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PubMed2003

[Is the Swiss population gaining body weight? Body mass index in insurance applications between 1950 and 1990].

In this study 4435 insurance applications to the Swiss Life insurance company ("Rentenanstalt") by individuals aged 20-39 years from the time period 1950-1990 were evaluated. Each application contained the self-reported body weight, height, and other informations such as martial status or city of residence. For each individual the body mass index (BMI) was computed and the prevalence of overweight and obesity for each year was calculated using standard definitions. This is the first study which tries to determine the prevalence rates of overweight and obesity in Switzerland over time. The absolute body weight (kg) increased continuously from 1950 to the year 2000. The most pronounced increase was seen in individuals (aged 20-29 years) above the 90th percentile of body weight and BMI, i.e. already overweight and/or obese individuals showed the largest increase in body weight. In men (aged 20-29 years) the prevalence of overweight increased between 1980 and 1990 by more than 10% to a prevalence rate of 25%. In women (aged 20-29 years) the prevalence of overweight increased continuously from 1960 onward and reached a rate of 10.5% in 1990. In the age group of the 30-39 years old individuals no change in the prevalence rates was observed. These data suggest that there is a trend for an increased prevalence of overweight in Switzerland. Since the study sample was not representative for the Swiss population the results have to be interpreted with caution only. Nevertheless the results are in agreement with the trends in other countries and it can be assumed that similar developments do occur also in Switzerland.

Adult↗
PubMed2001

Body proportions, body composition and pubertal development of children in competitive sports.

The aim of this study was primarily to investigate anthropometric variables, body composition and pubertal development in children aged 9-13 participating in competitive sports. Secondly, the influence of age, sport, training hours and pubertal development/maternal menarcheal age on body composition and pubertal development was explored. A total of 183 (96 girls, 87 boys) children performing swimming (Sw), tennis (Te), European team handball (TH), and gymnastics (Gy) took part in the study. Anthropometric measurements and pubertal development were determined. The participants completed a questionnaire regarding hours of training per week and maternal menarcheal age. Significant differences in stature (z-scores) were found in both boys (Sw=0.06; Te=0.04; TH=0.05; Gy=-0.66, P<0.004) and girls (Sw=0.12; Te=0.19; TH=0.25; Gy=-0.96, P<0.004). In girls, sum of skinfolds in millimetres (Sw=33.4; Te=33.3; TH=41.0; Gy= 27.2, P<0.02) and body mass index z-scores (SW=0.00; Te=-0.27; TH=0.35; Gy=-0.25, P<0.001) were different between the sports. A regression analysis revealed that in girls, age and maternal menarcheal age were significantly associated with pubertal development (P<0.005 and P<0.01), respectively, and sport was associated with the sum of skinfolds (P<0.05). In boys, only age was significantly associated with pubertal development (P<0.005). In conclusion, anthropometric and body composition differences exist in athletes of both sexes from different sports but are more evident in females. Most importantly, we did not find any effect of training on body composition or pubertal development, confirming previous data that children in competitive sports are selected due to constitutional factors.

Adolescent↗
PubMed1992

National working conference on smoking and body weight. Task Force 1: Mechanisms relevant to the relations between cigarette smoking and body weight.

Careful, comprehensive, and empirical observations provide the building blocks of the sciences, whereas theory and mechanisms provide the "cement" to hold the blocks together and serve as blueprints to direct future building. This article resulted from several days of discussion regarding theories that may underlie the relation between cigarette smoking and body weight and the relation between smoking cessation and body weight. The working group composed of social and biological scientists who addressed this assignment considered what is already known within the smoking and body weight literature and also considered relevant findings from studies of smoking or body weight regulation that have not directly addressed the interaction of these variables. As expected, we were successful at listing some of what is not known and what is worth knowing. We also tried to identify fruitful possibilities for research activity that might clarify mechanisms of action and eventually lead to theoretical development. Because we do not believe that the present state of our deliberations merits the label of theories, we decided, instead, to report the summary of these deliberations as potential mechanisms relevant to the relation between smoking and body weight.

Adult↗
PubMed1976

Hydroelectrolytic determination in paraplegics (total body water; exchangeable sodium and total body potassium).

Measurements of total body water and total exchangeable sodium, by isotopic dilution, and of total body potassium by whole body counting of the naturally occurring 40K isotope, were performed on stabilised paraplegic or tetraplegic subjects. Nineteen patients were investigated by the complete set of tests, six by only body counting. The results of total body potassium are expressed, following a uniform scale, as "relative values", which were established by the processing of reference values, from numberous paired healthy subjects.

Adolescent↗
PubMed2004

High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat.

OBJECTIVE: The objectives were to study the relationships of insulin resistance with generalized and abdominal obesity, and body fat patterning in urban postpubertal Asian Indian children. DESIGN: Cross-sectional, population-based epidemiological study. SUBJECTS: In all, 250 (155 males and 95 females) healthy urban postpubertal children. MEASUREMENTS: Anthropometric profile, percentage of body fat (%BF), fasting serum insulin, and lipoprotein profile. RESULTS: Fasting insulin correlated significantly with body mass index (BMI), %BF, waist circumference (WC), central and peripheral skinfold thicknesses and sum of four skinfold thicknesses (Sigma 4SF) in both sexes, and with systolic blood pressure and waist-to hip circumference ratio (W-HR) in males only. Consistent increase in fasting insulin was noted with increasing values of central skinfold thickness at each tertile of peripheral skinfold thickness, WC, and %BF. Central skinfold thickness correlated with fasting insulin even after adjusting for WC, W-HR, and %BF. The odds ratios (OR) (95% CI) of hyperinsulinemia (fasting insulin concentrations in the highest quartile) were 4.7 (2.4-9.4) in overweight subjects, 8 (4.1-15.5) with high %BF, 6.4 (3.2-12.9) with high WC, 3.7 (1.9-7.3) with high W-HR, 6.8 (3.3-13.9) with high triceps skinfold thickness, 8 (4.1-15.7) with high subscapular skinfold thickness, and 10.1 (5-20.5) with high Sigma 4SF. In step-wise multiple logistic regression analysis, %BF [OR (95% CI): 3.2 (1.4-7.8)] and Sigma 4SF [OR (95% CI): 4.5 (1.8-11.3)] were independent predictors of hyperinsulinemia, similar to insulin resistance assessed by HOMA (homeostatic model of assessment) in the study. CONCLUSION: A high prevalence of insulin resistance in postpubertal urban Asian Indian children was associated with excess body fat, abdominal adiposity, and excess truncal subcutaneous fat. Primary prevention strategies for coronary heart disease and diabetes mellitus in Asian Indians should focus on the abnormal body composition profile in childhood.

Abdomen↗
PubMed1978

Concurrent estimation of total body and exchangeable body sodium in hypertension.

1. Total-body neutron-activation analysis in vivo was carried out in 11 hypertensive subjects to measure simultaneously the total body content of sodium, chlorine, calcium, phosphorus and nitrogen. 2. There was a highly significant correlation between total body sodium measured by activation analysis and total exchangeable sodium measured by a standard isotope-dilution technique (r = 0.92, P less than 0.001). Exchangeable sodium averaged 80.3% of total body sodium. 3. The measured values of chlorine, calcium, phosphorus and nitrogen were similar to those for healthy subjects reported by others. 4. Activation analysis in vivo appears promising as an additional tool for investigating sodium metabolism in hypertension, as it is the only method available for determining the total body content of this element. The radiation dose (1 rem) is sufficiently low to permit repeated measurements in the same subject.

Adult↗
PubMed1991

Influence of anabolic steroids on body composition, blood pressure, lipid profile and liver functions in body builders.

The effects of anabolic steroids on body composition, blood pressure, lipid profile and liver functions were studied in male body builders who received a weekly i.m. injection of nandrolone-decanoate (100 mg) or placebo for 8 weeks in a double blind way. In addition, 5 body builders received the same dosage of nandrolone-decanoate or placebo, in a double blind cross-over design during two 8-week periods, interspersed by 12 weeks. Anabolic steroids induced a 25-27% decrease in HDL-cholesterol, which was virtually reversed 6 weeks after cessation of drug use. In the SAD group an increase in diastolic blood pressure was observed, which returned to pre-anabolic values approximately 6 weeks after cessation of drug administration. No deleterious effects of anabolic drugs on plasma activity of liver enzymes were found. Increases in lean body mass were found in all groups, though the increase in the subjects who received anabolic steroids was superior to that in the placebo-treated subjects. The increase in lean body mass suggests increases in muscle mass.

Adult↗
PubMed2006

Body size, body proportions, and encephalization in a Middle Pleistocene archaic human from northern China.

The unusual discovery of associated cranial and postcranial elements from a single Middle Pleistocene fossil human allows us to calculate body proportions and relative cranial capacity (encephalization quotient) for that individual rather than rely on estimates based on sample means from unassociated specimens. The individual analyzed here (Jinniushan) from northeastern China at 260,000 years ago is the largest female specimen yet known in the human fossil record and has body proportions (body height relative to body breadth and relative limb length) typical of cold-adapted populations elsewhere in the world. Her encephalization quotient of 4.15 is similar to estimates for late Middle Pleistocene humans that are based on mean body size and mean brain size from unassociated specimens.

Animals↗
PubMed1978

Estimation of body fat and lean body mass from anthropometric dimensions in adult Indian women.

Mean values and standard deviations of body fat and lean body mass of 65 young Indian women aged 20-25 years were 9.00 kg, SD 6.14 and 36.02 kg, SD 3.99 respectively. Body fat per cent was 18.72 SD 10.48. On selective stepwise multiple linear regression analysis, the measurements selected for predicting body fat % were maximum thigh girth, chest diameter, height up to gluteal furrow and shoulder diameter, all four together giving a multiple correlation coefficient of 0.88. For predicting lean body mass, the measurements selected were stature, upper arm length, lower thigh girth and chest diameter, all four together giving a multiple correlation coefficient of 0.84.

Adipose Tissue↗
PubMed1995

[Investigations of empty body weight gain, on protein, fat and energy disposition as well as on utilization of metabolizable energy for energy deposition in black and white bulls. 1. Empty body weight gain].

Six series of individual feeding experiments (altogether 544 animals) with different energy supply and connected with steps slaughteries and whole-body analyses, constructed carried out and analysed upon the same aspects, were regression analytically interpreted with the aim of quantify the relation of empty body weight to live weight. The relation of empty body weight to live weight showed a nonlinear dependence on the live weight as well as on the age of animals. The assessment of the metabolizability of energy of the diet as an additional variable reduced the residual variation considerably. Therefore from the knowledge of live weight or age of the animals, and the metabolizability of energy of the diet the relation of empty body weight to live weight of black and white bulls could be calculated. Moreover, the relation of empty body weight gain to live weight gain in dependence on live weight and live weight gain was investigated.

Animal Feed↗
PubMed2003

Body mass index, change in body silhouette, and risk of asthma in the E3N cohort study.

To evaluate the impact of body mass index (BMI) (weight (kg)/height (m)(2)) and change in body silhouette on asthma risk, the authors investigated a cohort of women participating in the E3N Cohort Study in France from 1990 to 1993. The authors identified 372 incident cases of asthma among 67229 women aged 40-65 years at baseline. Data were analyzed using proportional hazard models to determine the risk of asthma incidence in relation to BMI and body silhouette. Reported BMI at baseline was related to the incidence of asthma, with a significantly increased risk corresponding to increasing BMI quintiles (test for trend: p < 0.001). Compared with a BMI of 20-21.4 (second quintile), women with a BMI >or=27 had double the risk of incident asthma after adjustment for potentially confounding factors (multivariate relative risk = 2.02, 95% confidence interval: 1.38, 2.98). Increase in body mass between menarche and the start of the follow-up study was significantly related to asthma risk (for an increase of two silhouettes, relative risk = 1.66, 95% confidence interval: 1.18, 2.32). The authors conclude that a high BMI is significantly related to the risk of asthma incidence and that an increase in body silhouette between menarche and adulthood is related to the incidence of asthma later in life.

Adult↗
PubMed1980

A distinct form of adult polyglucosan body disease with massive involvement of central and peripheral neuronal processes and astrocytes: a report of four cases and a review of the occurrence of polyglucosan bodies in other conditions such as Lafora's disease and normal ageing.

We have described 4 patients with progressive lower and upper motor neuron deficits, marked sensory loss in the legs, 'neurogenic bladder', and, in 2 of the 4, dementia. Autopsy of two revealed a profusion of microscopic bodies resembling corpora amylacea or Lafora bodies, but restricted to processes of neurons and astrocytes. Similar (but especially large) bodies were seen within axons of sural nerves taken at biopsy from the other two patients. A general term--'polyglucosan body'--is introduced to refer to these structures in all the circumstances in which they may occur, such as in Lafora's disease, in a syndrome of longstanding double athetosis, in some cases of amyotrophic lateral sclerosis, in type IV glycogenosis, in diabetic rats, and in the normal course of ageing. Except in type IV glycogenosis, the causes for accumulation of polyglucosan bodies are unknown. They may damage tissue by more than one mechanism--probably by impeding axonal flow and impairing perivascular diffusion of metabolites.

Aged↗
PubMed1997

The "obsessive" cosmetic surgery patient: a consideration of body image dissatisfaction and body dysmorphic disorder.

"Obsessive" cosmetic surgery patients often present as "hyper-focused" on their appearance. We may best be able to understand these patients through examining their thoughts and feelings about their body image. This paper reviews the relationship between physical appearance, body image dissatisfaction, and the pursuit of cosmetic surgery. An extreme form of body image dissatisfaction, Body Dysmorphic Disorder (BDD), which may characterize many "obsessive" patients, is also discussed. Recommendations for assessing patients' body image concerns include a comprehensive history as well as specific questions about appearance-related concerns.

Adolescent↗
PubMedDate not supplied

Body mass index does not influence response to treatment, nor does body weight change with lower doses of conjugated estrogens and medroxyprogesterone acetate in early postmenopausal women.

OBJECTIVE: To determine the effects of lower doses of conjugated estrogens (CE) alone or in combination with medroxyprogesterone acetate (MPA) on body weight and to evaluate the influence of body mass index (BMI) on the effect of lower-dose CE or CE/MPA on vasomotor symptoms, vaginal atrophy, bone mineral density (BMD), endometrial safety, and side effects such as endometrial bleeding and breast pain. DESIGN: In this large clinical trial [the Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) study], 2,673 healthy, postmenopausal women with intact uteri were randomized for 1 year of CE 0.625, CE 0.625/MPA 2.5, CE 0.45, CE 0.45/MPA 2.5, CE 0.45/MPA 1.5, CE 0.3, CE 0.3/MPA 1.5 (all doses mg/d), or placebo. Weight, BMI, number and severity of hot flushes, vaginal atrophy (as determined by the vaginal maturation index), bleeding profiles, breast pain, and endometrial biopsies were evaluated. A subset of 822 women was randomized into a 2-year substudy to evaluate changes in BMD with lower-dose CE or CE/MPA regimens. RESULTS: After 1 year of treatment, a small but significant (P < 0.05) gain in body weight from baseline was observed in all arms of the study, the largest increase in body weight occurring in the placebo group [1.15 +/- 0.21 (SE) kg]. Body mass index had no significant effect on changes from baseline for vasomotor symptoms, bleeding patterns, vaginal atrophy, BMD, endometrial safety, or breast pain when analyzed both by analysis of covariance with baseline BMI as covariate or when participants were grouped into BMI less than 25 kg/m and BMI of 25 kg/m or greater. In placebo-treated women, vaginal atrophy was significantly greater (P < 0.05) in women with a BMI less than 25 kg/m compared with a BMI of 25 kg/m or greater. CONCLUSIONS: Lower- and standard-dose regimens of CE or CE/MPA are not associated with greater weight gain than placebo. In addition, BMI does not seem to influence effects of these regimens on vasomotor symptoms, vaginal atrophy, bleeding profiles, BMD, endometrial safety, or breast pain.

Body Mass Index↗
PubMed2006

Eukaryotic lipid body proteins in oleogenous actinomycetes and their targeting to intracellular triacylglycerol inclusions: Impact on models of lipid body biogenesis.

Bacterial neutral lipid inclusions are structurally related to eukaryotic lipid bodies. These lipid inclusions are composed of a matrix of triacylglycerols (TAGs) or wax esters surrounded by a monolayer of phospholipids. Whereas the monolayers of lipid bodies from animal and plant cells harbor specific classes of proteins which are involved in the structure of the inclusions and lipid homoestasis, no such proteins are known to be associated with bacterial lipid inclusions. The present study was undertaken to reveal whether the mammalian lipid body proteins perilipin A, adipose differentiation-related protein, and tail-interacting protein of 47 kDa (TIP47), which comprise the so called PAT family proteins, and the maize (Zea mays L.) oleosin are targeted to prokaryotic TAG bodies in vivo. When fused to enhanced green fluorescent protein, all proteins except the oleosin were mainly located at the surfaces of lipid inclusions when heterologously expressed in the recombinant actinomycetes Rhodococcus opacus PD630 and Mycobacterium smegmatis mc(2)155. A more detailed intracellular distribution analysis of TIP47 in recombinant R. opacus cells by immunocytochemical labeling of ultrathin cryosections and freeze fracture replicas revealed a substantial amount of TIP47 protein also pervading the cores of the inclusions. We discuss the impact of these results on the current model of lipid body biogenesis in prokaryotes.

Actinobacteria↗
PubMed2006

Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake.

Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27 degrees C or 22 degrees C and pair fed the same diet for 21 weeks (95% of ad libitum intake at 27 degrees C). In the second experiment, TRAMP mice were housed at 27 degrees C or 22 degrees C and fed the same diet ad libitum for 21 weeks. Despite a similar calorie intake, pair-fed mice at 27 degrees C (PF27) were heavier (28.3 +/- 3.3 versus 17.6 +/- 1.6 g at 21 weeks; P < 0.001; mean +/- SD) and had greater fat (6.4 +/- 2.1 versus 1.9 +/- 0.3 g; P < 0.001) and lean mass (P < 0.001) than pair-fed mice at 22 degrees C. Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05). In contrast, ad libitum-fed mice housed at 22 degrees C consumed approximately 30% more calories than ad libitum-fed mice at 27 degrees C, but there was no difference between groups in body composition or cancer progression. These results imply that the ability of calorie restriction to inhibit or delay cancer incidence and progression is mediated in part by changes in energy balance, body mass, and/or body composition rather than calorie intake per se, suggesting that excess calorie retention, rather than consumption, confers cancer risk.

Adenocarcinoma↗
PubMed1977

Body weight change over the life span and longevity for C57BL/6J mice and mutations which differ in maximal body weight.

Body weights were obtained monthly for mutant groups with the C57BL/6J genetic background which differ in body weight (bg, c,J Ay, ob), and for a control group (C57BL/6J) (n = 16, N = 80). The mean longevity was significantly lower for all mutant groups compared with the mean longevity of the control group. Although obese mice (ob) had a shorter life span than other mutant groups, mice which also attained a very high body weight (yellow, Ay) did not differ significantly in longevity from thin mutant mice. Moreover, peak body weight was positively correlated with longevity for all mouse groups. All mouse groups showed a terminal decline in body weight except the albino group which gained weight throughout life. In general, long-lived mice obtained a greater terminal weight loss than short-lived mice within groups. The major finding of this study was that within each group there was a negative relationship obtained between growth rate and longevity.

Aging↗
PubMed2006

'Body image is for girls': a qualitative study of boys' body image.

Although a considerable and informative literature on boys' body image is beginning to emerge, this literature has been guided strongly by theorizing about female body image. The present study aimed to gain access to boys' own ideas and terminology regarding their body image. The participants (aged 14 to 16 years) said that they are satisfied with their appearance, but some conceded their physical appearance to be more important than they like to admit. Boys do not believe that the mass media influences their body image and said they do not talk about body image because it is a feminine or gay issue.

Adolescent↗