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Occlusion versus air exposure on full-thickness biopsy wounds.

The benefits of moisture-retaining dressings on wound healing are well documented in experimental animal models but not in humans. To examine the effect of occlusion, the effects of three brands of synthetic occlusive dressings (Comfeel Plus, DuoDerm CGF, OpSite) were compared with air exposure in epithelial resurfacing and proliferation in acute, full-thickness skin wounds in humans. In 10 healthy males, four 4 mm standardised wounds were made with a sterile punch biopsy on each lower extremity. Epithelialisation of the wounds was assessed histologically and blindly postwounding on days 7 and 14. Wound margin epidermal proliferation was evaluated immunohistochemically with Ki67. Epithelial percentage coverage increased significantly (p = 0.007) with the occlusive dressings (62 +/- 6%, mean +/- SEM), compared with air exposure, (39 +/- 7%) on day 7 but not on day 14 (p = 0.500). Epidermal cell proliferation showed no significant intergroup difference on either day. Treatment with occlusive dressings increased early epithelial migration of acute full-thickness biopsy wounds compared with air exposure in healthy men.

Adult↗

Treatment of psoriasis with triamcinolone acetonide 0.1% under occlusion: a comparison of two hydrocolloid dressings.

A clinical, randomized, parallel study was undertaken to compare the efficacy of a widely known steroid preparation, triamcinolone acetonide 0.1% cream, in occlusion with two different hydrocolloid dressings, namely Duoderm and Actiderm, in the treatment of chronic plaques of psoriasis. A total of 23 patients with psoriasis were entered in the study. Two similar psoriatic plaques were identified in each patient, triamcinolone acetonide cream was applied, and a randomized table assigned the sides of the body to which each dressing was to be used for each patient. Changing of the dressing, with reapplication of the cream was done every 48 hours on each side until the lesions cleared or for a maximum of three weeks. At the end of the three weeks-therapy, period, 12 lesions had totally cleared with Duoderm and 13 with Actiderm. Seven lesions had achieved either marked or moderate improvement with duoderm and the same results were observed with Actiderm. Only three of 22 had mild improvement with Duoderm and two of 22 with Actiderm. No side effect were noted and none of the patients became worse during this treatment. This study demonstrated the beneficial effects of triamcinolone acetonide 0.1% cream under occlusion with two different hydrocolloid dressings in the treatment of chronic resistant plaques of psoriasis. The use of a hydrocolloid dressing in combination with steroid adds another therapeutic option for the treatment of chronic localized psoriatic lesions.

Adolescent↗

Different demand on temporary skin substitutes for different indications.

In the past, the authors centred their attention on the effect of various skin substitutes on dermal burns. In the present study, the effect of various synthetic and biological skin substitutes on full thickness skin defects was studied. Experiments were carried out on laboratory pigs; the effect of various materials was evaluated in excised full thickness burns and in tangentially excised dermal burns. A parallel study was carried out in burned patients. It was concluded that for different indications, different qualities (or properties) of temporary skin substitutes are desirable or preferable. None of the materials available to date has all desirable qualities for all types of skin defects.

Animals↗

Synthetic membranes. Use in diabetic ulcers.

Diabetic ulcers may increase patient morbidity and mortality, necessitating fast and effective treatment to obtain wound closure. Synthetic membranes, when appropriately used, provide a simple and efficient means of treating more superficial lesions. When used as an adjunct to proper wound debridement and care, successful closure can be expected.

Biocompatible Materials↗

[Primary closure of split thickness skin donor sites using surgical foil].

The advantages of using an operation foil for wound dressing when split thickness skin grafts have been taken are presented. For some years we have used an air and steam permeable plastic foil for wound dressing in cases where split thickness skin grafts have been taken. The advantages of this procedure in our opinion are: It minimizes postoperative pain. It allows inspection of the wound whenever it appears desirable because of the transparency of the foil. It reduces the cost of wound dressing and also nursing procedures.

Humans↗