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At least 793 records · Page 44Linked to original sources
PubMed1991

Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs.

The purpose of this study was to evaluate the early wound healing events of bone around press-fit titanium implants inserted with and without the concurrent application of a combination of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-I). Nine months prior to implant placement all mandibular premolar teeth were extracted in 8 beagle dogs. Subsequently, 40 specially manufactured titanium implants with 2 transverse holes in the apical section were press fit into precise recipient sites in the dogs' mandibles. The dogs were sacrificed at 7 and 21 days following implant placement yielding 12 PDGF-B/IGF-I treated and 8 control (placebo gel or non-treated) implants for each observation period. Coded undecalcified sections were analyzed for: 1) percentage of implant surface in contact with new bone; 2) percentage of peri-implant space filled with new bone; and 3) percentage of implant hole filled with new bone. An analysis of variance was used to determine significant differences among the treatment groups. At 7 days, the percentage of bone fill in the peri-implant spaces and the percentage of implant surface in contact with new bone were both significantly increased in PDGF-B/IGF-I treated sites (P less than 0.01 for both groups). There was less than 1.5% fill of the implant holes in both treated and control sites (no significant differences). At 21 days the percentage of bone fill in the peri-implant spaces was significantly increased in the PDGF-B/IGF-I treated sites (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMedDate not supplied

Prefabrication of vascularized bone graft using guided bone regeneration.

This article describes the prefabrication of a vascularized bone graft composed of autologous particulate cancellous bone and marrow (PCBM), a vessel bundle, and a biodegradable membrane. The PCBM was placed around the saphenous vessel bundle of rats and rolled with a biodegradable membrane of L-lactide-epsilon-caprolactone copolymer to prepare the prefabricated vascularized bone graft (group A). As controls, combinations of PCBM and membrane (group B), vessel bundle and membrane (group C), and PCBM and vessel bundle (group D) were prepared. A radiographic study revealed radio-opacity in the implantation site of group A 1 week later, in contrast to the other groups. Newly formed bone in the membrane roll was histologically confirmed, and neomicrovasculature circulating from the vessel bundle through the newly formed bone tissue was observed. The increase in alkaline phosphatase activity and osteocalcin content was significant for the group A preparation compared with the other groups. We concluded that the combination of autologous PCBM, a vessel bundle, and a biodegradable membrane was promising in the prefabrication of vascularized bone with good blood circulation.

Absorbable Implants↗
PubMed1995

Evaluation of a high-density polytetrafluoroethylene (n-PTFE) membrane as a barrier material to facilitate guided bone regeneration in the rat mandible.

The purpose of this investigation was to evaluate the use of high-density polytetrafluorethylene (n-PTFE) membranes to facilitate guided tissue regeneration (GTR) in the rat. The concept of guided tissue regeneration is based on the hypothesis that if the non-osteogenic connective tissue cells are mechanically blocked from entering a bone defect, selective re-population of the defect by osteoblasts will occur. Bilateral through-and-through defects of critical size were created in the mandibular angle of 12 rats. The experimental side was covered on both the medial and lateral aspects of the mandible with high-density n-PTFE membrane, with the opposite side serving as a control. Histological analysis revealed osteogenic tissue completely bridging the defect by two weeks. After six weeks of healing, osteogenic repair was observed at the margins of the defects, with islands of woven bone seen in the central areas. After 10 weeks of healing, complete ossification was observed on the n-PTFE-treated side. The control defects exhibited very little osseous regeneration, and rounding of the defect margins was observed after 10 weeks of healing. These results indicate that high-density n-PTFE can serve effectively as a guided tissue regeneration barrier in certain bone defects.

Animals↗
PubMed1997

Guided bone regeneration in dental implant treatment using a bioabsorbable membrane.

The aim of this study was to evaluate an osteopromotive technique, using a bioabsorbable membrane, for its ability to restitute bone over buccal fenestration and dehiscence defects following fixture installation. 11 patients requiring dental implant treatment and exhibiting sufficient vertical height of the maxilla and compromised bucco-palatal dimensions, as determined clinically and radiographically, were included in the study. 17 Brånemark titanium fixtures were placed with buccal defects which were augmented by a bioabsorbable membrane, Resolut. No complications were observed post-operatively. At 6-8 months, abutment connection was performed, and clinical evaluation of the healed defect area was made. The number of exposed buccal threads at fixture installation (median 8; range 2-19), and abutment connection (median 0; range 0-5), respectively, was compared. Out of the 17 fixtures; 14 exhibited complete coverage with bone, whereas 3 showed some remaining threads. A small punch biopsy taken at abutment connection in an area where the membrane had been placed showed a combination of dense connective tissue and bone. Radiographic evaluation of the marginal periimplant bone level is in progress and results to date show a median bone loss of 1.2 mm after a loading period of 4-6 months. Results show that fixture dehiscence and fenestrations, augmented with this bioabsorbable membrane, demonstrate a highly significant amount of new bone formation.

Aged↗