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Influence of physical fitness in determining the impact of stressful life events on physical and psychologic health.

To determine whether physical fitness (aerobic capacity) moderated the relationship between stressful life events and subsequent illness, 112 subjects first reported their life changes (stress) for the preceeding 12 months and then had their fitness assessed with a submaximal bicycle ergometer test. For the next 9 weeks, the subjects kept records concerning their physical health (e.g., ailments, doctor visits, medication usage), and at the end of that period they completed forms that measured psychologic symptoms (e.g., depression, anxiety, alienation). Multiple regression analyses revealed that a high level of life stress during the preceding year was related to poorer subsequent physical health for subjects with a low level of fitness in particular. Life stress was found to have little impact on the subsequent physical health of fit subjects. Similar results were found for depression. These results indicate that fitness does moderate the stress-illness relationship and suggest that increasing fitness may be a way of diminishing the effects of unavoidable stress.

Adolescent↗

Experimental manipulation of aerobic fitness and the response to psychosocial stress: heart rate and self-report measures.

To determine whether aerobic fitness training alters response to psychosocial stress, 38 males were randomly assigned to either aerobic, anaerobic (weight-lifting), or waiting-list control groups. Experimental groups met three to four times per week in 1-hr sessions aimed at improving either cardiovascular endurance or muscular strength. Aerobic fitness level, heart rate and subjective response to laboratory psychosocial stress, and self-reports of daily stress, coping resources and psychologic symptoms were assessed prior to and following 10 weeks of training. Although posttraining fitness measures confirmed the effectiveness of aerobic training, no group differences were seen on laboratory or self-report measures. However, for aerobic trainers alone, fitness improvement tended to correlate with faster heart rate recovery following psychosocial stress. Fitness improvement was not correlated with any other psychologic changes. This experiment provides only modest support for the hypothesis that aerobic training alters response to psychosocial stress. It is suggested that future work on the psychologic effects of aerobic fitness explore the contribution of training parameters as well as subject characteristics.

Adult↗

Physical fitness capacity and absenteeism of police officers.

Police officers (n = 514) were studied to determine the relationship between physical fitness capacity and annual absenteeism rate. Hierarchical regression analyses revealed that for officers aged 34 years and younger, only 5% of the variability in absenteeism could be accounted for by age, sex, and physical fitness variables. For officers 35 years old and older, 7% of the variability was explained by these variables, and a bicycle ergometer score was a significant predictor of absenteeism. Each individual test and an overall physical fitness score were classified into five levels. ANOVAs revealed no significant differences between overall fitness levels and absenteeism. However, men 35 and over who were most fit on the bicycle ergometer test had fewer absences, and women 34 and under who were thinnest had more absences. In conclusion, at least among police officers, the extent to which physical fitness capacity can predict absenteeism is low.

Absenteeism↗

Associations between estimated aerobic fitness and cardiovascular risk factors in adults with different levels of abdominal obesity.

BACKGROUND: We investigated the association between estimated aerobic fitness and cardiovascular risk factors, and how the association is affected by abdominal obesity. DESIGN: Cross-sectional population study. METHODS: Participants comprised 3820 adults aged 25 to 64 years from the FINRISK 2002 Study in Finland. Aerobic fitness was estimated using a non-exercise test. Waist-to-hip ratio (WHR), blood pressure, total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, HDL-C to total cholesterol ratio, and gamma-glutamyl transferase (GGT) levels were measured by standardized methods. RESULTS: After controlling for age, smoking and alcohol consumption, aerobic fitness was inversely associated with systolic (P=0.027) and diastolic (P<0.001) blood pressure, total cholesterol (P=0.009), triglycerides (P=0.001), and GGT (P<0.001), and directly associated with HDL-C (P<0.001) and HDL-C to total cholesterol ratio (P<0.001) in men. In women, inverse associations were found for diastolic blood pressure (P=0.027) and triglycerides (P<0.001), and direct association for HDL-C (P<0.001) and HDL-C to total cholesterol ratio (P<0.001). Waist-to-hip ratio was independently associated with a better risk factor profile in both sexes. Interactions were found between fitness and WHR in relation to total cholesterol (P=0.001), HDL-C to total cholesterol ratio (P=0.005), triglycerides (P=0.001), and systolic (P=0.009) and diastolic (P<0.001) blood pressure among men only. CONCLUSIONS: Our data suggest that good estimated aerobic fitness is associated with a better cardiovascular risk factor profile, regardless of the level of abdominal obesity in Finnish men and women. Men in the highest WHR third seem to have more benefit of aerobic fitness on their cardiovascular risk levels than men with lower WHR.

Adult↗

Association between back pain and physical fitness in adolescents.

STUDY DESIGN: A cross-sectional study of 9413 adolescents. OBJECTIVES: To study the associations between back pain, physical activity, and physical fitness. SUMMARY OF BACKGROUND DATA: A high physical fitness level, and especially muscle endurance in the back muscles, is associated with lower risk of back pain, but little is known about other types of physical fitness and back pain in adolescents. METHODS: A cross-sectional study of 3956 boys and 5457 girls 17 years of age. The associations between self-reported back pain and different types of physical fitness and self-reported physical activity were analyzed in high schoolchildren in Denmark. RESULTS: Back pain was reported by 43% of the girls and 37% of the boys. Back pain was associated with low isometric muscle endurance in the back extensors, and the highest quartile had a lower risk of back pain (odds ratio = 0.71; 95% confidence interval, 0.62-0.82) within the last month. No associations were found to aerobic fitness, functional strength, flexibility, or physical activity level after adjustment for muscle endurance. More girls than boys experienced back pain, and it was more common in taller adolescents. CONCLUSION: Children with high isometric muscle endurance were less likely to report back pain. No other measures of physical fitness or level of self-reported physical activity were linked to back pain reporting.

Adolescent↗

Empirical versus trial set fitting systems for accelerated orthokeratology.

PURPOSE: To compare the short-term clinical performance of two reverse-geometry rigid contact lens systems for accelerated orthokeratology with different fitting approaches and designs: an experimental lens that was fitted empirically (No. 7 Contact Lens Laboratory, Ltd.) and a more established lens using a trial set system, the BE lens (NKL). METHODS: Twenty-four subjects were enrolled in a clinical study in which the two reverse-geometry lenses were worn contralaterally for seven nights. The No. 7 lens was manufactured based on subject keratometric readings, refraction, and horizontal visible iris diameter. The BE lens was fitted in accordance with fitting guidelines provided by the manufacturer and included the use of proprietary computer software in addition to an overnight trial before lens ordering. Data were collected at baseline, day 1, and day 7 (morning and afternoon). Unaided visual acuity, best-corrected visual acuity, subjective refraction, corneal topography, biomicroscopy (corneal staining), and subjective reaction were recorded at each visit. RESULTS: Nine subjects (18 eyes) completed the study. All eyes fitted with the No. 7 lens and 67% of the eyes fitted with the BE lens were within +/-1.00 diopter of the attempted correction after seven nights of lens wear. There was more myopic reduction (F = 16.2, P=0.0002), better unaided high-contrast visual acuity (F = 8.7, P=0.005) and low-contrast visual acuity (F = 9.5, P=0.003), and more change in corneal numerical eccentricity (F = 8.6, P=0.005) with the BE lens than with the No. 7 lens. There were no significant differences between the lenses for best-corrected visual acuity, change in apical radius, corneal staining, and subjective reaction. DISCUSSION: Both lens types investigated in this study were effective in temporarily reducing myopia and in providing good unaided visual acuity during the day (without lenses) in subjects with low levels of myopia. Subjective reaction showed that the lenses were perceived as being equally effective, but clinical data showed that the BE lens effected more myopic reduction and better unaided visual acuity than did the No. 7 lens during the 7-day period investigated.

Adult↗

Depressive mood symptoms and fatigue after exercise withdrawal: the potential role of decreased fitness.

OBJECTIVE: Depressive symptomatology is more prevalent among sedentary than physically active individuals. The present prospective study examines whether withdrawal of regular aerobic activity provokes depressive mood symptoms and fatigue, and to what extent reductions in fitness levels contribute to the development of these symptoms. METHODS: Forty participants (mean age of 31.3 +/- 7.5 years, 55% women) who exercised regularly (> or = 30 minutes aerobic exercise > or = 3 times/week) were randomized to aerobic exercise withdrawal (n = 20) or to continue regular exercise (n = 20) for 2 weeks. Protocol adherence was documented using ambulatory actigraphy. Negative mood was measured with the Profile of Mood States (POMS), depressive symptoms with the Beck Depression Inventory-II (somatic and cognitive-affective components), and fatigue with the Multidimensional Fatigue Inventory (MFI). Fitness levels were documented by cycle ergometry testing. RESULTS: Fatigue and somatic depressive symptoms emerged after 1 week of exercise withdrawal (p = .05) and subsequently predicted the development of cognitive-affective depressive symptoms at 2 weeks (beta = 0.62; p = .046). Exercise withdrawal also resulted in increased negative mood (POMS; p < or = .01), and this increase was correlated with decreases in fitness level (r = -0.36, p = .03). Decreased fitness was related to increased POMS fatigue (p = .003) when statistically adjusting for baseline fitness levels and group condition. CONCLUSION: Depressed mood and fatigue are commonly observed in individuals deprived of usual exercise activities, and the increase in fatigue may be partially mediated by reduced fitness levels. These findings may explain mood changes in response to short-term exercise withdrawal such as injuries and recovery from medical procedures that do not require full bedrest.

Adult↗

Doping in fitness sports: estimated number of unreported cases and individual probability of doping.

AIMS: Recent studies have suggested that the use of doping substances and particularly of anabolic androgenic steroids (AAS) is often practised by fitness centre visitors. These studies employed direct interview techniques and questionnaires to assess the estimated number of unreported cases of doping. Because people hesitate to provide compromising information about themselves, these techniques are subject to response errors. In this study we applied an alternative interview technique to assess more accurately unreported cases of doping in fitness centres. DESIGN AND PARTICIPANTS: The present investigation employed the randomized response technique (RRT) to reduce response errors. A cohort of 500 people from 49 fitness centres participated in this study. FINDING: The RRT revealed a high prevalence of doping (12.5%). In addition, and most importantly, the present RRT study revealed an alarmingly high prevalence of illicit drug use, specifically of cocaine use, that has been severely underestimated by previous studies. CONCLUSIONS: The RRT confirmed previously estimated rates of AAS use assessed by direct interview techniques and voluntary questionnaires, but uncovered a much higher usage rate of illicit drugs among fitness centre visitors. This outcome enabled us to construct a 'probability' rating for the use of doping substances in fitness centre visitors. Given its high prevalence and the predominant use of AAS, doping among fitness centre visitors is an issue of extreme relevance for the health care system. Our study may help to characterize further doping substance users and to develop and apply prevention and intervention programmes specifically to individuals at high risk.

Adult↗

Social structure and intracohort variation in physical fitness among elderly males in a traditional Third World society.

This paper examines the relationship between physical fitness and activity among elderly males in the traditional rural community of Chetbesi, Nepal. It takes advantage of the unique character of the Hindu caste system to implement a quasiexperimental research design that approximates random assignment to high and low activity levels. The members of the Sarki caste have lower heart rates and systolic blood pressure, relative to other castes, at each of three submaximal workloads and during recovery from bicycle ergometer exercise. Direct observation and physiologic monitoring show that the Sarkis engage in more frequent and extended periods of heavy labor. Thus intracohort variation in physical fitness and activity patterns among the Chetbesi elderly is a function of birth into a socially defined group rather than of self-selection. This pattern of differential fitness may typify the process of aging in many stratified traditional and modernizing societies where socially delimited segments of the population perform the bulk of the hard work. Intrapopulation differences aside, comparison of Sarkis and non-Sarkis with other samples reveals that both lie within the reported range of variation. The rural, unmechanized, agricultural lifestyle and mountain environment of Chetbesi do not result in exceptional fitness for residents. The Chetbesi data suggest that the popular notion that aging is less debilitating in traditional agrarian societies located in rugged mountain terrains may be a myth. The demonstration of the influence of social forces on physical fitness suggests that future research might concentrate profitably on identifying social structures that produce high levels of physical fitness.

Aged↗

Effects of fitness test type, teacher, and gender on exercise intrinsic motivation and physical self-worth.

This study compared effects on exercise intrinsic motivation and physical self-worth of taking either the President's Challenge or the Fitnessgram fitness test battery. Three teachers administered the battery to seventh and eighth grade students (N = 370). The only significant effect involving fitness test type on intrinsic motivation was a test-teacher-gender interaction on the interest-enjoyment subscale of the Intrinsic Motivation Inventory (IMI). Main effects occurred for gender on intrinsic motivation and physical self-worth (PSW). Finally, using a Fitness Level x Gender x Fitness Test Type design, a main effect occurred for fitness level on all four IMI subscales, and also on PSW. While results supported the construct validity of IMI and PSW scales, they did not support the theory-based premise that fitness test batteries would produce different motivational and self-perception outcomes. Results are discussed with reference to the limitations and delimitations of the field-based study.

Adolescent↗

Interrelationships among food intake, somatic traits, and physical fitness in 10.5- to 15.5-year old children from Eastern Poland.

The aim of the study was to establish the relationships between energy intake and dietary quality with somatic variables and physical fitness. Energy intake and nutrition quality were assessed from 24-hr dietary recall questionnaires, and physical fitness was measured by applying the EIROFIT tests. Interrelationships between all those variables (simple, partial, and multiple correlation coefficients) were computed from standardized values. The somatic and physical fitness variables related more strongly on the nutrition quality than on the energy intake. Well-nourished children were taller, heavier, and more physically fit than the poorly nourished ones. We believe that dietary quality affected physical fitness indirectly by influencing somatic development. Energy intake did not contribute significantly to the total variance of the physical fitness factor.

Adolescent↗

Repeated emergence and fitness heterogeneity of KPC-33 in ST11 Klebsiella pneumoniae under ceftazidime-avibactam pressure.

Ceftazidime-avibactam (CZA) is an important therapeutic option for infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae. However, CZA exposure also selects for emergent KPC variants. Their in vivo evolutionary patterns, fitness consequences, and underlying molecular mechanisms remain unclear. We performed a longitudinal multiomics analysis of 35 clonally related ST11 KPC-producing K. pneumoniae isolates collected from eight hospitalized patients during clinical follow-up, most of whom had received CZA therapy. Whole-genome sequencing, antimicrobial susceptibility testing, in vitro competition assays, enzyme kinetic analysis, and transcriptomic sequencing were used to systematically characterize the within-host evolutionary dynamics of KPC variants and the fitness heterogeneity of KPC-33. Multiple KPC variants were identified during longitudinal follow-up, among which KPC-33 was the most frequently detected. Among the seven patients who received CZA treatment, KPC-33 was detected in longitudinal isolates from four patients. It was also identified in patient P3, who had not received CZA, whereas other variants were only sporadically identified. Biochemical analysis showed that KPC-33 exhibited an altered kinetic profile relative to KPC-2, characterized by reduced catalytic turnover and altered substrate affinity. KPC-33 did not exhibit a uniform and pronounced fitness defect but instead showed marked strain-dependent heterogeneity. Strains with higher competitive fitness generally showed only limited transcriptional changes, whereas those with lower fitness were accompanied by broader transcriptional remodeling. In this longitudinal cohort, KPC-33 was repeatedly detected, predominantly under CZA-associated selective conditions. Its fitness consequences were clearly strain background dependent and may be associated with the extent of transcriptional remodeling. These findings provide new evidence for understanding the in vivo evolution of CZA resistance.

KPC-33↗

Fitness and health measurement in air crew.

To fulfil the various tasks and roles efficiently in the Royal Air Force good health is implicit but 'fitness' is not so specifically defined. Fitness relates to a task; it does not describe a state of health. Using a system of submaximal measurement of oxygen uptake (VO2), skinfold thickness, weight and health parameters involving an actuarial scaled questionnaire and blood pressure measurement, a fitness profile was developed evaluating health and fitness. The physiologic characteristics of eighty-two aircrew, 90% fast-jet, fixed-wing and 10% rotary wing employed in search and rescue duties, were investigated in evaluating and developing the fitness profile. The results suggest that individual strengths and weaknesses can be identified simply and economically in a framework of physically educating the individual and also where necessary motivating him to make minor lifestyle modifications, the objective being to ensure his health compatible with his task fitness.

Adipose Tissue↗

Long term effects of smoking on physical fitness and lung function: a longitudinal study of 1393 middle aged Norwegian men for seven years.

OBJECTIVE: To study association between smoking habits and long term decline in physical fitness and lung function in middle aged men who remained healthy. DESIGN: Baseline and follow up measurements performed during 1972-5 and 1980-2 respectively. SETTING: National University Hospital of Oslo, Norway. SUBJECTS: 1393 men aged 40-59 at baseline who were all healthy at baseline and at follow up. MAIN OUTCOME MEASURES: Forced expiratory volume in one second and physical fitness (defined as total work done during a symptom limited bicycle ergometer test divided by body weight. RESULTS: Initial fitness was substantially lower among 347 persistent smokers than among 791 persistent non-smokers (1349 J/kg v 1618 J/kg), as was initial forced expiratory volume (3341 ml v 3638 ml). Mean (95% confidence interval) decline in fitness over 7.2 years was 217 (185 to 249) J/kg among smokers compared with 86 (59 to 113) J/kg among non-smokers (P < 0.001). Corresponding declines in forced expiratory volume were 271 (226 to 316) ml in smokers and 116 (85 to 147) ml in non-smokers (P < 0.001). Differences between smokers and non-smokers remained practically unchanged after adjustment for age and level of physical activity. Changes in fitness and forced expiratory volume among 199 men who had stopped smoking mimicked the findings for persistent non-smokers, and 56 men who started smoking presented findings close to those of persistent smokers. CONCLUSION: Decline in physical fitness and lung function among healthy middle aged men was considerably greater among smokers than among non-smokers and could not be explained by differences in age and physical activity.

Adult↗

Health implications of musculoskeletal fitness.

Although it is well documented that physical activity participation can bring about improvements in musculoskeletal fitness, related health implications have only been substantiated in the elderly. Currently, interpretations of the results of musculoskeletal fitness appraisals for the general population are based largely on an intuitive belief that enhanced musculoskeletal fitness is associated with higher levels of health throughout adulthood. Musculoskeletal fitness was measured in 312 females and 259 males aged 15-69 years. Health levels were determined using two previously validated questionnaires and expressed as composite health scores derived from principal components analysis. Grip strength, push strength, pull strength, push-ups, and trunk forward flexion were significant predictors of health scores after controlling for the potentially confounding effects of gender age, aerobic fitness, waist circumference, and smoking status. These findings indicate that musculoskeletal fitness is related to health in males and females aged 15 to 69 years.

Adolescent↗

Supervision of occupational fitness assessments.

Controversy continues regarding an appropriate level of supervision for occupational fitness assessments. A bout of vigorous physical activity can augment the immediate risk of a cardiac catastrophe by a factor of 5-100 depending on age, cardiac risk factors, and the physical and emotional circumstances of the participant. However, if a person engages regularly in such activity, the immediate risk is more than offset by an improvement in prognosis during intervening periods of rest. During demanding physical work, there is a small but measurable risk of sudden death (3 to 7 episodes per 100,000 personnel per year). The risk associated with a brief (< 15 min) but vigorous occupational fitness assessment is so low as to preclude attempts to reduce it still further by direct medical supervision. If testing encourages an increase in personal fitness, any immediate increase in risk is enormously offset by a reduction in the number of cardiac deaths while resting. Furthermore, evidence is unconvincing that the average medical practitioner can prevent or treat any emergencies that may arise better than a well-trained professional fitness and lifestyle consultant (PFLC), a person certified by the Canadian Society for Exercise Physiology who has had frequent opportunities to practice the necessary skills. Since occupational fitness assessments are not diagnostic procedures, they appear to fall outside the jurisdiction of medical licensing bodies. In the absence of a history of cardiovascular disease, supervision of such assessments is safely and appropriately undertaken by the PFLC. Unnecessary insistence on medical supervision could preclude annual evaluation of occupational fitness and a resulting enhancement of physical condition, thus increasing rather than diminishing the risk to the worker.

Cardiopulmonary Resuscitation↗

Carotid baroreflex responsiveness in high-fit and sedentary young men.

The influence of fitness on cardiac vagal activity and baroreflex-mediated control of heart rate has not been clearly established in humans. Therefore, we studied resting cardiac vagal activity by evaluating respiratory sinus arrhythmia (RSA) and examined carotid-cardiac baroreflex responsiveness with a neck collar in 11 high-fit and 9 sedentary [based on maximal O2 consumption (VO2max) and history of physical activity] healthy young men (19-31 yr of age). Resting cardiac vagal activity was determined from the standard deviation of 100 consecutive resting R-R intervals. Baroreflex responsiveness was determined from the R-R interval responses to neck suction and pressure (repeated trials of 5-s stimuli of -20, -40, and 35 mmHg). Both RSA and the bradycardic (R-R interval) responses to neck suction of -40 mmHg were significantly greater (P less than 0.05) in the high-fit individuals (RSA, 116.5 +/- 11.5 ms; neck-suction response, 145.3 +/- 17.0 ms; mean +/- SE) compared with sedentary subjects (RSA, 65.2 +/- 6.6 ms; neck-suction response, 86.9 +/- 12.5 ms). Responses of the high-fit volunteers to the other intensities of neck stimuli (-20 and 35 mmHg) showed a similar trend but were not significantly different from those of the sedentary volunteers. The baroreflex slope derived from these data was significantly greater in the high-fit subjects (4.00 +/- 0.39 ms/mmHg) compared with the sedentary controls (2.53 +/- 0.28 ms/mmHg). These data suggest that resting cardiac vagal activity is greater, carotid-to-cardiac activity is well maintained, and baroreflex sensitivity, i.e., slope, is augmented in high-fit subjects.

Adult↗

Influence of aerobic fitness and body fatness on tolerance to uncompensable heat stress.

This study examined the independent and combined importance of aerobic fitness and body fatness on physiological tolerance and exercise time during weight-bearing exercise while wearing a semipermeable protective ensemble. Twenty-four men and women were matched for aerobic fitness and body fatness in one of four groups (4 men and 2 women in each group). Aerobic fitness was expressed per kilogram of lean body mass (LBM) to eliminate the influence of body fatness on the expression of fitness. Subjects were defined as trained (T; regularly active with a peak aerobic power of 65 ml x kg LBM(-1) x min(-1)) or untrained (UT; sedentary with a peak aerobic power of 53 ml x kg LBM(-1) x min(-1)) with high (High; 20%) or low (Low; 11%) body fatness. Subjects exercised until exhaustion or until rectal temperature reached 39.5 degrees C or heart rate reached 95% of maximum. Exercise times were significantly greater in T(Low) (116 +/- 6.5 min) compared with their matched sedentary (UT(Low); 70 +/- 3.6 min) or fatness (T(High); 82 +/- 3.9 min) counterparts, indicating an advantage for both a high aerobic fitness and low body fatness. However, similar effects were not evident between T(High) and UT(High) (74 +/- 4.1 min) or between the UT groups (UT(Low) and UT(High)). The major advantage attributed to a higher aerobic fitness was the ability to tolerate a higher core temperature at exhaustion (the difference being as great as 0.9 degrees C), whereas both body fatness and rate of heat storage affected the exercise time as independent factors.

Adult↗