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Results for “KERATOSIS”

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At least 793 records · Page 44Linked to original sources
PubMed1993

Clinical misdiagnosis of squamous cell carcinoma in situ as seborrheic keratosis. A prospective study.

BACKGROUND: Seborrheic keratoses have on rare occasion been reported to undergo malignant transformation. OBJECTIVE: Our purpose was to examine the incidence and distribution of squamous cell carcinomas (SCCs) in situ arising in clinically banal-appearing seborrheic keratoses. METHODS: We prospectively selected such cases over a 6-month period of time from routinely accessioned specimens to a dermatopathology service. RESULTS: We found 1.4% of clinically diagnosed seborrheic keratoses to be SCCs in situ. These lesions were more common in elderly persons and were more likely to occur on the head and neck, suggesting the role of cumulative sun damage in the transformation of such lesions. CONCLUSION: Malignant transformation of seborrheic keratoses, although rare, appears to occur more frequently in the elderly on the head and neck. Because this change is not necessarily accompanied by clinically discernable changes, more careful scrutiny of such lesions may be of therapeutic rather than cosmetic significance in this population.

Adult↗
PubMed2004

Melanoma within the seborrheic keratosis.

Seborrheic keratoses (SKs) are common benign nonmelanocytic epidermal tumors with characteristic clinical features, which are thought to allow a straightforward diagnosis in most situations. As a result, it is an accepted practice to destroy them without histopathologic confirmation. However, systematic reviews of histologic specimens reveal an erroneous clinical diagnosis or associated malignant tumors in a number of cases, including malignant melanomas. We describe a patient with a clinically typical-appearing SK, which was biopsied and histologically proven to be a malignant melanoma arising in the SK. Our report is a reminder that the reliability of clinical diagnosis of SKs needs to be questioned. In addition, a biopsy of SKs is not only warranted but necessary in order to identify a malignant melanoma that would otherwise be misdiagnosed or even completely missed.

Aged↗
PubMed2005

Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer.

BACKGROUND: Development of actinic keratoses (AK) involves some of the same processes as nonmelanoma skin cancer and may serve as a marker for overall increased risk of skin cancer. OBJECTIVE: The objective of this study was to examine the risk of developing skin cancer in an elderly population with and without AK. METHODS: This was a retrospective observational study. Data from the 1992-1998 Medicare Current Beneficiary Study were used in the analyses. RESULTS: Multivariate analysis showed that the risk (odds ratio [OR]) of developing nonmelanoma or melanoma was increased more than sixfold (p < or = .0001) in patients with AK. An increased risk of skin cancer was found in whites (OR 4.3; p < or = .01) and increased age by year (OR 1.04; p < or = .01). Women were less likely to develop skin cancer (OR 0.58; p < or = .01). CONCLUSION: Using data from a nationally representive sample of the Medicare population, this study demonstrates that elders with AK are a population at high risk of developing cutaneous cancer.

Aged↗
PubMed1976

Lichenoid benign keratosis.

One hundred thirty-eight patients who presented with solitary cutaneous lesions appearing clinically as papules or plaques and histologically showing a lichenoid tissue reaction were studied. Many of the lesions occurred in sites not usually exposed to sunlight and histologically the lesions did not show significant atypical change in keratinocytes and many did not show evidence of solar elastosis in the superficial corium. Our study indicates that the lesions are benign keratoses showing a lichenoid tissue reaction or lichenoid benign keratoses.

Adolescent↗
PubMed1993

Seborrheic keratosis-like lesions in epidermodysplasia verruciformis.

A light microscopic study of 6 verrucous lesions with clinical features of seborrheic keratoses (SK) occurring on sun-exposed skin of 4 patients with epidermodysplasia verruciformis (EV) was performed. We observed the typical histological findings of SK in all cases. In addition, koilocytotic effects suggestive of EV were observed in the upper prickle layer and stratum granulosum. In 2 lesions, we also noted bowenoid changes suggesting possible early malignant transformation. Immunohistochemical study confirmed the presence of HPV in these lesions.

Adult↗
PubMed2006

Acral keratosis with eosinophilic dermal deposits: a distinctive clinicopatholgic entity or colloid milium redux?

AIMS: The differential diagnosis of acral keratoses is broad. Encompassing a variety of infectious, heritable and degenerative disorders, emphasis upon the clinical setting and histologic subtlety are often required to arrive at the correct diagnosis. Herein, we report on a series of adult patients who presented with agminated or solitary papules of the distal finger found on histologic examination to contain amorphous eosinophilic deposits. RESULTS: The eosinophilic deposits were found in close proximity to the overlying epithelium and devoid of apoptotic keratinocytes, plasma cells, or vascular thickening reminiscent of amyloidosis or hyalinosis cutis. Special and immunostains yielded eosinophilic material that was elastin and Protein P negative. Despite a similar histomorphologic appearance to colloid milium, typical clinical features of this entity were not present. CONCLUSION: The etiologic significance of this condition is unknown. Potential sources of the material and a discussion of the differential diagnosis follow.

Aged↗