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PubMed2003

Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus).

Highly efficient and practical methodology for the syntheses of D- and l-4,5-O-isopropylidene-2-cyclopentenone (9 and 22), versatile intermediates for the synthesis of carbocyclic nucleosides, have been developed via a ring-closing metathesis reaction from d-ribose in eight steps. The utility of D- and l-4,5-O-isopropylidene-2-cyclopentenone is demonstrated by their application for the preparation of D-cyclopentyl-6-azauridine 12 and D-cyclopentenyl-5-halocytosine nucleosides (33-35) using Mitsunobu reaction to introduce pyrimidine bases as potential antiviral agents. Preliminary antiviral activity against orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosides are described.

Antiviral Agents↗

PubMed1985

Beyond smallpox eradication.

This paper highlights 2 important, under-recognized lessons of the Smallpox Eradication Program (SEP). The 1st lesson is that the discipline and enthusiasm of that vertical campaign could be applied to an attack on several high priority diseases or conditions simultaneously, to great advantage. The 2nd lesson is that eradication of selected diseases remains a uniquely useful tool for advancing the public's health.

Communicable Diseases↗

PubMed1979

[Use of immobilized proteinases for purification of sheep smallpox virus].

A possible use of papain and trypsin immobilized on Biogel P-100 for purification of DNA-containing sheep smallpox viruses was studied. It was shown that the enzymes depolymerize tissue proteins, resulting in a 90% purification of the viruses without causing any considerable morphological changes in the virion structure. It was concluded that fixed proteinases can be effectively used at the final stage of purification of tissue virus-containing suspensions.

Animals↗

PubMedDate not supplied

[Detection of smallpox antibodies in human serum using the labeled-antibody technic].

Ninety-seven samples of human sera with various amounts of smallpox antibody were simultaneously compared in ELISA and HI test, and 26 of them were also studied in NT. Alongside with HI and NT, ELISA was shown to be highly sensitive and reproducible, and useful for simultaneous examination of a large number of sera.

Antibodies, Viral↗

PubMed1963