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At least 793 records · Page 44Linked to original sources
PubMed2001

On velocity estimation using speckle decorrelation.

Quantitative estimation of blood velocity using Doppler techniques is fundamentally limited because only the axial component can be detected. Speckle decorrelation resulting from scatterer motion may be used to compute non-axial components and to obtain quantitative flow information. Based on both simulations and experimental results, it is shown that the decorrelation technique is feasible only for constant flows. If flow gradients are present, the correlation between two signals along the same line of observation may be significantly affected by the gradients. Therefore, the decorrelation method cannot be used for quantitative flow estimation if flow gradients are not accurately measured and effects on signal correlation are not fully compensated. Results in this paper show that accurate estimation of flow gradients is practically difficult. It is further shown that effects of signal-to-noise ratio (SNR) on the correlation must also be taken into account for quantitative flow analysis.

Biomedical Engineering↗
PubMed2001

Finite element simulation and modeling of 2-D arrays for 3-D ultrasonic imaging.

Issues of modeling and design of 2-D arrays in three dimensions with finite element code are discussed. These ultrasonic arrays are used for real time dynamic imaging of the heart. Topics include optimization, sensitivity, and performance and methods to speed up the run times required for computer simulations of large three-dimensional models. Empirical results from 45 x 45 2-D arrays are also presented.

Biomedical Engineering↗
PubMed2002

The use of the SPSA method in ECG analysis.

The classification, monitoring, and compression of electrocardiogram (ECG) signals recorded of a single patient over a relatively long period of time is considered. The particular application we have in mind is high-resolution ECG analysis, such as late potential analysis, morphology changes in QRS during arrythmias, T-wave alternants, or the study of drug effects on ventricular activation. We propose to apply a modification of a classical method of cluster analysis or vector quantization. The novelty of our approach is that we use a new distortion measure to quantify the distance of two ECG cycles, and the class-distortion measure is defined using a min-max criterion. The new class-distortion-measure is much more sensitive to outliers than the usual distortion measures using average-distance. The price of this practical advantage is that computational complexity is significantly increased. The resulting nonsmooth optimization problem is solved by an adapted version of the simultaneous perturbation stochastic approximation (SPSA) method of. The main idea is to generate a smooth approximation by a randomization procedure. The viability of the method is demonstrated on both simulated and real data. An experimental comparison with the widely used correlation method is given on real data.

Algorithms↗
PubMed2002

A successive cancellation algorithm for fetal heart-rate estimation using an intrauterine ECG signal.

In this paper, we present a two-stage successive cancellation (SC) algorithm that sequentially separates fetal and maternal heartbeats from an intrauterine electrocardiogram (IuECG) signal containing both fetal and maternal QRS complexes. The ECG signal is modeled as a series of fetal, maternal, and noise events. Peak detection is first employed to locate the potential fetal and maternal QRS complexes, referred to as candidate events. Each stage automatically generates a template of a source from the candidate events in the initialization period, and thereafter performs classification of the remaining candidate events based on a template matching technique. The detected events of the stronger signal are subtracted from the composite ECG signal prior to initialization and classification of the weaker signal. Once the fetal and maternal complexes are successfully detected and separated, a counting mechanism is utilized to derive the corresponding heart rates. Computer simulation results on real IuECG data demonstrate the effectiveness of the SC algorithm.

Algorithms↗
PubMed2002

Decomposition of field-induced transmembrane potential responses of single cardiac cells.

In this study, we used a multi-site optical mapping system to record field-induced responses of single cells isolated from guinea pig hearts. The cells were stained with voltage sensitive dye di-8-ANEPPS and stimulated with two uniform field (S1-S2) pulses along their longitudinal axes. The first pulse (S1 = 5 ms, <10 V/cm) was applied during rest and elicited an action potential. The second pulse (S2 = 10 ms, 4-50 V/cm) was applied 15 ms after the break of the S1 pulse (during the action potential plateau). The transmembrane potential responses, Vm(F)s, were optically recorded from up to 12 sites along the cell length using a fiber optic based optical mapping system at a resolution of 17 or 25 microm. The field-induced Vm(F)s had a complex spatio-temporal pattern. We show that these responses can be decomposed into simpler components. The first component, termed the differential-mode component (Vmd(F)), is like the response of a passive cell. The second component, termed the common-mode component (Vmc(F)), is identical all along the cell and adds a constant offset to the differential mode response of various sites along the cell length, to produce the total Vm(F) responses of the cell.

Algorithms↗
PubMed2002

Narrowband auscultatory blood pressure measurement.

Auscultatory blood pressure measurement uses the presence and absence of acoustic pulses generated by an artery (i.e., Korotkoff sound), detected with a stethoscope or a sensitive microphone, to noninvasively estimate systolic and diastolic pressures. Unfortunately, in high noise situations, such as ambulatory environments or when the patient moves moderately, the current auscultatory blood pressure method is unreliable, if at all possible. Empirical evidence suggests that the pulse beneath an artery occlusion travels relatively slow compared with the speed of sound. By placing two microphones along the bicep muscle near the brachial artery under the occlusion cuff, a similar blood pressure pulse appears in the two microphones with a relative time delay. The acoustic noise, on the other hand, appears in both microphones simultaneously. The contribution of this paper is to utilize this phenomenon by filtering the microphone waveforms to create spatially narrowband information signals. With a narrowband signal, the microphone signal phasing information is adequate for distinguishing between acoustic noise and the blood pressure pulse. By choosing the microphone spacing correctly, subtraction of the two signals will enhance the information signal and cancel the noise signal. The general spacing problem is also presented.

Acoustics↗