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PubMedDate not supplied

Fibroma of tendon sheath originating from the knee joint capsule.

We present a rare case of fibroma of the tendon sheath originating from the posterior joint capsule of the knee in a 50-year-old man. Magnetic resonance (MR) imaging revealed a lesion posterior to the medial femoral condyle. The lesion showed hypointensity on all T1-weighted, T2-weighted, short tau inversion recovery (STIR), and contrast-enhanced T1-weighted images. Plain computed tomographic (CT) scans showed a lesion with isodensity to muscle. The lesion showed no enhancement on postcontrast CT scans.

Fibroma↗
PubMed1987

Multiple cemento-ossifying fibroma.

This report concerns a case of multiple cemento-ossifying fibroma involving the maxilla and mandible of a 55-year-old Japanese male. The clinical, radiographic and histopathological findings are presented and discussed.

Fibroma↗
PubMed1988

Central odontogenic fibroma.

An example of a central odontogenic fibroma is presented. This is a rare, benign neoplasm which affected the molar region of the left side of the mandible of a 63-year-old female Caucasian. Histologically, it consisted of fibroblast-like cells lying in a rather myxomatous delicate collagenous stroma. Few islands of odontogenic epithelium were also found. At the ultrastructural level, the tumour cells contained large numbers of fine filaments with focal densities similar to those described in smooth muscle cells. They also showed a moderately developed r ER. These features are consistent with cells referred to as myofibroblasts.

Calcinosis↗
PubMed1990

Juvenile ossifying fibroma. Report of four cases.

The present investigation concerns 4 patients with juvenile ossifying fibroma (JOF) whose data are analyzed together with 30 cases from the literature. The tumour mainly occurs in juveniles, 79% of the patients being 15 years or younger. Radiologically as well as at surgery, the lesion is demarcated from its surroundings. Histologically, JOF is unique in showing a loose-fibroblastic stroma that contains garland-like strands of osteoid with entrapped osteoblasts, the latter feature not being observed in other fibro-osseous lesions. JOF responds very well to conservative treatment that provided permanent cure in all cases with adequate follow-up data.

Child↗
PubMed2001

Vascular complications associated with a large cardiac fibroma.

A case is reported of a 30-year-old patient with an intrapericardial tumour with heart failure. After the diagnostic protocol, surgery was performed initially without extra-corporeal circulation (ECC). Due to the location, size and to the large connection with the most important vascular structures, the ascending aorta ruptured accidentally during resection and was replaced after using ECC in emergency. The post-surgical course was regular and the tumour was identified histologically as a fibroma.

Adult↗
PubMedDate not supplied

Pathology of the heart and conduction system in a case of sudden death due to a cardiac fibroma in a 6-month-old child.

A 6-month-old female infant considered to be in good health died suddenly and unexpectedly. Post-mortem examination was requested, with clinical diagnosis of sudden infant death syndrome. Gross examination revealed, however, the presence of a cardiac mass 4.5 X 4 x 3.5 cm in diameter. Histological examination of the heart confirmed the presence of a cardiac fibroma. In the present case, the sudden death could have been due to the left ventricular outflow obstruction, as much as to conductive disturbances caused by overstretching and compression of the atrioventricular node and of the bundle branches. Hemodynamic and conductive abnormalities are presumed to have provoked bradycardia degenerating into ventricular fibrillation and sudden death. Necroscopy studies of sudden death should always include histological examination of the cardiac conduction system but seldom do.

Female↗
PubMed1997

Desmoplastic fibroma of the mandible in a child: report of a case.

A 6-year-old girl was seen with a history of progressive trismus and expansion of the right mandible over a 9-month period. Desmoplastic fibroma was diagnosed on biopsy. This report reviews the diagnostic criteria and surgical management of this uncommon primary bone tumor of the maxillofacial region.

Biopsy↗
PubMed2000

Collagenous fibroma (desmoplastic fibroblastoma): a unique presentation as a goiter in an 88-year-old man.

Collagenous fibroma (desmoplastic fibroblastoma) is a recently described entity in the medical literature. This entity has been reported in various locations, including the upper extremities, posterior neck, upper back, lower extremities, abdominal wall, and hip. We report an interesting case of an 88-year-old man who presented with an apparent goiter involving the right anterolateral neck. Histologic studies revealed a well-circumscribed, paucicellular lesion composed of stellate and spindle-shaped fibroblasts separated by bundles of collagen. No mitotic figures, necrosis, or calcification was observed. The stellate and spindle-shaped cells were positive for vimentin and focally positive for desmin, indicating myofibroblastic differentiation. Our case exemplifies the diagnostic difficulties that these tumors may pose from the clinical and radiologic standpoint when they clinically present as a goiter.

Aged↗
PubMed2002

Establishment of human cementifying fibroma cell lines by transfection with temperature-sensitive simian virus-40 T-antigen gene and hTERT gene.

Human cementifying fibroma (HCF) is a benign fibro-osseous neoplasm of periodontal ligament (PDL) origin containing varying amounts of mineralized material resembling cementum. In the present study, we established cell lines from HCF, which were detected in the mandible of a 54-year-old Japanese man. To obtain immortalized cell clones, we undertook transfection with temperature-sensitive simian virus-40 (SV40) T-antigen and hTERT into HCF cells. Cells transfected with SV40 T-antigen entered "crisis" state between passages 22 and 35, but activation of telomerase by transfection with hTERT in the SV40-transformed HCF cells resulted in bypass of the crisis and maintenance over passage 200. HCF cell lines decreased the expression of SV40 T-antigen and the activity of cell proliferation at a nonpermissive temperature (39 degrees C) in comparison with that at a permissive temperature (33 degrees C). High activities of alkaline phosphatase and mineralization and the expression of type I collagen, osteocalcin, osteopontin, and bone sialoprotein by reverse transcription-polymerase chain reaction (RT-PCR) were observed in HCF cells at 39 degrees C. Overall, these findings suggest that: (i) HCF cell lines may represent a novel in vitro human cell model for the study of the regulatory mechanism of differentiation and proliferation of the human PDL; and (ii) transfection of plasmids encoding the temperature-sensitive SV40 T-antigen gene and hTERT gene may be useful for obtaining immortalized cell lines from benign human tumor and, probably, nonneoplastic human tissues.

Alkaline Phosphatase↗
PubMed1975

Combined approach for massive nasopharyngeal fibroma.

A combined approach by the transpalatal and transmaxillary routes has proved to be a better technique for total surgical extirpation of extensive nasopharyngeal fibroma, and it has been used already in seven cases without recurrence over a period of three years. The transmaxillary route includes removal of the middle one-third of the maxilla, i.e. the lateral, medial and posterior walls of the maxilla with the inferior turbinate bone.

Adolescent↗
PubMed1981

Pathogenesis of juvenile nasopharyngeal fibroma. (A new concept).

Fifteen cases of juvenile nasopharyngeal fibromata have been studied clinically and histologically, and their structure has been compared to that of genital erectile tissue obtained from autopsies of foetuses and children. A similarity in the structure of these two tissue could be observed. A concept of juvenile nasopharyngeal fibroma as arising from misplaced sequestrated genital erectile tissue during foetal development, is discussed; and support is given to this view by anatomical, clinical and histological data.

Adolescent↗
PubMed1997

Cemento-ossifying fibroma of the petromastoid region: case report and review of the literature.

The cemento-ossifying fibroma (COF) is a mesodermal, non-odontogenic tumour of ectopic multipotential periodontal membrane blast cells. It is aggressive, locally destructive, and has a high recurrence rate. A case report of COF of the petromastoid region is presented. This location has not been described until now. Trauma may act as a trigger to sudden growth of the atopic periodontal tissue. Due to the aggressive behaviour of this tumour and its frequent recurrence radical surgery is needed.

Adult↗
PubMed2002

Ameloblastomatoid, central odontogenic fibroma: an epithelium-rich variant.

Two cases are presented of a central odontogenic fibroma (OF) in the mandible of a middle-aged female, which posed considerable difficulty in microscopic diagnosis. These well-demarcated but non-encapsulated intraosseous tumors had hybrid features of both OF and ameloblastoma. Their clinical findings are more in keeping with the putative OF rather than ameloblastoma. The present lesions alert pathologists to this unusual type of central OF in order to avoid misdiagnosis.

Adult↗
PubMed1998

Cemento-ossifying fibromas in the jaws of Hong Kong Chinese.

OBJECTIVE: To determine the clinical and radiological features of cemento-ossifying fibroma (COF) in a Chinese population. METHODS: Twenty cases of COF found in Chinese patients for whom the clinical notes, radiographs and histopathology reports were available, were reviewed to determine their clinical and radiological features. Overall size was measured digitally from the radiographs. RESULTS: All COFs occurred in females and most frequently in the third and fourth decades. Seventeen COFs were in the mandible and three in the maxilla. Eighteen COFs had well-defined margins and were round or avoid in shape. Four were radiolucent and 15 mixed density. COFs tended to be smaller in women in their early to middle-40s and larger in older women. CONCLUSIONS: The clinical and radiological features of this Chinese series were broadly consistent with those of non-Chinese populations reported previously. The principal difference was that all 20 patients were female.

Adult↗
PubMed1998

Juvenile ossifying fibroma of the mandible. An 8 year radiological follow-up.

An 8-year follow-up of a juvenile ossifying fibroma in the left mandible of a 4-year-old boy is presented. The case demonstrated initial lack of radiological evidence of demarcation and subsequent eccentric enlargement, selective tooth displacement and a multilocular appearance in areas of active growth. An aneurysmal bone cyst and a decrease in the bone content was present in the excision specimen.

Child, Preschool↗
PubMed2001

Evaluation of an ossifying fibroma using three-dimensional computed tomography.

We describe the appearance of a mandibular ossifying fibroma in spiral computed tomography-based multiplanar (MPR) and three-dimensional (3D) reconstruction using computer graphics. The usefulness of the interactive reconstructed images, especially using a vascular protocol, for qualitative and quantitative analyses is demonstrated. This technique is an important adjunct to evaluation with conventional axial CT.

Adolescent↗
PubMed2004

Dermatofibrosarcoma protuberans association with nuchal-type fibroma.

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a hypercellular, storiform, CD34-positive low-grade sarcoma with honeycomb entrapment of fat, which typically involves the trunk and extremities. Nuchal-type fibroma (NTF ) is a paucicellular, CD34-positive fibrous tumor with fat entrapment, which may occur in both nuchal and extranuchal locations and in association with Gardner syndrome. METHODS: We report the association of DFSP with NTF in a 43-year-old male with no personal or family history of Gardner syndrome. RESULTS: The patient had a past history of a DFSP removed from his back, which recurred 2 years later and was re-excised. Additionally, the patient had a typical NTF, in the posterior neck, removed at the same time. Histopathologic examination of the recurrent back lesion demonstrated a composite lesion with typical appearances of DFSP, centrally, blending into an NTF-like appearance, peripherally. Both components expressed CD34 and CD99, and lacked elastin. A review of the microscopic slides of the patient's previously excised DFSP revealed an identical lesion with surrounding NTF-like areas. CONCLUSION: While an association between NTF and fibromatosis has recently been reported, this is to our knowledge the first report of an association between NTF and DFSP. The morphologic findings suggest that there may be a continuum between these two CD34-positive lesions that have a tendency to infiltrate adipose tissue and recur.

12E7 Antigen↗
PubMed2000

Multiple acral fibromas in a patient with familial retinoblastoma: a cutaneous marker of tumour-suppressor gene germline mutation?

We report a 40-year-old patient with familial retinoblastoma also affecting his elder son, who developed multiple fibromas on the periungual or subungual areas of all the fingers. Molecular analysis disclosed a loss of heterozygosity for the RB1 gene in the larger tumour, with disappearance of the normal allele and persistence of the mutated allele only. The similarity of this observation with distal fibrous tumours encountered in other diseases with germline mutations of tumour-suppressor genes such as neurofibromatosis type 1, tuberous sclerosis and multiple endocrine neoplasia type 1 led to the hypothesis that multiple acral benign tumours with a fibrous component might be a cutaneous marker of tumour suppressor gene germline mutation with low sensitivity but high specificity.

Adult↗