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At least 793 records · Page 44Linked to original sources
PubMed2005

[Management of hypertension in elderly patients with stroke].

Hypertension is the most significant risk factor for stroke. Recently, many mega-studies have been shown that antihypertensive therapy reduced the incidence of stroke not only for normal elderly but also for patients with a past history of stroke. To prevent the recurrences of stroke, tighter control of blood pressure is thought to be required than used to be. According to the recent Japanese guidelines for hypertension, desirable blood pressure should be 140/90 mmHg or less for the patients with stroke.

Aged↗
PubMed1989

[Antihypertensive therapy using metipamide VUFB].

In a group of 17 patients with mild hypertension the antihypertensive effect of Metipamide VUFB was investigated. In the course of fourteen weeks' treatment the mean blood pressure declined from 20.5/13.3 kPa to 17.3/11.2 kPa and at the end of the investigation the diastolic blood pressure readings were normal in all patients. Echocardiography revealed a slight decline of the total peripheral resistance. The natriuretic effect was confirmed which is in the foreground of the antihypertensive action of metipamide. Investigation of side-effects of treatment revealed in 12 patients hypokaliaemia calling for substitution treatment, or when used clinically, a combination with a potassium sparing diuretic. There was a rise of the AST and ALT activity. The renal function did not change. The clinically significant drop of serum uric acid was striking. Glucose tolerance and serum lipids were not affected.

Adult↗
PubMed1989

[The effect of metipamide on levels of sodium and potassium in erythrocytes].

The effect of metipamide on the level of Na+ and K+ in erythrocytes was studied in patients with essential hypertension. The control series consisted of healthy normotonics. In normotonics Nai+ and Ki+ were not affected in vitro, whereas in hypertonics Nai+ was found to be significantly increased (p less than 0.01) and Ki+ decreased (p less than 0.025). In vivo two subgroups of hypertonics were established: a) hypertonics with normal content of Nai+ (6.9 +/- 0.3.10(-3) mol/l) and b) hypertonics with increased content of Nai+ (9.2 +/- 0.3.10(-3) mol/l compared to 7.3 +/- 0.1.10(-3) mol/l, p less than 0.005). With respect to the given heterogeneity of the series, the response to metipamide treatment failed to be uniform. A part of the patients responded to therapy by diminished Nai+, manifesting one of the potential mechanisms of the antihypertensive effect of metipamide. The significant drop of Ki+ recorded in both subgroups of patients in the course of treatment demonstrated the potassium depleting effect of the drug.

Adult↗
PubMedDate not supplied

[New hypotensive drugs].

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Angiotensin-Converting Enzyme Inhibitors↗