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At least 775 records · Page 43Linked to original sources
PubMed1981

Non-invasive thymoma with widespread blood-borne metastasis.

A 49 year-old woman with multiple coin lesions in both lungs died three months after admission to hospital for progressive neurologic manifestations due to increasing intracranial pressure. At autopsy, neoplastic lesions were found in the anterior mediastinum, lungs, spleen, cerebrum, liver, right kidney and right ovary. Microscopically, the tumor was composed predominantly of epithelial cells which were arranged in an hemangiopericytoma-like pattern. Rosette formation was also prominent. This case was diagnosed as a thymoma with widespread blood-borne metastasis. Previous reports of metastasizing thymomas are very uncommon.

Brain Neoplasms↗
PubMed1990

Massive bleeding after fine needle aspiration of liver angiosarcoma.

Open or closed biopsy of liver angiosarcoma is a life-threatening procedure. A case of massive bleeding after fine needle aspiration of the liver is reported in a patient having an angiosarcoma of the liver and spleen. Fine needle aspiration seems a hazardous procedure in this disease.

Abdomen↗
PubMed1989

En bloc resection for contiguous upper abdominal invasion by adenocarcinoma of the colon.

Although en bloc resection for contiguous invasion by adenocarcinoma of the colon is a well-recognized principle, it is difficult to assess the efficacy of this principle when upper abdominal viscera are involved. This study was undertaken to better define this subgroup. Seventeen patients were studied over a period of 20 years who underwent extended resections for colonic adenocarcinoma with upper abdominal organ invasion. The age range was 30 to 81 years (average, 61 years). There was a male-to-female ratio of greater than 2:1. The duration of presenting symptoms was as short as 4 days and as long as 18 months (average, 4.3 months). The most common complaint was weight loss (13/17). The next most common complaints were abdominal pain (10/17), bowel complaints (5/17), and septic symptoms (4/17). A single organ was involved in 7 instances, but multiple organs were involved in most cases. The frequency of involvement was the stomach, spleen, and duodenum (5 each), abdominal wall and diaphragm (4 each), pancreas and liver (3 each). There were 2 perioperative deaths and 9 other major complications. The most common cause of morbidity and mortality was septic in nature in 8 of the 11 instances. All 3 patients with pancreatic resections had postoperative complications; none were fatal. Five patients survived over 10 years, three were 5-year survivors, and two are living and free of disease at less than 5 years. Excluding the two perioperative deaths, four of the five patients who died in less than 5 years had documented recurrences.

Abdominal Neoplasms↗
PubMed1976

Mesothelioma of spermatic cord: electron microscopic and histochemical characteristics of its mucopolysaccharides.

A mesothelioma of the spermatic cord occurred at the site of multiple hernial repairs. The aggressive biologic behavior of this tumor is exhibited by its early lymph node invasion and extensive metastases to the pleural cavities, lungs, and spleen. These tumor cells contained a large amount of stable of stable glycogen-like carbohydrate insoluble in formalin and tolerating postmortem changes. Electron microscopy revealed features similar to those mesotheliomas arising from body cavities.

Female↗
PubMed1996

Metastasis-related cell functions in primary and metastatic tumor cells of AKR lymphoma.

The metastatic phenotype is of extreme complexity. To complete all the stages of metastasis, the tumor cell must possess a whole series of functional abilities. Multiple biological markers are therefore needed to achieve a deeper understanding of the metastatic phenotype. In the present study we compared primary (PT) to metastatic tumor (MT) cells of two AKR lymphoma variants with respect to several cellular functions relevant to various steps of tumor dissemination. The MT cells of the TAU-44 variant had a higher capacity than the PT cells to attach to endothelial monolayers and ECM, exhibited a more elevated motility and a higher capacity to grow in the spleen as a metastatic target organ. However, the TAU-44-MT cells had a lower ability to grow in the kidney than the PT cells. The TAU-33-MT cells had a higher ability to attach to endothelial cells and to grow in both spleen and kidney but were less motile compared to PT cells. Metastatic cells showed, on the whole, higher ability to perform in most, but not all, stage-specific models than primary tumor cells.

Animals↗
PubMed2004

Isolated diffuse hemangiomatosis of the spleen: case report and review of literature.

Small localized hemangiomas are common neoplasms of the spleen. Isolated diffuse splenic hemangiomatosis, however, is very rare. This lesion can be accompanied by severe hypersplenism and other complications. We report on a case with significant splenomegaly caused by diffuse hemangiomatosis, which was an incidental finding without any clinical disorders. After splenectomy, the normal parenchyma was found to be widely replaced by multiple spongy nodules. Histologically, cavernous vessels were distributed throughout the whole organ, with endothelial cells expressing vimentin, factor VIII and CD 31, but not CD8. Splenic sinus lining cells exhibited a strongly positive reaction with CD8, which became faint and disrupted in highly dilated sinuses in the vicinity of cavernous vessels. In some areas, there seemed to be a gradual transition from cystically dilated splenic sinuses to cavernous vessels. The differential diagnosis must consider other splenic vascular tumors, such as littoral cell angioma, lymphangioma, peliosis of the spleen, and hamartoma. The pathogenesis of diffuse splenic hemangiomatosis is controversial, and a malformative or neoplastic origin is under debate. A derivation from splenic sinusoidal cells was suggested by some authors, but was rejected by others. Our findings cannot exclude a neoplastic origin from splenic sinuses but, finally, the etiology and pathogenesis of this vascular lesion remain uncertain.

Adult↗