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Computers↗
PubMed1979

Computerized gas-liquid chromatographic method for content uniformity analysis of dicyclomine hydrochloride capsules and tablets.

An automated, computerized method is presented for the content uniformity determination of dicyclomine hydrochloride capsules and tablets, using up to 4 automatic sampler-equipped gas chromatographs interfaced with a minicomputer. A 3% OV-17 column is used with anthracene as an internal standard. Five sample injections are bracketed by standard mixtures containing about 90 and 110% of the labeled dicyclomine hydrochloride. Data are taken on-line simultaneously from each gas chromatograph and a computer-generated report is produced. Calculations use a BASIC program with linear fit of the 90 and 110% standard mixture. Individual tablet or capsule results are printed in milligrams and per cent declared, including summary calculations of average, high, low, standard deviation, and coefficient of variation. The GLC results are comparable (within 1%) to those obtained using the USP procedure.

Autoanalysis↗
PubMed1980

[Number of retinal ganglion cells and visual discriminative performance in split-chiasma rats].

The relationship between post-operative retention, learning and transfer of visual discriminative tasks and number of retinal ganglion cells undegenerated after chiasma section was analyzed with a multiple linear regression program, stepwise procedure. Post-op retention of an intensity discrimination task significantly depends on the number of retinal ganglion cells in the most spared eye. Post-op learning and transfer of an orientation discrimination task significantly depends on 1) the total number of undegenerated ganglion cells and 2) their uniform distribution in both eyes.

Animals↗