i.c.v. administration of NOS inhibitors, or for that matter any other CNS effector, should therefore be interpreted with extreme caution.

Animals↗
PubMed1984

The naming disorder of dementia.

Naming impairment is a common feature of the language disorder of dementia, yet agreement has not been reached on its mechanisms. In this study, the confrontation naming performance of twelve demented subjects was compared to that of age-matched controls. Naming deficits were studied in relation to overall language and cognitive dysfunction and analysed to assess the importance of both perceptual and linguistic factors. Naming dysfunction occurred even in mild dementia, in patients whose overall language function remained normal, and worsened in proportion to the degree both of language deficit and overall cognitive dysfunction. Perceptual difficulty and word frequency, but not word length, were important determinants of naming performance in demented patients.

Aged↗
PubMed1996

A category-specific naming impairment after temporal lobectomy.

Unilateral temporal lobectomy patients and normal control subjects were tested in a speeded naming task with pictures of living and nonliving things that were equated for name frequency, familiarity, and visual complexity. Although right temporal lobectomy patients and normal subjects performed equally well with the living relative to nonliving things, left temporal lobectomy patients were disproportionately impaired at naming nonliving things. This result has several implications: First, it supports the existence of category-specific naming impairments. In particular, it undermines the proposal that living-nonliving dissociations are artifactual, resulting from the greater difficulty of living things. Second, it demonstrates an asymmetry in the neural representation of nonliving things, in favor of the left hemisphere. Third, it casts doubt on the hypothesis that the anterior temporal cortices are convergence zones that are particularly necessary for the naming of living things.

Adolescent↗
PubMed1989

Differential recovery in naming in bilingual aphasics.

Language performance in a sample of 30 Catalan-Spanish bilingual aphasics was studied using three nominal tasks (naming, pointing, and translation). We compared performance between the two languages before and after therapy and also compared the improvements made in each language. Therapy was carried out in only one language, namely Catalan. Significant differences between the two languages were initially seen in the naming and translation tasks while after treatment significant differences were observed in the naming and pointing tasks. Analysis of covariance was carried out to control the influence of the initial performance on improvements. Performance in the naming task improved more in the treated language (Catalan) than in the nontreated language. We conclude that both differential impairment and recovery of languages in bilingual aphasics is seen not only in rare cases but also in studies of larger samples.

Adult↗
PubMed1990

Naming consistency in Alzheimer's disease.

Although lexical semantic deficits are postulated to play a prominent role in the anomia of Alzheimer's disease, it is unclear whether the primary disturbance is one of lexical access or one of lexical semantic loss. Response consistency on a naming task is one means of evaluating the underlying source of naming impairment. Access dysfunction usually implies variable word-finding difficulty, while a theory of lexical loss predicts that many word names would be consistently unavailable. Nineteen Alzheimer's disease patients were administered a visual confrontation naming task (the Boston Naming Test) on two occasions 6 months apart. Eighty percent of errors occurred consistently at both times; only 20% of errors occurred on only one occasion. Response consistency occurred significantly more often than expected under the assumption of no response consistency. Findings support the hypothesis that anomia in Alzheimer's disease is in part due to a loss of lexical semantic information.

Aged↗
PubMedDate not supplied

Legitimacy of the names of subspecies of Campylobacter fetus proposed by Véron and Chatelain, 1980.

Since the publication of the 8th edition of Bergey's Manual of determinative bacteriology, there has been considerable confusion concerning the names of 2 subspecies and the types of the subspecies of Campylobacter fetus (Smith and Taylor, 1919) Sebald and Véron, 1980. Despite the documentation of the names C. fetus subsp. fetus (Smith and Taylor) Véron and Chatelain and C. fetus subsp. venerealis (Florent) Véron and Chatelain, which appear in the "Approved lists of bacterial names", the influence of Smibert's description in the 8th edition of Bergey's Manual continues. To stabilize the nomenclature and to avoid or reject the use of names which may cause error or confusion, this paper will focus on the legitimacy of the 2 subspecific names of C. fetus proposed by Véron and Chatelain.

Campylobacter↗
PubMed2006

Sodium sensitivity of arterial blood pressure in L-NAME hypertensive but not eNOS knockout mice.

The present studies determined the sensitivity of mean arterial pressure (MAP) to sodium intake in endothelial nitric oxide synthase (eNOS) knockout mice, wild-type mice (C56BL/6J), and wild-type mice intravenously administered the nonspecific NOS inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME, 8.6 mg/kg/d). Arterial blood pressure was measured from chronically implanted femoral arterial catheters in conscious, freely moving mice. The MAP was unaltered from the low sodium ( approximately 200 microEq/d) intake level of 106 +/- 3 mm Hg in wild-type mice when sodium intake was increased to approximately 1000 microEq/d (n = 12). Chronic administration of L-NAME to wild-type mice led to a sodium-dependent increase in MAP from 111 +/- 7 mm Hg to 124 +/- 5 mm Hg when the mice were placed on an elevated sodium intake (n = 7). In contrast to the L-NAME-treated mice, MAP was unaltered in eNOS knockout mice (n = 8) when sodium intake was increased (128 +/- 3 mm Hg v 129 +/- 5 mm Hg). These experiments demonstrate that eNOS knockout and L-NAME-treated wild-type mice are hypertensive relative to wild-type controls when sodium intake is elevated, but only L-NAME-treated mice exhibited a sodium-sensitive increase in MAP. Therefore, nitric oxide produced by eNOS does not appear to be important in the physiologic adaptation to elevated sodium chloride intake.

Animals↗
PubMed2005

Evidence of a highly specific relationship between rapid automatic naming of digits and text-reading speed.

This paper explores the specificity of the relationship between rapid automatic naming and reading fluency. Reading accuracy, rate, and fluency was measured among a sample of 67 children, the majority of whom were very poor readers. Regression analyses revealed that phonological processing tasks predicted reading accuracy and comprehension whereas rapid digit (but not picture) naming predicted reading accuracy and rate. After further controlling reading accuracy, digit naming was still a significant predictor of reading rate. This suggests that rapid alphanumeric naming is a highly specific predictor of reading rate and that rapid digit naming and phonological processing are distinct contributors to different aspects of reading in poor readers.

Automatism↗
PubMed2005

Variable solutions to the same problem: aberrant practice effects in object naming by three aphasic patients.

Although deficits in confrontation naming are a common consequence of damage to the language areas of the left cerebral hemisphere, some patients with aphasia show relatively good naming ability. We measured effects of repeated practice on naming latencies for a set of pictured objects by three aphasic patients with near-normal naming ability and by neurologically intact young and older adults. While the non-injured participants showed a systematic reduction in overall mean latencies and reduced trial-to-trial latency variability, the aphasic patients did not. Examination of the latency distributions suggests that successful naming by aphasic patients may come about by different underlying operations.

Adolescent↗
PubMed2007

Episodic and semantic memory influences on picture naming in Alzheimer's disease.

This study investigated the relationship between semantic and episodic memory as they support lexical access by healthy younger and older adults and individuals with Alzheimer's disease (AD). In particular, we were interested in examining the pattern of semantic and episodic memory declines in AD (i.e., word-finding difficulty and impaired recent memory) vis-à-vis more preserved remote memories. We administered a picture naming task in which the episodic period of the pictures and whether the pictured items were unique to one period or commonly used across periods were varied. Groups of younger adults (N=40), healthy older adults (N=20) and older adults with AD (N=18) were asked to name drawings of objects in four conditions: dated unique, contemporary unique, dated common, and contemporary common. The results indicated that all participants named items that were common to both episodic periods more successfully than items unique to one period. An interaction was observed such that the healthy older and AD groups were more successful in retrieving names of objects presented in the dated compared to contemporary unique conditions, whereas the younger adults showed the reverse pattern. These results indicate that naming ability is affected both by the cumulative frequency of using an item over a lifetime and by when an item was first acquired. The findings support a theoretical stance which proposes an enduring reciprocal link between semantic and episodic memory. This theoretical relationship has practical implications for the development of intervention strategies when interacting with persons who have AD.

Adult↗
PubMed2006

Cortical activation during word reading and picture naming in dyslexic and non-reading-impaired children.

OBJECTIVE: In a recent study on picture naming and word reading in dyslexics and control children we found a combination of normal picture retrieval times and severe reading impairments in dyslexics. Therefore, we hypothesize that brain response patterns differ between patients and controls during word reading, but are similar in picture naming as a non-letter mediated task. METHODS: Time course of brain activation was investigated by magnetoencephalography during word reading and picture naming in 9 dyslexic children and 13 age-matched controls (aged 9-10 years). RESULTS: We found 5 consecutive activations spreading from occipito-parietal to temporo-frontal sites. Group differences occurred only during reading: a delayed response in temporal superior and angular gyri at 235-285 ms and absence of activation in anterior temporal and inferior frontal regions at 430-530 ms for dyslexics. CONCLUSIONS: Problems in phonological processing are reflected in delay of early activity and absence of late activity in language related brain regions. From the lack of group differences during picture naming, we conclude the presence of two pathways: a phonological/orthographic one for word reading, which is disturbed in dyslexics, and a visual one for picture naming, which can be unaffected in dyslexics. SIGNIFICANCE: Evidence is provided for different pathways for the processing of letter-mediated and visual-eidetic information. This knowledge may be important for dyslexics in the context of coping with everyday demands and for training of relevant skills.

Auditory Perception↗
PubMed2005

Semantic similarity and grammatical class in naming actions.

Italian speakers were asked to name pictures of actions (e.g. "bere", to drink). Pictures were presented at the same time as distracter words that were semantically related or unrelated to the picture names, and were of the same or different grammatical class (verbs or nouns). Half of the participants named the actions as verbs in citation form, the other half as verbs inflected for third person singular or plural. We found a reliable semantic interference effect. Crucially, we also observed a significant interaction between naming context and grammatical class: naming latencies were slower for verb distracters in the inflected form condition, but not in the citation form condition. The results are taken to provide evidence for the separability of semantics and grammatical class.

Humans↗
PubMed2004

Consistent (but not variable) names as invitations to form object categories: new evidence from 12-month-old infants.

Recent research documents that for infants just beginning to produce words on their own, novel words highlight commonalities among named objects and, in this way, serve as invitations to form categories. The current experiment identifies more precisely the source of this invitation. We asked whether applying a consistent name to a set of distinct objects is crucial to categorization, or whether variable names might serve the same conceptual function. The evidence suggests that for 12-month-old infants, consistency in naming is critical. Infants hearing a single consistent novel noun for a set of distinct objects successfully formed object categories. Infants hearing different novel nouns for the same set of objects did not. These results lend strength and greater precision to the argument that naming has powerful and rather nuanced conceptual consequences for infants as well as for mature speakers.

Female↗
PubMed2006

In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study.

It has been reported that increased nitric oxide synthase (NOS) expression and nitric oxide (NO) production may play an important role in cancer biology. The aim of this study was to determine the roles of NO in tumour cellular proliferation and DNA or RNA synthesis, and to investigate the therapeutic potential of NOS inhibitors in oral cancer. After exposure to different concentrations of the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), the growth of TSCCa cells, established from a patient with squamous cell carcinoma of the tongue, was evaluated using MTT and crystal violet assay. DNA or RNA synthesis, inducible/endothelial NOS (iNOS/eNOS) mRNA expression and NO production were then examined to determine the possible mechanisms of inhibitory effects of L-NAME on TSCCa cells. L-NAME had an inhibitory effect on TSCCa cell growth in both a concentration- and time-dependent manner. Acridine orange staining revealed that DNA and/or RNA synthesis of TSCCa cells was reduced after treatment with L-NAME. An in situ hybridisation (ISH) study showed clearly that L-NAME down-regulated eNOS and iNOS mRNA expression and this was followed by a decrease in NO production. It is postulated that the NOS/NO pathway may be implicated in cellular proliferation and DNA or RNA synthesis of cancer cells, apart from promoting tumour angiogenesis. Further studies have provided with new insight into the mechanisms by which NOS/NO takes part in oral carcinogenesis, and possible therapeutic interventions based on the NOS/NO pathway for tumour progression control.

Acridine Orange↗
PubMed2005

Monolingual and bilingual children's use of mutual exclusivity in the naming of whole objects.

In two experiments, the use of mutual exclusivity in the naming of whole objects was examined in monolingual and bilingual 3- and 6-year-olds. Once an object has a known name, then via principles of mutual exclusivity it is often assumed that a new name given to the object must refer to some part, substance, or other property of the object. However, because bilingual children must suspend mutual exclusivity assumptions between languages, they may be more willing to accept two names for an object within a language. In the current research, the use of mutual exclusivity in the naming of whole objects was found across monolingual and bilingual children, although older bilingual children were significantly less inclined to use mutual exclusivity than were older monolingual children. These results are discussed in terms of differences in monolingual and bilingual children's word learning.

Child↗
PubMed2006

Phoneme monitoring in silent naming and perception in adults who stutter.

UNLABELLED: The present study investigated phonological encoding skills in persons who stutter (PWS). Participants were 10 PWS (M=31.8 years, S.D.=5.9) matched for age, gender, and handedness with 12 persons who do not stutter (PNS) (M=24.3 years, S.D.=4.3). The groups were compared in a phoneme monitoring task performed during silent picture naming. The phonological complexity of the target items in the task was varied such that participants monitored either compound words or noun phrases. Performance in this task was compared to phoneme monitoring performed on aurally presented target words to investigate whether any differences observed in silent naming were also evident in perception. Analysis of the response time data, in milliseconds, indicated that PWS were significantly slower as compared to PNS in phoneme monitoring during silent naming; group differences were not obtained in the perception task. The groups were also comparable in the response time to phoneme monitoring within compound words and noun phrases in both silent naming and perception. The findings suggested that PWS were slower in the encoding of segmental, phonological units during silent naming. Furthermore, absence of such differences in perception ruled out a general monitoring deficit in PWS. Findings are interpreted within the context of the psycholinguistic theories of stuttering that postulate phonological encoding and/or monitoring as a causal variable in stuttering. EDUCATIONAL OBJECTIVES: As a result of this activity, the participant should: (1) describe relevant literature on phonological encoding skills in children and adults who stutter, (2) identify paradigms that can be used to investigate phonological processing in PWS, and (3) discuss the role of phonological encoding in speech production.

Adolescent↗
PubMed2004

Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been shown to prevent or reverse hypertrophy of the LV in several models of left ventricular hypertrophy. The aim of the present study was to determine whether treatment with simvastatin can prevent hypertension, reduction of tissue nitric oxide synthase activity and left ventricular (LV) remodeling in NG-nitro-L-arginine methyl ester(L-NAME)-induced hypertension. Four groups of rats were investigated: control, simvastatin (10 mg/kg), L-NAME (40 mg/kg) and L-NAME + simvastatin (in corresponding doses). Animals were sacrificed and studied after 6 weeks of treatment. The decrease of NO-synthase activity in the LV, kidney and brain was associated with hypertension, LV hypertrophy and fibrosis development and remodeling of the aorta in the L-NAME group. Simvastatin attenuated the inhibition of NO-synthase activity in kidney and brain, partly prevented hypertension development and reduced the concentration of coenzyme Q in the LV. Nevertheless, myocardial hypertrophy, fibrosis and enhancement of DNA concentration in the LV, and remodeling of the aorta were not prevented by simultaneous simvastatin treatment in the L-NAME treated animals. We conclude that the HMG-CoA reductase inhibitor simvastatin improved nitric oxide production and partially prevented hypertension development, without preventing remodeling of the left ventricle and aorta in NO-deficient hypertension.

Animals↗