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The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation.

Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.

Blotting, Northern↗

Cluster headache in women: evidence of hypofertility(?) Headaches in relation to menstruation and pregnancy.

Two hundred and forty-nine patients with cluster headache have been studied, 215 male and 34 female (ratio 6.3:1). Twenty-five of the 26 fertile female cluster patients stated that their headaches had no relation to menstrual periods. Eight had had 13 pregnancies since the onset of cluster headache. Six of them experienced remission of their headache during pregnancy. Four women with cluster headache had a history of infertility or premature menopause. Parity rate was low in patients who contracted cluster headache as nulliparae; it was lower than in those who contracted the disease after earlier pregnancy or post menopause, and also significantly lower than in 99 consecutive women with migraine. Significant differences were also found when the numbers of childbirths in the cluster patients were compared with total fertility rates up to successive ages for birth cohorts in the general population of Swedish women.

Adult↗

[Recurrent menstruation-associated pneumothorax--catamenial pneumothorax].

The case of a 28-year old patient with a rare complication of an extensive endometriosis externa is described. A spontaneous pneumothorax occurred on 3 occasions corresponding each time with the start of the menstrual period. The various hypotheses on the aetiology and treatment of this rare condition are reviewed. To date only 65 patients with this interesting clinical entity have been recorded.

Adult↗

[Sonographic criteria of ovarian function in menstruation cycles].

The sonographic equivalent of the morphological changes of the ovaries in the physiologic menstrual cycle is the periodic evidence of cystic or solid ovarian structures. The selection of the follicle destined for ovulation occurs from a number of many small antral follicles. The initial polymicro follicular reaction the timing of selection differentiates the follicular phase in the selection and in the maturation phase. The selection phase is the limiting temporal part of the cycle. The maturation occurs usually in a unifollicular manner. The daily growth of the dominant follicle (maturation rate) is in most cases not constant. Usually an intraindividual or inter-individual variability of the maturation rate of a mean 2.5 mm per day is present. Preovulatory a non significant delay in the maturation occurs. The sonographic prediction of ovulation is indirect and determined by the timing of selection, the size of the selected follicle, the maturation rate and the size of the preovulatory follicle. The diameter of the dominant preovulatory follicle is 23.1 +/- 2.8 mm. In individual cases solid structures in the preovulatory follicle are recognized which probably correspond to the cumulus oophorus. The corpus luteum structure is significantly larger than the preovulatory follicle with a size of 28.1 +/- 6.7 mm. Corpus luteum cysts can persist until the maturation phase of the next menstrual cycle. The shift from corpus luteum to dominant follicle of the next menstrual cycle can occur alternating between ovaries or homolaterally .

Corpus Luteum↗