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Results for “Histocompatibility Testing”

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At least 793 records · Page 44Linked to original sources
PubMed1990

[The HLA crossmatching test before thrombocyte transfusion. Comparison of 3 methods].

Weak accessory HLA antibodies in HLA sera were assessed by three test--the microlymphocytotoxic, antiglobulin cytotoxic and fluorescent cytotoxic test. Most frequently they were detected by the antiglobulin cytotoxic test (69.64%), followed by the fluorescent cytotoxic test (55.73%) and least frequently by the microlymphocytotoxic test (45.77%). From the results ensues that the antiglobulin cytotoxic test is a suitable method of crossmatch before thrombocyte transfusions to patients who developed reactions after transfusions or where therapy failed although the crossmatch was performed by the microlymphocytotoxic test between the donor's lymphocytes and the patient's serum and the test was negative.

Blood Transfusion↗
PubMed1977

HLA typing of leukemic cells and lymphoblastoid cell lines: effects of non-HLA antibodies in common typing sera.

Several laboratories have recently observed that common HLA typing sera contain antibodies to various nonHLA antigens, including leukemia-associated antigens and normal platelet, granulocyte, or B-lymphocyte-specific alloantigens. In order to study the possible effects of these antibodies on HLA typing data in leukemia, several of these sera were adsorbed with HLA typed platelets, purified B-lymphocytes, cultured lymphoblasts, or mononuclear cells from patients with active leukemia of various types, and retested for residual activity against previously reacting cells. The results indicate that many of the reactions of leukemia cells to HLA typing sera represent reactions to nonHLA antibodies, many of which are directed against antigens common to cultured lymphoblasts, leukemia cells of several types, and normal B-cells. In the absence of family studies or prior serum adsorption, caution should be used in interpretation of all data related to HLA antigens in leukemia.

Antibodies↗
PubMed1989

[Cross-reactivity of HLA antigens of the donor and patient--a cause of unsuccessful thrombocyte transfusion in patients with HLA antibodies].

In the microlymphocytotoxic test, specific HLA sera reacted positively with 74.74% of 99 examined samples of lymphocytes which failed to have corresponding HLA antigens yet contained HLA antigens cross-reacting with the given HLA antibody. In the serum of some patients HLA antibodies were established against HLA antigens cross-reacting with the antigens of the patient. The results show that it is not suitable to select thrombocyte and leukocyte donors on the basis of cross-reacting antigens. Therapy of patients with HLA antibodies may be clinically unsuccessful and even result in posttransfusion reaction. Patients who do not have HLA antibodies may develop them.

Antilymphocyte Serum↗
PubMed1988

Studies on recombination within the mouse H-2 complex: IV. Characterization of new recombinant haplotypes H-2t7, H-2t8, H-2as2, and H-2as3.

Four new intra-H-2 recombinants were characterized serologically and functionally. In two of these recombinants, B10.ASR1 and B10.ASR7, crossing over occurred between the A alpha and E alpha subregions, very probably in E beta since most intra-I region recombinants thus far investigated at the DNA level appear to involve recombination within the E beta gene. In the other two recombinants, B10.ASR2 and B10.ARS8, crossing over occurred between the S and D subregions. B10.ASR2 and B10.ASR8, crossing over occurred between the S and D subregions. B10.ASR7, which is serologically indistinguishable from B10.BASR1 and B10.S(8R), slightly stimulates and strongly responds to both of these strains in MLR. The probable location of the B10.S(8R) stimulatory product is E beta. The H-2 composition of B10.ASR1 is closest to that of B10.S(9R) and B10.HTT; therefore, precise definition of the cross-over point at the DNA level will be of particular interest.

Animals↗
PubMed1977

Positive cross-match for B-lymphocyte antigens (IA like) and kidney allograft behaviour.

We describe six cases of kidney graft performed against a positive anti-B lymphocyte cross-match. These antibodies were found after retrospective and systematic screening of the effect of the recipient sera upon donor frozen B lymphocytes. As opposed to the consequences of anti-HLA "SD" preimmunisation, none of the transplantation rapported here failed by acute rejection. The benefic role of anti-B lymphocyte antibodies "Ia like" present at the time of grafting is then suggested.

Antibodies↗