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The Diet Quality Index-International (DQI-I) provides an effective tool for cross-national comparison of diet quality as illustrated by China and the United States.

A composite measure of diet has been preferred to an index of a single nutrient or food in the area of dietary assessment. However, the lack of such a tool for cross-national comparisons has restricted the ability to compare diet quality between countries using an overall measure of diet. In this study, we created a tool called the Diet Quality Index-International (DQI-I) for global monitoring and exploration of diet quality across countries. The major categories of the index components are variety, adequacy, moderation and overall balance. Using the tool, this research presents a cross-national comparison of diet quality between China and the United States, incorporating comparable national in-depth diet data. The mean of the DQI-I score was slightly higher in China than in the United States. By major categories of the DQI-I, dietary variety was better achieved in the U.S. diet; moderation and overall balance of intakes were better accomplished in China. The DQI-I was successful in capturing variability in intakes of food and nutrients in both countries. Some distinct patterns of poor quality diet in each country were also identified. As demonstrated in this study, the DQI-I provides an effective means of cross-national comparative work for global understanding of diet quality. Furthermore, the dietary problem areas identified by the DQI-I may be useful in guiding the development of programs to improve public health.

China↗

Differences in nitrogen metabolism between protein-deficient and energy-deficient rats with similarly restricted growth rates.

Paired groups of rats whose growth rates were restricted to similar degrees by feeding either protein- or energy-deficient diets had very different patterns of nitrogen metabolism. The protein-deficient animals showed evidence of dysadaptation in that liver protein was much more reduced than in the energy-deficient ones, whereas total muscle protein was higher. Plasma albumin concentrations decreased only in animals fed the low protein diet; with energy restriction a small but significant rise in albumin was seen. Although plasma amino acid concentration fell in both protein- and energy-restricted groups, a distorted pattern, with a markedly raised non-essential:essential amino acid ratio was found only in the protein-deficient rats. These differences in nitrogen metabolism could not be explained on the basis of variations in the plasma concentrations of insulin, corticosterone or growth hormone. The relationship of these changes to the development of kwashiorkor in man, and the use of plasma albumin and amino acid as indicators of inappropriate internal distribution of protein, resulting in dysadaptation, are discussed.

Amino Acids↗

Selected tobacco-use behaviors and dietary patterns among high school students--United States, 1991.

In the United States, 30% of all cancer deaths and 87% of lung cancer deaths are attributable to tobacco use (1); approximately 35% of all cancer deaths are associated with diet (2). Because tobacco-use behaviors and dietary patterns (particularly diets high in fat and low in fruits, vegetables, and grains) established during youth may extend into adulthood and may increase the risk for cancer and other chronic diseases, these behaviors should be monitored and addressed among youth (1,3). This article presents self-reported data on the prevalence of selected tobacco-use behaviors and dietary patterns associated with risk for cancer and other chronic diseases among U.S. students in grades 9-12 during 1991.

Adolescent↗

Dietary patterns and the adenomacarcinoma sequence of colorectal cancer.

BACKGROUND: Food components of a diet are highly related, so that building up dietary patterns may help understand the relationship between chronic diseases and diet, and identify high risk groups that need preventive advice. AIM: The aim of this study was to determine dietary patterns associated with the colorectal adenoma-carcinoma pathway. METHODS: We performed a two-step analysis using first principal component analysis to select the most appropriate food groups, then a hierarchical agglomerative clustering method, in order to determine dietary patterns in 1372 subjects included in a case-control study. Patients with hyperplastic polyps (n = 103), adenomas < 10 mm, (n = 154) or larger adenomas (n = 208) were then compared with polyp-free controls (n = 426), and colorectal cancer cases (n = 171) compared with population controls (n = 309) using unconditional logistic regression adjusted on age and gender. RESULTS: Cluster analysis determined five food patterns. Cluster 1 identified a low-energy diet; cluster 2 a high-starch, highfat, and low-fruit diet; cluster 3 a high-processed meat, -energy, -alcohol, and -starchy foods diet; cluster 4 a high-fish, -cereals, -honey, -olive oil, -fruit and -vegetables diet; and cluster 5 a high-flour, -sugar, -chocolate, -animal fats, and -eggs diet. Logistic regression identified cluster 2 [corrected] as significantly associated with risk of small adenomas (OR = 1.7; 95% confidence interval 1.0-2.7), large adenomas (OR = 1.9; 1.2-3.0) and cancers (OR = 1.7; 1.1-2.8) compared with cluster 1 [corrected] Cluster 4 diet was inversely associated with risk of small adenomas (OR = 0.4; 0.2-1.0). There was no relationship between patterns and risk of hyperplastic polyps. Multiple adjustment decreased the strength of the relationships with cluster 2 [corrected] which remained significantly associated with adenomas, but not cancer. CONCLUSION: A lowenergy diet appeared as protective all along the adenoma-carcinoma sequence, contrary to a high-energy, high-processed meat and -animal fat diet.

Adenocarcinoma↗

Effects of high risk and low risk diets for colon carcinogenesis on fecal microflora and steroids in man.

We investigated the effects of a high meat mixed Western diet and a nonmeat diet, representing the dietary pattern of high and low risk areas for colon cancer, respectively, on fecal microflora dn on bile acid and neutral sterol patterns in man. The total anaerobic microflora as well as the count of Bacteroides, Bifidobacterium, Peptococcus, and anaerobic Lactobacillus were significantly higher during the period of consumption of a high meat mixed Western diet comparted with the nonmeat-diet consumption period. The difference in total fecal bile acid excretion was not significant between the two dietary periods. Fecal excretion of microbially modified bile acids and neutral sterols was decreased when subjects eating a high meat diet transferred to a nonmeat diet. These results support the fact that diet plays a modifying role on the composition of intestinal microflora, bile acids, and neutral sterols.

Adult↗

Using research on the obesity pandemic as a guide to a unified vision of nutrition.

OBJECTIVE: To focus on factors that play a major role in our rapid, global nutritional changes. DESIGN: A range of studies are summarised: these show how an understanding of social, economic and technological change at the global, national and community levels affects diet, activity, and body composition patterns and trends. These studies are used to demonstrate the value of the key global, national, community, household and individual factors that should define the field of nutrition. SETTING: The focus is global. RESULT: Large shifts have occurred in diet and in physical activity patterns--particularly in the last one or two decades of the twentieth century. These changes are reflected in nutritional outcomes such as changes in average stature, body composition and morbidity. Understanding the rapidity of these changes and the underlying factors at the global, national and community levels is critical for creating a science of nutrition that can prevent disease and sustain the health and integrity of humans. CONCLUSION: The vision of the nutrition field is one where scholars who work on many levels will intersect; equal weight in the nutrition profession will be provided to all dimensions as they are welcomed into the field of nutrition--particularly those that will directly or indirectly affect dietary patterns, physical activity patterns, and energetics. This vision of the nutrition field is one where scholars from a range of disciplines and perspectives meet to work together with the goal being a focus on improving nutritional status and the human condition.

Diet↗

Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease.

Since no information is available on bone derangements in subclinical coeliac disease (CD), we evaluated bone mineral density (BMD, expressed as z score) at lumbar spine, by X-ray dual-photon absorptiometry, and serum indices of bone metabolism and remodeling in 14 subclinical or silent patients, 10 classical patients, and 15 healthy volunteers all on a gluten-containing diet. In the subclinical group, BMD at lumbar spine was significantly higher than in the classical group (-1.3 +/- 0.8, 73% vs. -2.6 +/- 0.6, 88%, respectively; p < 0.001), but significantly lower than in volunteers (+0.4 +/- 1.1, 104%; p < 0.001). Similar changes were observed in serum calcium, whereas, as regards parathyroid hormone, no significant difference was found between subclinical and classical patients. 25-vitamin D was significantly lower, and 1,25-vitamin D was significantly higher in subclinical and classical patients than in healthy volunteers. Indices of bone remodeling were higher in the subclinical and classical groups than in the volunteers, but lower in the subclinical than in classical patients. Eight subclinical and 8 classical patients were reexamined after a period of gluten-free diet (GFD), and in both groups BMD had significantly improved. Our results show that osteopenia is a frequent feature also in subclinical CD, although the extent of bone and mineral metabolism derangements is lower than in classical CD. GFD is able to normalize BMD in subclinical and to significantly improve it in classical patients.

Absorptiometry, Photon↗

Fatty acid patterns of human milk.

An analysis of the fatty acid content of 110 early morning samples of breast milk from 26 mothers shows a shift in the fatty acid pattern toward higher values for C 18:2 fatty acids than those reported previously. This shift has paralleled an increase in the use of vegetable oils and an increase in the P/S ratio of the American diet. The fatty acid pattern varied from day to day only for C 18:1. There were no significant variations among morning, midday, and evening values for samples provided by eight mothers.

Circadian Rhythm↗

Fecal excretion pattern of bile acids in rats fed high fat diets and neomycin in induced colon tumorigenesis.

Neomycin augments colon tumorigenesis in 1,2 - dimethylhydrazine treated rats fed polyunsaturated fat diet and decreases fecal cholic acid excretion, while it inhibits tumorigenesis with increased cholic acid and decreased deoxycholic acid excretions in rats fed high cholesterol diet. Participation of other fecal bile acids seems to be insignificant in relation to colon carcinogenesis.

1,2-Dimethylhydrazine↗

Development and partial metabolic characterization of a dietary cholesterol-resistant colony of rabbits.

A colony of New Zealand white rabbits has been developed which, when fed a cholesterol-supplemented diet, exhibit unusual resistance to hypercholesterolemia and atherosclerosis, disorders usually observed in normal cholesterol-fed rabbits. When resistant rabbits (RT) were fed a normal low cholesterol diet (ND), their plasma lipoprotein patterns were significantly different from those of normal rabbits (NR) fed the same diet. The low density lipoprotein cholesterol (LDL-c)/high density lipoprotein cholesterol (HDL-c) ratio and LDL-c/very low density lipoprotein cholesterol (VLDL-c) ratio were lower in the resistant rabbits. The hydrated density of HDL of the normal-responsive rabbits was greater than that of the resistant rabbits. LDL from resistant rabbits contained a lower proportion of esterified cholesterol and protein than LDL from normal rabbits. Peripheral mononuclear cells from resistant rabbits bound about 30% more 125I-labeled rabbit LDL than mononuclear cells from normal rabbits. These results demonstrate that the plasma cholesterol levels of these animals is at least partly under genetic control and that compositional differences exist between the major plasma lipoprotein classes of normal and resistant rabbits even during the ingestion of low-cholesterol diet. The results indicate that at least a part of the difference in the cholesterolemic responses between the two rabbit groups is due to an enhanced LDL uptake by the mononuclear cells, and presumably by other somatic cells of the resistant group.

Animals↗