Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Torso”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 775 records · Page 43Linked to original sources
PubMed1993

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase.

Formation of the tail region of the Drosophila larva requires the activities of the terminal class genes. Genetic and molecular analyses of these genes suggests that localized activation of the receptor tyrosine kinase torso at the posterior egg pole triggers a signal transduction pathway. This pathway, mediated through the serine/threonine protein kinase D-raf and the protein tyrosine phosphatase corkscrew, controls the domains of expression of the transcription factors tailless and huckebein. In this paper, we report the molecular and developmental characterization of mutations in the D-raf gene. We show that mutations that alter conserved residues known to be necessary for kinase activity are associated with a null phenotype, demonstrating that D-raf kinase activity is required for its role in torso signaling. Another mutation, D-rafPB26, which prematurely truncates the kinase domain shows a weaker maternal effect phenotype that is strikingly similar to the corkscrew maternal effect phenotype, suggesting that a lower amount of kinase activity decreases the terminal signaling pathway. Finally, molecular and developmental characterization of two mutations that affect the late D-raf zygotic function(s) implies a novel role for D-raf in cell fate establishment in the eye. One of these mutations, D-rafC110, is associated with a single amino acid change within the putative D-raf regulatory region, while the other, D-rafHM-7, most likely reduces the wild-type amount of D-raf protein.

Amino Acid Sequence↗
PubMed1995

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

Within the Drosophila embryo, tube and the protein kinase pelle transduce an intracellular signal generated by the transmembrane receptor Toll. This signal directs import of the rel-related protein dorsal into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. We show by immunolocalization that tube protein associates with the plasma membrane during interphase. We also find that tube sequences required for signaling interact with pelle in a yeast two-hybrid assay. We demonstrate that fusion of the pelle catalytic domain to the transmembrane receptor torso is sufficient to induce ventral fates; this activity is independent of Toll or tube. Lastly, we find that fusion of the tube protein to torso also induces ventral fates, but only in the presence of functional pelle. We propose a model wherein tube activates pelle by recruiting it to the plasma membrane, thereby propagating the axis-determining signal.

Animals↗
PubMed2000

Signaling specificities of fibroblast growth factor receptors in early Xenopus embryo.

Formation of mesoderm and posterior structures in early Xenopus embryos is dependent on fibroblast growth factor (FGF) signaling. Although several FGF receptors (FGFRs) are expressed in the early embryo, their respective role in these processes remains poorly understood. We provide evidence that FGFR-1 and FGFR-4 signals elicit distinct responses both in naive and neuralized ectodermal cells. We show that naive ectodermal cells expressing a constitutively active chimeric torso-FGFR-1 (t-R1) are converted into mesoderm in a Ras-dependent manner, while those expressing torso-FGFR-4 (t-R4) differentiate into epidermis without significant activation of Erk-1. In neuralized ectoderm, expression of t-R4 causes the up-regulation of the midbrain markers En-2 and Wnt-1, but not of the hindbrain nor the spinal cord markers Krox20 and Hoxb9. Mutation of tyr(776) in the phospholipase C-(gamma) binding consensus sequence YLDL of t-R4 completely abolishes En-2 and Wnt-1 induction. In contrast to t-R4, platelet derived growth factor (PDGF)-dependent FGFR-1 activation in neuralized ectodermal cells expressing a chimeric PDGFR-FGFR-1 receptor results in the expression of Krox20 and Hoxb9. A similar effect is observed when an inducible form of oncogenic Raf is expressed, therefore implicating FGFR-1 and Raf in the transduction of FGF-caudalizing signals in neural tissue. Our results suggest that FGFR-1 and FGFR-4 transduce distinct signals in embryonic cells, and mainly differ in their ability to activate the Ras/MAPK pathway.

Animals↗
PubMed1986

Heat loss from deer mice (Peromyscus): evaluation of seasonal limits to thermoregulation.

This paper investigates the influence of seasonal adaptations to thermoregulatory heat loss for deer mice (Peromyscus) during summer and winter. A general, mechanistic model of heat transfer through fur was evaluated for the structural properties of the fur of deer mice. The model was validated against heat production determined from mice exposed to a range of radiative (wall) temperatures (tr) at air temperatures (ta) of 15, 27 and 34 degrees C. Calculated heat loss from the appendages was subtracted from the measured heat production to yield heat loss from the furred torso. This calculated torso heat loss agreed closely with the predicted fur heat loss for all conditions, as shown by a regression slope near 1 (0.99). Simulations using models of fur and appendage heat loss reveal that the winter increase in thermogenic (heat production) capacity has a greater effect than changes in fur properties in expanding the limits to thermoregulation. Both wind and a clear night sky increase heat loss and can limit thermoregulation to air temperatures above those found in deer mice habitats during winter (-25 degrees C). Thus, despite seasonal adaptations, these simulations indicate that thermoregulation is not possible under certain winter conditions, thereby restricting deer mice to within the protected environment of the leaf litter or snow tunnels.

Acclimatization↗
PubMed2006

[11C]metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma.

BACKGROUND: Pheochromocytomas are rare tumors of chromaffin cells for which the optimal management is surgical resection. Precise diagnosis and localization may be elusive. We evaluated whether positron emission tomography (PET) scanning with the combination of [18F]fluorodeoxyglucose (FDG) and the norepinephrine analogue [11C]metahydroxyephedrine (mHED) would allow more exact diagnosis and localization. METHODS: Fourteen patients with suspected pheochromocytoma were evaluated by anatomical imaging (computed tomography or magnetic resonance imaging) and [131I]metaiodobenzylguanidine (MIBG) planar imaging. PET imaging was performed by using mHED with dynamic adrenal imaging, followed by a torso survey and FDG with a torso survey. Images were evaluated qualitatively by an experienced observer. RESULTS: Eight patients had pathology-confirmed pheochromocytoma. Of the other six, two patients had normal adrenal tissue at adrenalectomy, and the other four had subsequent clinical courses inconsistent with a diagnosis of pheochromocytoma. In four of eight patients with pheochromocytoma, MIBG failed to detect one or more sites of pathology-confirmed disease. The mHED-PET detected all sites of confirmed disease, whereas FDG-PET detected all sites of adrenal and abdominal disease, but not bone metastases, in one patient. MIBG and FDG-PET results were all negative in the six patients without pheochromocytoma. One patient with adrenal medullary hyperplasia had a positive mHED-PET scan. PET scanning aided the decision not to operate in three of six patients. The resolution of PET functional imaging was superior to that of MIBG. CONCLUSIONS: PET scanning for pheochromocytoma offers improved quality and resolution over current diagnostic approaches. PET may significantly influence the clinical management of patients with a suspicion of these tumors and warrants further investigation.

3-Iodobenzylguanidine↗
PubMed1995

Effect of swimming suit design on the energy demands of swimming.

Eight competitive male swimmers completed a standardized 365.8 m (400 yd) freestyle swimming trial at a fixed pace (approximately 90% of maximal effort) while wearing a torso swim suit (TOR) or a standard racing suit (STD). Oxygen uptake (VO2), blood lactate, heart rate (HR), and distance per stroke (DPS) measurements were obtained. In addition, a video-computer system was used to collect velocity data during a prone underwater glide following a maximal leg push-off from the side of the pool while wearing the TOR and STD suits. These data were used to calculate the total distance covered during the glides. VO2 (3.76 +/- 0.16 vs 3.92 +/- 0.18 l.min-1) and lactate (8.08 +/- 0.53 vs, 9.66 +/- 0.66 mM) were significantly (P < 0.05) lower during the TOR trial than the STD trial. HR was not different (P > 0.05) between the TOR (170.1 +/- 5.1 b.min-1) and STD (173.5 +/- 5.7 b.min-1) trials. DPS was significantly greater during the TOR (2.70 +/- 0.066 m.stroke-1) versus STD (2.58 +/- 0.054 m.stroke-1) trial. A significantly greater total distance was covered during the prone glide while wearing the TOR (2.05 +/- 0.067 m) compared to the STD (2.00 +/- 0.080 m) suit. These findings demonstrate that a specially designed torso suit reduces the energy demand of swimming compared to a standard racing suit which may be due to a reduction in body drag.

Adult↗
PubMed2005

Do current sports brassiere designs impede respiratory function?

PURPOSE: Although sports brassieres are more effective in limiting breast motion and related breast pain when compared with standard fashion brassieres, some females do not wear sports brassieres during physical activity, as they perceive them to be too tight around the torso, possibly impeding their performance during physical activity. The purpose of this study was to determine whether breast hypertrophy, breast momentum, and/or wearing a sports brassiere impeded respiratory function at rest and during physical activity. METHODS: Twenty-two active women completed standard resting spirometry maneuvers while not wearing a brassiere. All subjects then completed maximal cycle ergometer testing in two breast support conditions (sports brassiere and no brassiere (NB)), followed by submaximal treadmill exercise tests under three breast support conditions (sports brassiere, no brassiere and fashion brassiere) while standard spirometry, brassiere pressure and comfort were measured. RESULTS: The sports brassiere imparted significantly more pressure on smaller breasted females' torsos when compared with the fashion brassiere (0.861 +/- 0.247 and 0.672 +/- 0.254 N.cm(-2), respectively), although this increased pressure did not appear to significantly affect measured lung volumes or brassiere comfort scores. Brassiere size affected maximal exercise ability (relative VO(2peak): smaller breasted NB: 49.84 +/- 6.15 mL.kg(-1).min(-1); larger breasted NB: 40.76 +/- 4.47 mL.kg(-1).min(-1)) as well as some temporal measures of resting and submaximal respiration. However, no significant difference was found between the no brassiere and brassiere conditions in regards to measured lung volumes. CONCLUSIONS: As no significant restriction to exercise performance or respiratory mechanics was found when subjects wore sports brassieres, it was concluded that active females should wear a sports brassiere during physical activity to reduce breast motion and related breast pain.

Adult↗
PubMed1981

Applications of multipole expansion.

With use of a homogeneous torso model, dipole and quadrupole sensitivity was determined for unipolar leads from many sites on the thoracic surface. Representatives of non-dipolar maps were obtained from the sensitivity of each of unipolar leads to the 5 rectangular components of the quadrupole. Over-all sensitivity to the quadrupole or the magnitude of the lead tensor was calculated from the measurements and mapped over the torso surface. This map indicates relative proximity of the thoracic surface and gives a theoretical basis for the selection of electrode locations in the surface mapping technique.

Electrocardiography↗
PubMed1987

The body surface distribution of the QT interval in patients with previous myocardial infarction and normal subjects.

In spite of the clinical importance of the QT interval, its body surface distribution is still unclear. To determine the spatial distribution of the QT interval, we studied 20 normal subjects and 45 patients with previous myocardial infarction (25, anterior; 20, infero-posterior). Unipolar electrocardiograms were recorded from 87 torso sites. The QT interval in each lead was determined semi-automatically. In normal subjects, the longer QT intervals were located on the left anterior chest and the right shoulder portion. And, the relatively shorter QT intervals were shown on the right inferior chest. In the anterior MI group, the remarkably longer QT intervals were located on the left anterior chest. In the infero-posterior MI group, the longer QT intervals were found on the left lateral and back. In both MI groups, the sites of longer QT intervals corresponded to the sites of infarcted area. In the aneurysm (+) subgroup of the anterior MI group, the remarkably longer QT intervals could be found on the left anterior chest, while in the aneurysm (-) subgroup, these characteristic patterns could not be recognized. Our data suggest that QT intervals are not equal on a torso. In patients with myocardial infarction, the sites of prolonged QT intervals corresponded to the sites of infarcted area. The QT interval was thought to have some bearing on the abnormal repolarization of the residual myocardium in the infarcted area.

Aneurysm↗
PubMed1995

Non-destructive elemental analysis of vertebral body trabecular bone using muonic X-rays.

Non-destructive elemental analysis with muonic X-rays was performed on human vertebral bone and lumbar torso phantoms. It can provide quantitative information on all elements in small deep-seated localized volumes. The experiment was carried out using the superconducting muon channel at TRIUMF in Vancouver, Canada and a lithium drifted germanium detector with an active area of 18.5 cm2. The muon channel produced backward-decayed negative muons with wide kinetic energy range from 0.5 to 54.2 MeV. The muon beam was collimated to a diameter of 18 mm. The number of incoming muons was about 4 x 10(6) approximately 5 x 10(7) per data point. In the measurements with human vertebral bones fixed with neutralized formaldehyde, the correlation coefficient between calcium content measured by muons and by atomic absorption analysis was 0.99 and the level of significance was 0.0003. In the measurements with lumbar torso phantoms, the correlation coefficient between calcium content measured by muons and by atomic absorption analysis was 0.99 and the level of significance was 0.02. The results suggest that elemental analysis in vertebral body trabecular bone using muonic X-rays closely correlates with measurements by atomic absorption analysis.

Adolescent↗
PubMed1996

Patient dose measurements from femoral angiography.

Investigation of patient dose from femoral angiography requires detailed logging of dose-area product (DAP) measurements, which is time-consuming and only possible on small numbers of patients. A simple model for the femoral angiogram study consists of two regions; lower limbs and torso. The experimental phantom was the abdominal and pelvic sections of a Rando phantom, and two 10 cm diameter water filled cylinders to represent a lower limb. DAP rate during screening, and the DAP per spot film exposure were obtained in two rooms. Total DAP values were measured on 100 patients in each room. The median screening time and number of spot film exposures were divided between the two regions. The DAP from screening and spot films for each region was estimated by combining the phantom and patient data. The total DAP predicted by the model agreed to within 7% of the median DAP from the patient studies Conversion to effective dose gave 9.0 mSv for the newer room compared with 2.8 mSv for the older room. In the newer room it was estimated that digital spot film exposure contributed 88% of the total effective dose. In the same room, exposure of the torso contributed 98% of the total effective dose. The model will enable interpretation of total DAP measurements made from femoral angiogram studies without the need for detailed DAP measurements on every patient. Attempts to reduce patient dose from femoral angiography must concentrate on reduction of the number and dose per exposure from abdominal and pelvic digital spot films.

Femoral Artery↗
PubMed1991

Noninvasive measurement of central venous pressure by neck inductive plethysmography.

Bedside estimation of the height at which the internal jugular veins collapse, referenced to a standard hemodynamic location, theoretically reflects central venous pressure. This method has never been demonstrated as accurate when compared to invasive CVP measurements because of the great clinical skills and time required to visually identify the internal jugular venous waveform. Since the principles of the bedside method are sound, we utilized them in conjunction with the neck inductive plethysmograph, a device which has the capability of recording internal jugular venous and carotid arterial waveforms. The respiratory distortion of these vascular waveforms was eliminated by employing a digital bandpass filter, making it easy to identify the venous and arterial waveforms on the videoscreen of a personal computer. The upper torso was positioned while observing the videoscreen until the vascular waveform was seen as a mixed arteriovenous waveform, signifying intermittent internal jugular venous collapse. The height of the internal jugular vein above the phlebostatic axis was obtained by external measurement and recorded as CVPni in cm H2O. In 43 patients, 86 percent of CVPni (NIP) values fell within 20 percent CVPi (invasive catheter measurements) over a range of CVP from 0 to 19 cm H2O. In an additional seven patients, CVPi was greater than the height that the upper torso could be elevated and an arterial waveform could not be obtained. Here, CVPni was recorded as the value at least exceeding the value measured. In two other patients, obstruction of an internal jugular vein gave spuriously low values of CVPni. Our study indicates that this new neck inductive plethysmographic method is accurate compared to invasive catheter measurements of CVP and should serve as a safe, noninvasive alternative in situations where such measurements are required.

Adult↗
PubMed2002

Numerical calculations of switched magnetic field gradients during magnetic resonance imaging.

During magnetic resonance imaging (MRI) pulse-sequences the human body is exposed to switched magnetic gradient fields. These gradients become stronger and are switched faster for fast imaging. Effects resulting from these fields with trapezoidal waveforms are on the one hand sensory perception of induced currents and on the other hand muscular and cardiac stimulation. All three components of the current density induced by gradient pulse sequence were analysed in a high-resolution model of the human torso. The evaluation of the calculated data was performed thoroughly in the region of the heart muscle of the torso model to find out how different waveforms of the switched gradient field influence strength and direction of induced currents.

Electrocardiography↗
PubMed2000

Effects of vehicle interior geometry and anthropometric variables on automobile driving posture.

The effects of vehicle package, seat, and anthropometric variables on posture were studied in a laboratory vehicle mockup. Participants (68 men and women) selected their preferred driving postures in 18 combinations of seat height, fore-aft steering wheel position, and seat cushion angle. Two seats differing in stiffness and seat back contour were used in testing. Driving postures were recorded using a sonic digitizer to measure the 3D locations of body landmarks. All test variables had significant independent effects on driving posture. Drivers were found to adapt to changes in the vehicle geometry primarily by changes in limb posture, whereas torso posture remained relatively constant. Stature accounts for most of the anthropometrically related variability in driving posture, and gender differences appear to be explained by body size variation. Large intersubject differences in torso posture, which are fairly stable across different seat and package conditions, are not closely related to standard anthropometric measures. The findings can be used to predict the effects of changes in vehicle and seat design on driving postures for populations with a wide range of anthropometric characteristics.

Anthropometry↗
PubMed2006

A laboratory study of the effects of wrist splint orthoses on forearm muscle activity and upper extremity posture.

OBJECTIVE: To evaluate the effects of wrist splint orthoses (WSOs) on forearm muscle activity and upper extremity/torso postures. BACKGROUND: WSOs are ubiquitous in industry, but the literature as to their biomechanical effects is limited. METHOD: Study 1: Participants performed single-plane wrist exertions with or without a WSO while the electromyographic (EMG) activity of the flexor carpi radialis, flexor carpi ulnaris, and extensor carpi ulnaris was captured. Study 2: Participants performed simple computer jumper installation tasks with or without a WSO while upper extremity/torso postures were recorded. RESULTS: Study 1: A significant interaction between WSOs and wrist angle was observed in the response of forearm muscles (e.g., normalized EMG of the flexor carpi radialis increased from 4.2% to 15.9% as flexion increased from 0 degree to 36 degrees in the orthosis conditions, whereas in the no-orthosis condition it remained approximately 5% at all wrist flexion angles). Study 2: WSOs were found to effect wrist, torso, and shoulder postures, with the orthoses creating a 48% decrease (36 degrees vs. 18.6 degrees) in wrist flexion and 80% decrease (15 degrees vs. -3 degrees) in ulnar deviation but at a cost of increased shoulder abduction of 22% (36.5 degrees vs. 44.5 degrees) and increased lateral bend of torso of 30% (6 degrees vs. 7.8 degrees). CONCLUSIONS: WSOs increased forearm muscle activity at large wrist deviation angles and induced awkward shoulder postures in tasks requiring significant wrist deviation. APPLICATION: Use of WSOs in occupational settings should be carefully considered relative to task requirements, as orthoses may do more harm than good.

Adult↗
PubMed2005

Electromyographical analysis and comparison of selected abdominal training devices with a traditional crunch.

The present study compared the muscle activity elicited by selected abdominal training devices with muscle activity elicited by a traditional crunch. Forty-six adults participated in the study. The exercise devices tested included the Ab-ONE, Perfect Abs Roller, Ab Scissor, Ab Swing, 6SecondAbs, and the Torso Track. For those devices with variable resistances, all were tested at their high resistance setting. Surface electromyography (EMG) was recorded from the upper and lower portions of the rectus abdominis and the external oblique during each repetition. EMG values were analyzed using repeated measures analyses of variance (ANOVA) and pairwise comparisons. EMG measurements for each abdominal muscle analyzed were highly reliable and differed significantly across the exercises tested. Muscle activity for the upper and lower portions of the rectus abdominis for a normal crunch was lower than for the Ab-ONE, the same as for the Perfect Abs Roller, and higher than for the Ab Scissor, Ab Swing, 6SecondAbs, and Torso Track. External oblique muscle activity for a traditional crunch was higher than for the Perfect Abs Roller and did not differ from the other devices. These results support previous findings that portable abdominal devices are most effective if they not only mimic the mechanics of a traditional crunch, but also provide external resistance to increase involvement of the abdominal musculature.

Abdominal Muscles↗
PubMed2005

Configural processing of biological motion in human superior temporal sulcus.

Observers recognize subtle changes in the movements of others with relative ease. However, tracking a walking human is computationally difficult, because the degree of articulation is high and scene changes can temporarily occlude parts of the moving figure. Here, we used functional magnetic resonance imaging to test the hypothesis that the superior temporal sulcus (STS) uses form cues to aid biological movement tracking. The same 10 healthy subjects detected human gait changes in a walking mannequin in two experiments. In experiment 1, we tested the effects of configural change and occlusion. The walking mannequin was presented intact or with the limbs and torso apart in visual space and either unoccluded or occluded by a set of vertical white bars. In experiment 2, the effects of inversion and occlusion were investigated, using an intact walking mannequin. Subjects reliably detected gait changes under all stimulus conditions. The intact walker produced significantly greater activation in the STS, inferior temporal sulcus (ITS), and inferior parietal cortex relative to the apart walker, regardless of occlusion. Interestingly, STS and ITS activation to the upright versus inverted walker was not significantly different. In contrast, superior parietal lobule and parieto-occipital cortex showed greater activation to the apart relative to intact walker. In the absence of an intact body configuration, parietal cortex activity increased to the independent movements of the limbs and torso. Our data suggest that the STS may use a body configuration-based model to process biological movement, thus forming a representation that survives partial occlusion.

Adult↗
PubMed1997

Solar protection of children at the beach.

BACKGROUND: Excessive sun exposure during childhood has been associated with subsequent development of skin cancers. Children have been advised to avoid sun exposure, use protective clothing, and apply sunscreen lotions, but how completely these recommendations are followed has not been studied. OBJECTIVE: To determine the extent of sun protection among children visiting lake beaches, the methods used, and the characteristics associated with more protection. DESIGN: Direct observations of children were linked with concurrent care giver/parent interviews. SUBJECTS/SETTING: A total of 871 children 2 to 9 years of age and their parents/care givers at freshwater beaches in 10 small New Hampshire towns during July and August 1995. OUTCOME MEASURES: Protection of the head, torso, and legs according to method used (hats, shirts, pants, sunscreen, or shade). RESULTS: Fifty-four percent of children were protected by at least one method for all three body surface regions, although 17% had no protection for any region. Sunscreen was used either alone or in combination with clothing for at least one region in 79%. Hats were used by 3%, shirts by 22%, and pants to the knee by 49%. Only 12% of observed children were in the shade. The region that was protected most often was the legs for boys (due to swim suit styles) followed by the torso for both sexes. The region most often unprotected was the legs for girls followed closely by the face for both boys and girls. Girls were significantly more likely to have no protection (31.2% female vs 7% male, chi2 83.3) due to better leg protection from swim trunks to the knees popular with boys. Full protection of all three regions was more common for children younger than 5 (odds ratio [OR] = 1.8, 95% confidence interval, [CI] 1.3-2.5), for children perceived to usually or always burn (OR = 2.0, 95% CI 1.4-2.7), for children whose parents had more than a high school education (OR = 1.8, 95% CI 1.3-2.5), and if the parents indicated receiving sun protection information from a school or clinician during the previous year (OR = 1.7, 95% CI 1.2-2.3). Approximately 51.6% of parents recalled receiving childhood solar protection advice in the past year from either their physician, a nurse, or a school/day care setting. CONCLUSIONS: Sunscreen provided the most common form of solar protection. Hats and shade were used rarely, and shirts were also underused. Although the sun protection of these children visiting the beach was substantial, nearly half were still not fully protected. Clinician advice within the past year was associated with better protection. Clinicians could increase their influence by providing more specific counseling about how to achieve full protection. Use of multiple methods of protection rather than just sunscreen and full protection rather than protection for just one or two body regions should be emphasized. It is helpful to remind families to protect the regions most frequently omitted from protection: girls' legs and boys' and girls' faces. Advice can be enhanced with patient education materials such as included in the "Slip" (on a shirt), "Slop" (on sunscreen), and "Slap" (on a hat) program developed in Australia and available through the American Cancer Society.

Adult↗