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PubMed1980

Evaluation of two sterility testing methods for intravenous admixtures.

The Addi-Chek Quality Control System (Millipore Corporation) and Ivex-2 Filterset (Abbott Laboratories) were evaluated to determine their effectiveness, applicability, and cost as part of a pharmacy quality-control program. Each method was tested using 50 solutions, 25 of which had been contaminated by inoculation with one of five micro-organisms; the other 25 solutions were used as controls. Aseptic technique was used, and procedures were carried out in a laminar air flow hood. Contaminated solutions were blinded from the person performing the tests. Addi-Chek detected contamination in all the inoculated solutions and in three of the uninoculated solutions. The latter may have been a result of adventitious contamination during the testing procedure. Ivex-2 detected contamination in 24 of the 25 inoculated solutions; no other contamination was found. The effectiveness of the methods in detecting low-level microbial contamination appears comparable. Both methods have been shown to be useful in the pharmacy setting, but Ivex-2 could be used to test for contamination when used as an in-line filter at the patient level. Ivex-2 is less expensive and warrants further evaluation in monitoring for microbial contamination during preparation and administration of intravenous solutions.

Boston↗
PubMed1987

Minimizing i.v. admixture waste in a 70-bed hospital.

The Pharmacy Department, concerned with the excessive number of IV medication doses wasted, developed a two-phase plan to deal with the problem. The first phase evaluated the daily cost of having a technician manually look through the nursing Medication Administration Records (MARs) for changes in IV orders, rather than depending upon the ward clerk to send them to the pharmacy. Then that amount was compared to the cost savings derived from not making, and wasting, discontinued medications. The second phase determined the cost savings obtained by recycling IV medications to a different patient if the primary patient no longer required the medication. The annual estimated savings from these two changes was $8,044.00.

Alabama↗