Excessive decrease in free water clearance induced by furosemide and ethacrynic acid in nephrogenic diabetes insipidus associated with renal tubular acidosis.
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Acidosis, Renal Tubular↗
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Results for “ETHACRYNIC ACID”
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Ethacrynic acid inhibition of exocytosis and ATP-ase activity in rabbit polymorphonuclear leukocytes (PMN's).
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Animals↗
Effect of ethacrynic acid on lymph flow and fluid partition in normal and ascitic dogs.
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Abdomen↗
Ethacrynic acid: assessment of saluretic and diuretic potency in patients with severe chronic renal failure.
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Adult↗
The mechanisms by which ethacrynic acid affects ion content, ion fluxes, volume and energy supply in the rat uterus.
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Adenosine Diphosphate↗
Influence of ethacrynic acid and ouabain on the oxygen consumption and potassium and sodium content of the kidney external medulla of the dog.
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Animals↗
[Immediate effects of a new diuretic-ethacrynic acid (MK-595)-on the metabolism of sodium, chloride, potassium and water in edematous conditions].
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Chlorides↗
Effects of several anions on ethacrynic acid high- and low-sensitive Mg-ATPase activities in microsomal fractions from rabbit cortical gray matter.
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Adenosine Triphosphatases↗
The effect of external ethacrynic acid and ouabain on the concentration and distribution of sodium, potassium and chloride in the amphibian oocyte measured by electron microprobe X-ray analysis [proceedings].
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Animals↗
Inhibition of sodium- and potassium-dependent adenosine triphosphatase by ethacrynic acid: ligand-induced modifications.
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Adenocarcinoma, Papillary↗
[Biphasic effect of ethacrynic acid on the sodium ion transport through biological membranes].
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Adenosine Triphosphate↗
[On the anti-complement and anti-platelet-aggregation action of furosemide and ethacrynic acid. Possibility of a mechanism of action released by the former saluretic in the treatment of acute renal insufficiency].
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Acute Kidney Injury↗
[Mechanism of the stimulating effect of furosemide, ethacrynic acid and novurit on renin secretion by the kidneys].
It was shown in chronic experiments on dogs that denervation of the kidneys does not eliminate the stimulant action of furosemid, etacrinic acid and novurit. Stoppage of the urine flow in dogs with a denervated single kidney did not lead to a complete removal of the stimulant effect of the diuretics on renin secretion.
Alkylmercury Compounds↗
[Change in renin activity in the venous blood plasma of dogs under the influence of furosemide, novurit, ethacrynic acid and mannitol].
Changes in the activity of renin in the venous blood plasma of dogs, its volume and the circulating blood volume (CBV) were studied in chronic tests under the effect many days of diuretics administration. A comparison of the plasms renin activity as against changes in the volume of plasma and CBV occurring under the effect of saluretics gives an idea on the factorc regulating the renin secretion by the kidneys.
Animals↗
Effects of furosemide and ethacrynic acid on the endocochlear direct current potential in normal and kanamycin sulfate-treated guinea pigs.
The effects of loop diuretics on the endocochlear direct current (DC) potential and the effective electrical resistance of the cochlear partition were studied. The effective electrical resistance was increased, and the endocohlear DC potential was decreased. The decrease in the endocohlear DC potential must not be caused by breaks in the electrical insulation of the cochlear partition. With loop diuretics the endocochlear DC potential decreased less in guinea pigs treated with kanamycin sulfate than it did in the control group. Two interpretations of these phenomena are presented.
Animals↗
[Ethacrynic acid does not disrupt homeostatic reactions of the kidneys to hemodynamic shifts].
Arterial pressure and diuresis were determined in anesthetized dogs against the background of single (15 mg/kg) and continuous (5 mg/kg/rhr) intravenous administration of uregit (etacrylic acid). Acute hemodynamic shifts produced by compression of common carotid arteries, vena cava anterior, intravenous administration of ephedrine (1 mg/kg) or of sodium nitrite (3 mg/kg) were attended by an increased renal excretion of sodium, potasium and water in hypertension and their passage - in hypertension. Mechaninisms governing the express regulation of the water and electrolytes homeostasis and their relation to the active transpor of sodium are considered. Arguments in favour of a conjecture as to the localization of the mechanism responsible for the express regulation of the electrolytes homeostasis in acute hemodynamic shifts are advanced.
Animals↗
[Experimental study on the therapeutic value of microwave on hearing loss due to ethacrynic acid ototoxicity].
Ischemia of the stria vascularis in the cochlea associated with temporal hearing loss was found in guinea pigs with intravenous othacrynic acid injection. Using this animal model, we studied the therapeutic value of low power density microwave on the ischemic stria vascularis. Experimental findings confirmed that microwave irradiation on the ear might prompt a quicker recovery of hearing. Meanwhile, milder pathological changes of the stria vascularis were shown either on light microscopy or on TEM in the microwave treated animals. Hence, it is suggested that microwave irradiation causes an improvement of microcirculation and an alleviation of lesions in the stria vascularis. The study has provided an experimental basis of microwave treatment for the hearing impairment due to microcirculation disorder in the inner ear.
Animals↗
Simultaneous analysis of flunixin, naproxen, ethacrynic acid, indomethacin, phenylbutazone, mefenamic acid and thiosalicylic acid in plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry.
Simple and reproducible high-performance liquid chromatographic (HPLC) and gas chromatographic-mass spectrometric (GC-MS) methods have been developed for the simultaneous analysis of several acidic drugs in horse plasma and urine. Although the capillary GC-MS column provided better separation of the drugs than the reversed-phase C8 (3 microns, 75 mm) HPLC column, the total analysis time with HPLC was shorter than the total analysis time with GC-MS. The HPLC system equipped with a diode-array detector provided simultaneous screening (limit of detection 100-500 ng/ml) and confirmation (limit 1.0 micrograms/ml) of the drugs. The HPLC system equipped with fixed-wavelength ultraviolet and fluorescence detectors provided a relatively sensitive screening [limit of detection 50-150 ng/ml for ultraviolet and 10 ng/ml for fluorescence (naproxen only) detectors] of the drugs. However, the positive samples had to be confirmed by using either the diode-array detector or the GC-MS system. The GC-MS system provided simultaneous screening and confirmation of the drugs at very low concentrations (20-50 ng/ml).
Analgesics↗